Mitochondrial biology expression arrays

ABSTRACT

This invention provides a library of genes involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of using such arrays. Genes and probe sequences involved in mitochondrial biology in humans and mice are provided. The arrays of this invention are useful for determining mitochondrial biology gene expression profiles. Mitochondrial biology gene expression profiles are useful for determining expression profiles diagnostic of physiological conditions; diagnosing physiological conditions; identifying biochemical pathways, genes, and mutations involved in physiological conditions; identify therapeutic agents useful for preventing and/or treating such physiological conditions; evaluating and/or monitoring the efficacy of such therapies, and creating and identifying animal models of human physiologic conditions. Arrays containing probes for all genes known to be involved in mitochondrial biology are provided, as well as arrays containing subsets of such probes.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Patent Application Ser. No. 60/316,323 filed Aug. 30, 2001, and to Canadian Patent Application Serial No. 2,356,540 filed Aug. 31, 2001, both of which is hereby incorporated in their entirety by reference to the extent not inconsistent with the disclosure herein.

BACKGROUND OF THE INVENTION

Mitochondrial disorders are a complex and polygenic group of conditions with the patient's symptoms varying due to differences in energetic threshold effect of various tissues and the stochastic nature of mtDNA segregation. Consequently, most mitochondrial disorders are best classified by their genetic cause rather than a biochemical or phenotypic profile (Shoffner, J. M., and Wallace, D. C., (1995) “Oxidative phosphorylation diseases,” In The Metabolic and Molecular Basis of Inherited Disease, C. R. Scriver, A. L. Beaudet, W. S. Sly and D. Valle, eds. (New York: McGraw-Hill), pp.1535-1609; Wallace, D. C., (1999) “Mitochondrial diseases in man and mouse” Science 283:1482-1488). Many mitochondrial diseases result from mutations in nuclear genes and a subset of these are known to act by destabilizing the mitochondrial genome. (Graham, B. et al., “A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/skeletal muscle isoform of the adenine nucleotide translocator,” [1997] Nature Genetics 16:226-234; Shoffner, J. M., and Wallace, D. C., “Oxidative phosphorylation diseases. Disorders of two genomes,” [1990] Advances in Human Genetics 19:267-330; Zhu, Z. et al., “SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh's syndrome” [1998] Nature Genetics 20:33743).

The analysis of mitochondrial function in cultured cells using somatic cell genetics has been instrumental in the characterization of human mitochondrial disorders. Ethidium bromide and R-6G treatment have been used to create ρ0 and mitochondria-less cell lines to analyze the maternal inheritance and biochemical phenotypes of many human mtDNA mutations (Chomyn, A. et al., “In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria,” [1991] Molecular and Cellular Biology 11:2236-2244; Jun, A. S. et al., “Use of transrnitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia,” [1996] Molecular and Cellular Biology 16:771-777; King, M. P. et al., “Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA Leu(UUR) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes,” [1992] Molecular and Cellular Biology 12:480490; Trounce, I. et al., “Cytoplasmic transfer of the mtDNA nt 8993 TG [ATP6] point mutation associated with Leigh's syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio,” [1994] Proc. Natl. Acad. Sci. U.S.A. 91:8334-8338). The creation of cybrid cell lines with identical nuclear backgrounds but different mtDNA genotypes allows the comparison of one mtDNA mutant to another without the potential interference of nuclear genome polymorphisms. These cybrid lines have generally been analyzed using biochemical techniques such as assaying cellular respiration or respiratory complex specific activities by enzymology. Some gene expression studies have been performed, but they have generally been done on single or small groups of genes (Heddi, A. et al., “Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP,” [1993] J. Biological Chemistry 268:12156-12163; Heddi, A. et al., “Coordinate induction of energy gene expression in tissues of mitochondrial disease patients” [1999] J Biol Chem 274:22968-76).

Gene expression has been extensively studied. Although the regulation of mRNA abundance by changes in transcription or RNA degradation is by no means the only mechanism that regulates protein levels in a cell, virtually all differences in cell type or state can be correlated to changes in the mRNA abundance of several genes (Alizadeh, A. A. et al., “Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling,” [2000] Nature 403:503-11; DeRisi, J. L. et al., “Exploring the metabolic and genetic control of gene expression on a genomic scale,” [1997] Science 278:680-686; Schena, M. et al., “Quantitative monitoring of gene expression patterns with a complementary DNA microarray” [1995] Science 270:467-70; Schena, M. et al., “Parallel human genome analysis: microarray-based expression monitoring of 1000 genes” [1996] Proc Natl Acad Sci USA 93:10614-9; Wallace D. C., grant abstract #2R01N502328-18; Kerstann, K. W. [2000] American Society for Human Genetics Abstract #1484; Kokoszka, J. E. [2000] American Society of Human Genetics Abstract #1618; Levy, S. E. [2001] American Society of Human Genetics Abstract #1501; Levy, S. E. [2000] “Genetic Alteration of the Mouse Mitochondrial Genome and Effects on Gene Expression,” Ph.D. Thesis, Emory University; Coskun, P. E. [2000] American Society of Human Genetics Abstract #1616; Sligh, J. E. [2000] American Society for Human Genetics Abstract #53; Murdock, D. G. [2000] American Society for Human Genetics Abstract #55; Levy S. E. [2000] Keystone Symposia Abstract 119; Wallace, D. C., Ellison Medical Foundation, Senior Scholar Award in Aging).

DNA microarray analysis has been used to study diffuse large B-cell lymphoma (DLBCL) where microarrays were used to expand the diagnosis of DLBCL (Alizadeh, A. A. et al., “Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling,” [2000] Nature 403:503-11). While standard histological and morphological techniques had defined subsets of DLBCL, array analysis revealed two clinically distinct classes. These two newly discovered classes were indistinguishable by standard pathology, but expression analysis showed a differential expression of hundreds of genes. Correlation of these molecular differences with differences in the progression of the disease and clinical outcome has revealed that these two classes of DLBCL could be considered separate diseases (Alizadeh, A. A. et al., “Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling,” [2000] Nature 403:503-11).

Mitochondrial DNA sequences have been associated with pathologies as described in U.S. Pat. Nos. 5,670,320, 5,296,349, 5,185,244, and 5,494,794. Publications on the subject of mitochondrial biology include: Scheffler I. E. (1999) Mitochondria, Wiley-Liss, New York; Lestienne, P., Ed. (1999) Mitochondrial Diseases: Models and Methods, Springer-Verlag, Berlin; Methods in Enzymology (2000) 322:Section V Mitochondria and Apoptosis, Academic Press, California; Mitochondria and Cell Death (1999) Princeton University Press, New Jersey; Papa S, Ferruciio G, and Tager J Eds. (1999) Frontiers of Cellular Biometics: Molecular Biology, Biochemistry, and Physiopathology, Kluwer Academic/Plenum Publishers, New York; Lemasters J and Nieminen A (2001) Mitochondria in Pathogenesis, Kluwer Academic/Plenum Publishers, New York; MITOMAP, http://www.gen.emory.edu/cgi-gin/MITOMAP; Wallace D. C. (2001) “A mitochondrial paradigm for degenerative diseases and aging,” Novartis Foundation Symposium 235:247-266; Wallace D C “Mitochondrial DNA in Aging and Disease” (August 1997) Scientific American 277:40-47; Wallace D. C. et al., “Mitochondrial biology, degenerative diseases and aging,” (1998) BioFactors 7:187-190; Heddi, A. et al., “Coordinate Induction of Energy Gene Expression in Tissues of Mitochondrial Disease Patients” (1999) JBC 274:22968-22976; Wallace, D. C. “Mitochondrial Diseases in Man and Mouse,” (1999) Science 283:1482-1488; Saraste, M. “Oxidative Phosphorylation at the fin de siecle” (1999) Science 283:1488-1493; Kokoszka et. al., “Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis,” (2001) PNAS 98:2278-2283; Wallace, D. C. (2001) Mental Retardation and Developmental Disabilities 7:158-166; Wallace D. C. (2001) Am. J Med. Gen. 106:71-93; and Wallace, D. C. (2001) EuroMit 5 Abstract.

The analysis of mitochondrial disorders has traditionally consisted of molecular and biochemical descriptions of the defect (Shoffner, J. M., and Wallace, D. C., (1995) “Oxidative phosphorylation diseases,” In The Metabolic and Molecular Basis of Inherited Disease, C. R. Scriver, A. L. Beaudet, W. S. Sly and D. Valle, eds. (New York: McGraw-Hill), pp. 1535-1609). Only a limited number of analyses of changes in oxidative phosphorylation (OXPHOS) genes expression have been performed in humans harboring mtDNA mutations (Heddi, A. et al., “Coordinate Induction of Energy Gene Expression in Tissues of Mitochondrial Disease Patients” (1999) JBC 274:22968-22976). The advent of mouse models for mitochondrial disease created by the inactivation of nuclear-encoded OXPHOS subunits has provided experimental material to study tissue-specific expression changes. (Murdock, D. G. et al., “Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator,” [1999] J. Biol. Chem. 274:14429-33.)

Nucleic acid arrays have been described, e.g., in U.S. Pat. No. 5,837,832, U.S. Pat. No. 5,807,522, U.S. Pat. No. 6,007,987, U.S. Pat. No. 6,110,426, WO 99/05324, 99/05591, WO 00/58516, WO 95/11995, WO 95/35505A1, WO 99/42813, JP10503841T2, GR3030430T3, ES2134481T3, EP804731B1, DE69509925C0, CA2192095AA, AU2862995A1, AU709276B2, AT180570, EP 1066506, and AU 2780499. Such arrays can be incorporated into computerized methods for analyzing hybridization results when the arrays are contacted with prepared sample nucleotides, e.g., as described in PCT Publication WO 99/05574, and U.S. Pat. Nos. 5,754,524; 6,228,575; 5,593,839; and 5,856,101. Methods for screening for disease markers are also known to the art, e.g., as described in U.S. Pat. Nos. 6,228,586; 6,160,104; 6,083,698; 6,268,398; 6,228,578; and 6,265,174.

All references cited herein are incorporated by reference in their entirety to the extent that they are not inconsistent with the disclosure herein. Citation of the above documents is not an admission that any of them are pertinent prior art.

SUMMARY OF THE INVENTION

This invention provides a library of genes involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of using such arrays. Genes and probe sequences involved in mitochondrial biology in humans and mice are provided. The arrays of this invention are useful for determining mitochondrial biology gene expression profiles. Mitochondrial biology gene expression profiles are useful for determining expression profiles diagnostic of energy metabolism-related physiological conditions; diagnosing such physiological conditions; identifying biochemical pathways, genes, and mutations involved in such physiological conditions; identifying therapeutic agents useful for preventing and/or treating such physiological conditions; evaluating and/or monitoring the efficacy of such therapies; and creating and identifying animal models of human energy metabolism-related physiological conditions. Arrays containing probes for all genes known to be involved in mitochondrial biology are provided, as well as arrays containing subsets of such probes. The mitochondrial biology expression arrays of this invention contain probes of genes not previously recognized to participate in mitochondrial biology.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a diagram of the mammalian mitochondrion showing mitochonrial energetics, and the relationship between energy production, reactive oxygen species (ROS) generation, and regulation of apoptosis.

FIG. 2 is a depiction of a hybridized mouse array of this invention. The picture of the hybridized array shows the image generated when the two channels representing the control or reference and experimental targets are overlaid. When viewed in color, the spots appear various shades of red, green and yellow. Red spots indicate a predominance of hybridization to control cDNAs, while green spots indicate the predominance of hybridization to the experimental target sample. Yellow spots indicate an equal hybridization of both samples. Spots that are yellow-green or orange when the array is shown in color are depicted as half yellow and green, or half red and yellow, respectively.

FIG. 3 shows the ρ0 LMEB4 cell line gene expression scatter plot. The scatter plot shows the distribution of gene expression ratio for the ρ0 LMEB4 sample. The diagonal dotted line indicates a ratio of 1 between the two samples. Any spot above the dotted line is up-regulated or more abundant in the ρ0 LMEB4 experimental sample compared to the LM(TK)-control. Any spot below the dotted line is down-regulated or less abundant in the experimental sample compared to the control.

FIG. 4 shows NZB heart gene expression scatter plot. The scatter plot shows the distribution of gene expression ratio for the NZB heart tissue sample. The diagonal dotted line indicates a ratio of 1 between the two samples. Any spot above the dotted line is up-regulated or more abundant in the NZB-mtDNA heart experimental sample compared to the “common” mtDNA control heart. Any spot below the dotted line is down-regulated or less abundant in the experimental sample compared to the control.

DETAILED DESCRIPTION OF THE INVENTION

An approach to examining the complex interaction between nuclear and cytoplasmic mitochondrial genes is through the use of arrays such as DNA arrays. DNA microarrays provide a means to profile the expression patterns of up to thousands of genes simultaneously, and knowing where and when a gene is expressed often provides insight into its biological function. The pattern of gene expression in a particular tissue or cell type can also provide detailed information about its state or condition.

Currently, DNA microarrays are the most efficient method to monitor correlative changes in gene expression and to investigate complex traits on a molecular level. Expression profiles assembled from multiple interrelated experiments are used to determine hierarchical connections between gene expression patterns underlying complex biological traits. These patterns are used to further define the molecular basis of complex disorders.

The mitochondrion is assembled from approximately 1000 protein-coding nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) genes. Thirteen protein-coding mitochondrial genes are known, as shown in Table 1. The codon usage table of the mtDNA is known. It differs slightly from the universal code. For example, UGA codes for tryptophan instead of termination, AUA codes for methionine instead of isoleucine, and AGA and AGG are terminators instead of coding for arginine. TABLE 1 Gene Map Locus^(a) Abbreviation Location^(b) NADH dehydrogenase 1 MTND1 ND1 3307-4262 NADH dehydrogenase 2 MTND2 ND2 4470-5511 NADH dehydrogenase 3 MTND3 ND3 10059-10404 NADH dehydrogenase 4L MTND4L ND4L 10470-10766 NADH dehydrogenase 4 MTND4 ND4 10760-12137 NADH dehydrogenase 5 MTND5 ND5 12337-14148 NADH dehydrogenase 6 MTND6 ND6 14149-14673 Cytochrome b MTCYB Cytb 14747-15887 Cytochrome c oxidase I MTCO1 COI 5904-7445 Cytochrome c oxidase II MTCO2 COII 7586-8269 Cytochrome c oxidase III MTCO3 COIII 9207-9990 ATP synthase 6 MTATP6 ATP6 8527-9207 ATP synthase 8 MTATP8 ATP8 8366-8572 ^(a,b)As defined on MitoMap, http://www.gen.emory.edu/cgi-bin/MITOMAP, which is numbered relative to the Cambridge Sequence (Genbank accession no. J01415 and Andrews et al. (1999), A Reanalysis and Revision of the Cambridge Reference Sequence for Human Mitochondrial DNA, Nature Genetics 23: 147.

As used herein “gene” refers to a unigene cluster, an expressed sequence, or a sequence that is transcribed and translated into a protein. Another word used in the art for “gene” is “locus.” The National Institutes of Health (NIH) have instituted the term “gene cluster” to refer to non-redundant sets of gene clusters. A stretch of DNA may be transcribed into several splice variants that share sequences, and these would be designated as belonging to one unigene cluster. As used herein “splice variant” refers to one version of several transcripts that are transcribed from one gene. As used herein “housekeeping gene” refers to a gene that is expressed at a similar level in almost all cell types.

As used herein “genes involved in mitochondrial biology” refers to mitochondrial genes and nuclear genes involved in cellular structures and functions such as intermediary metabolism, OXPHOS, mitochondrial transport, cellular bioenergetics, cellular biogenesis, cell cycle control, DNA replication, energy, metabolism, heat shock, stress, cellular matrix, cellular structural proteins, protein synthesis and translational control, signal transduction, transcription and transcriptional regulation, chromatin structure, reactive bxygen species (ROS) biology, and apoptosis.

“mtDNA” means mitochondrial DNA. “nDNA” means nuclear DNA.

As used herein “mitochondrial biology expression profile” refers to the expression patterns of genes involved in mitochondrial biology, such as is detected by probes derived from those genes, in a sample. The profile can be said to be of the sample or of the source from which the sample is derived. A profile may be measured independently, but a profile may also measured relative to a standard or control or other sample. A complete mitochondrial biology expression profile includes data on all genes known to be involved in mitochondrial biology for the species from which the sample is derived. The mitochondrial biology expression profile for a selected physiological condition is at least the expression pattern of genes determined to have altered expression diagnostic of that physiological condition, but the expression pattern of additional genes involved in mitochondrial biology may also be included.

As used herein “array” refers to an ordered set of isolated nucleic acid molecules or spots consisting of pluralities of substantially identical isolated nucleic acid molecules. Preferably the molecules are attached to a substrate. The spots or molecules are ordered so that the location of each (on the substrate) is known and the identity of each is known. Arrays on a micro scale can be called microarrays. Microarrays on solid substrates, such as glass or other ceramic slides, can be called gene chips or chips.

As used herein, an “isolated nucleic acid” is a nucleic acid outside of the context in which it is found in nature. An isolated nucleic acid is a nucleic acid the structure of which is not identical to that of any naturally occurring nucleic acid molecule. The term covers, for example: (a) a DNA which has the sequence of part of a naturally-occurring genomic DNA molecule but is not flanked by both of the coding or noncoding sequences that flank that part of the molecule in the genome of the organism in which it naturally occurs; (b) a nucleic acid incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally-occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion protein, or a modified gene having a sequence not found in nature.

As used herein “probe” refers to an isolated nucleic acid that is suitable for hybridizing to other nucleic acids when placed on a solid substrate. Probes for arrays can be as short as 20-30 nucleotides and up to as long as several thousand nucleotides. Probes can be single-stranded or double stranded. A probe usually comprises at least a partially known sequence that is used to investigate or interrogate the presence, absence, and/or amount of a complementing sequence. On the arrays of this invention, a probe is of such a sequence and the hybridization conditions of such stringency that each probe hybridizes substantially to only one type of nucleic acid per target sample.

As used herein, “target” or “target sample” refers to the collection of nucleic acids, e.g., reverse transcribed and labeled cDNA used as a prepared sample for array analysis. The target is interrogated by the probes of the array. A “target” or “target sample” may be a mixture of several prepared samples that are combined. For example, an experimental target sample may be combined with a differently labeled control sample and hybridized to an array, the combined samples being referred to as the “target” interrogated by the probes of the array. As used herein, “interrogated” means tested. Probes, targets, and hybridization conditions are chosen such that the probes are capable of interrogating the target, i.e., of hybridizing to complementary sequences in the target sample.

As used herein “physiological condition” refers to a healthy or unhealthy physiological state. As used herein “optimize an array for diagnosis” refers to selecting probes for an array such that only probes from genes necessary for diagnosis of one or more physiological conditions are included.

As used herein “printing” refers to the process of applying probes to a solid substrate, e.g., or applying arrays of probes to a solid substrate to make a gene chip. As used herein “glass slide” refers to a small piece of glass of the same dimensions as a standard microscope slide. As used herein, “prepared substrate” refers to a substrate that is prepared with a substance capable of serving as an attachment medium for attaching the probes to the substrate, such as poly Lysine.

As used herein “selective hybridization” refers to hybridization at moderate to high stringency such that only sequences of an appropriate homology can remain bound. Selective hybridization is hybridization performed at stringency conditions such that probes only hybridize to target sample nucleic acids that they are intended to hybridize with. Depending on the sequences of the probes and the target, the hybridization conditions are chosen to be appropriately selective. For example, if human sequences are used as probes for interrogating a human sample, selective hybridization could be at high stringency because, allowing for neutral polymorphism in humans, the sequences would be about 99-100% identical. When applying a chimpanzee target prepared sample to an array containing human sequence probes, selective hybridization would be at a lower stringency. Since hybridizing a target to an array is performed at one chosen hybridization stringency, probes are chosen so that they can undergo selective hybridization with the appropriate target molecules at the same hybridization stringency. As used herein “homology” refers to nucleotide sequence identity to a sequence, a molecule, or its complement.

As used herein “mouse sample” refers to a sample derived from a mouse or a cell line derived from a mouse. Similarly, as used herein, “human sample” refers to a sample derived from a human or a cell line derived from a human. Samples preferably contain total RNA or messenger RNA (mRNA). As used herein “total RNA” refers to a combination of several types of RNA, including MRNA, from a cell or a group of cell. As used herein, “MRNA” refers to messenger RNA or RNA that has a 3′ poly A tail. As used herein, a “prepared sample” or a “target” refers to a sample that has been labeled in preparation for array hybridization. A “prepared sample” or “target” is reverse transcribed and fluorescently labeled. As used herein “standard” refers to a sample or a dataset that is commonly used for comparison to unknown samples so that the unknown samples or datasets can be standardized for comparison to each other. As used herein, “control sample” and “reference sample” refer to samples that are used for comparison against an experimental sample.

As used herein, “clone” refers to an isolated nucleic acid molecule that may be stored in an organism such as E. coli. A clone is usually made of a vector and an insert. The insert usually contains a sequence of interest.

For mitochondrial diseases, the accuracy of current biochemical and phenotypic techniques has proven quite limited in distinguishing and diagnosing the various disorders. Recent technical and analytical advancements make it practical to analyze and quantitate the expression patterns of thousands of genes at once using arrays such as DNA microarrays. This invention applies these array techniques to the study of mitochondrial gene expression, in the design of specialized microarrays containing genes involved in mitochondrial biology. The arrays of this invention contain probes for genes not previously recognized to participate in mitochondrial biology.

Genes, or expressed sequences, involved in mitochondrial biology are involved in cellular structures and functions such as intermediary metabolism, OXPHOS, transport, cellular bioenergetics, cellular biogenesis, cell cycle control, DNA replication, energy, metabolism, heat shock, stress, cellular matrix, cellular structural proteins, protein synthesis and translational control, signal transduction, transcription and transcriptional regulation, chromatin structure, reactive oxygen species (ROS) biology and apoptosis. Alterations in mitochondrial functions are associated with a variety of physiological conditions including degenerative diseases. These functions are involved in many degenerative diseases. This invention provides a compilation of sequences involved in human and mouse mitochondrial biology.

The genes in the arrays of this invention were identified by a variety of techniques including searching databanks for sequences related to genes involved in processes similar to mitochondrial biology such as homologues of prokaryotic genes, and screening mitochondrial mutant cell lines and animal lines for genes having altered expression patterns. When a relevant gene was identified for one species, such as the mouse, the homologue for a second species, such as human, if known, was then included on the list of genes involved in mitochondrial biology for the second species. Mitochondrial mutant cell lines are cell lines that have at least one mutation in a gene involved in mitochondrial biology.

The microarrays or gene chips of this invention comprise probes placed in known positions on a solid substrate. A useful solid substrate is a specialized glass microscope slide. The arrays of this invention include arrays containing probes that detect some or all expressed sequences involved in mitochondrial biology in a selected species.

Arrays of this invention may contain control probes as well as probes for genes involved in mitochondrial biology. Controls that can be included on the arrays of this invention include hybridization controls and scanning controls. The controls can be positive or negative controls. One type of hybridization control is spotting the same probe for a gene involved in mitochondrial biology several times on one chip, each spot having different amounts of probe. This allows for the amount of probe of a given sequence to be optimized. Spotting too little probe may lead to a maximum hybridization signal resulting in a loss of data. Dimethyl sulfoxide (DMSO) can be used as a negative hybridization and scanning control. A spot of DMSO should give no signal. If there is any signal at a DMSO spot, the problem could be at hybridization or scanning steps. Plant sequences having sufficiently low homology with human and mouse sequences can be utilized as negative hybridization and scanning controls. Plant sequences should not give any signal. A signal at a plant spot could indicate a problem with hybridization, i.e. too low a hybridization stringency was used, or with scanning, i.e., the chip was inserted into the scanner at the incorrect orientation. Poly A can be used as a positive hybridization specificity/non specificity control. A poly A spot should always give intense hybridization. No signal at a poly A spot could be the result of use of too high a hybridization stringency. Cy3 or Cy5 incorporated into a PCR product can be a positive scanning control. A spot on an array of a PCR product, or any other nucleic acid, that includes fluorescent label, should always give a signal, and if this sequence has no homology with any other sequence in the target, there should only be a signal of the label included in the nucleic acid. Control probes and probes for genes involved in mitochondrial biology can be duplicated, triplicated, etc. on the chip as printing controls. Controls for arrays can be purchased from Stratagene (SpotReport™, La Jolla, Calif., USA).

Standard targets and reference targets are also useful with the arrays of this invention, as is known in the art. When a prepared sample target to be interrogated is applied to an array of this invention, the results of the test are measured, i.e. by scanning, and recorded. These results can be compared directly to other test results using a similar array. However, it is much more accurate to include a differently labeled standard target in the hybridization mix with the prepared sample target. The results of the experimental sample target are then standardized, so that they can be compared accurately to the results of hybridizations of other sample targets. If ten different prepared sample targets are hybridized to arrays of this invention, simultaneously with the same prepared standard target, then the results of the ten sample targets can be accurately compared to each other. A prepared reference or control target for comparison can also be particularly pertinent to the experiment being performed. A prepared reference target could be a target sample derived from the same cell type from an animal of the same sex, age, and nuclear background as the experimental target sample, except for one difference, such as a different phenotype or treatment. Comparing the results of the experimental target with the results of an appropriate reference target yields a profile associated with the one difference being tested. When the hybridization results of a first sample are compared to the hybridization results of a second sample, the comparison can occur while the hybridization results of the first sample are being measured and recorded, or afterwards, by comparing the measured and recorded hybridization results of the two samples.

Probes on an array may be as short as about 20-30 nucleotides long or as long as the entire gene or clone from which they are derived, which may be up to several kilobases. A probe sequence may be identical (have 100% homology) to the portion of the gene it hybridizes to or it may be a mutated sequence. Mutated probes have less than 100% homology, such as about 98% homology, about 95% homology, about 90% homology, about 80% homology, or about 75% homology, or less, with the portions of the genes to which they hybridize. Arrays are designed such that all probes on an array can hybridize to their corresponding genes at about the same hybridization stringency. Probes for arrays used for interrogating samples usually do not contain sequences such as repetitive sequences that would hybridize substantially with nucleic acids derived from more than one gene, i.e., transcripts or cDNAs. Probes for arrays should be unique at the hybridization stringencies used. Statistically, to be unique in the total human genome, probes should be at least about fifteen nucleotides long. A unique probe is only able to hybridize with one type of nucleic acid per target. A probe is not unique if at the hybridization stringency used, it hybridizes with nucleic acids derived from two different genes, i.e. related genes. The homology of the sequence of the probe to the gene and the hybridization stringency used help determine whether a probe is unique when testing a selected sample. Probes also may not hybridize with different nucleic acids derived from the same gene, i.e., splice variants. The location in the gene of the sequence used for the probe also helps determines whether a probe is unique when testing a selected sample. If the splice variants of a gene are known, ideally several different probes sequences are chosen from that gene for an array, such that each probe can only hybridize to nucleic acid derived from one of the splice variants. References for sequences of probes useful for arrays of this invention are compiled in Tables 3-5 and in the sequence listings. Other equivalent probes derived from the gene sequences from which the Tables 3-5 probes are derived, are also useful for the arrays of this invention. Arrays of this invention are used at hybridization conditions allowing for selective hybridization. At conditions of selective hybridization, probes hybridize with nucleic acid from only one gene. When an array is simultaneously hybridized with two targets or two prepared samples, each probe may hybridize with a nucleic acid in each prepared sample or target. When these two nucleic acids are from the same unigene cluster, the probe is said to hybridize with one gene, despite the fact that these nucleic acids may contain different labels.

Sequences of genes involved in mitochondrial biology from other species can be used to make probes that are useful in the arrays of this invention as long as they hybridize at about the same hybridization stringency as other probes on an array. Sequences that are only able to hybridize at a substantially lower stringency, such as plant sequences, are useful as negative controls.

The arrays of this invention can be utilized to determine profiles for related species by modifying the hybridization stringency appropriately. Sequence homology between organisms is known in the art. For example, human and chimpanzee sequences are about 98% identical. Consequently, human arrays are useful for profiling chimpanzees, with an appropriate lowering of the hybridization stringency. Hybridization stringency can be lowered by modifying hybridization components such as salt concentrations and hybridization and/or wash temperatures, as is known in the art.

The sequences useful for the arrays of this invention are useful for designing arrays for other species as well. To create an array for a new organism, the known sequences from the new organism, including expressed sequence tags (ESTs), are compared, by methods known to the art, with the sequences known to already be useful for other mitochondrial biology arrays. Sequence comparisons may be performed at the nucleic acid or polypeptide level. Homologous and analogous sequences from the new organism are thereby identified and selected for the new organism's mitochondrial array. The probes on the arrays of this invention are also useful as probes for identifying candidates for the new organism's array using molecular biology techniques that are standard in the art such as screening libraries.

All sequences given herein are meant to encompass the complementary strand, as well as double-stranded polynucleotides comprising the given sequence.

Microarrays of this invention can contain as few as two probes to as many as all the probes diagnostic of the selected physiological condition to be tested. Microarrays of this invention may also contain probes for all genes involved in mitochondrial biology. The arrays of this invention may contain probes for at least about five genes, at least about ten genes, at least about twenty-five genes, at least about fifty genes, at least about 100 genes, at least about 500 genes, or at least about 1000 genes. The mouse array may contain probes for at least about 950 genes and the human array may contain probes for at least about 600 genes. Arrays of this invention may comprise more than about five spots, more than about ten spots, more than about twenty-five spots, more than about one hundred spots, more than about 500 spots, or more than about 1000 spots.

Using microarrays may require amplification of target sequences (generation of multiple copies of the same sequence) of sequences of interest, such as by PCR or reverse transcription. As the nucleic acid is copied, it is tagged with a fluorescent label that emits light like a light bulb. The labeled nucleic acid is introduced to the microarray and allowed to react for a period of time. This nucleic acid sticks to, or hybridizes, with the probes on the array when the probe is sufficiently complementary to the labeled, amplified, sample nucleic acid. The extra nucleic acid is washed off of the array, leaving behind only the nucleic acid that has bound to the probes. By obtaining an image of the array with a fluorescent scanner and using software to analyze the hybridized array image, it can be determined if, and to what extent, genes are switched on and off, or whether or not sequences are present, by comparing fluorescent intensities at specific locations on the array. The intensity of the signal indicates to what extent a sequence is present. In expression arrays, high fluorescent signals indicate that many copies of a gene are present in a sample, and lower fluorescent signal shows a gene is less active. By selecting appropriate hybridization conditions and probes, this technique is useful for detecting single nucleotide polymorphisms (SNPs) and for sequencing. Methods of designing and using microarrays are continuously being improved (Relogio, A. et al. (2002) Nuc. Acids. Res. 30(1 l):e51; Iwasaki, H et al. (2002) DNA Res. 9(2):59-62; and Lindroos, K. et al. (2002) Nuc. Acids. Res. 30(14):E70).

Arrays of this invention may be made by any array synthesis methods known in the art such as spotting technology or solid phase synthesis. Preferably the arrays of this invention are synthesized by solid phase synthesis using a combination of photolithography and combinatorial chemistry. Some of the key elements of probe selection and array design are common to the production of all arrays. Strategies to optimize probe hybridization, for example, are invariably included in the process of probe selection. Hybridization under particular pH, salt, and temperature conditions can be optimized by taking into account melting temperatures and by using empirical rules that correlate with desired hybridization behaviors. Computer models may be used for predicting the intensity and concentration-dependence of probe hybridization.

Arrays, also called DNA microarrays or DNA chips, are fabricated by high-speed robotics, generally on glass but sometimes on nylon substrates, for which probes (Phimister, B. (1999) Nature Genetics 21s: 1-60) with known identity are used to determine complementary binding. An experiment with a single DNA chip can provide researchers information on thousands of genes simultaneously. There are several steps in the design and implementation of a DNA array experiment. Many strategies have been investigated at each of these steps: 1) DNA types; 2) Chip fabrication; 3) Sample preparation; 4) Assay; 5) Readout; and 6) Software (informatics).

There are two major application forms for the array technology: 1) Determination of expression level (abundance) of genes; and 2) Identification of sequence (gene/gene mutation). There appear to be two variants of the array technology, in terms of intellectual property, of arrayed DNA sequence with known identity: Format I consists of probe cDNA (500˜5,000 bases long) immobilized to a solid surface such as glass using robot spotting and exposed to a set of targets either separately or in a mixture. This method, “traditionally” called DNA microarray, is widely considered as having been developed at Stanford University. (R. Ekins and F. W. Chu “Microarrays: their origins and applications,” [1999] Trends in Biotechnology, 17:217-218). Format II consists of an array of oligonucleotide (20˜80-mer oligos) or peptide nucleic acid (PNA) probes synthesized either in situ (on-chip) or by conventional synthesis followed by on-chip immobilization. The array is exposed to labeled sample DNA, hybridized, and the identity/abundance of complementary sequences is determined. This method, “historically” called DNA chips, was developed at Affymetrix, Inc., which sells its photolithographically fabricated products under the GeneChip® trademark. Many companies are manufacturing oligonucleotide-based chips using alternative in-situ synthesis or depositioning technologies.

Probes on arrays can be hybridized with fluorescently-labeled target polynucleotides and the hybridized array can be scanned by means of scanning fluorescence microscopy. The fluorescence patterns are then analyzed by an algorithm that determines the extent of mismatch content, identifies polymorphisms, and provides some general sequencing information (M. Chee et al., [1996] Science 274:610). Selectivity is afforded in this system by low stringency washes to rinse away non-selectively adsorbed materials. Subsequent analysis of relative binding signals from array elements determines where base-pair mismatches may exist. This method then relies on conventional chemical methods to maximize stringency, and automated pattern recognition processing is used to discriminate between fully complementary and partially complementary binding.

Devices such as standard nucleic acid microarrays or gene chips, require data processing algorithms and the use of sample redundancy (i.e., many of the same types of array elements for statistically significant data interpretation and avoidance of anomalies) to provide semi-quantitative analysis of polymorphisms or levels of mismatch between the target sequence and sequences immobilized on the device surface. Such algorithms and software useful for statistical analysis are known to the art.

Using microarrays first requires amplification (generation of multiple copies of the same gene) of genes of interest, such as by reverse transcription. As the nucleic acid is copied, it is tagged with a fluorescent label that emits light like a light bulb. The labeled nucleic acid is introduced to the microarray and allowed to react for a period of time. This nucleic acid sticks to, or hybridizes, with the probes on the array when the probe is sufficiently complementary to the nucleic acid in the prepared sample. The extra nucleic acid is washed off of the array, leaving behind only the nucleic acid that has bound to the probes. By obtaining an image of the array with a fluorescent scanner and using software to analyze the hybridized array image, it can be determined if and to what extent genes are switched on and off, or whether or not sequences are present, by comparing fluorescent intensities at specific locations on the array. High fluorescent signals indicate that many copies of a gene are present in a prepared sample, and lower fluorescent signal shows a gene is less active. Expression levels for various genes under different conditions can be directly compared, such as for a cancer cell and a normal cell. Similarly, it can be determined what genes are turned on and off in response to certain stimuli such as a drug. Such information is valuable because it identifies genes in disease pathways and also is predictive of either efficacy or toxicity of drugs.

Detecting a particular polymorphism can be accomplished using two probes. One probe is designed to be perfectly complementary to a target sequence, and a partner probe is generated that is identical except for a single base mismatch in its center. In the Affymetrix system, these probe pairs are called the Perfect Match probe (PM) and the Mismatch probe (MM. They allow for the quantitation and subtraction of signals caused by non-specific cross-hybridization. The difference in hybridization signals between the partners, as well as their intensity ratios, serve as indicators of specific target abundance, and consequently of the sequence.

Arrays can rely on multiple probes to interrogate individual nucleotides in a sequence. The identity of a target base can be deduced using four identical probes that vary only in the target position, each containing one of the four possible bases. Alternatively, the presence of a consensus sequence can be tested using one or two probes representing specific alleles. To genotype heterozygous or genetically mixed samples, arrays with many probes can be created to provide redundant information, resulting in unequivocal genotyping.

Probes fixed on solid substrates and targets (nucleotide sequences in the sample) are combined in a hybridization buffer solution and held at an appropriate temperature until annealing occurs. Thereafter, the substrate is washed free of extraneous materials, leaving the nucleic acids on the target bound to the fixed probe molecules allowing for detection and quantitation by methods known in the art such as by autoradiograph, liquid scintillation counting, and/or fluorescence. As improvements are made in hybridization and detection techniques, they can be readily applied by one of ordinary skill in the art. As is well known in the art, if the probe molecules and target molecules hybridize by forming a strong non-covalent bond between the two molecules, it can be reasonably assumed that the probe and target nucleic acid are essentially identical, or almost completely complementary if the annealing and washing steps are carried out under conditions of high stringency. The detectable label provides a means for determining whether hybridization has occurred.

When using oligonucleotides or polynucleotides as hybridization probes, the probes may be labeled. In arrays of this invention, the target may instead be labeled by means known to the art. Target may be labeled with radioactive or non-radioactive labels. Targets preferably contain fluorescent labels.

Various degrees of stringency of hybridization can be employed. The more stringent the conditions are, the greater the complementarity that is required for duplex formation. Stringency can be controlled by temperature, probe concentration, probe length, ionic strength, time, and the like. Hybridization experiments are often conducted under moderate to high stringency conditions by techniques well know in the art, as described, for example in Keller, G. H., and M. M. Manak (1987) DNA Probes, Stockton Press, New York, N.Y., pp. 169-170, hereby incorporated by reference. However, sequencing arrays typically use lower hybridization stringencies, as is known in the art.

Moderate to high stringency conditions for hybridization are known to the art. An example of high stringency conditions for a blot are hybridizing at 68° C. in 5×SSC/5× Denhardt's solution/0.1% SDS, and washing in 0.2×SSC/0.1% SDS at room temperature. An example of conditions of moderate stringency are hybridizing at 680 C in 5×SSC/5× Denhardt's solution/0.1% SDS and washing at 42° C. in 3×SSC. The parameters of temperature and salt concentration can be varied to achieve the desired level of sequence identity between probe and target nucleic acid. See, e.g., Sambrook et al. (1989) vide infra or Ausubel et al. (1995) Current Protocols in Molecular Biology, John Wiley & Sons, New York, N.Y., for further guidance on hybridization conditions.

The melting temperature is described by the following formula (Beltz, G. A. et al., [1983] Methods of Enzymology, R. Wu, L. Grossman and K. Moldave [Eds.] Academic Press, New York 100:266-285).

-   Tm=81.5o C+16.6 Log[Na+]+0.41(+G+C)−0.61(% formamide)−600/length of     duplex in base pairs.

Washes can typically be carried out as follows: twice at room temperature for 15 minutes in I×SSPE, 0.1% SDS (low stringency wash), and once at TM-20o C for 15 minutes in 0.2×SSPE, 0.1% SDS (moderate stringency wash).

Nucleic acid useful in this invention can be created by Polymerase Chain Reaction (PCR) amplification. PCR products can be confirmed by agarose gel electrophoresis. PCR is a repetitive, enzymatic, primed synthesis of a nucleic acid sequence. This procedure is well known and commonly used by those skilled in this art (see Mullis, U.S. Pat. Nos. 4,683,195, 4,683,202, and 4,800,159; Saiki et al. [1985] Science 230:1350-1354). PCR is used to enzymatically amplify a DNA fragment of interest that is flanked by two oligonucleotide primers that hybridize to opposite strands of the target sequence. The primers are oriented with the 3′ ends pointing towards each other. Repeated cycles of heat denaturation of the template, annealing of the primers to their complementary sequences, and extension of the annealed primers with a DNA polymerase result in the amplification of the segment defined by the 5′ ends of the PCR primers. Since the extension product of each primer can serve as a template for the other primer, each cycle essentially doubles the amount of DNA template produced in the previous cycle. This results in the exponential accumulation of the specific target fragment, up to several million-fold in a few hours. By using a thermostable DNA polymerase such as the Taq polymerase, which is isolated from the thermophilic bacterium Thermus aquaticus, the amplification process can be completely automated. Other enzymes that can be used are known to those skilled in the art.

Polynucleotide sequences of the present invention can be truncated and/or mutated such that certain of the resulting fragments and/or mutants of the original full-length sequence can retain the desired characteristics of the full-length sequence. A wide variety of restriction enzymes that are suitable for generating fragments from larger nucleic acid molecules are well known. In addition, it is well known that Bal31 exonuclease can be conveniently used for time-controlled limited digestion of DNA. See, for example, Maniatis (1982) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, New York, pages 135-139, incorporated herein by reference. See also Wei et al. (1983) J. Biol. Chem. 258:13006-13512. By use of Bal3l exonuclease (commonly referred to as “erase-a-base” procedures), the ordinarily skilled artisan can remove nucleotides from either or both ends of the subject nucleic acids to generate a wide spectrum of fragments that are functionally equivalent to the subject nucleotide sequences. One of ordinary skill in the art can, in this manner, generate hundreds of fragments of controlled, varying lengths from locations all along the original molecule. The ordinarily skilled artisan can routinely test or screen the generated fragments for their characteristics and determine the utility of the fragments as taught herein. It is also well known that the mutant sequences can be easily produced with site-directed mutagenesis. See, for example, Larionov, O. A. and Nikiforov, V. G. (1982) Genetika 18(3):349-59; and Shortle, D. et al., (1981) Annu. Rev. Genet. 15:265-94, both incorporated herein by reference. The skilled artisan can routinely produce deletion-, insertion-, or substitution-type mutations and identify those resulting mutants that contain the desired characteristics of wild-type sequences, or fragments thereof.

Thus, mutational, insertional, and deletional variants of the disclosed nucleotide sequences can be readily prepared by methods which are well known to those skilled in the art. These variants can be used in the same manner as the exemplified primer sequences so long as the variants have substantial sequence homology with the original sequence. As used herein, substantial sequence homology refers to homology that is sufficient to enable the variant polynucleotide to function in the same capacity as the polynucleotide from which the probe was derived. Homology is greater than 80%, greater than 85%, greater than 90%, or greater than 95%. The degree of homology or identity needed for the variant to fimction in its intended capacity depends upon the intended use of the sequence. It is well within the skill of a person trained in this art to make mutational, insertional, and deletional mutations that are equivalent in function or are designed to improve the function of the sequence or otherwise provide a methodological advantage.

Percent sequence identity of two nucleic acids may be determined using the algorithm of Karlin and Altschul (1990) Proc. Natl. Acad. Sci. USA 87:2264-2268, modified as in Karlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90:5873-5877. Such an algorithm is incorporated into the NBLAST and XBLAST programs of Altschul et al. (1990) J. Mol. Biol. 215:402-410. BLAST nucleotide searches are performed with the NBLAST program, score=100, wordlength=12, to obtain nucleotide sequences with the desired percent sequence identity. To obtain gapped alignments for comparison purposes, Gapped BLAST is used as described in Altschul et al. (1997) Nucl. Acids. Res. 25:3389-3402. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (NBLAST and XBLAST) are used. See http://www.ncbi.nih.gov.

Standard techniques for cloning, DNA isolation, amplification and purification, for enzymatic reactions involving DNA ligase, DNA polymerase, restriction endonucleases and the like, and various separation techniques useful herein are those known and commonly employed by those skilled in the art. A number of standard techniques are described in Sambrook et al. (1989) Molecular Cloning, Second Edition, Cold Spring Harbor Laboratory, Plainview, New York; Maniatis et al. (1982) Molecular Cloning, Cold Spring Harbor Laboratory, Plainview, New York; Wu (ed.) (1993) Meth. Enzymol. 218, Part I; Wu (ed.) (1979) Meth. Enzymol. 68; Wu et al. (eds.) (1983) Meth. Enzymol. 100 and 101; Grossman and Moldave (eds.) Meth. Enzymol. 65; Miller (ed.) (1972) Experiments in Molecular Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York; Old and Primrose (1981) Principles of Gene Manipulation, University of California Press, Berkeley; Schleif and Wensink (1982) Practical Methods in Molecular Biology; Glover (Ed.) (1985) DNA Cloning Vol. I and II, IRL Press, Oxford, UK; Hames and Higgins (Eds.) (1985) Nucleic Acid Hybridization, IRL Press, Oxford, UK; Setlow and Hollaender (1979) Genetic Engineering: Principles and Methods, Vols. 14, Plenum Press, New York; and Ausubel et al. (1992) Current Protocols in Molecular Biology, Greene/Wiley, New York, N.Y. Abbreviations and nomenclature, where employed, are deemed standard in the field and commonly used in professional journals such as those cited herein.

The arrays of this invention are useful for defining expression signatures or profiles for mitochondrial diseases, as well as distinguishing clinical disorders that result from OXPHOS dysfunction, oxidative stress, apoptosis, and aging. The microarrays of this invention are useful for providing profiles for whole classes of mitochondrial diseases that have common underlying pathophysiological mechanisms. The data obtained from using these arrays are useful in the identification of pathways involved in these diseases and in the design of efficient therapies for treating these diseases.

The arrays of this invention are useful for determining mitochondrial biology expression profiles and for sample evaluation using those profiles. The arrays of this invention are useful for diagnosis, for identifying pathways, genes, and mutations involved in physiological conditions, for creating animal models of human physiological conditions, and for designing curative and preventative therapies and evaluating their effectiveness.

The arrays of this invention are useful for determining mitochondrial biology expression profiles of organisms, such as humans, mice, and closely related species; tissues and organs of such organisms; cell types of such organisms; and cell lines derived from such organisms. An individual can be tested at any age, including as a fetus, neonate, infant, child, adolescent, mature adult, senior, and deceased. Using standard targets, the arrays of this invention are useful for comparing mitochondrial biology profiles of different individuals or cells.

The arrays of this invention are useful for determining the profile associated with a physiological condition such as an energy-metabolism-related physiological condition. Physiological conditions can be healthy conditions or pathological conditions. Examples of healthy conditions in humans are centenaria and physical fitness. An example of a pathological condition in humans is Leigh's syndrome (LS). By determining profiles from individuals, with and without such physiological conditions, and comparing them, the mitochondrial biology profile representative and descriptive of the physiological condition can be determined, such as for humans in Examples 4-5. Profiles can similarly be determined for cells lines with phenotypes or genotypes associated with physiological conditions, such as in Examples 13-15. Profiles can also be determined for non-human animals, including mouse strains, with physiological conditions as in Examples 8-12, 16, and 19. The arrays of this invention are useful for determining the range of normal variation of expression of genes involved in mitochondrial biology, as in Example 20. When the arrays of this invention are used to determine a profile associated with a physiological condition, prepared target samples or pooled prepared target samples, of individuals with and without the physiological condition, but otherwise similar, are hybridized to an array of this invention. The hybridization of the prepared samples are measured and compared to, if possible, determine a profile associated with the physiological condition. The profile may be optimized by statistical analysis, as is known in the art, to only contain profile data on probes necessary for diagnosing the physiological condition.

The profile associated with a physiological condition can then be used for diagnosis or evaluation using the arrays of this invention, such as in Example 7. The profile of the physiological condition can be analyzed and the analysis used to optimize an array for diagnosis of the physiological condition. An optimized array for diagnosis of a physiological condition minimally contains at least one probe for the one or more genes that have altered expression levels in the context of the physiological condition, and probes for enough genes to eliminate other likely diagnoses. Diagnosis involves collecting a sample from an individual who might have the physiological condition, and determining the profile of the prepared sample using an array of this invention, using an array containing probes for all genes involved in mitochondrial biology or fewer probes with at least as many probes as necessary for an array optimized for diagnosis of the physiological condition. The profile of the individual is then compared to the profile of the physiological condition, and the comparison is analyzed to determine the likelihood that the individual has the physiological condition. Arrays of this invention can also be used for screening individuals who are not suspected of having the particular physiological condition. A sample is collected from such an individual, prepared, and the mitochondrial biology profile of the individual is determined using an array of this invention, e.g., an array containing probes for all genes involved in mitochondrial biology. The profile of this individual is then compared to known mitochondrial biology profiles of one or more physiological conditions that the individual may have, to determine if the profile of the individual is indicative of a diagnosable physiological condition. As demonstrated in Example 16, the arrays of this invention are also useful for detecting profiles indicative of physiological conditions before the appearance of other symptoms.

The profile of, or associated with, a physiological condition is also useful for identifying biochemical pathways affected by the physiological condition and genes involved in causation of the physiological condition. If a profile of a physiological condition demonstrates alteration in the expression of a gene, that gene is a candidate for sequencing to identify a mutation causing the physiological condition. If a profile demonstrates alteration of expression of several genes, then genes known to regulate those are candidates for sequencing to identify a mutation causing the physiological condition. Example 3 describes using the arrays of this invention for the identification of mutations associated with physiological conditions.

The profile of a physiological condition is useful for creating and/or identifying animal models of human physiological conditions. The profile of a physiological condition may suggest types of mutations, such as knockouts, to create in order to mimic the physiological condition in an animal. The arrays of this invention are also useful for screening genetically engineered or other mutated populations to identify an individual animal having a similar profile, and thus associated with the physiological condition.

The same individual can be profiled, using arrays of this invention, repeatedly over time or after exposure to various environmental conditions, thereby determining the effects of time or exposure. Equivalent individuals can also be profiled, using the arrays of this invention, at different ages or after exposure to different environmental conditions, thereby determining the effects of time or exposure. For example, a control group of mice of a particular genotype and of a particular age can be compared, using the arrays of this invention, to a group of experimental mice of the same genotype and age, that has been exposed to a certain environmental hazard, to determine the effects of the environmental hazard. Cell lines, as well as organisms, can be profiled after exposure to different environmental conditions, as in Example 15. Arrays of this invention are also useful for determining the effects of aging. Examples 8 and 19 demonstrate differences in profiles at different ages.

Therapy is an environmental condition, the effects of which can be tested using the arrays of this invention. Identification of the pathways affected in a physiological condition allows identification of therapies useful to treat individuals having the physiological condition. For example, if profiles are determined for the effects of classes of therapeutic agents, as new physiological conditions are profiled, relevant therapeutic agents can be easily identified. The profile of a physiological condition is useful for testing candidate therapies for treating individuals with the physiological condition. Any individual, with or without the physiological condition, an animal model of the physiological condition in humans, or a cell line representative of an individual with the physiological condition, can be treated with a candidate therapy. A sample for profiling is collected after treatment, prepared, the profile is determined using an array of this invention, and compared to the profile of the same individual before treatment or to equivalent individuals or cells without treatment to determine the effect of the treatment. Therapies reversing the effects of the physiological condition can thereby be identified. Preventative therapies and therapies causing desired physiological conditions can similarly be identified.

The arrays of this invention are useful for monitoring the effectiveness of a therapy for a particular individual as well as for a population. The profile of a diagnosed individual can be determined, the individual given a therapy, and then the profile of the individual determined again, using the arrays of this invention. The therapy can be modified and the profile retested, until a satisfactory treated profile is obtained.

Arrays containing probes hybridizing at moderate to high stringency with human genes involved in mitochondrial biology are used for assaying prepared samples from humans, human cell lines, and prepared samples from closely related species. Arrays containing probes hybridizing at moderate to high stringency with mouse genes involved in mitochondrial biology are used for assaying prepared samples from mice, mouse cell lines, and prepared samples from closely related species.

The arrays of this invention are made using probes for genes involved in mitochondrial biology. Probes can be selected and generated from the lists of clones and sequences in Tables 3-5, or from sequences and clones representing genes involved in mitochondrial biology not listed in these tables. Probes can be generated in vitro by nucleic acid synthesis, PCR, cloning techniques or other techniques known in the art. Flanking or vector sequence may be minimized in the probe. Probes generated from Research Genetics clones (ResGen/Invitrogen, Carlsbad, Calif.) can be amplified by PCR as described in Example 22. Optionally, control probes are also selected for the arrays of this invention. Examples of clones and sequences for making control probes are listed in Table 6, SEQ ID NOS:3041-3044. If housekeeping genes are chosen as positive controls, usually they are derived from the same species as the non-control probes. Housekeeping gene probes are available from Stratagene (Spot Report™, La Jolla, Calif., USA).

Examples of housekeeping genes are shown in Table 2. Housekeeping genes generally have a consistent amount of expression in all cells. Using the arrays of this invention, the expression of the 25 housekeeping genes listed in Table 2 were compared in 4 cell lines, LMEB4, NZB, 501-1, and the LM(TK)-cell line grown in media supplemented with glucose, pyruvate, and uridine (GUP). Some variability was present between cell lines. Housekeeping genes were also tested in 6 different mouse tissue samples (brain, heart, liver, kidney, spleen and muscle) in two strains of mice, CAP^(R) and NZB. Variation was again present, but slight. TABLE 2 Description Functional Class Actin-gamma Structural gene A272 Capping protein Structrual gene Glyceraldehyde phosphate dehydrogenase Metabolism-glycolysis DNA ligase I DNA repair/synthesis β-actin Structural Alkaline Phosphatase Unclassified 40s Ribosomal protein S15 Protein synthesis Hypozanthine phosphoribosyl transferase Metabolism-nucleotide (HPRT) Ribosomal protein L15 Protein synthesis Ribosomal Protein S29 Protein translation Acient ubiquinating protein Metabolism-protein Glyceraldehyde 3-phosphate dehydrogenase Metabolism-glycolysis Actin-α (skeletal muscle) Structural Murine ornithine decarboxylase Metabolism-amino acid calcium binding protein Cab45 Calcium homeostasis Ribosomal protein L1A Protein synthesis RNA splicing protein RNA processing Actin-gamma (smooth muscle) Structural gene E2F transcription factor Transcriptional regulation Ubiquitin Unclassified Myosin 1 Structural HPRT Metabolism-nucleotide Phospholipase A2 (14-3-3 zeta/delta) Signal transduction HPRT Metabolism-nucleotide Ribosomal protein L3 Protein synthesis

Arrays can be printed on solid substrates, e.g., glass microscope slides. Before printing, slides are prepared to provide a substrate for binding as in Example 23. Arrays can be printed using any printing techniques and machines known in the art. Printing involves placing the probes on the substrate, attaching the probes to the substrate, and blocking the substrate to prevent non-specific hybridization, as described in Example 24.

Samples useful for analyses using the arrays of this invention include total RNA samples and mRNA samples. RNA samples can be prepared as described in Example 25. An RNA sample is reverse transcribed into cDNA and simultaneously labeled, i.e. with one member of a two-color fluorescent system, such as Cy3-dCTP/Cy5-dCTP as described in Example 26. The arrays are hybridized with the prepared sample and washed at appropriate stringencies accounting for the choices of sample and probes of the array. The hybridization stringency can be higher when the probe sequence has higher homology with the gene it interrogates and when the probe is larger. A reference target, standard target, or other sample target for direct comparison may be prepared and hybridized simultaneously to the same array. A prepared sample will not degrade during hybridization and is labeled. Prepared samples are reverse transcribed and fluorescently labeled.

Hybridization results can be measured and analyzed using equipment and software available in the art as described in Example 27. Before finalizing data, preliminary results are preferably normalized by methods known in the art. An example of normalization appears in Example 29. Analysis includes determination of statistical significance. Measurement may include normalization and analysis, including statistical analysis. Resulting data are typically stored in computer files.

Mitochondrial biology expression microarrays are useful for detecting alterations in gene expression caused by alterations in mitochondrial biology. Although commercially available total genome expression arrays from companies such as Incyte Pharmaceuticals or Affymetrix contain probes for ten to twenty times as many genes as the arrays of this invention, the commercially available arrays have limitations. Several genes and probes that have been included on the arrays of this invention are not available on the commercial arrays. The commercial arrays are also very expensive and the large data sets resulting from them can be rather cumbersome to analyze and manipulate. The smaller, more focused arrays of this invention allow the expression patterns of hundreds of mitochondrial genes to be monitored quickly and efficiently. This study shows that a custom-designed microarray for mitochondrial biology expression studies, including probes for nuclear as well as mitochondrial genes, is an effective tool for the analysis of gene expression changes caused by alterations in functions resulting from a mutation in a gene involved in mitochondrial biology or other changes in metabolic state. The cell line experiments in Examples 13-17 and 20 have been particularly informative in demonstrating the specificity and sensitivity of the arrays of this invention while the mouse tissue experiments in Examples 8-12 and 16-17 have shown the consistency of the arrays of this invention.

Clones used to generate probes are listed in Tables 3-5. Clones range from about 1 kb to about 4 kb. The inserts of most clones have been sequenced on the 5′ and 3′ ends. Sequences of the 5 and 3′ ends of the clones are usually about 200 nt to about 800 nt and are provided herein. Probes may be generated via several methods. For example, the clones listed in Tables 3-5 may be obtained commercially, the inserts purified and used as probes. Alternatively, a 5′ or 3 sequence given in the sequence listings hereof may be used to design an oligonucleotide which may be synthesized and used to probe a library to identify a cDNA or genomic clone that is equivalent to the clone used to generate the original sequence. This newly identified cDNA or genomic equivalent clone may be used to generate a probe. Alternatively, a pair of sequences from the sequence listings, representing the 5 and 3′ ends of one clone, may be used to design PCR primers, which may be used to PCR amplify an isolated nucleic acid that is quivalent to the insert of the corresponding clone from which the 5′ and 3′ were derived. This isolated nucleic acid may be used as a probe. Probes should not contain a vector sequence that hybridizes with any sequence in a sample. Methods for designing PCR primers and designing oligonucleotides for screening libraries are known in the art.

EXAMPLES Example 1

Human Mitochondrial Biology Array

A human mitochondrial biology array is made from clones representing 650 expressed sequences involved in mitochondrial biology. The clones used to make probes that are placed on the array are shown in Table 3 which references SEQ ID NOS: 1-994 provided herein setting forth the 5′ and 3′ sequences from these clones. The clones identified in Table 3 are used to make a set of probes called Human Probe Set #1. Control sequences are also placed this array. Controls include, but are not limited to blanks, DMSO, probes derived from plant sequences, sequence(s) not involved in mitochondrial biology, and poly adenine (40-60 nucleotides long). TABLE 3 SEQ ID ResGen UniGene NO Clone ID Gene Complete Gene Name GenBank Cluster ID 1 mtDNA - 12S ribosome Mitochondrial DNA 12S 2 mtDNA - 16S ribosome Mitochondrial DNA 16s 3 mtDNA - ATP6 Mitochondrial DNA ATP6 4 mtDNA - ATP8 Mitochondrial DNA ATP8 5 mtDNA - COX1 Mitochondrial DNA COX1 6 mtDNA - COX2 Mitochondrial DNA COX2 7 mtDNA - COX3 Mitochondrial DNA COX3 8 mtDNA - CYT B Mitochondrial DNA CYTb 9 mtDNA - ND1 Mitochondrial DNA ND1 10 mtDNA - ND2 Mitochondrial DNA ND2 11 mtDNA - ND3 Mitochondrial DNA ND3 12 mtDNA - ND4 Mitochondrial DNA ND4 13 mtDNA - ND4L Mitochondrial DNA ND4L 14 mtDNA - ND5 Mitochondrial DNA ND5 15 mtDNA - ND6 Mitochondrial DNA ND6 16 213890 DECR1 2,4-dienoyl CoA reductase H72937 Hs.81548 17 213890 DECR1 2,4-dienoyl CoA reductase H72938 Hs.81548 18 588911 OAS1 2′,5′-oligoadenylate synthetase 1 AA146773 Hs.82396 19 588911 OAS1 2′,5′-oligoadenylate synthetase 1 AA146772 Hs.82396 20 1576254 2′,5′-oligoadenylate 2′,5′-oligoadenylate synthetase 1 AA954880 Hs.82396 synthetase 1 21 1057786 OAS2 (splice-variant) 2′-5′oligoadenylate synthetase 2 AA568217 22 2190112 A38234 2-OXOGLUTARATE AI610813 DEHYDROGENASE E1 COMPONENT 23 814444 CRSP9 33 kDa transcriptional co-activator AA459244 Hs.7558 24 814444 CRSP9 33 kDa transcriptional co-activator AA459465 Hs.7558 25 896949 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A AA779417 reductase 26 290111 HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A N62195 Hs.77910 synthase 1 (soluble) 27 290111 HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A N76492 Hs.77910 synthase 1 (soluble) 28 757222 HMGCS2 3-hydroxy-3-methylglutaryl-Coenzyme A AA496148 synthase 2 (mitochondrial) 29 757222 HMGCS2 3-hydroxy-3-methylglutaryl-Coenzyme A AA496149 synthase 2 (mitochondrial) 30 109310 HAAO 3-hydroxyanthranilate 3,4-dioxygenase T80846 31 109310 HAAO 3-hydroxyanthranilate 3,4-dioxygenase T80921 32 1635163 HAAO 3-hydroxyanthranilate 3,4-dioxygenase AI005031 33 66564 BDH 3-hydroxybutyrate dehydrogenase (heart, T67057 Hs.76893 mitochondrial) 34 66564 BDH 3-hydroxybutyrate dehydrogenase (heart, T67058 Hs.76893 mitochondrial) 35 838366 HMGCL 3-hydroxymethyl-3-methylglutaryl- AA458779 Hs.831 Coenzyme A lyase (hydroxymethylglutaricaciduria) 36 838366 HMGCL 3-hydroxymethyl-3-methylglutaryl- AA458172 Hs.831 Coenzyme A lyase (hydroxymethylglutaricaciduria) 37 28469 OXCT 3-oxoacid CoA transferase R13381 38 28469 OXCT 3-oxoacid CoA transferase R40897 39 591540 PHGDH 3-phosphoglycerate dehydrogenase AA158735 40 591540 PHGDH 3-phosphoglycerate dehydrogenase AA159852 41 266720 PDPK1 3-phosphoinositide dependent protein N22904 kinase-1 42 266720 PDPK1 3-phosphoinositide dependent protein N31292 kinase-1 43 666169 MTR 5-methyltetrahydrofolate-homocysteine AA233640 methyltransferase 44 666169 MTR 5-methyltetrahydrofolate-homocysteine AA233650 methyltransferase 45 814765 AKAP1 A kinase anchor protein, 149 kD AA454947 Hs.78921 46 814765 AKAP1 A kinase anchor protein, 149 kD AA455326 Hs.78921 47 2364633 A32422 A32422 AI744652 48 2308263 A40487 A40487 AI671604 49 2240514 AAP1′ AAP1′ AI637909 50 2266774 ABF2 ABF2 AI590841 51 36393 ACAT2 acetyl-Coenzyme A acetyltransferase 2 R25823 (acetoacetyl Coenzyme A thiolase) 52 36393 ACAT2 acetyl-Coenzyme A acetyltransferase 2 R46821 (acetoacetyl Coenzyme A thiolase) 53 45376 ACAA2 acetyl-Coenzyme A acyltransferase 2 H07926 Hs.32500 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 54 45376 ACAA2 acetyl-Coenzyme A acyltransferase 2 H08029 Hs.32500 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 55 262932 ACO2 Aconitase 2, mitochondrial H99699 Hs.75900 56 366511 No Data Actin, alpha 1, skeletal muscle AA026609 57 366511 No Data Actin, alpha 1, skeletal muscle AA026720 58 867606 ACTB actin, beta AA780815 59 428215 ACTL6 actin-like 6 AA001745 Hs.103180 60 428215 ACTL6 actin-like 6 AA001815 Hs.103180 61 896962 ACADS acyl-Coenzyme A dehydrogenase, C-2 to AA676663 Hs.127610 C-3 short chain 62 298155 ACADM Acyl-Coenzyme A dehydrogenase, C-4 to N70794 Hs.79158 C-12 straight chain 63 140131 ACADL acyl-Coenzyme A dehydrogenase, long R66005 Hs.1209 chain 64 140131 ACADL acyl-Coenzyme A dehydrogenase, long R66006 Hs.1209 chain 65 243100 ACADSB acyl-Coenzyme A dehydrogenase, H95792 Hs.81934 short/branched chain 66 243100 ACADSB acyl-Coenzyme A dehydrogenase, H96140 Hs.81934 short/branched chain 67 810358 ACADVL Acyl-Coenzyme A dehydrogenase, very AA464163 Hs.82208 long chain 68 810358 ACADVL Acyl-Coenzyme A dehydrogenase, very AA464228 Hs.82208 long chain 69 85450 ACOX2 acyl-Coenzyme A oxidase 2, branched T71713 Hs.9795 chain 70 85450 ACOX2 acyl-Coenzyme A oxidase 2, branched T71782 Hs.9795 chain 71 772304 ANT2 Adenine nucleotide translocator 2 AA404486 Hs.79172 (fibroblast) 72 772304 ANT2 Adenine nucleotide translocator 2 AA405477 Hs.79172 (fibroblast) 73 755855 ANT3 adenine nucleotide translocator 3 (liver) AA496376 Hs.164280 74 755855 ANT3 adenine nucleotide translocator 3 (liver) AA496654 Hs.164280 75 853570 ANT3 Adenine nucleotide translocator 3 (liver) AA663439 Hs.164280 76 868757 AK1 Adenylate kinase 1 AA775325 Hs.76240 77 2010933 KAD2_HUMAN ADENYLATE KINASE ISOENZYME 2 AI361029 78 40026 ANT1 ADP, ATP CARRIER PROTEIN, R53337 Hs.2043 HEART/SKELETAL MUSCLE ISOFORM T1 79 40026 ANT1 ADP, ATP CARRIER PROTEIN, R53942 Hs.2043 HEART/SKELETAL MUSCLE ISOFORM T1 80 46248 ADPRT ADP-ribosyltransferase (NAD+; poly H09923 Hs.177766 (ADP-ribose) polymerase) 81 46248 ADPRT ADP-ribosyltransferase (NAD+; poly H09924 Hs.177766 (ADP-ribose) polymerase) 82 589276 AFG3L2 AFG3 (ATPase family gene 3, yeast)-like 2 AA147320 Hs.29385 83 589276 AFG3L2 AFG3 (ATPase family gene 3, yeast)-like 2 AA147413 Hs.29385 84 1018253 AIF AIF AA570483 85 855624 ALDH1 aldehyde dehydrogenase 1, soluble AA664101 Hs.76392 86 47853 ALDH4 aldehyde dehydrogenase 4 (glutamate H11346 Hs.77448 gamma-semialdehyde dehydrogenase; pyrroline-5-carboxylate dehydrogenase) 87 47853 ALDH4 aldehyde dehydrogenase 4 (glutamate H11369 Hs.77448 gamma-semialdehyde dehydrogenase; pyrroline-5-carboxylate dehydrogenase) 88 197657 ALDH5 ALDEHYDE DEHYDROGENASE, R93550 Hs.169517 MITOCHONDRIAL X PRECURSOR 89 197657 ALDH5 ALDEHYDE DEHYDROGENASE, R93551 Hs.169517 MITOCHONDRIAL X PRECURSOR 90 1917741 AOX1 aldehyde oxidase 1 AI343711 Hs.81047 91 2154324 AGPS alkylglycerone phosphate synthase AI445035 92 1520618 GABT_HUMAN AMINOBUTYRATE AA910669 AMINOTRANSFERASE 93 813651 ALAS1 aminolevulinate, delta-, synthase 1 AA447761 Hs.78712 94 813651 ALAS1 aminolevulinate, delta-, synthase 1 AA453691 Hs.78712 95 753346 ALAS2 aminolevulinate, delta-, synthase 2 AA406485 Hs.79103 (sideroblastic/hypochromic anemia) 96 753346 ALAS2 aminolevulinate, delta-, synthase 2 AA410346 Hs.79103 (sideroblastic/hypochromic anemia) 97 248631 AMT aminomethyltransferase (glycine cleavage N59532 Hs.102 system protein T) 98 248631 AMT aminomethyltransferase (glycine cleavage N78273 Hs.102 system protein T) 99 1556306 ANT3 ANT3 AA916851 100 471597 API5L1 API5-like 1 AA035435 Hs.227913 101 471597 API5L1 API5-like 1 AA035436 Hs.227913 102 127032 API2 apoptosis inhibitor 2 R07870 Hs.127799 103 127032 API2 apoptosis inhibitor 2 R07927 Hs.127799 104 2285739 API3 apoptosis inhibitor 3 AI628066 105 927606 ARAL-1 ARAL-1 AA535370 106 1704180 XNHUDM ASPARTATE AMINOTRANSFERASE AI096615 107 360778 ATM Ataxia telangiectasia mutated (includes AA016254 Hs.194382 complementation groups A, C and D) 108 360778 ATM Ataxia telangiectasia mutated (includes AA016988 Hs.194382 complementation groups A, C and D) 109 845519 ATP5C1 ATP SYNTHASE GAMMA CHAIN, AA644234 Hs.155433 MITOCHONDRIAL PRECURSOR 110 813712 ATP5F1 ATP synthase, H+ transporting, AA453765 Hs.181101 mitochondrial F0 complex, subunit b, isoform 1 111 813712 ATP5F1 ATP synthase, H+ transporting, AA453849 Hs.181101 mitochondrial F0 complex, subunit b, isoform 1 112 193106 ATP5G3 ATP synthase, H+ transporting, H47080 Hs.429 mitochondrial F0 complex, subunit c (subunit 9) isoform 3 113 193106 ATP5G3 ATP synthase, H+ transporting, H47164 Hs.429 mitochondrial F0 complex, subunit c (subunit 9) isoform 3 114 487373 ATP5G1 ATP synthase, H+ transporting, AA046701 Hs.80986 mitochondrial F0 complex, subunit c (subunit 9), isoform 1 115 487373 ATP5G1 ATP synthase, H+ transporting, AA046489 Hs.80986 mitochondrial F0 complex, subunit c (subunit 9), isoform 1 116 809876 ATP5G2 ATP synthase, H+ transporting, AA455126 Hs.89399 mitochondrial F0 complex, subunit c (subunit 9), isoform 2 117 809876 ATP5G2 ATP synthase, H+ transporting, AA464312 Hs.89399 mitochondrial F0 complex, subunit c (subunit 9), isoform 2 118 825312 ATP5J ATP synthase, H+ transporting, AA504540 Hs.73851 mitochondrial F0 complex, subunit F6 119 825312 ATP5J ATP synthase, H+ transporting, AA504465 Hs.73851 mitochondrial F0 complex, subunit F6 120 392622 ATP5B ATP synthase, H+ transporting, AA708298 Hs.25 mitochondrial F1 complex, beta polypeptide 121 856650 ATP5D ATP synthase, H+ transporting, AA669314 Hs.89761 mitochondrial F1 complex, delta subunit 122 1472150 ATP5O ATP synthase, H+ transporting, AA873577 Hs.76572 mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) 123 2098508 ATP2B2 ATP2B2 AI421603 Hs.89512 124 1753047 ATP50 ATP50 AI184610 125 1173869 ATP5A1 ATP5A1 AA640573 126 964121 ATP5C1 ATP5C1 AA507388 127 1736058 ATP5F1 ATP5F1 AI126623 128 307873 ATP2B4 ATPase, Ca++ transporting, plasma N93024 Hs.995 membrane 4 129 307873 ATP2B4 ATPase, Ca++ transporting, plasma W21376 Hs.995 membrane 4 130 1435103 ATP2A3 ATPase, Ca++ transporting, ubiquitous AA857542 Hs.5541 131 266312 ATP7B ATPase, Cu++ transporting, beta N26536 Hs.84999 polypeptide (Wilson disease) 132 266312 ATP7B ATPase, Cu++ transporting, beta N35647 Hs.84999 polypeptide (Wilson disease) 133 384078 ATP6DV ATPase, H+ transporting, lysosomal AA702541 Hs.106876 (vacuolar proton pump) 31 kD 134 825170 ATP6A1 ATPase, H+ transporting, lysosomal AA504160 Hs.255352 (vacuolar proton pump), alpha polypeptide, 70 kD, isoform 1 135 825170 ATP6A1 ATPase, H+ transporting, lysosomal AA504159 Hs.255352 (vacuolar proton pump), alpha polypeptide, 70 kD, isoform 1 136 1323203 ATP6B2 ATPase, H+ transporting, lysosomal AA877194 Hs.1697 (vacuolar proton pump), beta polypeptide, 56/58 kD, isoform 2 137 461522 ABCB7 ATP-binding cassette, sub-family B AA705237 Hs.125856 (MDR/TAP), member 7 138 1709773 MCX1 ATP-DEPENDENT CLP PROTEASE AI131257 139 1467799 KIAA0705 atrophin-1 interacting protein 1 AA883236 Hs.22599 140 852273 AZF1 AZF1 AA772863 141 2367249 B42665 B42665 AI741963 142 194384 BTF3 Basic transcription factor 3 R83000 Hs.101025 143 194384 BTF3 Basic transcription factor 3 R82957 Hs.101025 144 342181 BCL2 B-cell CLL/lymphoma 2 W63749 Hs.79241 145 342181 BCL2 B-cell CLL/lymphoma 2 W61100 Hs.79241 146 826182 BCL6 B-cell CLL/lymphoma 6 (zinc finger AA521434 protein 51) 147 814899 BNIP3L BCL2/adenovirus E1B 19 kD-interacting AA465697 Hs.132955 protein 3-like 148 235938 BAK1 BCL2-antagonist/killer 1 H52672 149 235938 BAK1 BCL2-antagonist/killer 1 H52673 150 2125819 BAX BCL2-associated X protein AI565203 151 1916575 BIK BCL2-interacting killer (apoptosis- AI347538 inducing) 152 1568561 BCL2L1 BCL2-like 1 AA931820 Hs.180372 153 2297154 BCS1 BCS1 AI670836 154 813444 BZRP benzodiazapine receptor (peripheral) AA455945 Hs.202 155 813444 BZRP benzodiazapine receptor (peripheral) AA455554 Hs.202 156 627125 BID BH3 interacting domain death agonist AA190401 157 627125 BID BH3 interacting domain death agonist AA190546 158 1573108 BCKDK branched chain alpha-ketoacid AA970731 Hs.20644 dehydrogenase kinase 159 756490 BCAT2 branched chain aminotransferase 2, AA436410 Hs.101408 mitochondrial 160 756490 BCAT2 branched chain aminotransferase 2, AA481353 Hs.101408 mitochondrial 161 740801 BCKDHA branched chain keto acid dehydrogenase AA477298 Hs.78950 E1, alpha polypeptide (maple syrup urine disease) 162 740801 BCKDHA branched chain keto acid dehydrogenase AA477297 Hs.78950 E1, alpha polypeptide (maple syrup urine disease) 163 770835 BCKDHB Branched chain keto acid dehydrogenase AA427739 Hs.1265 E1, beta polypeptide (maple syrup urine disease) 164 770835 BCKDHB Branched chain keto acid dehydrogenase AA434304 Hs.1265 E1, beta polypeptide (maple syrup urine disease) 165 129431 EST BRCA2(?) R11316 Hs.188591 166 129431 EST BRCA2(?) R11315 Hs.188591 167 83605 CPS1 carbamoyl-phosphate synthetase 1, T61078 Hs.50966 mitochondrial 168 83605 CPS1 carbamoyl-phosphate synthetase 1, T61180 Hs.50966 mitochondrial 169 1675950 CRHU5 CARBONIC ANHYDRASE V AI052226 PRECURSOR 170 744417 CRAT Carnitine acetyltransferase AA621218 Hs.12068 171 133565 CPT1A carnitine palmitoyltransferase I, liver R28631 Hs.29331 172 133565 CPT1A carnitine palmitoyltransferase I, liver R32561 Hs.29331 173 415978 CPT1A carnitine palmitoyltransferase I, liver W85710 Hs.29331 174 415978 CPT1A carnitine palmitoyltransferase I, liver W86378 Hs.29331 175 120106 CASP1 caspase 1, apoptosis-related cysteine T95052 protease (interleukin 1, beta, convertase) 176 120106 CASP1 caspase 1, apoptosis-related cysteine T95149 protease (interleukin 1, beta, convertase) 177 30170 CASP3 caspase 3, apoptosis-related cysteine R14760 protease 178 30170 CASP3 caspase 3, apoptosis-related cysteine R42530 protease 179 429574 CASP3 caspase 3, apoptosis-related cysteine AA011445 protease 180 429574 CASP3 caspase 3, apoptosis-related cysteine AA011446 protease 181 745143 CASP6 caspase 6, apoptosis-related cysteine AA626710 protease 182 279691 CD2AP CD2-associated protein N48329 Hs.30490 183 279691 CD2AP CD2-associated protein N49054 Hs.30490 184 1558965 CDC2L cholinesterase-related cell division AA917769 Hs.155266 controller 185 324885 C11ORF4 chromosome 11 open reading frame 4 W48701 Hs.75859 186 324885 C11ORF4 chromosome 11 open reading frame 4 W48700 Hs.75859 187 1573778 C11ORF13 chromosome 11 open reading frame 13 AA970526 Hs.72925 188 110772 C14ORF2 chromosome 14 open reading frame 2 T90621 Hs.109052 189 110772 C14ORF2 chromosome 14 open reading frame 2 T83147 Hs.109052 190 897448 C2ORF1 chromosome 2 open reading frame 1 AA489478 Hs.14454 191 1060841 CIT1 CITRATE SYNTHASE, AA568724 MITOCHONDRIAL PRECURSOR 192 310519 F10 COAGULATION FACTOR X N98524 Hs.47913 PRECURSOR 193 310519 F10 COAGULATION FACTOR X W31088 Hs.47913 PRECURSOR 194 436062 CPO coproporphyrinogen oxidase AA700808 Hs.89866 (coproporphyria, harderoporphyria) 195 161476 COQ5 COQ5 H25602 196 161476 COQ5 COQ5 H25556 197 2338136 COX11.1-11.2 COX11.1-11.2 AI703310 198 1902314 COX15.1 COX15.1 AI301929 199 1318021 COX5A COX5A AA769095 200 2326019 COX5B COX5B AI688757 Hs.1342 201 2301230 COX5B COX5B AI699318 202 2097122 COX6A1 COX6A1 AI421088 203 986164 COX6A2 COX6A2 AA548887 204 2277616 COX6B COX6B AI690478 205 971851 COX7A1 COX7A1 AA515958 206 937944 COX7A2 COX7A2 AA563616 207 2019469 CKMT1 creatine kinase, mitochondrial 1 AI369378 Hs.153998 (ubiquitous) 208 795965 CKMT2 Creatine kinase, mitochondrial 2 AA460480 Hs.80691 (sarcomeric) 209 795965 CKMT2 Creatine kinase, mitochondrial 2 AA461048 Hs.80691 (sarcomeric) 210 771327 NIFS cysteine desulfurase AA476245 Hs.194692 211 771327 NIFS cysteine desulfurase AA476244 Hs.194692 212 196189 CYB5 Cytochrome b-5 R92281 Hs.83834 213 196189 CYB5 Cytochrome b-5 R91950 Hs.83834 214 840894 COX6A1 CYTOCHROME C OXIDASE AA482243 Hs.180714 POLYPEPTIDE VIA-LIVER PRECURSOR 215 840894 COX6A1 CYTOCHROME C OXIDASE AA482340 Hs.180714 POLYPEPTIDE VIA-LIVER PRECURSOR 216 824068 COX5A cytochrome c oxidase subunit Va AA490735 217 824068 COX5A cytochrome c oxidase subunit Va AA491224 218 298965 COX6B Cytochrome c oxidase subunit VIb N71160 Hs.174031 219 298965 COX6B Cytochrome c oxidase subunit VIb W05541 Hs.174031 220 1472754 COX6B cytochrome c oxidase subunit VIb AA872391 Hs.174031 221 838568 COX6C cytochrome c oxidase subunit VIc AA456931 Hs.74649 222 838568 COX6C cytochrome c oxidase subunit VIc AA457006 Hs.74649 223 1475803 COX7A1 cytochrome c oxidase subunit VIIa AA872125 Hs.114346 polypeptide 1 (muscle) 224 1601947 COX7A2 cytochrome c oxidase subunit VIIa AI002403 Hs.182684 polypeptide 2 (liver) 225 884511 COX7B cytochrome c oxidase subunit VIIb AA629999 Hs.75752 226 884480 COX7C cytochrome c oxidase subunit VIIc AA629719 Hs.3462 227 1469230 COX8 cytochrome c oxidase subunit VIII AA862813 Hs.81097 228 160126 COX10 Cytochrome c oxidase subunit X (heme H21868 Hs.77513 A: farnesyltransferase 229 160126 COX10 Cytochrome c oxidase subunit X (heme H21869 Hs.77513 A: farnesyltransferase 230 1455394 CYC1 cytochrome c-1 AA865265 Hs.697 231 194949 CYP3A7 Cytochrome P450 IIIA7 (P450-HFLa) R91078 Hs.172323 232 194949 CYP3A7 Cytochrome P450 IIIA7 (P450-HFLa) R91077 Hs.172323 233 1724630 S14367 CYTOCHROME P450 XIA1 AI183397 234 85561 CYP2A7 cytochrome P450, subfamily IIA T73031 Hs.252937 (phenobarbital-inducible), polypeptide 7 235 85561 CYP2A7 cytochrome P450, subfamily IIA T72259 Hs.252937 (phenobarbital-inducible), polypeptide 7 236 246619 CYP2C8 Cytochrome P450, subfamily IIC N53136 (mephenytoin 4-hydroxylase) 237 246619 CYP2C8 Cytochrome P450, subfamily IIC N58566 (mephenytoin 4-hydroxylase) 238 195712 CYP2C9 Cytochrome P450, subfamily IIC R89492 Hs.167529 (mephenytoin 4-hydroxylase), polypeptide 9 239 195712 CYP2C9 Cytochrome P450, subfamily IIC R89491 Hs.167529 (mephenytoin 4-hydroxylase), polypeptide 9 240 1467195 CYP11B1 cytochrome P450, subfamily XIB (steroid AA884709 Hs.2610 11-beta-hydroxylase), polypeptide 1 241 149737 EST Cytochrome P450, subfamily XIX H00592 Hs.141142 (aromatization of androgens) 242 149737 EST Cytochrome P450, subfamily XIX R82738 Hs.141142 (aromatization of androgens) 243 284620 EST Cytochrome P450, subfamily XXI N64794 Hs.124918 (steroid 21-hydroxylase, congenital adrenal hyperplasia) 244 284620 EST Cytochrome P450, subfamily XXI N77388 Hs.124918 (steroid 21-hydroxylase, congenital adrenal hyperplasia) 245 266146 CYP24 cytochrome P450, subfamily XXIV N21576 Hs.89663 (vitamin D 24-hydroxylase) 246 266146 CYP24 cytochrome P450, subfamily XXIV N30976 Hs.89663 (vitamin D 24-hydroxylase) 247 295843 CYP27A1 cytochrome P450, subfamily XXVIIA N66957 Hs.82568 (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1 248 2043415 DAPK1 death-associated protein kinase 1 AI371096 Hs.153924 249 2364396 DEHUH2 DEHUH2 AI740677 250 125722 DGUOK deoxyguanosine kinase R07560 Hs.77494 251 125722 DGUOK deoxyguanosine kinase R07506 Hs.77494 252 2096376 S25665 DIHYDROLIPOAMIDE AI419467 ACETYLTRANSFERASE COMPONENT 253 813648 DLD dihydrolipoamide dehydrogenase (E3 AA453679 Hs.74635 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) 254 813648 DLD dihydrolipoamide dehydrogenase (E3 AA447748 Hs.74635 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) 255 271006 DLAT dihydrolipoamide S-acetyltransferase (E2 N29901 Hs.115285 component of pyruvate dehydrogenase complex) 256 271006 DLAT dihydrolipoamide S-acetyltransferase (E2 N42953 Hs.115285 component of pyruvate dehydrogenase complex) 257 815564 DLST Dihydrolipoamide S-succinyltransferase AA456824 Hs.196416 (E2 component of 2-oxo-glutarate complex) 258 815564 DLST Dihydrolipoamide S-succinyltransferase AA456899 Hs.196416 (E2 component of 2-oxo-glutarate complex) 259 1308945 DIHYDROLIPOAMIDE DIHYDROLIPOAMIDE AA748401 SUCCINYLTRANSFERASE SUCCINYLTRANSFERASE 260 1308945 DIHYDROLIPOAMIDE DIHYDROLIPOAMIDE AA746285 SUCCINYLTRANSFERASE SUCCINYLTRANSFERASE 261 417385 Dihydroorotate Dihydroorotate dehydrogenase W88472 Hs.125846 dehydrogenase 262 417385 Dihydroorotate Dihydroorotate dehydrogenase W89035 Hs.125846 dehydrogenase 263 611027 dihydroorotate dihydroorotate dehydrogenase AA173122 Hs.94925 dehydrogenase 264 611027 dihydroorotate dihydroorotate dehydrogenase AA173225 Hs.94925 dehydrogenase 265 884539 DKFZP566D143 DKFZP566D143 protein AA629804 266 630013 MSH2 DNA repair protein MSH2 AA219060 Hs.78934 267 630013 MSH2 DNA repair protein MSH2 AA219061 Hs.78934 268 666425 PLCG1 DNA topoisomerase I AA232856 Hs.317 269 666425 PLCG1 DNA topoisomerase I AA233029 Hs.317 270 810787 HSPF1 DNAJ PROTEIN HOMOLOG 1 AA481758 Hs.82646 271 810787 HSPF1 DNAJ PROTEIN HOMOLOG 1 AA481022 Hs.82646 272 1914863 DYSF dysferlin, limb girdle muscular dystrophy AI310142 Hs.143897 2B (autosomal recessive) 273 773399 DMD dystrophin (muscular dystrophy, AA425649 Hs.169470 Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 274 773399 DMD dystrophin (muscular dystrophy, AA427831 Hs.169470 Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 275 796197 DMD Dystrophin (muscular dystrophy, AA461118 Hs.169470 Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 276 796197 DMD Dystrophin (muscular dystrophy, AA461435 Hs.169470 Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 277 781017 EGR2 early growth response 2 (Krox-20 AA446027 Hs.1395 (Drosophila) homolog) 278 781017 EGR2 early growth response 2 (Krox-20 AA446300 Hs.1395 (Drosophila) homolog) 279 180512 ENC1 ectodermal-neural cortex (with BTB-like R85090 Hs.104925 domain) 280 1744035 A31998 ELECTRON TRANSFER AI192719 FLAVOPROTEIN ALPHA-SUBUNIT 281 2274670 S32482 ELECTRON TRANSFER AI683530 FLAVOPROTEIN BETA-SUBUNIT 282 2267229 S62767 ELONGATION FACTOR TU AI609398 283 745542 ECHS1 enoyl Coenzyme A hydratase, short AA626255 Hs.76394 chain, 1, mitochondrial 284 344272 EMP3 epithelial membrane protein 3 W73810 Hs.9999 285 344272 EMP3 epithelial membrane protein 3 W73748 Hs.9999 286 253725 EST EST N21972 Hs.43052 287 287569 EST EST N62122 Hs.83313 288 287569 EST EST N78351 Hs.83313 289 489755 EST EST AA099554 Hs.246174 290 489755 EST EST AA101991 Hs.246174 291 609989 No Data EST AA169176 292 609989 No Data EST AA169296 293 511012 AGPS EST - putative alkylglycerone phosphate AA099787 synthase 294 511012 AGPS EST - putative alkylglycerone phosphate AA102257 synthase 295 449504 EST EST, Weakly similar to predicted using AA777928 Hs.121993 Genefinder [C. elegans] 296 47005 EST ESTs H09825 Hs.6818 297 47005 EST ESTs H09920 Hs.6818 298 79655 EST ESTs T62655 Hs.11039 299 79655 EST ESTs T62509 Hs.11039 300 126229 EST ESTs R06313 Hs.77677 301 126229 EST ESTs R06258 Hs.77677 302 129606 EST ESTs R16545 Hs.70333 303 129606 EST ESTs R16603 Hs.70333 304 165837 EST ESTs R86713 Hs.87595 305 165837 EST ESTs R86712 Hs.87595 306 248669 EST ESTs N59553 Hs.8941 307 248669 EST ESTs N78295 Hs.8941 308 254004 EST ESTs N22302 Hs.177861 309 254004 EST ESTs N75187 Hs.177861 310 259462 LOC54675 ESTs N29545 Hs.3569 311 290505 EST ESTs N67991 Hs.30487 312 290505 EST ESTs N80413 Hs.30487 313 341901 EST ESTs W61374 Hs.11317 314 429942 EST ESTs AA034062 Hs.38750 315 784214 EST ESTs AA446865 Hs.14018 316 784214 EST ESTs AA446980 Hs.14018 317 898222 EST ESTs AA598602 Hs.13434 318 1636741 ESTs ESTs AI017846 Hs.169539 319 113206 EST ESTs, Highly similar to ARGINYL- T83996 Hs.15395 TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR [Saccharomyces cerevisiae] 320 113206 EST ESTs, Highly similar to ARGINYL- T83997 Hs.15395 TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR [Saccharomyces cerevisiae] 321 825386 ATP5JD ESTs, Highly similar to ATP AA504246 Hs.64593 SYNTHASE D CHAIN, MITOCHONDRIAL [Bos taurus] 322 782439 ATP5I ESTs, Highly similar to ATP AA431433 Hs.85539 SYNTHASE E CHAIN, MITOCHONDRIAL [Cricetulus longicaudatus] 323 782439 ATP5I ESTs, Highly similar to ATP AA431836 Hs.85539 SYNTHASE E CHAIN, MITOCHONDRIAL [Cricetulus longicaudatus] 324 434968 ATP5E ESTs, Highly similar to ATP AA700688 Hs.177530 SYNTHASE EPSILON CHAIN, MITOCHONDRIAL PRECURSOR [Bos taurus] 325 82874 EST ESTs, Highly similar to ATPASE T69273 Hs.241336 INHIBITOR, MITOCHONDRIAL PRECURSOR [Rattus norvegicus] 326 82874 EST ESTs, Highly similar to ATPASE T69348 Hs.241336 INHIBITOR, MITOCHONDRIAL PRECURSOR [Rattus norvegicus] 327 290753 CS ESTs, Highly similar to CITRATE N67639 Hs.239760 SYNTHASE, MITOCHONDRIAL PRECURSOR [Sus scrofa] 328 290753 CS ESTs, Highly similar to CITRATE W01297 Hs.239760 SYNTHASE, MITOCHONDRIAL PRECURSOR [Sus scrofa] 329 731308 CS ESTs, Highly similar to CITRATE AA416759 Hs.239760 SYNTHASE, MITOCHONDRIAL PRECURSOR [Sus scrofa] 330 731308 CS ESTs, Highly similar to CITRATE AA416746 Hs.239760 SYNTHASE, MITOCHONDRIAL PRECURSOR [Sus scrofa] 331 283943 EST ESTs, Highly similar to ELONGATION N50802 Hs.41066 FACTOR G, MITOCHONDRIAL PRECURSOR [Rattus norvegicus] 332 283943 EST ESTs, Highly similar to ELONGATION N55159 Hs.41066 FACTOR G, MITOCHONDRIAL PRECURSOR [Rattus norvegicus] 333 359723 EST ESTs, Highly similar to ELONGATION AA011122 Hs.41066 FACTOR G, MITOCHONDRIAL PRECURSOR [Rattus norvegicus] 334 359723 EST ESTs, Highly similar to ELONGATION AA010761 Hs.41066 FACTOR G, MITOCHONDRIAL PRECURSOR [Rattus norvegicus] 335 430733 EST ESTs, Highly similar to AA677960 Hs.3585 HYPOTHETICAL 16.5 KD PROTEIN IN PAS8-EGT2 INTERGENIC REGION [Saccharomyces cerevisiae] 336 1114960 ETFDH ESTs, Highly similar to AA602015 Hs.30661 HYPOTHETICAL 29.2 KD PROTEIN IN PHD1-PTM1 INTERGENIC REGION [Saccharomyces cerevisiae] 337 1030791 EST ESTs, Highly similar to AA609009 Hs.63304 HYPOTHETICAL 44.9 KD PROTEIN IN ERG7-NMD2 INTERGENIC REGION [Saccharomyces cerevisiae] 338 950700 PP ESTs, Highly similar to INORGANIC AA608572 Hs.184011 PYROPHOSPHATASE [Bos taurus] 339 322218 EST ESTs, Highly similar to ISOLEUCYL- W37993 Hs.55609 TRNA SYNTHETASE, MITOCHONDRIAL [Saccharomyces cerevisiae] 340 322218 EST ESTs, Highly similar to ISOLEUCYL- W37992 Hs.55609 TRNA SYNTHETASE, MITOCHONDRIAL [Saccharomyces cerevisiae] 341 417801 LOC51264 ESTs, Highly similar to W88752 Hs.7736 MITOCHONDRIAL 60S RIBOSOMAL PROTEIN L2 PRECURSOR [Saccharomyces cerevisiae] 342 417801 LOC51264 ESTs, Highly similar to W88848 Hs.7736 MITOCHONDRIAL 60S RIBOSOMAL PROTEIN L2 PRECURSOR [Saccharomyces cerevisiae] 343 753602 EST ESTs, Highly similar to AA479944 Hs.42484 MITOCHONDRIAL CARRIER PROTEIN RIM2 [Saccharomyces cerevisiae] 344 753602 EST ESTs, Highly similar to AA478847 Hs.42484 MITOCHONDRIAL CARRIER PROTEIN RIM2 [Saccharomyces cerevisiae] 345 629916 TIM17B ESTs, Highly similar to AA219179 Hs.19105 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17 [Saccharomyces cerevisiae] 346 629916 TIM17B ESTs, Highly similar to AA219178 Hs.19105 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17 [Saccharomyces cerevisiae] 347 191826 EST ESTs, Highly similar to H40449 Hs.34401 MITOCHONDRIAL RNA SPLICING PROTEIN MRS3 [Saccharomyces cerevisiae] 348 191826 EST ESTs, Highly similar to H40448 Hs.34401 MITOCHONDRIAL RNA SPLICING PROTEIN MRS3 [Saccharomyces cerevisiae] 349 70201 EST ESTs, Highly similar to T50082 Hs.34401 MITOCHONDRIAL RNA SPLICING PROTEIN MSR4 [Saccharomyces cerevisiae] 350 70201 EST ESTs, Highly similar to T50019 Hs.34401 MITOCHONDRIAL RNA SPLICING PROTEIN MSR4 [Saccharomyces cerevisiae] 351 488386 EST ESTs, Highly similar to AA046639 Hs.34401 MITOCHONDRIAL RNA SPLICING PROTEIN MSR4 [Saccharomyces cerevisiae] 352 488386 EST ESTs, Highly similar to AA046778 Hs.34401 MITOCHONDRIAL RNA SPLICING PROTEIN MSR4 [Saccharomyces cerevisiae] 353 611467 NDUFS6 ESTs, Highly similar to AA176453 Hs.49767 MITOCHONDRIAL TRIFUNCTONAL ENZYME ALPHA SUBUNIT PRECURSOR [Homo sapiens] 354 611467 NDUFS6 ESTs, Highly similar to AA176931 Hs.49767 MITOCHONDRIAL TRIFUNCTONAL ENZYME ALPHA SUBUNIT PRECURSOR [Homo sapiens] 355 179336 SDHA ESTs, Highly similar to SUCCINATE H50345 Hs.469 DEHYDROGENASE [Homo sapiens] 356 179336 SDHA ESTs, Highly similar to SUCCINATE H50378 Hs.469 DEHYDROGENASE [Homo sapiens] 357 843335 SUCLG1 ESTs, Highly similar to SUCCINYL- AA485965 Hs.7043 COA LIGASE [Rattus norvegicus] 358 843335 SUCLG1 ESTs, Highly similar to SUCCINYL- AA489575 Hs.7043 COA LIGASE [Rattus norvegicus] 359 825229 LOC51017 ESTs, Highly similar to CGI-113 protein AA504139 Hs.19077 [H. sapiens] 360 825229 LOC51017 ESTs, Highly similar to CGI-113 protein AA504401 Hs.19077 [H. sapiens] 361 814271 Est ESTs, Highly similar to CGI-116 protein AA459002 Hs.18885 [H. sapiens] 362 814271 Est ESTs, Highly similar to CGI-116 protein AA459222 Hs.18885 [H. sapiens] 363 811062 LOC51629 ESTs, Highly similar to CGI-69 protein AA485441 Hs.237924 [H. sapiens] 364 811062 LOC51629 ESTs, Highly similar to CGI-69 protein AA485607 Hs.237924 [H. sapiens] 365 417803 EST ESTs, Highly similar to hypothetical W88753 Hs.166406 protein [H. sapiens] 366 417803 EST ESTs, Highly similar to hypothetical W88859 Hs.166406 protein [H. sapiens] 367 878316 ESTs ESTs, Highly similar to small zinc finger- AA670296 Hs.109571 like protein [H. sapiens] 368 504689 EST ESTs, Moderately similar to 3- AA149172 Hs.55781 OXOACYL-[ACYL-CARRIER- PROTEIN] SYNTHASE II [Escherichia coli] 369 504689 EST ESTs, Moderately similar to 3- AA149171 Hs.55781 OXOACYL-[ACYL-CARRIER- PROTEIN] SYNTHASE II [Escherichia coli] 370 238907 D6S52E ESTs, Moderately similar to ABC1 H67876 Hs.243960 PROTEIN PRECURSOR [Saccharomyces cerevisiae] 371 238907 D6S52E ESTs, Moderately similar to ABC1 H67202 Hs.243960 PROTEIN PRECURSOR [Saccharomyces cerevisiae] 372 435314 EST ESTs, Moderately similar to 5- AA699919 Hs.114018 AMINOLEVULINIC ACID SYNTHASE MITOCHONDRIAL PRECURSOR, ERYTHROID-SPECIFIC [H. sapiens] 373 839027 EST ESTs, Moderately similar to CGI-24 AA487499 protein [H. sapiens] 374 839027 EST ESTs, Moderately similar to CGI-24 AA487715 protein [H. sapiens] 375 321354 EST ESTs, Moderately similar to MSG1- W32403 Hs.18349 related protein [H. sapiens] 376 321354 EST ESTs, Moderately similar to MSG1- W32980 Hs.18349 related protein [H. sapiens] 377 824911 EST ESTs, Weakly similar to/prediction AA489022 Hs.5080 378 824911 EST ESTs, Weakly similar to/prediction AA489118 Hs.5080 379 85384 EST ESTs, Weakly similar to anon2A5 T71965 Hs.10964 [D. melanogaster] 380 85384 EST ESTs, Weakly similar to anon2A5 T72105 Hs.10964 [D. melanogaster] 381 757265 EST ESTs, Weakly similar to aralar1 AA426113 Hs.183047 [H. sapiens] 382 490753 FLJ20420 ESTs, Weakly similar to head-elevated AA133166 Hs.6693 expression in 0.9 kb [D. melanogaster] 383 343555 EST ESTs, Weakly similar to mitochondrial W69379 Hs.62669 inner membrane protease 1 [S. cerevisiae] 384 343555 EST ESTs, Weakly similar to mitochondrial W69378 Hs.62669 inner membrane protease 1 [S. cerevisiae] 385 198312 KIAA0719 ESTs, Weakly similar to R94191 Hs.21198 MITOCHONDRIAL PRECURSOR PROTEINS IMPORT RECEPTOR [Neurospora crassa] 386 198312 KIAA0719 ESTs, Weakly similar to R94290 Hs.21198 MITOCHONDRIAL PRECURSOR PROTEINS IMPORT RECEPTOR [Neurospora crassa] 387 511257 KIAA0719 ESTs, Weakly similar to AA088722 Hs.21198 MITOCHONDRIAL PRECURSOR PROTEINS IMPORT RECEPTOR [Neurospora crassa] 388 511257 KIAA0719 ESTs, Weakly similar to AA088799 Hs.21198 MITOCHONDRIAL PRECURSOR PROTEINS IMPORT RECEPTOR [Neurospora crassa] 389 324651 EST ESTs, Weakly similar to W47099 Hs.19513 MITOCHONDRIAL RESPIRATORY FUNCTION PROTEIN 1 [Saccharomyces cerevisiae] 390 324651 EST ESTs, Weakly similar to W47223 Hs.19513 MITOCHONDRIAL RESPIRATORY FUNCTION PROTEIN 1 [Saccharomyces cerevisiae] 391 429222 EST ESTs, Weakly similar to MSF1 AA004210 Hs.3945 PROTEIN [S. cerevisiae] 392 429222 EST ESTs, Weakly similar to MSF1 AA007411 Hs.3945 PROTEIN [S. cerevisiae] 393 754537 EST ESTs, Weakly similar to myosin beta AA406291 heavy chain, cardiac and skeletal muscle [H. sapiens] 394 754537 EST ESTs, Weakly similar to myosin beta AA421979 heavy chain, cardiac and skeletal muscle [H. sapiens] 395 897557 EST ESTs, Weakly similar to myosin beta AA497024 Hs.179817 heavy chain, cardiac and skeletal muscle [H. sapiens] 396 897557 EST ESTs, Weakly similar to myosin beta AA489606 Hs.179817 heavy chain, cardiac and skeletal muscle [H. sapiens] 397 812169 EST ESTs, Weakly similar to PROBABLE AA456042 Hs.7807 MITOCHONDRIAL 40S RIBOSOMAL PROTEIN S5 [S. cerevisiae] 398 208531 EST ESTs, Weakly similar to PUTATIVE H61979 Hs.7994 MITOCHONDRIAL CARRIER YBR291C [Saccharomyces cerevisiae] 399 208531 EST ESTs, Weakly similar to PUTATIVE H61978 Hs.7994 MITOCHONDRIAL CARRIER YBR291C [Saccharomyces cerevisiae] 400 435509 tRNAleu ESTs, Weakly similar to similar to AA701379 leucyl-tRNA synthetase [C. elegans] 401 43662 EST ESTs, Weakly similar to similar to H05645 Hs.21262 mitochrondrial carrier protein [C. elegans] 402 43662 EST ESTs, Weakly similar to similar to H05644 Hs.21262 mitochrondrial carrier protein [C. elegans] 403 53385 EST ESTs, Weakly similar to Similar to R16231 Hs.106620 NAD(P) transhydrogenase, mitochondrial [C. elegans] 404 53385 EST ESTs, Weakly similar to Similar to R16232 Hs.106620 NAD(P) transhydrogenase, mitochondrial [C. elegans] 405 84880 EST ESTs, Weakly similar to VISC PROTEIN T74882 Hs.12239 [Escherichia coli] 406 84880 EST ESTs, Weakly similar to VISC PROTEIN T74939 Hs.12239 [Escherichia coli] 407 845419 FANCA Fanconi anemia, complementation group A AA644129 Hs.86297 408 624634 FDX1 ferredoxin 1 AA187349 Hs.744 409 624634 FDX1 ferredoxin 1 AA188427 Hs.744 410 365149 FECH ferrochelatase (protoporphyria) AA025142 Hs.26 411 365149 FECH ferrochelatase (protoporphyria) AA025157 Hs.26 412 1469138 FGA Fibrinogen, A alpha polypeptide AA865707 Hs.90765 413 131839 FOLR1 folate receptor 1 (adult) R24635 Hs.73769 414 131839 FOLR1 folate receptor 1 (adult) R24530 Hs.73769 415 146605 FPRL1 formyl peptide receptor-like 1 R80041 Hs.99855 416 146605 FPRL1 formyl peptide receptor-like 1 R79948 Hs.99855 417 490600 FOSL2 FOS-like antigen 2 AA101617 Hs.155210 418 490600 FOSL2 FOS-like antigen 2 AA101616 Hs.155210 419 279790 FMR1 Fragile X mental retardation 1 N48355 Hs.89764 420 279790 FMR1 Fragile X mental retardation 1 N49132 Hs.89764 421 669419 FRDA Friedreich ataxia AA253413 Hs.95998 422 669419 FRDA Friedreich ataxia AA253388 Hs.95998 423 469412 FH Fumarate hydratase AA026917 Hs.75653 424 469412 FH Fumarate hydratase AA026918 Hs.75653 425 842839 FUS fusion, derived from t(12; 16) malignant AA486284 liposarcoma 426 842839 FUS fusion, derived from t(12; 16) malignant AA489305 liposarcoma 427 81289 ACTG2 Gamma-actin, enteric smooth muscle T60048 Hs.77443 form 428 288663 GJB1 gap junction protein, beta 1, 32 kD N62394 (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) 429 288663 GJB1 gap junction protein, beta 1, 32 kD N79360 (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) 430 2338827 GCDH_HUMAN GCDH_HUMAN AI693352 431 66534 GCKR glucokinase (hexokinase 4) regulatory T67007 Hs.89771 protein 432 66534 GCKR glucokinase (hexokinase 4) regulatory T67006 Hs.89771 protein 433 471498 GNS glucosamine (N-acetyl)-6-sulfatase AA035347 Hs.2703 (Sanfilippo disease IIID) 434 122636 G6PC Glucose-6-phosphatase T98886 Hs.242 435 122636 G6PC Glucose-6-phosphatase T98887 Hs.242 436 166236 G6PD glucose-6-phosphate dehydrogenase R87497 437 166236 G6PD glucose-6-phosphate dehydrogenase R88192 438 753775 GMPR Glucose-6-phosphate dehydrogenase AA406242 Hs.1435 439 753775 GMPR Glucose-6-phosphate dehydrogenase AA410375 Hs.1435 440 361565 GLUD1 glutamate dehydrogenase 1 AA018372 Hs.77508 441 361565 GLUD1 glutamate dehydrogenase 1 AA017175 Hs.77508 442 51702 GOT1 glutamic-oxaloacetic transaminase 1, H22856 Hs.597 soluble (aspartate aminotransferase 1) 443 51702 GOT1 glutamic-oxaloacetic transaminase 1, H22855 Hs.597 soluble (aspartate aminotransferase 1) 444 841370 GOT2 Glutamic-oxaloacetic transaminase 2, AA487739 Hs.170197 mitochondrial (aspartate aminotransferase 2) 445 841370 GOT2 Glutamic-oxaloacetic transaminase 2, AA487521 Hs.170197 mitochondrial (aspartate aminotransferase 2) 446 810999 GPX1 glutathione peroxidase 1 AA485362 Hs.76686 447 810999 GPX1 glutathione peroxidase 1 AA485517 Hs.76686 448 587847 GPX2 Glutathione peroxidase 2, gastrointestinal AA135289 Hs.2704 449 587847 GPX2 Glutathione peroxidase 2, gastrointestinal AA135152 Hs.2704 450 855523 GPX3 Glutathione peroxidase 3 (plasma) AA664180 Hs.172153 451 1555659 GPX3 glutathione peroxidase 3 (plasma) AI147534 Hs.172153 452 448619 GSR Glutathione reductase AA777289 Hs.121524 453 811792 GSS Glutathione synthetase AA463458 Hs.82327 454 628418 GPD1 glycerol-3-phosphate dehydrogenase 1 AA192547 Hs.255718 (soluble) 455 628418 GPD1 glycerol-3-phosphate dehydrogenase 1 AA193116 Hs.255718 (soluble) 456 428756 GPD2 glycerol-3-phosphate dehydrogenase 2 AA005219 Hs.93201 (mitochondrial) 457 428756 GPD2 glycerol-3-phosphate dehydrogenase 2 AA005218 Hs.93201 (mitochondrial) 458 42558 GATM glycine amidinotransferase (L- R61229 Hs.75335 arginine: glycine amidinotransferase) 459 42558 GATM glycine amidinotransferase (L- R61228 Hs.75335 arginine: glycine amidinotransferase) 460 134748 GCSH glycine cleavage system protein H R28294 Hs.77631 (aminomethyl carrier) 461 134748 GCSH glycine cleavage system protein H R28081 Hs.77631 (aminomethyl carrier) 462 248261 GLDC glycine dehydrogenase (decarboxylating; N78083 Hs.27 glycine decarboxylase, glycine cleavage system protein P) 463 248261 GLDC glycine dehydrogenase (decarboxylating; N58494 Hs.27 glycine decarboxylase, glycine cleavage system protein P) 464 45632 GYS1 glycogen synthase 1 (muscle) H08446 Hs.772 465 45632 GYS1 glycogen synthase 1 (muscle) H08732 Hs.772 466 245920 GYS2 glycogen synthase 2 (liver) N72934 Hs.82614 467 245920 GYS2 glycogen synthase 2 (liver) N52282 Hs.82614 468 1502027 MGE1 GrpE-like protein cochaperone mRNA AA887226 469 2250688 GT GT AI659294 470 841008 GBP1 Guanylate binding protein 1, interferon- AA486849 Hs.62661 inducible, 67 kD 471 841008 GBP1 Guanylate binding protein 1, interferon- AA486850 Hs.62661 inducible, 67 kD 472 796341 CLCN3 H. sapiens RNA for CLCN3 AA461332 Hs.174139 473 796341 CLCN3 H. sapiens RNA for CLCN3 AA459750 Hs.174139 474 300237 No Data H. sapiens DAP-3 mRNA N78611 475 300237 No Data H. sapiens DAP-3 mRNA W07332 476 341246 CLPP H. sapiens mRNA for CLPP W58658 Hs.74362 477 341246 CLPP H. sapiens mRNA for CLPP W58337 Hs.74362 478 1031185 MCSP H. sapiens mRNA for mitochondrial AA609976 Hs.111850 capsule selenoprotein 479 259842 PMPCB H. sapiens mRNA for M-phase N29844 Hs.184211 phosphoprotein, mpp11 480 259842 PMPCB H. sapiens mRNA for M-phase N57262 Hs.184211 phosphoprotein, mpp11 481 810942 IDH3G H. sapiens mRNA for NAD (H)-specific AA459380 Hs.75253 isocitrate dehydrogenase gamma subunit precursor 482 810942 IDH3G H. sapiens mRNA for NAD (H)-specific AA459606 Hs.75253 isocitrate dehydrogenase gamma subunit precursor 483 530282 NDUFA1 H. sapiens mRNA for NADH AA111999 Hs.74823 dehydrogenase 484 530282 NDUFA1 H. sapiens mRNA for NADH AA083784 Hs.74823 dehydrogenase 485 813815 NR1I3 H. sapiens mRNA for orphan nuclear AA447727 Hs.83623 hormone receptor 486 813815 NR1I3 H. sapiens mRNA for orphan nuclear AA447889 Hs.83623 hormone receptor 487 810959 ARHGDIA H. sapiens mRNA for rho GDP- AA459400 Hs.159161 dissociation Inhibitor 1 488 810959 ARHGDIA H. sapiens mRNA for rho GDP- AA459625 Hs.159161 dissociation Inhibitor 1 489 506032 TIM17 H. sapiens mRNA for TIM17 preprotein AA708446 Hs.20716 translocase 490 814526 EST H. sapiens seb4D mRNA AA459363 491 814526 EST H. sapiens seb4D mRNA AA459588 492 814460 SURF5 H. sapiens SURF-5 mRNA AA459247 Hs.78354 493 814460 SURF5 H. sapiens SURF-5 mRNA AA459472 Hs.78354 494 1671299 HRK harakiri, BCL2-interacting protein AI083676 Hs.87247 (contains only BH3 domain) 495 1417985 EST heat shock 10 kD protein 1 (chaperonin AA878786 Hs.203620 10) 496 1417985 EST heat shock 10 kD protein 1 (chaperonin AI791247 Hs.203620 10) 497 1870305 HSPB2 heat shock 27 kD protein 2 AI245337 Hs.78846 498 1354618 HSPF2 heat shock 40 kD protein 2 AA830392 Hs.172847 499 755904 HSPA1A HEAT SHOCK 70 KD PROTEIN 1 AA496544 Hs.8997 500 1604342 HSPA9B heat shock 70 kD protein 9B (mortalin-2) AA987644 Hs.3069 501 884719 HSPA10 HEAT SHOCK COGNATE 71 KD AA629567 Hs.180414 PROTEIN 502 253009 HSPCA HEAT SHOCK PROTEIN HSP 90- H88540 Hs.180532 ALPHA 503 253009 HSPCA HEAT SHOCK PROTEIN HSP 90- H88588 Hs.180532 ALPHA 504 824031 HSJ2 heat shock protein, DNAJ-like 2 AA490946 505 824031 HSJ2 heat shock protein, DNAJ-like 2 AA491132 506 1606894 HSF4 heat shock transcription factor 4 AA999776 Hs.75486 507 562101 HERC1 hect (homologous to the E6-AP (UBE3A) AA211496 Hs.255561 carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 508 562101 HERC1 hect (homologous to the E6-AP (UBE3A) AA211544 Hs.255561 carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 509 85259 HMOX1 heme oxygenase (decycling) 1 T71757 Hs.202833 510 85259 HMOX1 heme oxygenase (decycling) 1 T71606 Hs.202833 511 745116 HMOX2 Heme oxygenase (decycling) 2 AA626370 Hs.83853 512 433307 HNF6A hepatocyte nuclear factor 6, alpha AA699732 Hs.73168 513 840158 HK1 Hexokinase 1 AA485271 Hs.118625 514 840158 HK1 Hexokinase 1 AA485272 Hs.118625 515 1338040 C46157 HEXOKINASE D, LIVER ISOZYMES AA811712 516 211780 No Data Hexosaminidase B (beta polypeptide) H71868 517 211780 No Data Hexosaminidase B (beta polypeptide) H71081 518 767441 HEXB hexosaminidase B (beta polypeptide) AA417946 Hs.51043 519 767441 HEXB hexosaminidase B (beta polypeptide) AA418121 Hs.51043 520 970591 HMG1 High-mobility group (nonhistone AA683085 Hs.189509 chromosomal) protein 1 521 363103 HMG2 High-mobility group (nonhistone AA019511 Hs.80684 chromosomal) protein 2 522 363103 HMG2 High-mobility group (nonhistone AA019203 Hs.80684 chromosomal) protein 2 523 80924 HO3 histidyl-tRNA synthetase T70104 Hs.77798 524 80924 HO3 histidyl-tRNA synthetase T70037 Hs.77798 525 812246 HLCS holocarboxylase synthetase (biotin- AA455043 Hs.79375 [proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) 526 712577 HCCS HOLOCYTOCHROME C-TYPE AA281548 Hs.88859 SYNTHETASE 527 712577 HCCS HOLOCYTOCHROME C-TYPE AA281549 Hs.88859 SYNTHETASE 528 611075 HOXA1 homeo box A1 AA173231 529 611075 HOXA1 homeo box A1 AA173290 530 244146 APAF1 Homo sapiens apoptotic protease N51014 Hs.77579 activating factor 1 (Apaf-1) mRNA, complete cds 531 244146 APAF1 Homo sapiens apoptotic protease N72045 Hs.77579 activating factor 1 (Apaf-1) mRNA, complete cds 532 288796 BNIP2 Homo sapiens BCL2/adenovirus E1B N62514 Hs.155596 19 kD-interacting protein 2 (BNIP2) mRNA, complete cds 533 432620 NOD1 Homo sapiens caspase recruitment AA699441 domain 4 (NOD1) mRNA 534 853506 23956 Mrna Homo sapiens clone 23956 mRNA, AA663549 Hs.8128 partial cds 535 288888 EST Homo sapiens clone 640 unknown N62617 Hs.44563 mRNA, complete sequence 536 288888 EST Homo sapiens clone 640 unknown N78388 Hs.44563 mRNA, complete sequence 537 271102 CCS Homo sapiens copper chaperone for N30404 Hs.5002 superoxide dismutase (CCS) mRNA, complete cds 538 489823 COX17 Homo sapiens COX17 mRNA, complete AA099855 Hs.16297 cds 539 489823 COX17 Homo sapiens COX17 mRNA, complete AA099320 Hs.16297 cds 540 487348 DYMPLE Homo sapiens dynamin-like protein AA045529 Hs.180628 mRNA, complete cds 541 487348 DYMPLE Homo sapiens dynamin-like protein AA040651 Hs.180628 mRNA, complete cds 542 359982 BNIP3 Homo sapiens E1B 19K/Bcl-2-binding AA063521 Hs.79428 protein Nip3 mRNA, nuclear gene encoding mitochondrial protein, complete cds 543 359982 BNIP3 Homo sapiens E1B 19K/Bcl-2-binding AA035669 Hs.79428 protein Nip3 mRNA, nuclear gene encoding mitochondrial protein, complete cds 544 395436 HUEL Homo sapiens embryonic lung protein AA757427 Hs.44053 (HUEL) mRNA, complete cds 545 1472184 HUEL Homo sapiens embryonic lung protein AA873264 Hs.44053 (HUEL) mRNA, complete cds 546 129644 SSH3BP1 Homo sapiens eps8 binding protein e3B1 R16667 Hs.24752 mRNA, complete cds 547 129644 SSH3BP1 Homo sapiens eps8 binding protein e3B1 R16666 Hs.24752 mRNA, complete cds 548 563574 FRG1 Homo sapiens FRG1 mRNA, complete AA113339 Hs.203772 cds 549 563574 FRG1 Homo sapiens FRG1 mRNA, complete AA112636 Hs.203772 cds 550 83279 TIM23 Homo sapiens inner mitochondrial T68317 Hs.11866 membrane translocase Tim23 (TIM23) mRNA, nuclear gene encoding mitochondrial protein, complete cds 551 83279 TIM23 Homo sapiens inner mitochondrial T68386 Hs.11866 membrane translocase Tim23 (TIM23) mRNA, nuclear gene encoding mitochondrial protein, complete cds 552 455123 KIAA0429 Homo sapiens KIAA0430 mRNA, AA676805 Hs.77694 complete cds 553 300590 APACD Homo sapiens mRNA for ATP binding N80741 Hs.153884 protein, complete cds 554 300590 APACD Homo sapiens mRNA for ATP binding W07537 Hs.153884 protein, complete cds 555 129146 COX7RP Homo sapiens mRNA for COX7RP, R10896 Hs.30888 complete cds 556 129146 COX7RP Homo sapiens mRNA for COX7RP, R10947 Hs.30888 complete cds 557 745314 HIRIPS Homo sapiens mRNA for HIRA- AA625581 Hs.17368 interacting protein HIRIP5 558 810316 KIAA0631 Homo sapiens mRNA for KIAA0631 AA464206 Hs.75154 protein, partial cds 559 810316 KIAA0631 Homo sapiens mRNA for KIAA0631 AA464139 Hs.75154 protein, partial cds 560 490778 QP-C Homo sapiens mRNA for low molecular AA133191 Hs.3709 mass ubiquinone-binding protein, complete cds 561 131653 RPMS12 Homo sapiens mRNA for mitochondrial R23752 Hs.9964 ribosomal protein S12 562 131653 RPMS12 Homo sapiens mRNA for mitochondrial R23806 Hs.9964 ribosomal protein S12 563 344825 LAS Homo sapiens mRNA for putative lipoic W72965 Hs.53531 acid synthetase, partial 564 344825 LAS Homo sapiens mRNA for putative lipoic W76202 Hs.53531 acid synthetase, partial 565 345621 CXX1 Homo sapiens mRNA for putatively W72596 Hs.255532 prenylated protein 566 345621 CXX1 Homo sapiens mRNA for putatively W76590 Hs.255532 prenylated protein 567 450574 SCA7 Homo sapiens mRNA for spinocerebellar AA704255 Hs.108447 ataxia 7 568 123474 SCD Homo sapiens mRNA for stearoyl-CoA R00707 Hs.119597 desaturase 569 123474 SCD Homo sapiens mRNA for stearoyl-CoA R00706 Hs.119597 desaturase 570 855890 cDNA Homo sapiens mRNA; cDNA AA630320 Hs.255914 DKFZp586C0722 (from clone DKFZp586C0722) 571 770043 NDUFV1 Homo sapiens NADH: ubiquinone AA427570 Hs.7744 dehydrogenase 51 kDa subunit (NDUFV1) mRNA, nuclear gene encoding mitochondrial protein, complete cds 572 770043 NDUFV1 Homo sapiens NADH: ubiquinone AA427652 Hs.7744 dehydrogenase 51 kDa subunit (NDUFV1) mRNA, nuclear gene encoding mitochondrial protein, complete cds 573 859228 IDH1 Homo sapiens NADP-dependent AA666366 Hs.11223 isocitrate dehydrogenase (IDH) mRNA, complete cds 574 124753 ABCD4 Homo sapiens peroxisomal membrane R02189 Hs.94395 protein 69 (PMP69) mRNA, complete cds 575 293104 PHYH Homo sapiens peroxisomal phytanoyl- N91990 Hs.172887 CoA alpha-hydroxylase (PAHX) mRNA, complete cds 576 293104 PHYH Homo sapiens peroxisomal phytanoyl- N63845 Hs.172887 CoA alpha-hydroxylase (PAHX) mRNA, complete cds 577 1629264 hTIM44 Homo sapiens putative mitochondrial AI003393 Hs.123178 inner membrane protein import receptor (hTIM44) mRNA, nuclear gene encoding mitochondrial protein, complete cds 578 399532 RPA40 Homo sapiens RNA polymerase I subunit AA733038 Hs.5409 hRPA39 mRNA, complete cds 579 787938 SLC4A4 Homo sapiens sodium bicarbonate AA452278 Hs.5462 cotransporter (HNBC1) mRNA, complete cds 580 138189 WFS1 Homo sapiens transmembrane protein R53910 Hs.26077 (WFS1) mRNA, complete cds 581 138189 WFS1 Homo sapiens transmembrane protein R53911 Hs.26077 (WFS1) mRNA, complete cds 582 266106 YWHAE Human 14-3-3 epsilon mRNA, complete N21624 Hs.79474 cds 583 266106 YWHAE Human 14-3-3 epsilon mRNA, complete N28863 Hs.79474 cds 584 45464 AK2 Human adenylate kinase 2 (adk2) mRNA, H09730 Hs.171811 complete cds 585 45464 AK2 Human adenylate kinase 2 (adk2) mRNA, H10488 Hs.171811 complete cds 586 795543 AOE372 Human antioxidant enzyme AOE37-2 AA459663 Hs.83383 mRNA, complete cds 587 241481 CASP10 Human apoptotic cysteine protease Mch4 H80712 Hs.5353 (Mch4) mRNA, complete cds 588 241481 CASP10 Human apoptotic cysteine protease Mch4 H80711 Hs.5353 (Mch4) mRNA, complete cds 589 897774 APRT Human APRT gene for adenine AA598510 Hs.28914 phosphoribosyltransferase 590 810552 REA Human B-cell receptor associated protein AA464669 Hs.7771 (hBAP) mRNA, partial cds 591 810552 REA Human B-cell receptor associated protein AA464567 Hs.7771 (hBAP) mRNA, partial cds 592 2326129 BBC3 Human Bcl-2 binding component 3 AI688112 Hs.87246 (bbc3) mRNA, partial cds 593 795729 BAD Human Bcl-2 binding component 6 AA460291 Hs.76366 (bbc6) mRNA, complete cds 594 795729 BAD Human Bcl-2 binding component 6 AA461579 Hs.76366 (bbc6) mRNA, complete cds 595 814478 BCL2A1 Human Bcl-2 related (Bfl-1) mRNA, AA459263 Hs.227817 complete cds 596 814478 BCL2A1 Human Bcl-2 related (Bfl-1) mRNA, AA459491 Hs.227817 complete cds 597 212198 TP53BP2 Human Bcl2, p53 binding protein H69153 Hs.44585 Bbp/53BP2 (BBP/53BP2) mRNA, complete cds 598 212198 TP53BP2 Human Bcl2, p53 binding protein H69077 Hs.44585 Bbp/53BP2 (BBP/53BP2) mRNA, complete cds 599 432581 Novel Gene Human BRCA2 region, mRNA sequence AA699390 Hs.184938 CG012 600 433111 BAC clone CIT987SK-A- Human Chromosome 16 BAC clone AA680407 Hs.47278 735G6 CIT987SK-A-735G6 601 782635 NDUFAB1 Human Chromosome 16 BAC clone AA447569 Hs.5556 CIT987SK-A-735G6 602 782635 NDUFAB1 Human Chromosome 16 BAC clone AA448553 Hs.5556 CIT987SK-A-735G6 603 669471 23589 mRNA Human clone 23589 mRNA sequence AA234889 Hs.11506 604 669471 23589 mRNA Human clone 23589 mRNA sequence AA253479 Hs.11506 605 771173 23732 mRNA Human clone 23732 mRNA, partial cds AA443497 Hs.81281 606 771173 23732 mRNA Human clone 23732 mRNA, partial cds AA429483 Hs.81281 607 745606 23759 mRNA Human clone 23759 mRNA, partial cds AA626336 Hs.118666 608 323500 CASP6 Human cysteine protease Mch2 isoform W45688 Hs.3280 alpha (Mch2) mRNA, complete cds 609 323500 CASP6 Human cysteine protease Mch2 isoform W44316 Hs.3280 alpha (Mch2) mRNA, complete cds 610 71420 CYP2C9 Human cytochrome P4502C9 (CYP2C9) T47787 mRNA, clone 65 611 71420 CYP2C9 Human cytochrome P4502C9 (CYP2C9) T47788 mRNA, clone 65 612 754490 SLC25A16 Human GT mitochondrial solute carrier AA411554 Hs.180408 protein homologue mRNA, complete cds 613 754490 SLC25A16 Human GT mitochondrial solute carrier AA410572 Hs.180408 protein homologue mRNA, complete cds 614 1734348 Go-alpha Human guanine nucleotide-binding AI188097 Hs.169647 regulatory protein (Go-alpha) gene 615 826204 FLII Human homolog of D. melanogaster AA521453 Hs.83849 flightless-I gene product mRNA, partial cds 616 144777 HAX1 Human HS1 binding protein HAX-1 R76263 Hs.15318 mRNA, nuclear gene encoding mitochondrial protein, complete cds 617 144777 HAX1 Human HS1 binding protein HAX-1 R76544 Hs.15318 mRNA, nuclear gene encoding mitochondrial protein, complete cds 618 261481 CUL3 Human Hs-cul-3 mRNA, partial cds H98621 Hs.78946 619 261481 CUL3 Human Hs-cul-3 mRNA, partial cds N25142 Hs.78946 620 233581 HIP2 Human huntingtin interacting protein H78483 Hs.155485 (HIP2) mRNA, complete cds 621 233581 HIP2 Human huntingtin interacting protein H78385 Hs.155485 (HIP2) mRNA, complete cds 622 363086 CKMT1 Human mitochondrial creatine kinase AA019482 Hs.153998 (CKMT) gene, complete cds 623 363086 CKMT1 Human mitochondrial creatine kinase AA019332 Hs.153998 (CKMT) gene, complete cds 624 1390584 MIPEP Human mitochondrial intermediate AA843592 Hs.68583 peptidase precursor (MIPEP) mRNA, mitochondrial gene encoding mitochondrial protein, complete cds 625 134269 POLRMT Human mitochondrial RNA polymerase R31115 Hs.153880 mRNA, nuclear gene encoding mitochondrial protein, complete cds 626 134269 POLRMT Human mitochondrial RNA polymerase R31174 Hs.153880 mRNA, nuclear gene encoding mitochondrial protein, complete cds 627 781050 PFDN5 Human mRNA for c-myc binding protein, AA446453 Hs.80686 complete cds 628 781050 PFDN5 Human mRNA for c-myc binding protein, AA430010 Hs.80686 complete cds 629 451706 POLA Human mRNA for DNA polymerase AA707650 Hs.74090 alpha-subunit 630 41541 EST Human mRNA for KIAA0017 gene, R52789 Hs.253023 complete cds 631 41541 EST Human mRNA for KIAA0017 gene, R52788 Hs.253023 complete cds 632 842818 KARS Human mRNA for KIAA0070 gene, AA486374 Hs.3100 partial cds 633 842818 KARS Human mRNA for KIAA0070 gene, AA486220 Hs.3100 partial cds 634 280496 KIAA0123 Human mRNA for KIAA0123 gene, N51632 Hs.75353 partial cds 635 859627 KIAA0185 Human mRNA for KIAA0185 gene, AA666405 Hs.255573 partial cds 636 783698 KIAA0188 Human mRNA for KIAA0188 gene, AA446822 Hs.81412 partial cds 637 783698 KIAA0188 Human mRNA for KIAA0188 gene, AA446821 Hs.81412 partial cds 638 347031 KIAA0195 Human mRNA for KIAA0195 gene, W79511 Hs.80540 complete cds 639 347031 KIAA0195 Human mRNA for KIAA0195 gene, W79398 Hs.80540 complete cds 640 753248 KIAA0381 Human mRNA for KIAA0381 gene, AA406231 Hs.100113 partial cds 641 753248 KIAA0381 Human mRNA for KIAA0381 gene, AA406503 Hs.100113 partial cds 642 108208 HADHB Human mRNA for mitochondrial 3- T69767 Hs.146812 ketoacyl-CoA thiolase beta-subunit of trifunctional protein, complete cds 643 108208 HADHB Human mRNA for mitochondrial 3- T70752 Hs.146812 ketoacyl-CoA thiolase beta-subunit of trifunctional protein, complete cds 644 869538 NDUFA4 Human NADH: ubiquinone AA680322 Hs.108661 oxidoreductase MLRQ subunit mRNA, complete cds 645 810452 TOM34 Human putative outer mitochondrial AA457118 Hs.76927 membrane 34 kDa translocase hTOM34 mRNA, complete cds 646 127197 CXORF6 Human Xq28 mRNA, complete cds R08270 Hs.20136 647 127197 CXORF6 Human Xq28 mRNA, complete cds R08271 Hs.20136 648 811108 TRIP6 Human zyxin related protein ZRP-1 AA485677 Hs.119498 mRNA, complete cds 649 811108 TRIP6 Human zyxin related protein ZRP-1 AA485807 Hs.119498 mRNA, complete cds 650 79828 HD Huntingtin (Huntington disease) T64094 Hs.79391 651 79828 HD Huntingtin (Huntington disease) T64015 Hs.79391 652 1752540 HIP1 huntingtin interacting protein 1 AI150389 653 1566230 HYAL3 hyaluronoglucosaminidase 3 AI140794 Hs.129910 654 2095653 GLO4 HYDROXYACYLGLUTATHIONE AI420642 HYDROLASE 655 141966 HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 R68803 Hs.38586 beta- and steroid delta-isomerase 1 656 141966 HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 R68906 Hs.38586 beta- and steroid delta-isomerase 1 657 126243 HMBS Hydroxymethylbilane synthase R06321 Hs.82609 658 126243 HMBS Hydroxymethylbilane synthase R06263 Hs.82609 659 321163 HSU79253 hypothetical protein W53000 Hs.56155 660 321163 HSU79253 hypothetical protein W52999 Hs.56155 661 280507 HPRT1 Hypoxanthine phosphoribosyltransferase N47312 Hs.82314 1 (Lesch-Nyhan syndrome) 662 280507 HPRT1 Hypoxanthine phosphoribosyltransferase N47311 Hs.82314 1 (Lesch-Nyhan syndrome) 663 2216141 IFM1 IFM1 AI654459 664 767034 ILVBL ilvB (bacterial acetolactate synthase)-like AA424288 Hs.78880 665 767034 ILVBL ilvB (bacterial acetolactate synthase)-like AA451741 Hs.78880 666 1606837 IMPDH2 IMP (inosine monophosphate) AA996028 Hs.75432 dehydrogenase 2 667 50754 MTIF2 INITIATION FACTOR IF-2, H18070 Hs.149894 MITOCHONDRIAL PRECURSOR 668 111981 G1P3 interferon, alpha-inducible protein (clone T84633 Hs.179972 IFI-6-16) 669 111981 G1P3 interferon, alpha-inducible protein (clone T91807 Hs.179972 IFI-6-16) 670 491763 IL1B Interleukin 1, beta AA150507 Hs.126256 671 491763 IL1B Interleukin 1, beta AA156711 Hs.126256 672 2119594 IDH1 ISOCITRATE DEHYDROGENASE AI399657 673 869375 IDH2 Isocitrate dehydrogenase 2 (NADP+), AA679907 Hs.252546 mitochondrial 674 2168168 ETFB isocitrate dehydrogenase 3 (NAD+) alpha AI565774 (IDH3A), 675 755474 IARS isoleucine-tRNA synthetase AA410636 676 755474 IARS isoleucine-tRNA synthetase AA419192 677 810325 IVD isovaleryl Coenzyme A dehydrogenase AA464149 Hs.77510 678 810325 IVD isovaleryl Coenzyme A dehydrogenase AA464216 Hs.77510 679 2148505 JC4913 JC4913 AI469831 680 809707 JUNB jun B proto-oncogene AA454711 Hs.198951 681 809707 JUNB jun B proto-oncogene AA456366 Hs.198951 682 1474284 KAI1 kangai 1 (suppression of tumorigenicity AA922309 Hs.25409 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) 683 845441 KIAA0016 KIAA0016 gene product AA644550 Hs.75187 684 2241563 KIHUA3 KIHUA3 AI632351 685 21738 HADHSC L-3-hydroxyacyl-Coenzyme A T65482 Hs.7153 dehydrogenase, short chain 686 21738 HADHSC L-3-hydroxyacyl-Coenzyme A T65407 Hs.7153 dehydrogenase, short chain 687 884644 LAMR1 Laminin receptor (2H5 epitope) AA629897 Hs.181357 688 704360 LCFA_HUMAN LCFA_HUMAN AA279565 689 1256792 MAD4 Mad4 homolog AA875977 Hs.102402 690 1908746 MDH1 MALATE DEHYDROGENASE AI302237 691 1636908 MDH2 malate dehydrogenase 2, NAD AI000271 Hs.111076 (mitochondrial) 692 2010949 ME2 malic enzyme 2, mitochondrial AI361039 Hs.75342 693 896921 ME3 malic enzyme, NADP+-dependent, AA779401 Hs.2838 mitochondrial 694 814211 M6PR Mannose-6-phosphate receptor (cation AA465223 Hs.75709 dependent) 695 814211 M6PR Mannose-6-phosphate receptor (cation AA465578 Hs.75709 dependent) 696 589115 MMP1 matrix metalloproteinase 1 (interstitial AA143201 collagenase) 697 589115 MMP1 matrix metalloproteinase 1 (interstitial AA143331 collagenase) 698 1574438 MMP11 matrix metalloproteinase 11 (stromelysin AA954935 Hs.155324 3) 699 196612 MMP12 matrix metalloproteinase 12 (macrophage R92994 Hs.1695 elastase) 700 196612 MMP12 matrix metalloproteinase 12 (macrophage R93037 Hs.1695 elastase) 701 251047 MMP17 matrix metalloproteinase 17 (membrane- H97792 Hs.159581 inserted) 702 784589 MMP15 Matrix metalloproteinase 2 AA443300 Hs.80343 703 784589 MMP15 Matrix metalloproteinase 2 AA443433 Hs.80343 704 470393 MMP7 matrix metalloproteinase 7 (matrilysin, AA031513 Hs.2256 uterine) 705 470393 MMP7 matrix metalloproteinase 7 (matrilysin, AA031514 Hs.2256 uterine) 706 2213770 CCHU Matrix metalloproteinase 7 (matrilysin, AI582304 uterine) 707 22040 MMP9 matrix metalloproteinase 9 (gelatinase B, T72581 92 kD gelatinase, 92 kD type IV collagenase) 708 22040 MMP9 matrix metalloproteinase 9 (gelatinase B, T64837 92 kD gelatinase, 92 kD type IV collagenase) 709 773266 MMP9 matrix metalloproteinase 9 (gelatinase B, AA425227 Hs.151738 92 kD gelatinase, 92 kD type IV collagenase) 710 773266 MMP9 matrix metalloproteinase 9 (gelatinase B, AA425503 Hs.151738 92 kD gelatinase, 92 kD type IV collagenase) 711 2091860 MMPL1 matrix metalloproteinase-like 1 AI382081 Hs.198265 712 240766 Data unavailable METALLOPROTEINASE INHIBITOR H80214 1 PRECURSOR 713 240766 Data unavailable METALLOPROTEINASE INHIBITOR H80215 1 PRECURSOR 714 2165301 DEHUMT methylene tetrahydrofolate AI497794 dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase 715 1473506 MMSA_HUMAN METHYLMALONATE- AA915881 SEMIALDEHYDE DEHYDROGENASE 716 2091562 S40622 METHYLMALONYL-COA MUTASE AI377286 PRECURSOR 717 278570 MITF Microphthalmia-associated transcription N66177 Hs.166017 factor 718 278570 MITF Microphthalmia-associated transcription N99168 Hs.166017 factor 719 768443 MGST1 microsomal glutathione S-transferase 1 AA495936 Hs.790 720 768443 MGST1 microsomal glutathione S-transferase 1 AA495935 Hs.790 721 629896 MAP1B MICROTUBULE-ASSOCIATED AA219045 Hs.103042 PROTEIN 1B 722 1084029 A56650 MITOCHONDRIAL 2- AA594052 OXOGLUTARATE/MALATE CARRIER PROTEIN 723 44255 RPML3 MITOCHONDRIAL 60S RIBOSOMAL H06113 Hs.79086 PROTEIN L3 724 44255 RPML3 MITOCHONDRIAL 60S RIBOSOMAL H05820 Hs.79086 PROTEIN L3 725 433553 CA5 Mitochondrial carbonic anhydrase AA699469 Hs.177446 726 1175538 A39018 MITOCHONDRIAL CARNITINE AA641442 PALMITOYLTRANSFERASE II PRECURSOR 727 324618 TSFM MITOCHONDRIAL ELONGATION W47015 Hs.3273 FACTOR TS PRECURSOR 728 324618 TSFM MITOCHONDRIAL ELONGATION W47014 Hs.3273 FACTOR TS PRECURSOR 729 2066585 LON-PEN MITOCHONDRIAL LON PROTEASE AI377406 HOMOLOG 730 133099 MMP1 Precursor MITOCHONDRIAL MATRIX R26234 PROTEIN P1 PRECURSOR 731 133099 MMP1 Precursor MITOCHONDRIAL MATRIX R26235 PROTEIN P1 PRECURSOR 732 448491 mrp2 MITOCHONDRIAL RIBOSOMAL AA777627 PROTEIN S14 733 1587031 HSPA9 MITOCHONDRIAL STRESS-70 AA948223 PROTEIN 734 814346 MTIF2 mitochondrial translational initiation AA458825 Hs.149894 factor 2 735 814346 MTIF2 mitochondrial translational initiation AA459016 Hs.149894 factor 2 736 1916771 MTRF1 mitochondrial translational release factor 1 AI347695 Hs.80683 737 1880757 MAP3K5 mitogen-activated protein kinase kinase AI268273 Hs.151988 kinase 5 738 2244621 MRF1 MRF1 AI656905 739 645006 MRP4 MRP4 AA197284 740 645006 MRP4 MRP4 AA205815 741 1933324 MPZ myelin protein zero (Charcot-Marie- AI351956 Hs.93883 Tooth neuropathy 1B) 742 302190 MLL myeloid/lymphoid or mixed-lineage W16724 Hs.199160 leukemia (trithorax (Drosophila) homolog) 743 302190 MLL myeloid/lymphoid or mixed-lineage N77807 Hs.199160 leukemia (trithorax (Drosophila) homolog) 744 842989 MYL6 MYOSIN LIGHT CHAIN ALKALI, AA488346 Hs.77385 NON-MUSCLE ISOFORM 745 842989 MYL6 MYOSIN LIGHT CHAIN ALKALI, AA488477 Hs.77385 NON-MUSCLE ISOFORM 746 814615 MTHFD2 NAD-dependent methylene AA480995 Hs.154672 tetrahydrofolate dehydrogenase cyclohydrolase 747 814615 MTHFD2 NAD-dependent methylene AA480994 Hs.154672 tetrahydrofolate dehydrogenase cyclohydrolase 748 773287 NDUFA2 NADH dehydrogenase (ubiquinone) 1 AA425211 Hs.163867 alpha subcomplex, 2 (8 kD, B8) 749 773287 NDUFA2 NADH dehydrogenase (ubiquinone) 1 AA425534 Hs.163867 alpha subcomplex, 2 (8 kD, B8) 750 1635681 NDUFA2 NADH dehydrogenase (ubiquinone) 1 AI017426 Hs.163867 alpha subcomplex, 2 (8 kD, B8) 751 950578 NDUFA5 NADH dehydrogenase (ubiquinone) 1 AA608515 Hs.83916 alpha subcomplex, 5 (13 kD, B13) 752 897987 NDUFA9 NADH dehydrogenase (ubiquinone) 1 AA598884 Hs.75227 alpha subcomplex, 9 (39 kD) 753 450896 NDUFB4 NADH dehydrognase (ubiquinone) 1 AA704675 beta subcomplex, 4 (15 kD, B15) 754 562409 NDUFS5 NADH dehydrogenase (ubiquinone) 1 AA214053 Hs.80595 beta subcomplex, 4 (15 kD, B15) 755 562409 NDUFS5 NADH dehydrogenase (ubiquinone) 1 AA214154 Hs.80595 beta subcomplex, 4 (15 kD, B15) 756 307933 NDUFB5 NADH dehydrogenase (ubiquinone) 1 N93053 Hs.19236 beta subcomplex, 5 (16 kD, SGDH) 757 307933 NDUFB5 NADH dehydrogenase (ubiquinone) 1 W21390 Hs.19236 beta subcomplex, 5 (16 kD, SGDH) 758 470861 NDUFB6 NADH dehydrogenase (ubiquinone) 1 AA034268 Hs.109646 beta subcomplex, 6 (17 kD, B17) 759 470861 NDUFB6 NADH dehydrogenase (ubiquinone) 1 AA032077 Hs.109646 beta subcomplex, 6 (17 kD, B17) 760 771089 NDUFB7 NADH dehydrogenase (ubiquinone) 1 AA428058 Hs.661 beta subcomplex, 7 (18 kD, B18) 761 771089 NDUFB7 NADH dehydrogenase (ubiquinone) 1 AA429046 Hs.661 beta subcomplex, 7 (18 kD, B18) 762 796513 NDUFC1 NADH dehydrogenase (ubiquinone) 1, AA460251 Hs.84549 subcomplex unknown, 1 (6 kD, KFYI) 763 796513 NDUFC1 NADH dehydrogenase (ubiquinone) 1, AA463815 Hs.84549 subcomplex unknown, 1 (6 kD, KFYI) 764 753457 NDUFS1 NADH dehydrogenase (ubiquinone) Fe—S AA406535 Hs.8248 protein 1 (75 kD) (NADH-coenzyme Q reductase) 765 753457 NDUFS1 NADH dehydrogenase (ubiquinone) Fe—S AA406536 Hs.8248 protein 1 (75 kD) (NADH-coenzyme Q reductase) 766 743811 NDUFS3 NADH dehydrogenase (ubiquinone) Fe—S AA634381 Hs.5273 protein 3 (30 kD) (NADH-coenzyme Q reductase) 767 377152 NDUFS4 NADH dehydrogenase (ubiquinone) Fe—S AA055101 Hs.10758 protein 4 (18 kD) (NADH-coenzyme Q reductase) 768 377152 NDUFS4 NADH dehydrogenase (ubiquinone) Fe—S AA055102 Hs.10758 protein 4 (18 kD) (NADH-coenzyme Q reductase) 769 502141 NDUFS8 NADH dehydrogenase (ubiquinone) Fe—S AA127014 Hs.90443 protein 8 (23 kD) (NADH-coenzyme Q reductase) 770 502141 NDUFS8 NADH dehydrogenase (ubiquinone) Fe—S AA128218 Hs.90443 protein 8 (23 kD) (NADH-coenzyme Q reductase) 771 1486260 NDUFV2 NADH dehydrogenase (ubiquinone) AA922326 Hs.51299 flavoprotein 2 (24 kD) 772 1676983 RDHUB5 NADH-CYTOCHROME B5 AI076798 REDUCTASE 773 1632011 NPR2 natriuretic peptide receptor B/guanylate AA994689 Hs.78518 cyclase B (atrionatriuretic peptide receptor B) 774 994950 NDUFA10 NDUFA10 AA555087 775 1588691 NDUFA2 NDUFA2 AA975360 776 929358 NDUFA3 NDUFA3 AA492039 777 2118546 NDUFA6 NDUFA6 AI524304 778 1270489 NDUFA7 NDUFA7 AA748476 779 171756 NDUFA8 NDUFA8 H18333 780 171756 NDUFA8 NDUFA8 H18364 781 1473135 NDUFAB1 NDUFAB1 AA873566 782 998616 NDUFB1 NDUFB1 AA535762 783 2170527 NDUFB10 NDUFB10 AI571333 784 1881693 NDUFB2 NDUFB2 AI290799 785 2103675 NDUFB3 NDUFB3 AI401200 786 2266937 NDUFB8 NDUFB8 AI608733 787 984496 NDUFB9 NDUFB9 AA526075 788 2277817 NDUFC2 NDUFC2 AI653801 789 1019401 NDUFS2 NDUFS2 AA551149 790 1585499 NDUFS5 NDUFS5 AA974058 791 51826 NNT nicotinamide nucleotide transhydrogenase H22944 Hs.18136 792 51826 NNT nicotinamide nucleotide transhydrogenase H24126 Hs.18136 793 1160732 NOS2A Nitric oxide synthase 2A (inducible, AA877840 Hs.193788 hepatocytes) 794 150466 EST Nitric oxide synthase 3 (endothelial cell) H01039 Hs.237163 795 150466 EST Nitric oxide synthase 3 (endothelial cell) H01788 Hs.237163 796 1468820 NOS3 nitric oxide synthase 3 (endothelial cell) AA884967 Hs.166373 797 755750 NME2 non-metastatic cells 2, protein (NM23B) AA496628 Hs.255790 expressed in 798 755750 NME2 non-metastatic cells 2, protein (NM23B) AA496512 Hs.255790 expressed in 799 207808 NFATC3 nuclear factor of activated T-cells, H59048 Hs.172674 cytoplasmic 3 800 207808 NFATC3 nuclear factor of activated T-cells, H59047 Hs.172674 cytoplasmic 3 801 1870662 A54868 nuclear respiratory factor 1 (NRF1) AI245773 802 567414 NFYB nuclear transcription factor Y, beta AA130846 803 783696 OAT ornithine aminotransferase (gyrate AA446819 Hs.75485 atrophy) 804 783696 OAT ornithine aminotransferase (gyrate AA446820 Hs.75485 atrophy) 805 796646 ODC1 Ornithine decarboxylase 1 AA460115 Hs.75212 806 796646 ODC1 Ornithine decarboxylase 1 AA461467 Hs.75212 807 1637751 OXA1L oxidase (cytochrome c) assembly 1-like AI001180 Hs.151134 808 1704170 OXA1HS oxoglutarate dehydrogenase (lipoamide) AI096611 809 233479 No Data Oxoglutarate dehydrogenase (lipoamide) H78910 810 233479 No Data Oxoglutarate dehydrogenase (lipoamide) H80138 811 1371793 OGDH oxoglutarate dehydrogenase (lipoamide) AA856769 Hs.168669 812 1632231 UQCRC1 P31930 UBIQUINOL-CYTOCHROME- AI005342 C REDUCTASE COMPLEX CORE PROTEIN I PRECURSOR 813 162775 DDX5 P68 PROTEIN H27564 Hs.76053 814 162775 DDX5 P68 PROTEIN H27646 Hs.76053 815 43884 PPIF PEPTIDYL-PROLYL CIS-TRANS H05580 Hs.173125 ISOMERASE, MITOCHONDRIAL PRECURSOR 816 43884 PPIF PEPTIDYL-PROLYL CIS-TRANS H05115 Hs.173125 ISOMERASE, MITOCHONDRIAL PRECURSOR 817 774726 PPIF peptidylprolyl isomerase F (cyclophilin AA442081 Hs.173125 F) 818 774726 PPIF peptidylprolyl isomerase F (cyclophilin AA442184 Hs.173125 F) 819 133273 PMP22 peripheral myelin protein 22 R26960 Hs.103724 820 133273 PMP22 peripheral myelin protein 22 R26732 Hs.103724 821 788518 PXMP3 Peroxisomal membrane protein 3 (35 kD, AA452566 Zellweger syndrome) 822 788518 PXMP3 Peroxisomal membrane protein 3 (35 kD, AA452747 Zellweger syndrome) 823 1476157 PXR1 peroxisome receptor 1 AA873073 Hs.158084 824 455263 PET112L PET112 (yeast homolog)-like AA677572 Hs.11127 825 951683 PHC PHC AA629980 826 843109 FARS1 phenylalanine-tRNA synthetase AA488691 Hs.57969 827 843109 FARS1 phenylalanine-tRNA synthetase AA486503 Hs.57969 828 842784 PHC phosphate carrier, mitochondrial AA486305 Hs.78713 829 842784 PHC phosphate carrier, mitochondrial AA486200 Hs.78713 830 346009 PFKL Phosphofructokinase (liver type) W72140 Hs.155455 831 346009 PFKL Phosphofructokinase (liver type) W77881 Hs.155455 832 489626 PFKM Phosphofructokinase, muscle AA099169 Hs.75160 833 489626 PFKM Phosphofructokinase, muscle AA101919 Hs.75160 834 183194 phospholipase A2, group IIA (platelets, H44953 synovial fluid) 835 183194 phospholipase A2, group IIA (platelets, H45000 synovial fluid) 836 77915 PLA2G2A phospholipase A2, group IIA (platelets, T61323 Hs.76422 synovial fluid) 837 77915 PLA2G2A phospholipase A2, group IIA (platelets, T61271 Hs.76422 synovial fluid) 838 2367279 PN0673 PN0673 AI741984 839 780947 POLD1 Polymerase (DNA directed), delta 1, AA429661 Hs.99890 catalytic subunit (125 kD) 840 780947 POLD1 Polymerase (DNA directed), delta 1, AA446151 Hs.99890 catalytic subunit (125 kD) 841 626206 POLG polymerase (DNA directed), gamma AA188761 Hs.80961 842 626206 POLG polymerase (DNA directed), gamma AA188629 Hs.80961 843 827129 POLRMT polymerase (RNA) mitochondrial (DNA AA521239 Hs.153880 directed) 844 2144562 PRAX-1 PRAX-1 AI452994 845 826211 PDCD2 Programmed cell death 2 AA521466 Hs.41639 846 814337 PCCB propionyl Coenzyme A carboxylase, beta AA459122 Hs.63788 polypeptide 847 814337 PCCB propionyl Coenzyme A carboxylase, beta AA459341 Hs.63788 polypeptide 848 950710 PCCA Propionyl-coA carboxylase alpha chain AA608575 Hs.80741 849 824568 KLK3 Prostate specific antigen AA490981 Hs.171995 850 843134 PBP Prostatic binding protein AA486514 Hs.80423 851 843134 PBP Prostatic binding protein AA485909 Hs.80423 852 261971 PRSM1 protease, metallo, 1, 33 kD N27227 Hs.183138 853 261971 PRSM1 protease, metallo, 1, 33 kD H98666 Hs.183138 854 375728 PRSM1 protease, metallo, 1, 33 kD AA033807 Hs.183138 855 51041 Est protoporphyrinogen oxidase H18633 Hs.123641 856 51041 Est protoporphyrinogen oxidase H18716 Hs.123641 857 247160 PPOX protoporphyrinogen oxidase N57891 Hs.100016 858 504452 PPOX protoporphyrinogen oxidase AA151249 Hs.100016 859 504452 PPOX protoporphyrinogen oxidase AA151248 Hs.100016 860 501939 HHCMA56 putative oxidoreductase AA128041 Hs.519 861 501939 HHCMA56 putative oxidoreductase AA128086 Hs.519 862 108378 PC pyruvate carboxylase T77729 Hs.89890 863 108378 PC pyruvate carboxylase T77728 Hs.89890 864 80374 PDHA1 Pyruvate dehydrogenase (lipoamide) T65833 Hs.1023 alpha 1 865 80374 PDHA1 Pyruvate dehydrogenase (lipoamide) T65758 Hs.1023 alpha 1 866 826077 PDHB pyruvate dehydrogenase (lipoamide) beta AA521401 Hs.979 867 279665 PDX1 Pyruvate dehydrogenase complex, lipoyl- N48320 Hs.74642 containing component X; E3-binding protein 868 279665 PDX1 Pyruvate dehydrogenase complex, lipoyl- N49046 Hs.74642 containing component X; E3-binding protein 869 1542260 PDHA2 PYRUVATE DEHYDROGENASE E1 AA927400 COMPONENT, ALPHA 870 1645668 PDK1 pyruvate dehydrogenase kinase, AI026814 Hs.159477 isoenzyme 1 871 66686 No Data QM PROTEIN T67270 872 66686 No Data QM PROTEIN T67271 873 590727 RENT1 regulator of nonsense transcripts 1 AA156342 Hs.12719 874 590727 RENT1 regulator of nonsense transcripts 1 AA156376 Hs.12719 875 624627 RRM2 Ribonucleotide reductase M2 polypeptide AA187351 Hs.75319 876 624627 RRM2 Ribonucleotide reductase M2 polypeptide AA188430 Hs.75319 877 788334 RPL23L ribosomal protein L23-like AA453015 Hs.3254 878 730124 RPL7 Ribosomal protein L7 AA412470 Hs.153 879 730124 RPL7 Ribosomal protein L7 AA412344 Hs.153 880 809578 RPS5 Ribosomal protein S5 AA456616 Hs.76194 881 809578 RPS5 Ribosomal protein S5 AA455795 Hs.76194 882 214133 FSRG1 RING3 PROTEIN H72520 Hs.75243 883 214133 FSRG1 RING3 PROTEIN H72918 Hs.75243 884 110744 SCO2 SCO (cytochrome oxidase deficient, T90560 Hs.180903 yeast) homolog 2 885 110744 SCO2 SCO (cytochrome oxidase deficient, T83097 Hs.180903 yeast) homolog 2 886 646657 SCO1 SCO1 (yeast homolog) cytochrome AA205413 Hs.14511 oxidase deficient 1 887 646657 SCO1 SCO1 (yeast homolog) cytochrome AA205579 Hs.14511 oxidase deficient 1 888 1074487 SDHD SDHD AA579646 889 951117 SHMT2 serine hydroxymethyltransferase 2 AA620477 (mitochondrial) 890 2138479 XNHUSP SERINE--PYRUVATE AI521720 AMINOTRANSFERASE 891 125183 SSBP single-stranded DNA-binding protein R05693 Hs.923 892 125183 SSBP single-stranded DNA-binding protein R05694 Hs.923 893 813678 SLC1A3 solute carrier family 1 (glial high affinity AA453823 Hs.75379 glutamate transporter), member 3 894 813678 SLC1A3 solute carrier family 1 (glial high affinity AA453742 Hs.75379 glutamate transporter), member 3 895 586990 SLC11A2 solute carrier family 11 (proton-coupled AA133656 Hs.57435 divalent metal ion transporters), member 2 896 586990 SLC11A2 solute carrier family 11 (proton-coupled AA133655 Hs.57435 divalent metal ion transporters), member 2 897 2029995 SLC12A7 solute carrier family 12 AI492956 Hs.172613 (potassium/chloride transporters), member 7 898 190732 SLC2A5 Solute carrier family 2 (facilitated glucose H38650 Hs.33084 transporter), member 5 899 190732 SLC2A5 Solute carrier family 2 (facilitated glucose H38733 Hs.33084 transporter), member 5 900 758304 SLC25A14 solute carrier family 25 (mitochondrial AA404241 Hs.194686 carrier, brain), member 14 901 758304 SLC25A14 solute carrier family 25 (mitochondrial AA401224 Hs.194686 carrier, brain), member 14 902 897107 SLC25A1 solute carrier family 25 (mitochondrial AA676877 Hs.111024 carrier; citrate transporter), member 1 903 878413 SLC25A11 solute carrier family 25 (mitochondrial AA670357 Hs.184877 carrier; oxoglutarate carrier), member 11 904 433350 SORD Sorbitol dehydrogenase AA700604 Hs.878 905 1256737 SPG7 spastic paraplegia 7, paraplegin (pure and AA876165 Hs.78497 complicated autosomal recessive) 906 682528 SCA1 spinocerebellar ataxia 1 AA256507 Hs.74520 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) 907 682528 SCA1 spinocerebellar ataxia 1 AA256508 Hs.74520 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) 908 128875 SCA2 Spinocerebellar ataxia 2 R10604 Hs.76253 (olivopontocerebellar ataxia 2, autosomal dominant) 909 128875 SCA2 Spinocerebellar ataxia 2 R10603 Hs.76253 (olivopontocerebellar ataxia 2, autosomal dominant) 910 447167 SFRS8 splicing factor, arginine/serine-rich 8 AA702973 Hs.84229 (suppressor-of-white-apricot, Drosophila homolog) 911 1934125 B34181 steroid 11-beta-hydroxylase AI334352 912 859858 STAR steroidogenic acute regulatory protein AA679454 Hs.3132 913 855395 SCP2 sterol carrier protein 2 AA664009 Hs.75760 914 824699 SUCA_HUMAN SUCA_HUMAN AA482206 915 80915 SDHA Succinate dehydrogenase 2, flavoprotein T70043 (Fp) subunit 916 80915 SDHA Succinate dehydrogenase 2, flavoprotein T70109 (Fp) subunit 917 797016 SDHB succinate dehydrogenase complex, AA463565 Hs.64 subunit B, iron sulfur (Ip) 918 797016 SDHB succinate dehydrogenase complex, AA463510 Hs.64 subunit B, iron sulfur (Ip) 919 366132 SDHC succinate dehydrogenase complex, AA062805 Hs.3577 subunit C, integral membrane protein, 15 kD 920 504145 LSC2 SUCCINATE-COA LIGASE AA132000 921 504145 LSC2 SUCCINATE-COA LIGASE AA131817 922 845630 SUCLA2 succinate-CoA ligase, ADP-forming, beta AA644577 Hs.182217 subunit 923 1571111 SCOT_HUMAN Succinyl CoA: 3-oxoacid CoA transferase AA936982 924 950489 SOD1 Superoxide dismutase 1 (Cu/Zn) AA599127 Hs.75428 925 1572467 SOD2 Superoxide dismutase 2 AA934677 926 346860 SOD2 superoxide dismutase 2, mitochondrial W78148 Hs.177781 927 346860 SOD2 superoxide dismutase 2, mitochondrial W79913 Hs.177781 928 840708 SOD2 Superoxide dismutase 2, mitochondrial AA488084 Hs.177781 929 840708 SOD2 Superoxide dismutase 2, mitochondrial AA487750 Hs.177781 930 1343732 SOD3 Superoxide dismutase 3, extracellular AA725564 Hs.2420 931 433474 SURF1 Surfeit 1 AA699560 Hs.3196 932 2114302 surfeit 1 surfeit 1 AI417847 Hs.3196 933 782797 SMN1 survival of motor neuron 1, telomeric AA448194 Hs.77306 934 704299 TAZ tafazzin (cardiomyopathy, dilated 3A (X- AA279440 Hs.79021 linked); endocardial fibroelastosis 2; Barth syndrome) 935 789376 TXNRD1 thioredoxin reductase 1 AA453335 Hs.13046 936 789376 TXNRD1 thioredoxin reductase 1 AA464849 Hs.13046 937 796000 MPST thiosulfate sulfurtransferase (rhodanese) AA461065 Hs.74097 938 796000 MPST thiosulfate sulfurtransferase (rhodanese) AA460495 Hs.74097 939 856167 TARS threonyl-tRNA synthetase AA630628 Hs.84131 940 205185 THBD Thrombomodulin H59861 Hs.2030 941 205185 THBD Thrombomodulin H60674 Hs.2030 942 246300 TIAL1 TIA1 cytotoxic granule-associated RNA- N59426 Hs.182741 binding protein-like 1 943 842846 TIMP2 tissue inhibitor of metalloproteinase 2 AA486280 Hs.246948 944 489519 TIMP3 tissue inhibitor of metalloproteinase 3 AA099153 Hs.245188 (Sorsby fundus dystrophy, pseudoinflammatory) 945 489519 TIMP3 tissue inhibitor of metalloproteinase 3 AA099251 Hs.245188 (Sorsby fundus dystrophy, pseudoinflammatory) 946 754106 TIMP3 tissue inhibitor of metalloproteinase 3 AA479202 Hs.245188 (Sorsby fundus dystrophy, pseudoinflammatory) 947 754106 TIMP3 tissue inhibitor of metalloproteinase 3 AA478662 Hs.245188 (Sorsby fundus dystrophy, pseudoinflammatory) 948 433481 TCF2 transcription factor 2, hepatic; LF-B3; AA699573 Hs.169853 variant hepatic nuclear factor 949 785845 TCF6L1 Transcription factor 6-like 1 AA449118 Hs.75133 (mitochondrial transcription factor 1-like) 950 785845 TCF6L1 Transcription factor 6-like 1 AA449551 Hs.75133 (mitochondrial transcription factor 1-like) 951 841334 STIP1 TRANSFORMATION-SENSITIVE AA487635 Hs.75612 PROTEIN IEF SSP 3521 952 841334 STIP1 TRANSFORMATION-SENSITIVE AA487427 Hs.75612 PROTEIN IEF SSP 3521 953 2114841 U66035 translocase of inner mitochondrial AI432207 membrane 8 954 970880 TPM4 tropomyosin 4 AA774983 Hs.102824 955 341328 TPM1 Tropomyosin alpha chain (skeletal W58092 Hs.77899 muscle) 956 341328 TPM1 Tropomyosin alpha chain (skeletal W58009 Hs.77899 muscle) 957 32621 WARS2 tryptophanyl tRNA synthetase 2 R43272 Hs.227274 (mitochondrial) 958 32621 WARS2 tryptophanyl tRNA synthetase 2 R18903 Hs.227274 (mitochondrial) 959 684582 WARS2 tryptophanyl tRNA synthetase 2 AA251354 Hs.227274 (mitochondrial) 960 684582 WARS2 tryptophanyl tRNA synthetase 2 AA251468 Hs.227274 (mitochondrial) 961 594079 TID1 tumorous imaginal discs (Drosophila) AA169872 Hs.6216 homolog 962 594079 TID1 tumorous imaginal discs (Drosophila) AA169567 Hs.6216 homolog 963 1569989 YWHAB tyrosine 3-monooxygenase/tryptophan 5- AA962407 Hs.182238 monooxygenase activation protein, beta polypeptide 964 1591788 YWHAZ tyrosine 3-monooxygenase/tryptophan 5- AA976477 Hs.75103 monooxygenase activation protein, zeta polypeptide 965 25499 UQCRH UBIQUINOL-CYTOCHROME C R11698 Hs.73818 REDUCTASE COMPLEX 11 KD PROTEIN PRECURSOR 966 25499 UQCRH UBIQUINOL-CYTOCHROME C R17676 Hs.73818 REDUCTASE COMPLEX 11 KD PROTEIN PRECURSOR 967 855843 UQCRB UBIQUINOL-CYTOCHROME C AA664284 Hs.131255 REDUCTASE COMPLEX 14 KD PROTEIN 968 1160934 UQCRC2 UBIQUINOL-CYTOCHROME C AA877491 REDUCTASE CORE PROTEIN 2 PRECURSOR 969 782800 UQCRFS1 UBIQUINOL-CYTOCHROME C AA448184 Hs.3712 REDUCTASE IRON-SULFUR SUBUNIT PRECURSOR 970 1955460 MAS2 UCR1_HUMAN P31930 UBIQUINOL- AI365986 CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN I 971 236034 UCP2 uncoupling protein 2 (mitochondrial, H61243 Hs.80658 proton carrier) 972 236034 UCP2 uncoupling protein 2 (mitochondrial, H61242 Hs.80658 proton carrier) 973 628529 EST uncoupling protein 3 (mitochondrial, AA192553 Hs.76640 proton carrier) 974 628529 EST uncoupling protein 3 (mitochondrial, AA192136 Hs.76640 proton carrier) 975 197932 UQCRB UQCRB R96352 Hs.77385 976 197932 UQCRB UQCRB R96395 Hs.77385 977 49464 UNG uracil-DNA glycosylase H15111 Hs.78853 978 49464 UNG uracil-DNA glycosylase H15112 Hs.78853 979 760148 UROD Uroporphyrinogen decarboxylase AA424441 Hs.78601 980 760148 UROD Uroporphyrinogen decarboxylase AA424344 Hs.78601 981 34778 VEGF vascular endothelial growth factor R45059 982 34778 VEGF vascular endothelial growth factor R19956 983 1762200 VDAC1 VDAC1 AI205945 984 1911533 VDAC3 VDAC3 AI268057 985 486221 VDAC1 Voltage-dependent anion channel 1 AA044059 Hs.149155 986 486221 VDAC1 Voltage-dependent anion channel 1 AA044113 Hs.149155 987 1434908 VDAC2 Voltage-dependent anion channel 2 AA857093 Hs.78902 988 796759 VDAC3 voltage-dependent anion channel 3 AA460728 Hs.7381 989 796759 VDAC3 voltage-dependent anion channel 3 AA460900 Hs.7381 990 815683 WBSCR9 Williams-Beuren syndrome chromosome AA485132 Hs.194688 region 9 991 815683 WBSCR9 Williams-Beuren syndrome chromosome AA485131 Hs.194688 region 9 992 878676 XRCC5 X-ray repair complementing defective AA775355 Hs.84981 repair in Chinese hamster cells 5 (double- strand-break rejoining; Ku autoantigen, 80 kD) 993 269381 ZNF148 zinc finger protein 148 (pHZ-52) N26148 994 745503 ZNF9 zinc finger protein 9 (a cellular retroviral AA625995 Hs.2110 nucleic acid binding protein)

Example 2

Mouse Mitochondrial Biology Array

A mouse mitochondrial biology array is made from clones representing expressed sequences. The clones placed on the array are shown in Table 4 which references sequence ID NOS:995-3040 provided herein setting forth the 5′ and 3′ sequences from these clones. See Tanaka, T. S. et al., (2000) “Genome-wide expression profiling of mid-gestation placenta and embryo using 15 k mouse developmental cDNA microarray” Proc. Natl. Acad. Sci. USA 97:9127-9132. Equivalent clones useful as probes are listed in Table 5. The clones listed in Table 4 are preferable to the clones listed in Table 5. The clones identified in Table 4 are used to make a set of probes called Mouse Probe Set #2. The clones identified in Table 5 are used to make a set of probes called Mouse Probe Set #3. Control sequences are also placed this array. Controls include, but are not limited to blanks, DMSO, probes derived from plant sequences, sequence(s) not involved in mitochondrial biology, and poly adenine (40-60 nucleotides long). Sequences used to make probes for the mouse mitochondrial genes can also be found in GenBank Accession No. J01420, which provides the complete mouse mitochondrial genome. Preferably, the probes used for ATP8 and ATP6 do not cross-hybridize with each other. TABLE 4 SEQ ID NO: NIA Clone No. Gene Clone_description GenBank Accession No. Unigene Cluster ID Function 995 H3001A07 Mm.42805 Mm.42805 Energy/Metabolism 996 H3001C04 major histocompatibility locus class III Mus musculus major histocompatibility Mm.7447 Transcription/Chromatin 997 region: butyrophilin-like protein gene, locus class III region: butyrophilin-like partial cds; Notch4, PBX2, RAGE, protein gene, partial cds; Notch4, lysophatidic acid acyl transferase-alpha, PBX2, RAGE, lysophatidic acid acyl palmitoyl-protein thioestera transferase-alpha, palmitoyl-protein thioestera 998 H3001F12 heparan sulfate (glucosamine) 3-O- Mus musculus heparan sulfate BG063066 Mm.100135 Energy/Metabolism 999 sulfotransferase 1 (Hs3st1), (glucosamine) 3-O-sulfotransferase 1 (Hs3st1), mRNA 1000 H3001H04 Rat farnesyltransferase beta subunit Rat farnesyltransferase beta subunit BG076556 Mm.28696 Energy/Metabolism 1001 mRNA, complete cds 1002 H3001H05 CPN10-like protein (Cpn10-rs1) gene Mus musculus CPN10-like protein BG063078 Mm.12970 Heat Shock/Stress 1003 (Cpn10-rs1) gene, complete cds 1004 H3002A01 NADH dehydrogenase (ubiquinone) 1 Homo sapiens NADH dehydrogenase BG076562 Mm.29683 Energy/Metabolism 1005 beta subcomplex, 7 (18 kD, B18) (ubiquinone) 1 beta subcomplex, 7 (NDUFB7), (18 kD, B18) (NDUFB7), mRNA 1006 H3002B09 cytochrome c gene (MC1) Mouse cytochrome c gene (MC1) BG063100 Mm.35389 Energy/Metabolism 1007 1008 H3002D03 gene prolyl oligopeptidase, exon 11, 12, 13, 14, Mus musculus gene for prolyl BG062950 Mm.90005 Energy/Metabolism 1009 15 and cds oligopeptidase, exon 11, 12, 13, 14, 15 and complete cds 1010 H3002E05 “Mus musculus RAB1, member RAS BG076435 Mm.14530 Signal Transduction 1011 oncogene family (Rab1), mRNA” 1012 H3002E06 dihydrolipoamide branched chain Mus musculus dihydrolipoamide BG076436 Mm.3636 Energy/Metabolism 1013 transacylase E2 (Dbt), branched chain transacylase E2 (Dbt), mRNA 1014 H3002E12 “Mus musculus aurora-related kinase 2 BG076440 Mm.3488 Signal Transduction 1015 (ARK2) mRNA, complete cds” 1016 H3002G11 glutamate-cysteine ligase catalytic Mus musculus glutamate-cysteine BG076460 Mm.4368 Energy/Metabolism 1017 subunit (GLCLC) ligase catalytic subunit (GLCLC) mRNA, complete cds 1018 H3003D05 DHPS Homo sapiens deoxyhypusine synthase BG063127 Mm.28091 Energy/Metabolism 1019 (DHPS), mRNA 1020 H3003D08 BAG2 Homo sapiens BCL2-associated BG076597 Mm.22449 Apoptosis 1021 athanogene 2 (BAG2), mRNA 1022 H3003F02 ribonucleotide reductase Mouse DNA for M2 subunit of mouse BG076613 Mm.99 Energy/Metabolism 1023 ribonucleotide reductase (EC 1.17.4.1) 1024 H3003F06 GluDH Mus musculus glutamate dehydrogenase BG076616 Mm.10600 Energy/Metabolism 1025 (Glud), mRNA 1026 H3003F07 “Mus musculus calmodulin (Calm), BG076617 Mm.2648 Signal Transduction 1027 mRNA” 1028 H3003H01 “Mus musculus adenylate cyclase 7 BG076632 Mm.141400 Signal Transduction 1029 (Adcy7), mRNA” 1030 H3004A02 ISCU1 (ISCU), alternatively spliced Homo sapiens ISCU1 (ISCU) mRNA, BG076641 Mm.29497 Energy/Metabolism 1031 complete cds, alternatively spliced 1032 H3004A04 mannosyl (alpha-1,3-)-glycoprotein Homo sapiens mannosyl (alpha-1,3-)- BG076643 Mm.86759 Energy/Metabolism 1033 beta-1,4-N- glycoprotein beta-1,4-N- acetylglucosaminyltransferase, acetylglucosaminyltransferase, isoenzyme B (MGAT4B), isoenzyme B (MGAT4B), mRNA 1034 H3004A09 sarco(endo)plasmic reticulum calcium Mus musculus sarco(endo)plasmic BG076647 Mm.100531 Energy/Metabolism 1035 ATPase (SERCA2) gene, promoter reticulum calcium ATPase (SERCA2) region, exons 1-3, and partial cds gene, promoter region, exons 1-3, and partial cds 1036 H3004B06 “Mouse mRNA for peripheral-type BG076653 Mm.1508 Signal Transduction 1037 benzodiazepine receptor, complete cds” 1038 H3004C06 Mm.34776 Heat Shock/Stress 1039 1040 H3004E03 “Mus musculus group V phospholipase BG063219 Mm.153446 Signal Transduction 1041 A2 mRNA, complete cds” 1042 H3004F07 “Mus musculus protein tyrosine BG076689 Mm.6355 Signal Transduction 1043 phosphatase 4a2 (Ptp4a2), mRNA” 1044 H3004G09 orotidine-5-monophosphate Mouse orotidine-5-monophosphate BG076701 Mm.13145 Energy/Metabolism 1045 decarboxylase, 3 end decarboxylase mRNA, 3 end 1046 H3004H01 TF-1 apoptosis related protein 19 Mus musculus TF-1 apoptosis related BG076705 Mm.21650 Apoptosis 1047 (Tfar19), protein 19 (Tfar19), mRNA 1048 H3004H06 protein arginine N-methyltransferase 1 Mus musculus protein arginine N- BG076710 Mm.27545 Energy/Metabolism 1049 (Mrmt1), alternatively spliced methyltransferase 1 (Mrmt1) mRNA, complete cds, alternatively spliced 1050 H3005A04 H19 and muscle-specific Nctc1 genes, Mus musculus H19 and muscle-specific BG076718 Mm.12970 Protein 1051 sequence Nctc1 genes, complete sequence Synthesis/Translational Control 1052 H3005A06 “Mus musculus mammalian relative of BG076720 Mm.2701 Heat Shock/Stress 1053 DnaJ (Mrj-pending), mRNA” 1054 H3005B03 thioredoxin reductase 1 (Txnrd1), Mus musculus thioredoxin reductase 1 BG076728 Mm.44552 Energy/Metabolism 1055 (Txnrd1), mRNA 1056 H3005B06 amidophosphoribosyltransferase Rattus norvegicus mRNA for BG076730 Mm.27743 Energy/Metabolism 1057 amidophosphoribosyltransferase 1058 H3005D01 dipeptidylpeptidase 4 (Dpp4), Mus musculus dipeptidylpeptidase 4 BG076746 Mm.1151 Energy/Metabolism 1059 (Dpp4), mRNA 1060 H3005D03 orotidine-5-monophosphate Mouse orotidine-5-monophosphate BG076748 Mm.802 Energy/Metabolism 1061 decarboxylase, 3 end decarboxylase mRNA, 3 end 1062 H3005E09 “Homo sapiens antiquitin 1 (ATQ1), BG076761 Mm.30250 Signal Transduction 1063 mRNA” 1064 H3005E10 M. musculus sodium/potassium ATPase M. musculus mRNA for BG076762 Mm.4550 Energy/Metabolism 1065 beta subunit sodium/potassium ATPase beta subunit 1066 H3005F06 “Mus musculus pelle-like protein BG076768 Mm.38241 Signal Transduction 1067 kinase mRNA, complete cds” 1068 H3005G01 glycerol-3-phosphate dehydrogenase Mouse mRNA for glycerol-3-phosphate BG076772 Mm.3711 Energy/Metabolism 1069 dehydrogenase, complete cds 1070 H3005G06 peptidylprolyl isomerase B (Ppib), Mus musculus peptidylprolyl isomerase BG076776 Mm.2412 Energy/Metabolism 1071 B (Ppib), mRNA 1072 H3005G12 methionyl tRNA synthetase Homo sapiens mRNA for methionyl BG063326 Mm.28173 Energy/Metabolism 1073 tRNA synthetase, complete cds 1074 H3006E03 cytochrome c-1 gene Human cytochrome c-1 gene, complete BG076814 Mm.29196 Apoptosis 1075 cds 1076 H3006E12 UDP-glucose: glycoprotein Homo sapiens UDP- BG076821 Mm.45651 Energy/Metabolism 1077 glucosyltransferase 1 (HUGT1), glucose: glycoprotein glucosyltransferase 1 (HUGT1), mRNA 1078 H3006G03 puromycin-sensitive aminopeptidase Mus musculus puromycin-sensitive BG076835 Mm.29824 Energy/Metabolism 1079 (Psa), aminopeptidase (Psa), mRNA 1080 H3006H05 “Mus musculus calmodulin synthesis BG076847 Mm.18041 Signal Transduction 1081 (CaM) cDNA, complete cds” 1082 H3006H10 “Mus musculus circadian locomoter BG063409 Mm.3552 Signal Transduction 1083 output cycles kaput (Clock), mRNA” 1084 H3007E02 glutathione S-transferase pi class Mus musculus glutathione S-transferase BG076872 Mm.426 Energy/Metabolism 1085 (mGSTpiA) and (mGSTpiB) genes pi class (mGSTpiA) and (mGSTpiB) genes, complete cds 1086 H3007G07 Mm.29713 Mm.29713 Energy/Metabolism 1087 1088 H3007G08 histidyl tRNA synthetase (Hars), Mus musculus histidyl tRNA synthetase BG076882 Mm.10528 Energy/Metabolism 1089 (Hars), mRNA 1090 H3008A02 H. sapiens gene 2-oxoglutarate carrier H. sapiens gene for 2-oxoglutarate BG076887 Mm.28466 Energy/Metabolism 1091 protein carrier protein 1092 H3008A05 Mus musculus GTP-binding protein BG076890 Mm.6698 Signal Transduction 1093 (mSara) homologue mRNA, complete cds 1094 H3008B05 Mus musculus dystroglycan 1 (DAG1) BG063514 Mm.7524 Matrix/Structural 1095 gene, exons 1 and 2 and complete cds Proteins 1096 H3008B06 ferritin heavy chain (Fth), Mus musculus ferritin heavy chain BG063515 Mm.1776 Energy/Metabolism 1097 (Fth), mRNA 1098 H3008B07 H3008B07 Energy/Metabolism 1099 1100 H3008B10 ATPase, H+ transporting, lysosomal I Mus musculus ATPase, H+ BG063518 Mm.19185 Energy/Metabolism 1101 (Atp6i), transporting, lysosomal I (Atp6i), mRNA 1102 H3008C02 “Mus musculus PKCq-interacting BG076907 Mm.29675 Signal Transduction 1103 protein PICOT (PICOT) mRNA, complete cds” 1104 H3008C07 tryptophan-2,3-dioxygenase (TDO), Mus musculus tryptophan-2,3- BG076911 Mm.21545 Energy/Metabolism 1105 dioxygenase (TDO), mRNA 1106 H3008C09 “HSP90 = heat shock protein [mice, AW538216 Mm.2180 Heat Shock/Stress 1107 heart, mRNA Partial, 806 nt]” 1108 H3008C12 adenylosuccinate lyase (Adsl), Mus musculus adenylosuccinate lyase BG076914 Mm.38151 Energy/Metabolism 1109 (Adsl), mRNA 1110 H3008D12 H3008D12 Energy/Metabolism 1111 1112 H3008E02 “Mus musculus caseinolytic protease, BG076923 Mm.15243 Signal Transduction 1113 ATP-dependent, (E. coli) proteolytic subunit homolog (Clpp), mRNA” 1114 H3008F09 Mm.3991 Mm.3991 Energy/Metabolism 1115 1116 H3008G05 Btk locus, alpha-D-galactosidase A Mus musculus Btk locus, alpha-D- Mm.30034 Matrix/Structural 1117 (Ags), ribosomal protein (L44L), and galactosidase A (Ags), ribosomal Proteins Brutons tyrosine kinase (Btk) genes protein (L44L), and Brutons tyrosine kinase (Btk) genes, complete cds 1118 H3008H06 M. musculus gene cathepsin D, exons 6-9 M. musculus gene for cathepsin D, exons AW538365 Apoptosis 1119 6-9 1120 H3008H07 serine palmitoyl transferase, subunit II Homo sapiens serine palmitoyl Mm.29034 1121 gene; and unknown genes transferase, subunit II gene, complete cds; and unknown genes 1122 H3009A09 Slc20a1 Mus musculus gibbon ape leukemia BG063583 Mm.16757 Energy/Metabolism 1123 virus receptor (Slc20a1) gene, exon 10 and complete cds 1124 H3009B04 Fen1 Mus musculus flap structure specific BG063590 Mm.2952 Energy/Metabolism 1125 endonuclease 1 (Fen1), mRNA 1126 H3009C03 Tgm1 Mus musculus transglutaminase 1, K BG076966 Mm.41964 Energy/Metabolism 1127 polypeptide (Tgm1), mRNA 1128 H3009C07 “Mus musculus heat shock protein, 86 kDa BG063605 Mm.1843 Heat Shock/Stress 1129 1 (Hsp86-1), mRNA” 1130 H3009D02 ATPase delta Rattus norvegicus delta subunit of F1F0 BG076975 Mm.22514 Energy/Metabolism 1131 ATPase gene, complete cds 1132 H3009E08 Cox8a Mus musculus cytochrome c oxidase, BG076988 Mm.14022 Energy/Metabolism 1133 subunit VIIIa (Cox8a), mRNA 1134 H3009G03 “Mus musculus lithium-sensitive myoinositol BG063641 Mm.8089 Signal Transduction 1135 monophosphatase A1 (IMPA1) mRNA, complete cds” 1136 H3010C12 mannosyl (alpha-1,6-)-glycoprotein Homo sapiens mannosyl (alpha-1,6-)- BG077070 Mm.24293 Energy/Metabolism 1137 beta-1,2-N- glycoprotein beta-1,2-N- acetylglucosaminyltransferase acetylglucosaminyltransferase (MGAT2), (MGAT2), mRNA 1138 H3010D10 tumor necrosis factor alpha converting Mus musculus tumor necrosis factor BG077079 Mm.105014 Apoptosis 1139 enzyme (TACE) gene, exon 3, sequence alpha converting enzyme (TACE) gene, exon 3, complete sequence 1140 H3010F06 H3010F06 Energy/Metabolism 1141 1142 H3010F07 programmed cell death 6 interacting Mus musculus programmed cell death 6 BG077095 Mm.29816 Apoptosis 1143 protein (Pdcd6ip), interacting protein (Pdcd6ip), mRNA 1144 H3011A03 protein-L-isoaspartate (D-aspartate) O- Mus musculus protein-L-isoaspartate BG077121 Mm.25293 Energy/Metabolism 1145 methyltransferase 1 (Pcmt1), (D-aspartate) O-methyltransferase 1 (Pcmt1), mRNA 1146 H3011B01 H. sapiens mitogen inducible gene mig-2 H. sapiens mitogen inducible gene mig- Mm.29842 Signal Transduction 1147 2, complete CDS 1148 H3011C08 H3011C08 Energy/Metabolism 1149 1150 H3011E06 mTim17a Mm.2368 1151 1152 H3011E10 Sid329 (Sid329), Mus musculus Sid329 (Sid329), mRNA Mm.21743 1153 1154 H3011H09 “House mouse mRNA for MAP kinase BG077180 Mm.57203 Signal Transduction 1155 kinase 3b, complete cds” 1156 H3012A05 serine palmitoyl transferase Homo sapiens serine palmitoyl 1157 transferase, subunit II gene, complete cds; and unknown genes 1158 H3012A07 “Mus musculus heat shock 70 protein BG077186 Mm.34184 Heat Shock/Stress 1159 (Hsc70) gene, complete cds” 1160 H3012C06 “Mus musculus scavenger receptor class BG077202 Mm.4603 Heat Shock/Stress 1161 B type I (mSR-BI) mRNA, complete cds” 1162 H3012F03 GLO1 Homo sapiens glyoxalase I (GLO1), BG077218 Mm.17362 Energy/Metabolism 1163 mRNA 1164 H3012F10 “Mus musculus c-src tyrosine kinase BG077222 Mm.21974 Signal Transduction 1165 (Csk), mRNA” 1166 H3012H04 “Mus musculus protein kinase Lkb1 BG063794 Mm.29947 Signal Transduction 1167 (Lkb1) and R29144/1 genes, partial cds” 1168 H3013B02 M. musculus vacuolar adenosine M. musculus mRNA for vacuolar BG077252 Mm.10727 Energy/Metabolism 1169 triphosphatase subunit B adenosine triphosphatase subunit B 1170 H3013B08 pyridoxal (pyridoxine, vitamin B6) Homo sapiens pyridoxal (pyridoxine, BG063905 Mm.26103 Energy/Metabolism kinase (PDXK), vitamin B6) kinase (PDXK), mRNA 1171 H3013C04 “Mus musculus mRNA, complete cds” AW539669 Mm.9846 Heat Shock/Stress 1172 1173 H3013D03 “Mus musculus RAB10, member RAS BG077272 Mm.21985 Signal Transduction 1174 oncogene family (Rab10), mRNA” 1175 H3013D11 Mouse metallothionein II (MT-II) gene BG063925 Mm.89170 Heat Shock/Stress 1176 1177 H3013E04 adenylyl cyclase-associated protein Homo sapiens adenylyl cyclase- Mm.43660 1178 (CAP), associated protein (CAP), mRNA 1179 H3013E07 dolichyl-phosphate alpha-N- Mus musculus dolichyl-phosphate BG063933 Mm.18353 Energy/Metabolism 1180 acetylglucosaminephosphotransferase 2 alpha-N- (Dpagt2), acetylglucosaminephosphotransferase 2 (Dpagt2), mRNA 1181 H3013F01 delta-aminolevulinate dehydratase (Lv), Mus musculus delta-aminolevulinate BG063937 Mm.6988 Energy/Metabolism 1182 dehydratase (Lv), mRNA 1183 H3013F02 “Mus musculus aurora-related kinase 1 BG077290 Mm.11738 Signal Transduction 1184 (ARK1) mRNA, complete cds” 1185 H3013G10 survivin40, survivin121, and Mus musculus survivin40, survivin121, BG077309 Mm.8552 Apoptosis 1186 survivin140 genes, alternative splice and survivin140 genes, alternative splice products products, complete cds 1187 H3014A05 partial aminopeptidase B (APB gene) Homo sapiens partial mRNA for BG077324 Mm.29706 Energy/Metabolism 1188 aminopeptidase B (APB gene) 1189 H3014A06 “Rattus norvegicus protein associating Mm.45272 Heat Shock/Stress with small stress protein PASS1 (Pass1) mRNA, complete cds” 1190 H3014A11 queuine tRNA-ribosyltransferase Mus musculus queuine tRNA- BG077329 Mm.24178 Energy/Metabolism 1191 (LOC60507), ribosyltransferase (LOC60507), mRNA 1192 H3014B06 Mm.29849 Mm.29849 Energy/Metabolism 1193 1194 H3014C08 Mus musculus surfeit gene 4 (Surf4), BG063996 Mm.2795 1195 mRNA 1196 H3014C10 Heat Shock/Stress 1197 1198 H3014C12 solute carrier family 28 (sodium- Mus musculus solute carrier family 28 BG077361 Mm.29510 Energy/Metabolism 1199 coupled nucleoside transporter), (sodium-coupled nucleoside member 2 (Slc28a2), transporter), member 2 (Slc28a2), mRNA 1200 H3014E06 UDP-Gal: betaGlcNAc beta 1,3- Mus musculus UDP-Gal: betaGlcNAc BG077355 Mm.11132 Energy/Metabolism 1201 galactosyltransferase, polypeptide 4 beta 1,3-galactosyltransferase, (B3galt4), polypeptide 4 (B3galt4), mRNA 1202 H3014E07 signal peptidase 21 kDa subunit Rattus norvegicus mRNA for signal BG077356 Mm.27800 Energy/Metabolism 1203 peptidase 21 kDa subunit, complete cds 1204 H3014F05 “Mus musculus S100 calcium-binding Mm.6523 Signal Transduction protein A13 (S100a13), mRNA” 1205 H3014F06 UDP-Gal: betaGlcNAc beta 1,4- Mus musculus UDP-Gal: betaGlcNAc BG077374 Mm.15622 Energy/Metabolism 1206 galactosyltransferase, polypeptide 1 beta 1,4-galactosyltransferase, (B4galt1), polypeptide 1 (B4galt1), mRNA 1207 H3014G07 phosphoprotein enriched in astrocytes Mus musculus phosphoprotein enriched BG064035 Mm.544 Apoptosis 1208 15 (Pea15), in astrocytes 15 (Pea15), mRNA 1209 H3014G08 protease (prosome, macropain) 26S Mus musculus protease (prosome, BG077385 Mm.665 Energy/Metabolism 1210 subunit, ATPase 5 (Psmc5), macropain) 26S subunit, ATPase 5 (Psmc5), mRNA 1211 H3014G09 protease (prosome, macropain) 26S Mus musculus protease (prosome, Mm.665 Energy/Metabolism 1212 subunit, ATPase 5 (Psmc5), macropain) 26S subunit, ATPase 5 (Psmc5), mRNA 1213 H3014H07 tyrosyl-tRNA synthetase (YARS), Homo sapiens tyrosyl-tRNA synthetase (YARS), BG077395 Mm.20353 Energy/Metabolism 1214 mRNA 1215 H3015A01 major histocompatibility locus class III Mus musculus major histocompatibility Mm.27416 1216 region: butyrophilin-like protein gene, locus class III region: butyrophilin-like partial cds; Notch4, PBX2, RAGE, protein gene, partial cds; Notch4, lysophatidic acid acyl transferase-alpha, PBX2, RAGE, lysophatidic acid acyl palmitoyl-protein thioestera transferase-alpha, palmitoyl-protein thioestera 1217 H3015B03 hypothetical protein FLJ10535 Homo sapiens hypothetical protein BG077413 Mm.24187 Energy/Metabolism 1218 (FLJ10535), FLJ10535 (FLJ10535), mRNA 1219 H3015C02 methionine adenosyltransferase alpha Homo sapiens methionine BG064075 Mm.29815 Energy/Metabolism 1220 subunit gene fragment adenosyltransferase alpha subunit gene fragment 1221 H3015D05 MSTP029 Homo sapiens MSTP029 mRNA, BG077438 Mm.30147 Energy/Metabolism 1222 complete cds 1223 H3015E06 Tnf receptor-associated factor 1 (Traf1), Mus musculus Tnf receptor-associated BG064103 Mm.12898 Apoptosis 1224 factor 1 (Traf1), mRNA 1225 H3016C10 Heat Shock/Stress 1226 1227 H3016D01 Mm.20201 Mm.20201 Energy/Metabolism 1228 1229 H3016D08 BCL2/adenovirus E1B 19 kDa- Mus musculus BCL2/adenovirus E1B BG077518 Mm.29820 Apoptosis 1230 interacting protein 3-like (Bnip31), 19 kDa-interacting protein 3-like (Bnip31), mRNA 1231 H3016E10 Mus musculus mG28K mRNA for BG077528 Mm.28954 1232 GTP-binding protein like 1, complete cds 1233 H3016F03 Tim44 Rattus norvegicus mRNA for Tim44, Mm.34791 Matrix/Structural 1234 complete cds Proteins 1235 H3016F07 M. musculus glutamyl-tRNA synthetase M. musculus mRNA for glutamyl-tRNA BG064194 Mm.27190 Energy/Metabolism 1236 synthetase 1237 H3016F11 Heat Shock/Stress 1238 H3017A02 ornithine decarboxylase antizyme 2 Mus musculus ornithine decarboxylase BG077570 Mm.675 Energy/Metabolism 1239 (Oaz2), antizyme 2 (Oaz2), mRNA 1240 H3017C11 “Mus musculus RAN guanine BG077598 Mm.143774 Signal Transduction 1241 nucleotide release factor (Rangnrf- pending), mRNA” 1242 H3017D04 “Homo sapiens hect (homologous to the BG064250 Mm.102717 Heat Shock/Stress 1243 E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (HERC1), mRNA” 1244 H3017E04 “Mus musculus cathepsin Z precursor BG077611 Mm.115 Signal Transduction 1245 (Ctsz) mRNA, complete cds” 1246 H3017E11 “Mus musculus retinoblastoma binding AW544081 Mm.1603 Heat Shock/Stress 1247 protein 7 (Rbbp7), mRNA” 1248 H3017G06 phenylalanyl tRNA synthetase beta Mus musculus phenylalanyl tRNA BG077633 Mm.28922 Energy/Metabolism 1249 subunit (Frsb) synthetase beta subunit (Frsb) mRNA, complete cds 1250 H3018A02 B4galt3 Mus musculus beta-1,4- BG077551 Mm.150720 Energy/Metabolism 1251 galactosyltransferase III (B4galt3), mRNA 1252 H3018A04 APB Homo sapiens partial mRNA for BG077553 Energy/Metabolism 1253 aminopeptidase B (APB gene) 1254 H3018A08 “Mus musculus Cctq gene for BG064304 Mm.17989 Heat Shock/Stress 1255 chaperonin containing TCP-1 theta subunit, complete cds” 1256 H3018A11 Cyp17 Mus musculus cytochrome P450, 17 BG064307 Mm.1262 Energy/Metabolism 1257 (Cyp17), mRNA 1258 H3018B08 thimet oligopeptidase Mus musculus thimet oligopeptidase BG077656 Mm.26995 Energy/Metabolism 1259 mRNA, complete cds 1260 H3018F06 Heat Shock/Stress 1261 1262 H3018G08 UDP-galactose 4 epimerase (GALE) Homo sapiens UDP-galactose 4 BG077710 Mm.20363 Energy/Metabolism 1263 epimerase (GALE) gene, complete cds 1264 H3019A07 ATP binding protein associated with Homo sapiens ATP binding protein Mm.28438 Energy/Metabolism cell differentiation (APACD), associated with cell differentiation (APACD), mRNA 1265 H3019B01 ATPase, Na+/K+ transporting, beta 1 Mus musculus ATPase, Na+/K+ BG077733 Mm.4550 Energy/Metabolism 1266 polypeptide (Atp1b1), transporting, beta 1 polypeptide (Atp1b1), mRNA 1267 H3019B03 acyl-coenzyme A: cholesterol acyl-coenzyme A: cholesterol BG077735 Mm.28099 Matrix/Structural 1268 acyltransferase [mice, peritoneal acyltransferase [mice, peritoneal Proteins macrophages,, 3041 nt] macrophages, mRNA, 3041 nt] 1269 H3019B10 Mus musculus microtubule-associated BG077742 Mm.12625 Matrix/Structural 1270 protein 4 (Mtap4), mRNA Proteins 1271 H3019C06 CGI-107 protein (LOC51012), Homo sapiens CGI-107 protein Mm.30065 1272 (LOC51012), mRNA 1273 H3019C11 core1 UDP-galactose: N- Mus musculus core1 UDP-galactose: N- BG077752 Mm.102752 Energy/Metabolism 1274 acetylgalactosamine-alpha-R beta 1,3- acetylgalactosamine-alpha-R beta 1,3- galactosyltransferase (C1galt1) galactosyltransferase (C1galt1) mRNA, complete cds 1275 H3019C12 “Mus musculus GTP-binding protein BG077753 Mm.6698 Signal Transduction 1276 (mSara) homologue mRNA, complete cds” 1277 H3019D09 “Mus musculus protein kinase C BG077758 Mm.425 Signal Transduction 1278 inhibitor (mPKCI) mRNA, complete cds” 1279 H3019E05 Mm.38994 Mm.38994 Energy/Metabolism 1280 1281 H3019E12 F1F0-type ATP synthase subunit d Homo sapiens F1F0-type ATP synthase BG077769 Mm.102755 Energy/Metabolism 1282 subunit d mRNA, complete cds 1283 H3019F05 Mouse tyrosine kinase (c-abl) mRNA BG077774 Mm.1318 Signal Transduction 1284 1285 H3019F06 domesticus tumor necrosis factor Mus musculus domesticus mRNA for BG077775 Mm.103353 Apoptosis 1286 receptor p60 homologue 1 (Tnfrh1 tumor necrosis factor receptor p60 gene) homologue 1 (Tnfrh1 gene) 1287 H3019F07 “Mus musculus serine/threonine kinase BG077776 Mm.8235 Signal Transduction 1288 10 (Stk10), mRNA” 1289 H3019F10 phosphomannomutase 2 (Pmm2), Energy/Metabolism 1290 1291 H3019G05 alkaline phosphatase 2, liver (Akp2), Mus musculus phosphomannomutase 2 BG077784 Mm.9699 Energy/Metabolism 1292 (Pmm2), mRNA 1293 H3019H07 ATPase-like vacuolar proton channel Mus musculus alkaline phosphatase 2, BG077796 Mm.1265 Energy/Metabolism 1294 (Atpl), liver (Akp2), mRNA 1295 H3019H11 H3019F10 Mus musculus ATPase-like vacuolar BG077799 Mm.30155 Energy/Metabolism 1296 proton channel (Atpl), mRNA 1297 H3020A02 nucleoside diphosphatase (ER-UDPase Mus musculus mRNA for nucleoside BG077800 Mm.10211 Energy/Metabolism 1298 gene) diphosphatase (ER-UDPase gene) 1299 H3020A07 serine palmitoyl transferase, subunit II Homo sapiens serine palmitoyl Mm.22626 1300 gene; and unknown genes transferase, subunit II gene, complete cds; and unknown genes 1301 H3020B08 ferritin light chain 1 (Ftl1), Mus musculus ferritin light chain 1 BG077812 Mm.7500 Energy/Metabolism 1302 (Ftl1), mRNA 1303 H3020C02 “Mouse metallothionein-I (MT-I) gene, BG077818 Mm.2041 Heat Shock/Stress 1304 5′ end” 1305 H3020D10 isocitrate dehydrogenase 3 (NAD+) Homo sapiens isocitrate dehydrogenase BG077913 Mm.29051 Energy/Metabolism 1306 alpha (IDH3A), 3 (NAD+) alpha (IDH3A), mRNA 1307 H3020E01 “Mus musculus wagneri gene for 105- BG064500 Mm.34828 Heat Shock/Stress 1308 kDa heat shock protein, exon 18 and complete cds” 1309 H3020H04 squalene epoxidase (Sqle), Mus musculus squalene epoxidase BG077950 Mm.22663 Energy/Metabolism 1310 (Sqle), mRNA 1311 H3020H07 BALB/c GDP-dissociation inhibitor Mus musculus BALB/c GDP- BG077953 Mm.28084 Energy/Metabolism 1312 (GDI-1), partial cds dissociation inhibitor (GDI-1) mRNA, partial cds 1313 H3020H10 man 6-P receptor (46MPR) Mouse man 6-P receptor (46MPR) BG064540 Mm.1358 Energy/Metabolism 1314 mRNA, complete cds 1315 H3021A02 programmed cell death 6 (Pdcd6), Mus musculus programmed cell death 6 BG077957 Mm.24254 Apoptosis 1316 (Pdcd6), mRNA 1317 H3021A11 small zinc finger-like protein (Tim13) Mus musculus small zinc finger-like BG077964 Mm.22201 Energy/Metabolism 1318 protein (Tim13) mRNA, complete cds 1319 H3021A12 M. musculus (clone S5) WRS M. musculus (clone S5) WRS mRNA for BG077965 Mm.38433 Energy/Metabolism 1320 tryptophan--tRNA ligase tryptophan--tRNA ligase 1321 H3021B05 M. musculus CI-23 kD gene M. musculus CI-23 kD gene BG077969 Mm.44227 Energy/Metabolism 1322 1323 H3021B08 mitochondrial carrier peroxisomal Mm.306 1324 membrane protein, 34 kDa member 17 PMP34 1325 H3021C09 H3021C09 Apoptosis 1326 1327 H3021D07 “Mus musculus proliferin related protein BG077825 Mm.3258 Signal Transduction 1328 (Plfr), mRNA” 1329 H3021E11 vacuolar adenosine triphosphatase Mus musculus vacuolar adenosine BG064589 Mm.29771 Energy/Metabolism 1330 subunit A gene triphosphatase subunit A gene, complete cds 1331 H3021F01 aspartyl aminopeptidase (Dnpep), Mus musculus aspartyl aminopeptidase BG077839 Mm.24680 Energy/Metabolism 1332 (Dnpep), mRNA 1333 H3021F08 “Mus musculus chaperonin subunit 7 BG077843 Mm.914 Heat Shock/Stress 1334 (eta) (Cct7), mRNA” 1335 H3021G03 “Mus musculus serine/threonine protein BG077848 Mm.1970 Signal Transduction 1336 phosphatase type 1 alpha mRNA, complete cds” 1337 H3021H03 “Mus musculus Ras suppressor protein 1 BG077860 Mm.905 Signal Transduction 1338 (Rsu1), mRNA” 1339 H3022A04 Cricetulus griseus Cricetulus griseus mRNA for BG064623 Mm.28864 Energy/Metabolism 1340 Phosphatidylglycerophosphate synthase Phosphatidylglycerophosphate synthase, complete cds 1341 H3022A05 “Mus musculus RAB23, member RAS BG077872 Mm.40644 Signal Transduction 1342 oncogene family (Rab23), mRNA” 1343 H3022B12 ribonuclease P (14 kD) (RPP14), Homo sapiens ribonuclease P (14 kD) BG064641 Mm.41801 Energy/Metabolism 1344 (RPP14), mRNA 1345 H3022D02 dolichyl-phosphate beta- Homo sapiens dolichyl-phosphate beta- BG064654 Mm.27890 Energy/Metabolism 1346 glucosyltransferase glucosyltransferase mRNA, complete cds 1347 H3022D03 galactokinase gene Mus musculus galactokinase gene, BG064655 Mm.2820 Energy/Metabolism 1348 complete cds 1349 H3022D09 beta-glucuronidase gene Mouse beta-glucuronidase gene, BG077995 Mm.3317 Energy/Metabolism 1350 complete cds 1351 H3022E01 GLUT4 vesicle protein, partial cds Mus musculus GLUT4 vesicle protein BG064664 Mm.29010 Energy/Metabolism 1352 mRNA, partial cds 1353 H3022E09 a disintegrin-like and metalloprotease Homo sapiens a disintegrin-like and BG078006 Mm.102791 Energy/Metabolism 1354 (reprolysin type) with thrombospondin metalloprotease (reprolysin type) with type 1 motif, 4 (ADAMTS4), thrombospondin type 1 motif, 4 (ADAMTS4), mRNA 1355 H3022F06 malic enzyme, supernatant (Mod1), Mus musculus malic enzyme, BG064680 Mm.29998 Energy/Metabolism 1356 supematant (Mod1), mRNA 1357 H3022G02 26S protease ATPase (mss1), partial Mus musculus 26S protease ATPase BG078023 Mm.2462 Energy/Metabolism 1358 cds (mss1) mRNA, partial cds 1359 H3022G03 26S protease ATPase (mss1), partial Mus musculus 26S protease ATPase BG078024 Mm.2462 Energy/Metabolism 1360 cds (mss1) mRNA, partial cds 1361 H3022H03 serine/threonine kinase 17b (apoptosis- Homo sapiens serine/threonine kinase BG078034 Mm.25559 Apoptosis 1362 inducing) (STK17B), 17b (apoptosis-inducing) (STK17B), mRNA 1363 H3022H06 “Mouse serine/threonine phosphatase- BG064691 Mm.849 Signal Transduction 1364 2C (PP2C) mRNA, complete cds” 1365 H3023A10 folylpolyglutamate synthetase precursor Mus musculus folylpolyglutamate BG064717 Mm.3830 Energy/Metabolism 1366 (Fpgs) synthetase precursor (Fpgs) mRNA, complete cds 1367 H3023B01 Heat Shock/Stress 1368 1369 H3023B11 “Mouse mRNA for HSP60 protein BG064728 Mm.1777 Heat Shock/Stress 1370 (clones 3T3-7, -9, and -M1)” 1371 H3023B12 Mouse cDNA for heat shock protein 65 BG064729 Mm.1777 Heat Shock/Stress 1372 1373 H3023C05 Homo sapiens nuclear receptor binding BG064733 Mm.22029 1374 protein (NRBP), mRNA 1375 H3023C07 peroxiredoxin 5 (Prdx5), Mus musculus peroxiredoxin 5 (Prdx5), BG064735 Mm.6587 Energy/Metabolism 1376 mRNA 1377 H3023C08 ribonucleotide reductase M1 (Rrm1), Mus musculus ribonucleotide reductase BG064736 Mm.656 Energy/Metabolism 1378 M1 (Rrm1), mRNA 1379 H3023C09 Mm.29735 Mm.29735 Energy/Metabolism 1380 1381 H3023D06 Mus musculus phosphoglycerate kinase BG064745 Mm.188 Signal Transduction 1382 (Pgk1-ps1) processed pseudogene 1383 H3023D08 glutamate pyruvate transaminase (GPT) Human glutamate pyruvate BG064747 Mm.30130 Energy/Metabolism 1384 gene transaminase (GPT) gene, complete cds 1385 H3023D09 partial xylosyltransferase II (XT-II Mus musculus partial mRNA for BG078081 Mm.100638 Energy/Metabolism 1386 gene) xylosyltransferase II (XT-II gene) 1387 H3023E11 SDHD gene small subunit of Homo sapiens SDHD gene for small BG078095 Mm.10406 Energy/Metabolism 1388 cytochrome b of succinate subunit of cytochrome b of succinate dehydrogenase dehydrogenase, complete cds 1389 H3023F02 “Mus musculus phosphatidylinositol-4- BG064765 Mm.3191 Signal Transduction 1390 phosphate 5-kinase, type 1 beta (Pip5k1b), mRNA” 1391 H3023F07 “Mus musculus Ccte gene for BG064769 Mm.1813 Heat Shock/Stress 1392 chaperonin containing TCP-1 epsilon subunit, complete cds” 1393 H3023F08 “Mus musculus Ccte gene for BG064770 Mm.1813 Heat Shock/Stress 1394 chaperonin containing TCP-1 epsilon subunit, complete cds” 1395 H3023F09 glucosamine-6-phosphate deaminase Mus musculus glucosamine-6- BG064771 Mm.22374 Energy/Metabolism 1396 (Gnpda) phosphate deaminase (Gnpda) mRNA, complete cds 1397 H3023F10 “Mus musculus heat shock protein, 86 BG064772 Mm.1843 Heat Shock/Stress 1398 kDa 1 (Hsp86-1), mRNA” 1399 H3023F12 “Mus musculus heat shock protein, 86 BG064774 Mm.1843 Heat Shock/Stress 1400 kDa 1 (Hsp86-1), mRNA” 1401 H3023G01 “Mus musculus heat shock protein, 86 BG064775 Mm.1843 Heat Shock/Stress 1402 kDa 1 (Hsp86-1), mRNA” 1403 H3023G05 phosphoribosyl pyrophosphate Mus musculus phosphoribosyl BG064779 Mm.25198 Energy/Metabolism synthetase 1 (Prps1), pyrophosphate synthetase 1 (Prps1), mRNA 1404 H3023H09 ferritin L-subunit gene exons 1-4 Mus musculus ferritin L-subunit gene BG064794 Mm.7500 Energy/Metabolism 1405 exons 1-4, complete cds 1406 H3023H10 ferritin L-subunit gene exons 1-4 Mus musculus ferritin L-subunit gene BG064795 Mm.7500 Energy/Metabolism 1407 exons 1-4, complete cds 1408 H3023H11 ferritin L-subunit gene exons 1-4 Mus musculus ferritin L-subunit gene BG064796 Mm.7500 Energy/Metabolism 1409 exons 1-4, complete cds 1410 H3023H12 lactate dehydrogenase 1, A chain Mus musculus lactate dehydrogenase 1, BG064797 Mm.26504 Energy/Metabolism 1411 (Ldh1), A chain (Ldh1), mRNA 1412 H3024A02 polymerase, gamma (Polg), Mus musculus polymerase, gamma BG064799 Mm.3616 DNA Replication 1413 (Polg), mRNA 1414 H3024A06 alcohol dehydrogenase 5 (Adh5), Mus musculus alcohol dehydrogenase 5 BG064803 Mm.3874 Energy/Metabolism 1415 (Adh5), mRNA 1416 H3024A11 DNA M2 subunit of ribonucleotide Mouse DNA for M2 subunit of mouse BG078138 Mm.99 Energy/Metabolism 1417 reductase (EC 1.17.4.1) ribonucleotide reductase (EC 1.17.4.1) 1418 H3024B03 “Mus musculus chaperonin subunit 3 BG064811 Mm.3576 Heat Shock/Stress 1419 (gamma) (Cct3), mRNA” 1420 H3024B04 “Mus musculus chaperonin subunit 3 BG064812 Mm.3576 Heat Shock/Stress 1421 (gamma) (Cct3), mRNA” 1422 H3024B05 “Mus musculus chaperonin subunit 3 BG064813 Mm.3576 Heat Shock/Stress 1423 (gamma) (Cct3), mRNA” 1424 H3024B06 “Mus musculus chaperonin subunit 3 BG064814 Mm.3576 Heat Shock/Stress 1425 (gamma) (Cct3), mRNA” 1426 H3024B12 Heat Shock/Stress 1427 1428 H3024C02 “Homo sapiens oxidative-stress BG078151 Mm.52786 Heat Shock/Stress 1429 responsive 1 (OSR1), mRNA” 1430 H3024C04 phosphoglycerate mutase 1 (Pgam1) Mus musculus phosphoglycerate BG064823 Mm.16783 Energy/Metabolism 1431 mutase 1 (Pgam1) mRNA, complete cds 1432 H3024C07 HEXA gene, exons 2-14 M. musculus HEXA gene, exons 2-14 BG064825 Mm.2284 Energy/Metabolism 1433 1434 H3024C11 “Mus musculus heat shock protein, 86 kDa BG064829 Mm.1843 Heat Shock/Stress 1435 1 (Hsp86-1), mRNA” 1436 H3024E08 direct IAP binding protein with low PI Mus musculus direct IAP binding BG064850 Mm.46716 Apoptosis 1437 protein with low PI mRNA, complete cds 1438 H3024F05 Mus musculus putative CCAAT binding BG064857 Mm.24169 Transcription/Chromatin 1439 factor 1 (mCBF) mRNA, alternatively spliced transcript mCBF1, complete cds 1440 H3024F06 serine hydroxymethyl transferase 1 Mus musculus serine hydroxymethyl BG078187 Mm.45993 Energy/Metabolism 1441 (soluble) (Shmt1), transferase 1 (soluble) (Shmt1), mRNA 1442 H3024F07 fumarate hydratase (FH), Homo sapiens fumarate hydratase (FH), BG064859 Mm.41502 Energy/Metabolism 1443 mRNA 1444 H3024G02 phosphoribosyl pyrophosphate Mus musculus phosphoribosyl BG064866 Mm.25198 Energy/Metabolism 1445 synthetase 1 (Prps1), pyrophosphate synthetase 1 (Prps1), mRNA 1446 H3024G03 K+ channel, sequence Rattus norvegicus K+ channel mRNA, BG078196 Mm.40482 Energy/Metabolism 1447 sequence 1448 H3024G07 Murine L-myc gene BG064871 Mm.1055 Signal Transduction 1449 1450 H3024H02 “Mus musculus p53 binding protein 1 BG078205 Mm.25231 Signal Transduction 1451 mRNA, partial cds” 1452 H3024H12 “Mus musculus breast heat shock 73 BG064886 Mm.2944 Heat Shock/Stress 1453 protein (hsc73) mRNA, complete cds” 1454 H3025A01 “Mus musculus interferon alpha BG078215 Mm.21761 Heat Shock/Stress 1455 responsive protein (15 kDa) (Ifrg15), mRNA” 1456 H3025C05 malate dehydrogenase, soluble (Mor2), Mus musculus malate dehydrogenase, BG064914 Mm.3156 Energy/Metabolism 1457 soluble (Mor2), mRNA 1458 H3025D10 Aga = aspartylglucosaminidase [mice, Aga = aspartylglucosaminidase [mice, BG064929 Mm.41591 Energy/Metabolism 1459 liver, brain, Partial, 1191 nt] liver, brain, mRNA Partial, 1191 nt] 1460 H3025E07 ADP-ribosylarginine hydrolase Mus musculus ADP-ribosylarginine BG064935 Mm.20047 Energy/Metabolism 1461 hydrolase mRNA, complete cds 1462 H3025F10 succinate dehydrogenase Ip subunit, Mus musculus succinate dehydrogenase BG064949 Mm.29141 Energy/Metabolism 1463 partial cds Ip subunit mRNA, partial cds 14641465 H3026B03 HSPC145 protein (HSPC145), Homo sapiens HSPC145 protein Mm.29904 (HSPC145), mRNA 1466 H3026B04 phosphoribosyl pyrophosphate Homo sapiens phosphoribosyl BG064988 Mm.27743 Energy/Metabolism 1467 amidotransferase (PPAT), pyrophosphate amidotransferase (PPAT), mRNA 1468 H3026B06 Mm.100588 Mm.100588 Energy/Metabolism 1469 1470 H3026B07 ADP-ribosylation factor 1 (Arf1), Mus musculus ADP-ribosylation factor BG078294 Mm.6836 Energy/Metabolism 1471 1 (Arf1), mRNA 1472 H3026B11 ATPase, Cu++ transporting, beta Mus musculus ATPase, Cu++ BG078297 Mm.102506 Energy/Metabolism 1473 polypeptide (Atp7b), transporting, beta polypeptide (Atp7b), mRNA 1474 H3026D06 tyrosine 3-monooxygenase/tryptophan Mus musculus tyrosine 3- BG065012 Mm.3308 Energy/Metabolism 1475 5-monooxygenase activation protein, eta monooxygenase/tryptophan 5- polypeptide (Ywhah), monooxygenase activation protein, eta polypeptide (Ywhah), mRNA 1476 H3026D10 “Mus musculus heat shock protein, BG065015 Mm.27897 Heat Shock/Stress 1477 DNAJ-like 2 (Hsj2), mRNA” 1478 H3026E07 cDNA FLJ12225 fis, clone Homo sapiens cDNA FLJ12225 fis, BG078316 Mm.12983 Energy/Metabolism 1479 MAMMA1001139, weakly similar to clone MAMMA101139, weakly SRE-2 PROTEIN similar to SRE-2 PROTEIN 1480 H3026F02 M. musculus GSHPx gene M. musculus GSHPx gene BG065030 Mm.1090 Energy/Metabolism 1481 1482 H3026F05 acetyl-Coenzyme A dehydrogenase, Mus musculus acetyl-Coenzyme A BG065033 Mm.18759 Energy/Metabolism 1483 short chain (Acads), dehydrogenase, short chain (Acads), mRNA 1484 H3026F06 H. sapiens phosphoenolpyruvate H. sapiens mRNA for BG078326 Mm.29856 Energy/Metabolism 1485 carboxykinase phosphoenolpyruvate carboxykinase 1486 H3026F07 “Mus musculus Ccth gene for BG065035 Mm.914 Heat Shock/Stress 1487 chaperonin containing TCP-1 eta subunit, complete cds” 1488 H3026F08 “Mus musculus Ccth gene for BG065036 Mm.914 Heat Shock/Stress 1489 chaperonin containing TCP-1 eta subunit, complete cds” 1490 H3026G10 mannose phosphate isomerase (MPI), Homo sapiens mannose phosphate BG078342 Mm.34830 Energy/Metabolism 1491 isomerase (MPI), mRNA 1492 H3026H09 methionine adenosyltransferase alpha Homo sapiens methionine BG065061 Mm.29815 Energy/Metabolism 1493 subunit gene fragment adenosyltransferase alpha subunit gene fragment 1494 H3026H11 puromycin-sensitive aminopeptidase Mus musculus puromycin-sensitive BG065063 Mm.29824 Energy/Metabolism 1495 (Psa), aminopeptidase (Psa), mRNA 1496 H3027A10 ATPase-like vacuolar proton channel Mus musculus ATPase-like vacuolar BG065073 Mm.30155 Energy/Metabolism 1497 (Atpl) proton channel (Atpl), mRNA 1498 H3027B02 “Homo sapiens SH3-domain binding BG078369 Mm.62046 Signal Transduction 1499 protein 4 (SH3BP4), mRNA” 1500 H3027C06 transient receptor potential-related Mus musculus transient receptor BG065092 Mm.33819 Energy/Metabolism 1501 protein (ChaK), potential-related protein (ChaK), mRNA 1502 H3027E05 uridine phosphorylase (Upp), Mus musculus uridine phosphorylase BG065114 Mm.4610 Energy/Metabolism 1503 (Upp), mRNA 1504 H3027E07 alpha-enolase (2-phospho-D-glycerate Mouse mRNA for alpha-enolase (2- BG078408 Mm.90587 Energy/Metabolism 1505 hydrolase) (EC 4.2.1.11) phospho-D-glycerate hydrolase) (EC 4.2.1.11) 1506 H3027E08 alpha-enolase (2-phospho-D-glycerate Mouse mRNA for alpha-enolase (2- BG078409 Mm.90587 Energy/Metabolism 1507 hydrolase) (EC 4.2.1.11) phospho-D-glycerate hydrolase) (EC 4.2.1.11) 1508 H3027E09 alpha-enolase (2-phospho-D-glycerate Mouse mRNA for alpha-enolase (2- BG078410 Mm.90587 Energy/Metabolism 1509 hydrolase) (EC 4.2.1.11) phospho-D-glycerate hydrolase) (EC 4.2.1.11) 1510 H3027F02 aspartyl-tRNA synthetase (DARS), Homo sapiens aspartyl-tRNA synthetase BG078414 Mm.28693 Energy/Metabolism 1511 (DARS), mRNA 1512 H3027F07 “Murine MAP kinase kinase 6c mRNA, BG065128 Mm.14487 Signal Transduction 1513 complete cds” 1514 H3027F12 “Mus musculus Cctd gene for BG078424 Mm.6821 Heat Shock/Stress 1515 chaperonin containing TCP-1 delta subunit, complete cds” 1516 H3027H04 “Homo sapiens heat shock protein 75 BG078439 Mm.38470 Heat Shock/Stress 1517 (TRAP1), mRNA” 1518 H3028A03 peptidylprolyl isomerase A (Ppia), Mus musculus peptidylprolyl isomerase BG078450 Mm.5246 Energy/Metabolism 1519 A (Ppia), mRNA 1520 H3028A04 peptidylprolyl isomerase A (Ppia), Mus musculus peptidylprolyl isomerase BG078451 Mm.5246 Energy/Metabolism 1521 A (Ppia), mRNA 1522 H3028A09 BTB and CNC homology 2 (Bach2), Mus musculus BTB and CNC homology BG065166 Mm.21908 Energy/Metabolism 1523 2 (Bach2), mRNA 1524 H3028B03 adenine nucleotide translocase-2 (Ant2) Mus musculus adenine nucleotide Mm.658 Energy/Metabolism 1525 translocase-2 (Ant2) mRNA, complete cds 1526 H3028C09 “Mus musculus adenosine kinase (Adk), BG065190 Mm.19352 Signal Transduction 1527 mRNA” 1528 H3028E01 death associated protein 3 (DAP-3 gene) Mus musculus mRNA for death BG078504 Mm.29028 Apoptosis 1529 associated protein 3 (DAP-3 gene) 1530 H3028E04 “Mus musculus protein phosphatase 2 BG078507 Mm.1034 Signal Transduction 1531 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (Ppp2r1a), mRNA” 1532 H3028F04 “Mus musculus cathepsin L (Ctsl), BG078497 Mm.930 Signal Transduction 1533 mRNA” 1534 H3028F05 kidney ornithine decarboxylase, clone Mouse kidney ornithine decarboxylase BG065221 Mm.15259 Energy/Metabolism 1535 pODC16, 3 end mRNA, clone pODC16, 3 end 1536 H3028F06 “Mus musculus RAB17, member RAS BG078499 Mm.46396 Signal Transduction 1537 oncogene family (Rab17), mRNA” 1538 H3028H11 “Mus musculus cathepsin H (Ctsh), BG065250 Mm.2277 Signal Transduction 1539 mRNA” 1540 H3029A03 peroxisomal trans 2-enoyl CoA Mus musculus peroxisomal trans 2- BG065254 Mm.29988 Energy/Metabolism 1541 reductase enoyl CoA reductase mRNA, complete cds 1542 H3029A05 cellular apoptosis susceptibility protein Mus musculus cellular apoptosis BG065256 Mm.22417 Apoptosis 1543 susceptibility protein mRNA, complete cds 1544 H3029B01 natural resistance associated Mus musculus natural resistance BG065264 Mm.1304 Energy/Metabolism 1545 macrophage protein-2 (Nramp2), C- associated macrophage protein-2 terminal exon alternative splice variant (Nramp2) mRNA, C-terminal exon alternative splice variant, complete cds 1546 H3029B02 “Mus musculus chaperonin subunit 3 BG078552 Mm.27804 Heat Shock/Stress 1547 (gamma) (Cct3), mRNA” 1548 H3029C05 NADH dehydrogenase (ubiquinone) 1, Homo sapiens NADH dehydrogenase BG078565 Mm.1893 Energy/Metabolism 1549 subcomplex unknown, 2 (14.5 kD, (ubiquinone) 1, subcomplex unknown, 2 B14.5b) (NDUFC2), (14.5 kD, B14.5b) (NDUFC2), mRNA 1550 H3029C06 Heat Shock/Stress 1551 1552 H3029E04 “Mus musculus Son of sevenless BG065298 Mm.6357 Signal Transduction 1553 homolog 1, (Drosophila)(Sos1), mRNA” 1554 H3029G12 nuclear mitotic apparatus protein 1 Homo sapiens nuclear mitotic apparatus Mm.102520 (NUMA1), protein 1 (NUMA1), mRNA 1555 H3030A03 Mouse cDNA for heat shock protein 65 BG078626 Mm.1777 Heat Shock/Stress 1556 1557 H3030B07 Mm.1776 Heat Shock/Stress 1558 1559 H3030C05 “Mus musculus activin receptor IIB BG065366 Mm.8940 Signal Transduction 1560 (Acvr2b), mRNA” 1561 H3030C06 “Mus musculus nucleoside diphosphate BG078650 Mm.1260 Signal Transduction 1562 kinase A long form mRNA, complete cds” 1563 H3030C11 H3030C11 Energy/Metabolism 1564 1565 H3030D10 pyruvate kinase M Mus musculus mRNA for pyruvate BG078663 Mm.2635 Energy/Metabolism 1566 kinase M, complete cds 1567 H3030D11 pyruvate kinase M Mus musculus mRNA for pyruvate BG078664 Mm.2635 Energy/Metabolism 1568 kinase M, complete cds 1569 H3030E04 Mm.26022 Mm.26022 Energy/Metabolism 1570 1571 H3030E05 glycine decarboxylase (P-protein) Human glycine decarboxylase (P- BG078669 Mm.27953 Energy/Metabolism 1572 protein) mRNA 1573 H3030E06 glycine decarboxylase (P-protein) Human glycine decarboxylase (P- BG078670 Mm.27953 Energy/Metabolism 1574 protein) mRNA 1575 H3030E10 “Mus musculus cathepsin B (Ctsb), BG078674 Mm.22753 Signal Transduction 1576 mRNA” 1577 H3030F09 Homo sapiens protein phosphatase 3 AW537455 Mm.142697 Matrix/Structural 1578 (formerly 2B), catalytic subunit, beta Proteins isoform (calcineurin A beta) (PPP3CB), mRNA 1579 H3030G01 Cochlear (clone 20F5) M. musculus partial cochlear mRNA BG078685 Mm.43671 Energy/Metabolism 1580 (clone 20F5) 1581 H3030G08 ATP synthase alpha subunit Mouse ATP synthase alpha subunit, BG078689 Mm.4069 Energy/Metabolism 1582 complete cds 1583 H3030G09 “Mus musculus Ca2+-independent BG065409 Mm.117103 Signal Transduction 1584 phospholipase A2 long form mRNA, complete cds” 1585 H3030H02 Bckdk Mus musculus branched chain ketoacid BG078694 Mm.8903 Signal Transduction 1586 dehydrogenase kinase (Bckdk), mRNA 1587 H3031A11 “Mus musculus protein kinase C BG078710 Mm.70272 Signal Transduction 1588 substrate 80K-H (Prkcsh), mRNA” 1589 H3031B06 cytosolic aminopeptidase P Homo sapiens cytosolic BG078715 Mm.99776 Energy/Metabolism 1590 aminopeptidase P mRNA, complete cds 1591 H3031C05 PIS1 gene phosphatidylinositol synthase Rattus norvegicus PIS1 gene for BG065447 Mm.28219 Energy/Metabolism 1592 phosphatidylinositol synthase, complete cds 1593 H3031C09 “Mus musculus putative intracellular BG078729 Mm.27063 Signal Transduction 1594 signaling protein (Trip6) mRNA, complete cds” 1595 H3031C12 Mus musculus N-myc downstream BG078732 Mm.4063 Transcription/Chromatin 1596 regulated 1 (Ndr1), mRNA 1597 H3031D03 aldolase 1, A isom (Aldo1), Mus musculus aldolase 1, A isoform BG065457 Mm.16763 Energy/Metabolism 1598 (Aldo1), mRNA 1599 H3031E10 S-adenosylhomocysteine hydrolase Mus musculus S-adenosylhomocysteine BG065475 Mm.2573 Energy/Metabolism 1600 (Ahcy), hydrolase (Ahcy), mRNA 1601 H3031E11 glyceraldehyde-3-phosphate Mus musculus glyceraldehyde-3- BG065476 Mm.5289 Energy/Metabolism 1602 dehydrogenase (Gapd), phosphate dehydrogenase (Gapd), mRNA 1603 H3031E12 fatty acid desaturase 1 (FADS1), Homo sapiens fatty acid desaturase 1 BG078755 Mm.30158 Energy/Metabolism 1604 (FADS1), mRNA 1605 H3031F01 ubiquinol-cytochrome c reductase core Homo sapiens ubiquinol-cytochrome c BG065478 Mm.972 Energy/Metabolism 1606 protein I (UQCRC1), reductase core porotein I (UQCRC1), mRNA 1607 H3031F08 “Mus musculus heat shock protein 40 BG065483 Mm.2982 Heat Shock/Stress 1608 (HSPF1), mRNA” 1609 H3031F12 M. musculus aspartate aminotransferase M. musculus aspartate aminotransferase BG078765 Mm.149089 Energy/Metabolism 1610 gene exon 10 and 3-flank gene exon 10 and 3-flank 1611 H3031G06 “Mus musculus heat shock protein, 110 kDa BG065493 Mm.1032 Heat Shock/Stress 1612 (Hsp110), mRNA” 1613 H3031G08 Mm.93266 Mm.93266 Energy/Metabolism 1614 1615 H3031G11 ATPase, H+ transporting, lysosomal Homo sapiens ATPase, H+ transporting, BG078776 Mm.22602 Energy/Metabolism 1616 (vacuolar proton pump) 9 kD (ATP6H), lysosomal (vacuolar proton pump) 9 kD (ATP6H), mRNA 1617 H3031H09 5-3 exoribonuclease 2 (Xrn2), Mus musculus 5-3 exoribonuclease 2 BG065507 Mm.3065 Energy/Metabolism 1618 (Xrn2), mRNA 1619 H3032A01 hypothetical protein PRO1197 Homo sapiens hypothetical protein BG065511 Mm.24565 Energy/Metabolism 1620 (PRO1197), PRO1197 (PRO1197), mRNA 1621 H3032A08 “Mus musculus heat shock 70 kD protein BG078795 Mm.918 Heat Shock/Stress 1622 5 (glucose-regulated protein, 78 kD) (Hspa5), mRNA” 1623 H3032A09 peroxisomal integral membrane protein Mus musculus mRNA for peroxisomal Mm.306 Matrix/Structural 1624 PMP34 integral membrane protein PMP34 Proteins 1625 H3032A12 glucose-6-phosphate dehydrogenase X- Mus musculus glucose-6-phosphate BG078799 Mm.27210 Energy/Metabolism 1626 linked (G6pdx), dehydrogenase X-linked (G6pdx), mRNA 1627 H3032C01 cytochrome c gene (MC1) Mouse cytochrome c gene (MC1) BG078810 Mm.35389 Energy/Metabolism 1628 1629 H3032C10 3-hydroxy-3-methylglutaryl-Coenzyme Homo sapiens 3-hydroxy-3- BG078816 Mm.2226 Energy/Metabolism 1630 A reductase (HMGCR), methylglutaryl-Coenzyme A reductase (HMGCR), mRNA 1631 H3032H02 phosphatidylcholine transfer protein-like Mus musculus phosphatidylcholine BG078855 Mm.28896 Energy/Metabolism 1632 (Pctpl), transfer protein-like (Pctpl), mRNA 1633 H3033A10 R. norvegicus gene 6-phosphofructo-2- R. norvegicus gene for 6-phosphofructo- BG078872 Energy/Metabolism 1634 kinase/fructose-2,6-biphosphatase (EC 2-kinase/fructose-2,6-biphosphatase (EC 2.7.1.105/EC 3.1.3.46) 2.7.1.105/EC 3.1.3.46) 1635 H3033B08 cytochrome c oxidase, subunit IV Mus musculus cytochrome c oxidase, BG078879 Mm.2136 Energy/Metabolism 1636 (Cox4), subunit IV (Cox4), mRNA 1637 H3033B11 serine protease inhibitor 3 (Spi3), Mus musculus serine protease inhibitor BG078882 Mm.147649 Energy/Metabolism 1638 3 (Spi3), mRNA 1639 H3033C02 “Mus musculus serine/threonine kinase BG078885 Mm.3794 Signal Transduction 1640 (sak-a) mRNA, complete cds” 1641 H3033E10 ectonucleotide Mus musculus ectonucleotide BG065640 Mm.27254 Energy/Metabolism 1642 pyrophosphatase/phosphodiesterase 1 pyrophosphatase/phosphodiesterase 1 (Enpp1), (Enpp1), mRNA 1643 H3034B11 ATP-binding cassette, sub-family B Mm.143731 Energy/Metabolism 1644 (MDR/TAP), member 12 ABC-me 1645 H3035A01 tumor necrosis factor, alpha-induced Mus musculus tumor necrosis factor, BG065761 Mm.4348 Apoptosis 1646 protein 2 (Tnfaip2), alpha-induced protein 2 (Tnfaip2), mRNA 1647 H3035B03 Mm.32746 Mm.32746 Energy/Metabolism 1648 1649 H3035D08 Mouse gene for beta-2-adrenergic BG079067 Mm.5598 Signal Transduction 1650 receptor 1651 H3035F02 “Mus musculus RNA-binding protein BG065817 Mm.2411 Signal Transduction 1652 isoform G3BP-2a (G3BP2) mRNA, complete cds” 1653 H3036B11 “Mus musculus Rho guanine nucleotide BG079136 Mm.3181 Signal Transduction 1654 exchange factor (GEF) 1 (Arhgef1), mRNA” 1655 H3036H01 “Mus musculus lysophosphatidic acid BG079186 Mm.4772 Signal Transduction 1656 receptor (vzg-1) mRNA, complete cds” 1657 H3037B01 kinesin-like 6 (mitotic centromere- Homo sapiens kinesin-like 6 (mitotic Mm.27828 Cell Cycle 1658 associated kinesin) (KNSL6), centromere-associated kinesin) (KNSL6), mRNA 1659 H3037F06 serine protease inhibitor, Kunitz type 1 Mus musculus serine protease inhibitor, BG079254 Mm.104955 Energy/Metabolism 1660 (Spint1), Kunitz type 1 (Spint1), mRNA 1661 H3037G12 “Mus musculus cAMP-specific BG066005 Mm.154704 Signal Transduction 1662 phosphodiesterase 4A (Pde4a) gene, exons 2 through 8 and PDE4A isoform 1 exon 1” 1663 H3038A06 “Mus musculus interferon alpha BG079287 Mm.21761 Heat Shock/Stress 1664 responsive protein (15 kDa) (Ifrg15), mRNA” 1665 H3038C07 potassium voltage-gated channel, Homo sapiens potassium voltage-gated BG079311 Mm.113278 Energy/Metabolism 1666 delayed-rectifier, subfamily S, member channel, delayed-rectifier, subfamily S, 3 (KCNS3), member 3 (KCNS3), mRNA 1667 H3038C09 phosphoribosyl pyrophosphate Homo sapiens phosphoribosyl BG079313 Mm.27703 Energy/Metabolism 1668 synthetase-associated protein 2 pyrophosphate synthetase-associated (PRPSAP2), protein 2 (PRPSAP2), mRNA 1669 H3038E03 PRKC, apoptosis, WT1, regulator Homo sapiens PRKC, apoptosis, WT1, BG079331 Mm.6617 Apoptosis 1670 (PAWR), regulator (PAWR), mRNA 1671 H3038E05 Mus musculus growth differentiation BG079333 Mm.4213 Signal Transduction 1672 factor 3 (Gdf3), mRNA 1673 H3038E10 methyltransferase COQ3 (COQ3), Homo sapiens methyltransferase COQ3 BG066071 Mm.5662 Energy/Metabolism 1674 (COQ3), mRNA 1675 H3039A05 “Mus musculus regulator of G-protein BG079374 Mm.13264 Signal Transduction 1676 signaling 11 mRNA, partial cds” 1677 H3039B09 “Mus musculus serine/threonine kinase BG066121 Mm.22584 Signal Transduction 1678 receptor associated protein (Strap), mRNA” 1679 H3039C11 “Mus musculus receptor tyrosine kinase BG066134 Mm.2901 Signal Transduction 1680 (Dtk) mRNA, complete cds” 1681 H3039D02 asparaginyl-tRNA synthetase (NARS), Homo sapiens asparaginyl-tRNA BG079401 Mm.29192 Energy/Metabolism 1682 synthetase (NARS), mRNA 1683 H3039E07 isocitrate dehydrogenase 3 (NAD+) beta Homo sapiens isocitrate dehydrogenase C78231 Mm.29590 Energy/Metabolism 1684 (IDH3B), 3 (NAD+) beta (IDH3B), mRNA 1685 H3039E08 “Mus musculus SH3-containing protein BG079417 Mm.4165 Signal Transduction 1686 SH3P2 mRNA, partial cds” 1687 H3039F05 ornithine aminotransferase (Oat), Mus musculus ornithine BG079424 Mm.42187 Energy/Metabolism 1688 aminotransferase (Oat), mRNA 1689 H3039G04 M. musculus seryl-tRNA synthetase M. musculus seryl-tRNA synthetase BG079434 Mm.28688 Energy/Metabolism 1690 (SERS), 5 end (SERS) mRNA, 5 end 1691 H3039G12 5-3 exoribonuclease 1 (Xrn1), Mus musculus 5-3 exoribonuclease 1 BG079441 Mm.5703 Energy/Metabolism 1692 (Xrn1), mRNA 1693 H3039H01 “Mus musculus calponin 2 (Cnn2), BG079442 Mm.21776 Signal Transduction 1694 mRNA” 1695 H3039H05 Mus musculus putative CCAAT binding BG079446 Mm.24169 1696 factor 1 (mCBF) mRNA, alternatively spliced transcript mCBF1, complete cds 1697 H3040A04 adenine phosphoribosyltransferase Mouse adenine BG079455 Mm.1786 Energy/Metabolism 1698 (APRT) phosphoribosyltransferase (APRT), complete cds 1699 H3040E11 palmitoyl-protein thioesterase (Ppt), Mus musculus palmitoyl-protein Mm.153740 1700 thioesterase (Ppt), mRNA 1701 H3041A02 NADH dehydrogenase (ubiquinone) 1 Homo sapiens NADH dehydrogenase BG079485 Mm.28293 Energy/Metabolism 1702 alpha subcomplex, 10 (42 kD) (ubiquinone) 1 alpha subcomplex, 10 (NDUFA10), (42 kD) (NDUFA10), mRNA 1703 H3041A04 lysyl-tRNA synthetase (KARS), Homo sapiens lysyl-tRNA synthetase BG066271 Mm.29949 Energy/Metabolism 1704 (KARS), mRNA 1705 H3041B11 mevalonate pyrophosphate Rattus norvegicus mevalonate BG079503 Mm.28146 Energy/Metabolism 1706 decarboxylase pyrophosphate decarboxylase mRNA, complete cds 1707 H3041F09 glucose transporter (GLUTX1 gene) Mus musculus mRNA for glucose BG066327 Mm.7241 Energy/Metabolism 1708 transporter (GLUTX1 gene) 1709 H3041G03 solute carrier family 15 (H+/peptide Mus musculus solute carrier family 15 BG079545 Mm.63479 Energy/Metabolism 1710 transporter), member 2 (Slc15a2), (H+/peptide transporter), member 2 (Slc15a2), mRNA 1711 H3041G08 protease (prosome, macropain) 26S Mus musculus protease (prosome, BG079550 Mm.665 Energy/Metabolism 1712 subunit, ATPase 5 (Psmc5), macropain) 26S subunit, ATPase 5 (Psmc5), mRNA 1713 H3041H03 major histocompatibility complex Mus musculus major histocompatibility BG079557 Mm.14808 Energy/Metabolism 1714 region NG27, NG28, RPS28, NADH complex region NG27, NG28, RPS28, oxidoreductase, NG29, KIFC1, Fas- NADH oxidoreductase, NG29, KIFC1, binding protein, BING1, tapasin, Fas-binding protein, BING1, tapasin, RalGDS-like, KE2, BING4, beta 1,3- RalGDS-like, KE2, BING4, beta 1,3- galactosyl transfera galactosyl transfera 1715 H3042A05 BCL2-associated athanogene 4 (BAG4), Homo sapiens BCL2-associated BG066354 Mm.27102 Apoptosis 1716 athanogene 4 (BAG4), mRNA 1717 H3042C08 “Mus musculus dual specificity BG079592 Mm.34912 Signal Transduction 1718 phosphatase 10 (Dusp10), mRNA” 1719 H3042D02 brain cDNA, clone MNCb-2243, similar Mus musculus brain cDNA, clone BG079597 Mm.28373 Apoptosis 1720 to Bcl2-associated athanogene 3 (Bag3), MNCb-2243, similar to Mus musculus Bcl2-associated athanogene 3 (Bag3), mRNA 1721 H3042F12 serine protease inhibitor 4 (Spi4), Mus musculus serine protease inhibitor BG079624 Mm.3093 Energy/Metabolism 1722 4 (Spi4), mRNA 1723 H3042G07 Mouse heat-shock protein hsp84 mRNA BG079631 Mm.2180 Heat Shock/Stress 1724 1725 H3043A03 “Mus musculus casein kinase II, alpha BG066436 Mm.23692 Signal Transduction 1726 1, related sequence 4 (Csnk2a1-rs4), mRNA” 1727 H3043F09 Mus musculus GNB3 gene for GTP- BG066499 Mm.22228 1728 binding protein beta3 subunit, complete cds 1729 H3043F12 ferrochelatase (Fech), Mus musculus ferrochelatase (Fech), BG066502 Mm.1070 1730 mRNA 1731 H3044B01 “Mus musculus Cctd gene for BG079699 Mm.36431 Heat Shock/Stress 1732 chaperonin containing TCP-1 delta subunit, complete cds” 1733 H3044E06 protease (prosome, macropain) 28 Mus musculus protease (prosome, BG066650 Mm.830 Energy/Metabolism 1734 subunit, alpha (Psme1), macropain) 28 subunit, alpha (Psme1), mRNA 1735 H3044G06 A10, partial cds Mus musculus A10 mRNA, partial cds BG066673 Mm.16898 Energy/Metabolism 1736 1737 H3045B02 cytosolic aminopeptidase P Homo sapiens cytosolic BG079790 Mm.99776 Energy/Metabolism 1738 aminopeptidase P mRNA, complete cds 1739 H3045B03 Mm.23710 Mm.23710 Energy/Metabolism 1740 1741 H3045B12 solute carrier family 12, member 7 Mus musculus solute carrier family 12, BG079799 Mm.155195 Energy/Metabolism 1742 (Slc12a7), member 7 (Slc12a7), mRNA 1743 H3045D07 NAALADase II protein Homo sapiens mRNA for NAALADase BG079815 Mm.7060 Energy/Metabolism 1744 II protein 1745 H3045D08 Mm.25054 Mm.25054 Energy/Metabolism 1746 1747 H3045E05 serine protease OMI (Omi), Mus musculus serine protease OMI BG079822 Mm.21880 Energy/Metabolism 1748 (Omi), mRNA 1749 H3046A03 DKFZP566O084 protein Homo sapiens DKFZP566O084 protein BG079861 Mm.21475 Energy/Metabolism 1750 (DKFZPS66O084), (DKFZP566O084), mRNA 1751 H3046A12 programmed cell death protein 7 Mus musculus programmed cell death BG066710 Mm.29193 Apoptosis 1752 (Pdcd7), protein 7 (Pdcd7), mRNA 1753 H3046C10 isopentenyl-diphosphate delta isomerase Homo sapiens isopentenyl-diphosphate BG079889 Mm.29847 Energy/Metabolism 1754 (IDI1), delta isomerase (IDI1), mRNA 1755 H3047B07 tripeptidyl peptidase II (Tpp2), Mus musculus tripeptidyl peptidase II BG066807 Mm.28867 Energy/Metabolism 1756 (Tpp2), mRNA 1757 H3047D01 Bos taurus creatine kinase Bos taurus mRNA for creatine kinase, BG079988 Mm.970 Energy/Metabolism 1758 complete cds 1759 H3047D05 gene encoding enoyl-CoA hydratase, H. sapiens gene encoding enoyl-CoA BG079992 Mm.24452 Energy/Metabolism 1760 exons 5, 6 & 7 hydratase, exons 5, 6 & 7 1761 H3047F02 vacuolar-adenosine trisphosphatase (V- Mus musculus mRNA for vacuolar- BG079910 Mm.25079 Energy/Metabolism 1762 ATPase) adenosine trisphosphatase (V-ATPase), complete cds 1763 H3047G12 C7-1 protein (C7-1) Rattus norvegicus C7-1 protein (C7-1) C80679 Mm.21961 Energy/Metabolism 1764 mRNA, complete cds 1765 H3048A05 isoprenylcysteine carboxyl Homo sapiens isoprenylcysteine BG080028 Mm.44565 Energy/Metabolism 1766 methyltransferase (ICMT), carboxyl methyltransferase (ICMT), mRNA 1767 H3048B11 cytochrome c oxidase, subunit VIIc Mus musculus cytochrome c oxidase, BG080036 Mm.24165 Energy/Metabolism 1768 (Cox7c), subunit VIIc (Cox7c), mRNA 1769 H3048E06 small zinc finger-like protein DDP2 Mus musculus small zinc finger-like BG080049 Mm.30718 Energy/Metabolism 1770 (Ddp2) protein DDP2 (Ddp2) mRNA, complete cds 1771 H3048G11 biliverdin reductase B (flavin reductase Homo sapiens biliverdin reductase B BG066946 Mm.24021 Energy/Metabolism 1772 (NADPH)) (BLVRB), (flavin reductase (NADPH)) (BLVRB), mRNA 1773 H3049D07 “Mus musculus Janus kinase 2 (Jak2), BG080085 Mm.25112 Signal Transduction 1774 mRNA” 1775 H3049F02 carbonyl reductase 3 (CBR3), Homo sapiens carbonyl reductase 3 BG067014 Mm.4512 Energy/Metabolism 1776 (CBR3), mRNA 1777 H3049G02 solute carrier family 16 Mus musculus solute carrier family 16 BG067025 Mm.9086 Energy/Metabolism 1778 (monocarboxylic acid transporters), (monocarboxylic acid transporters), member 1 (Slc16a1), member 1 (Slc16a1), mRNA 1779 H3049G04 “Mus musculus B-cell BG067027 Mm.28782 Signal Transduction 1780 leukemia/lymphoma 10 (Bcl10), mRNA” 1781 H3049G07 PGES prostaglandin E synthase Mus musculus PGES mRNA for BG067030 Mm.154682 Energy/Metabolism 1782 prostaglandin E synthase, complete cds 1783 H3050A12 mannosidase 1, beta (Man1b), Mus musculus mannosidase 1, beta BG080131 Mm.103874 Energy/Metabolism 1784 (Man1b), mRNA 1785 H3050B11 small zinc finger-like protein (Tim13) Mus musculus small zinc finger-like BG080141 Mm.142132 Energy/Metabolism 1786 protein (Tim13) mRNA, complete cds 1787 H3050C02 glutathione synthetase (Gss), Mus musculus glutathione synthetase BG067069 Mm.7504 Energy/Metabolism 1788 (Gss), mRNA 1789 H3050E05 putative dimethyladenosine transferase Homo sapiens putative BG080168 Mm.9563 Energy/Metabolism 1790 (HSA9761), dimethyladenosine transferase (HSA9761), mRNA 1791 H3050E08 diaphorase (NADH) (cytochrome b-5 Homo sapiens diaphorase (NADH) BG080169 Mm.22560 Energy/Metabolism 1792 reductase) (DIA1), (cytochrome b-5 reductase) (DIA1), mRNA 1793 H3050F12 hydroxysteroid 17-beta dehydrogenase 4 Mus musculus hydroxysteroid 17-beta BG080183 Mm.9569 Energy/Metabolism 1794 (Hsd17b4), dehydrogenase 4 (Hsd17b4), mRNA 1795 H3050G05 solute carrier family 7 (cationic amino Mus musculus solute carrier family 7 BG067114 Mm.4676 Energy/Metabolism 1796 acid transporter, y+ system), member 2 (cationic amino acid transporter, y+ (Slc7a2), system), member 2 (Slc7a2), mRNA 1797 H3050H06 “Mus musculus interferon regulatory BG067127 Mm.1246 Heat Shock/Stress 1798 factor 1 (Irf1), mRNA” 1799 H3050H11 Mm.25374 Mm.25374 Energy/Metabolism 1800 1801 H3051C06 Mm.7730 Heat Shock/Stress 1802 1803 H3051C07 “Mus musculus phospholipase D2 gene, BG080231 Mm.2538 Signal Transduction 1804 exons 13 through 25 and complete cds” 1805 H3051D07 cDNA FLJ13488 fis, clone Homo sapiens cDNA FLJ13488 fis, BG080243 Mm.22363 1806 PLACE1003915, weakly similar to clone PLACE1003915, weakly similar PROBABLE ARGINYL-TRNA to PROBABLE ARGINYL-TRNA SYNTHETASE, CYTOPLASMIC (EC SYNTHETASE, CYTOPLASMIC (EC 6.1.1.19) 6.1.1.19) 1807 H3051E06 aldehyde reductase 6, renal (Aldr6r- Mus musculus aldehyde reductase 6, BG080253 Mm.21268 Energy/Metabolism 1808 pending), renal (Aldr6r-pending), mRNA 1809 H3051F02 Mus musculus growth differentiation BG080261 Mm.9593 Signal Transduction 1810 factor 9 (Gdf9), mRNA 1811 H3051G07 guanosine monophosphate reductase Homo sapiens guanosine BG080277 Mm.25808 Energy/Metabolism 1812 (GMPR), monophosphate reductase (GMPR), mRNA 1813 H3052A03 potassium channel regulator 1 Rattus norvegicus potassium channel BG067226 Energy/Metabolism 1814 regulator 1 mRNA, complete cds 1815 H3052A04 malate dehydrogenase, soluble (Mor2), Mus musculus malate dehydrogenase, BG067227 Mm.3156 Energy/Metabolism 1816 soluble (Mor2), mRNA 1817 H3052B06 ATP-binding cassette, sub-family B Mus musculus ATP-binding cassette, BG080311 Mm.6404 Energy/Metabolism 1818 (MDR/TAP), member 1 (Abcb1), sub-family B (MDR/TAP), member 1 (Abcb1), mRNA 1819 H3052C08 coproporphyrinogen oxidase (Cpo), Mus musculus coproporphyrinogen BG080324 Mm.35820 Energy/Metabolism 1820 oxidase (Cpo), mRNA 1821 H3052D11 “Mus musculus adenylate kinase 2 BG067269 Mm.29460 Signal Transduction 1822 (Ak2), mRNA” 1823 H3052H05 “Homo sapiens rab3 GTPase-activating BG080373 Mm.28344 Signal Transduction 1824 protein, non-catalytic subunit (150 kD) (RAB3-GAP150), mRNA” 1825 H3052H11 asparaginyl-tRNA synthetase (NARS), Homo sapiens asparaginyl-tRNA BG080379 Mm.29192 Energy/Metabolism 1826 synthetase (NARS), mRNA 1827 H3053A12 “Mus musculus regulator of G-protein BG080390 Mm.28262 Signal Transduction 1828 signaling 2 mRNA, complete cds” 1829 H3053B07 tyrosine hydroxylase (Th), Mus musculus tyrosine hydroxylase BG067326 Mm.140599 Energy/Metabolism 1830 (Th), mRNA 1831 H3053C02 phosphoribosyl pyrophosphate Homo sapiens phosphoribosyl BG080402 Mm.25125 Energy/Metabolism 1832 synthetase-associated protein 1 pyrophosphate synthetase-associated (PRPSAP1), protein 1 (PRPSAP1), mRNA 1833 H3053C09 “Mus musculus nicotinic acetylcholine BG080409 Signal Transduction 1834 receptor alpha 5 subunit (Acra5) mRNA, partial cds” 1835 H3053E04 “Mus musculus calponin 1 (Cnn1), BG067357 Mm.4356 Signal Transduction 1836 mRNA” 1837 H3053G12 “Mus musculus polynucleotide kinase BG067384 Mm.29545 Signal Transduction 1838 3′-phosphatase (Pnkp), mRNA” 1839 H3053H06 citrin (Slc25a13) Mus musculus citrin (Slc25a13) BG083930 Mm.2124 Energy/Metabolism 1840 mRNA, complete cds 1841 H3054B05 “Mus musculus folate receptor 3 BG080476 Mm.86738 Signal Transduction 1842 (Folbp3) mRNA, complete cds” 1843 H3054B12 Nrf 2 Mus musculus p45 NF-E2 related factor BG067417 Mm.1025 1844 2 (Nrf 2) mRNA, complete cds 1845 H3054C02 Gadd45g Mus musculus growth arrest and DNA- BG067419 Mm.9653 Energy/Metabolism 1846 damage-inducible, gamma (Gadd45g), mRNA 1847 H3054C06 “Mus musculus phospholipase c BG080489 Mm.140 Signal Transduction 1848 neighboring(Png), mRNA” 1849 H3054C09 WNT-2 Mus musculus WNT-2 gene, partial cds; BG080492 Mm.43231 Energy/Metabolism 1850 putative ankyrin-related protein and cystic fibrosis transmembrane conductance regulator (CFTR) genes, section 2 of 2 of the complete cds; and unknown gene 1851 H3054D05 “Rattus norvegicus protein associating BG080499 Heat Shock/Stress 1852 with small stress protein PASS1 (Pass1) mRNA, complete cds” 1853 H3054F04 “Mus musculus gene for p70/p85 s6 BG067455 Mm.26901 Signal Transduction 1854 kinase, exon” 1855 H3054F05 lysozyme M Mouse lysozyme M gene, exon 4 BG067456 Mm.654 Energy/Metabolism 1856 1857 H3054F11 ATP6N1B Homo sapiens ATPase, H(+)- BG080527 Mm.26909 Energy/Metabolism 1858 transporting, lysosomal, noncatalytic accessory protein 1B (ATP6N1B), mRNA 1859 H3054F12 TR2L Mus musculus TR2L mRNA, partial cds BG080528 Apoptosis 1860 1861 H3055A07 “Homo sapiens mutated in colorectal BG080557 Mm.155210 Signal Transduction 1862 cancers (MCC), mRNA” 1863 H3055B08 major histocompatibility locus class III Mus musculus major histocompatibility Mm.1511 1864 region: butyrophilin-like protein gene, locus class III region: butyrophilin-like partial cds; Notch4, PBX2, RAGE, protein gene, partial cds; Notch4, lysophatidic acid acyl transferase-alpha, PBX2, RAGE, lysophatidic acid acyl palmitoyl-protein thioestera transferase-alpha, palmitoyl-protein thioestera 1865 H3055B10 inhibitor of kappa light polypeptide Mm.28269 Energy/Metabolism 1866 gene enhancer in B-cells, kinase beta IKK[b]|IKK2|IKK-2|IKK-beta 1867 H3055C04 “Mus musculus Ras-GTPase-activating BG080577 Mm.2038 Signal Transduction 1868 protein SH3-domain binding protein (G3bp-pending), mRNA” 1869 H3055C05 “Homo sapiens inositol 1,3,4- BG080578 Signal Transduction 1870 triphosphate 5/6 kinase (ITPK1), mRNA” 1871 H3055C10 ATP/GTP-binding protein (HEAB), Homo sapiens ATP/GTP-binding BG080583 Mm.21583 Energy/Metabolism 1872 protein (HEAB), mRNA 1873 H3055D02 aldolase B, fructose-bisphosphate Homo sapiens aldolase B, fructose- BG080587 Mm.87581 Energy/Metabolism 1874 (ALDOB), bisphosphate (ALDOB), mRNA 1875 H3055E07 TRAF family member associated NF- Mus musculus TRAF family member BG080604 Mm.1803 Apoptosis 1876 kappa B activator (TANK) associated NF-kappa B activator (TANK) mRNA, complete cds 1877 H3055F07 delta-aminolevulinate dehydratase (Lv), Mus musculus delta-aminolevulinate BG080616 Mm.90076 Energy/Metabolism 1878 dehydratase (Lv), mRNA 1879 H3055G02 dipeptidyl peptidase I precursor Mus musculus dipeptidyl peptidase I BG080623 Mm.684 Energy/Metabolism 1880 precursor mRNA, complete cds 1881 H3056A09 “M. musculus mRNA for inositol 1,4,5- BG067589 Mm.7800 Signal Transduction 1882 trisphosphate receptor (type 2)” 1883 H3056C11 DKFZP564O2082 protein Homo sapiens DKFZP564O2082 Mm.21826 1884 (DKFZP564O2082), protein (DKFZP564O2082), mRNA 1885 H3056D03 “Homo sapiens calponin 3, acidic BG080757 Mm.22171 Signal Transduction 1886 (CNN3), mRNA” 1887 H3056G10 thioredoxin 2 (TRX2) Homo sapiens thioredoxin 2 (TRX2) BG080633 Mm.3533 Energy/Metabolism 1888 mRNA, complete cds 1889 H3056H05 H3056H05 Energy/Metabolism 1890 1891 H3057C01 “Mus musculus interferon-related BG067699 Mm.168 Heat Shock/Stress 1892 developmental regulator 1 (Ifrd1), mRNA” 1893 H3057C08 GPX3 Mm.7156 Energy/Metabolism 1894 1895 H3057C10 bisphosphate 3-nucleotidase 1 (Bpnt1), Mus musculus bisphosphate 3- BG067708 Mm.18096 Energy/Metabolism 1896 nucleotidase 1 (Bpnt1), mRNA 1897 H3057D09 acetyl-Coenzyme A carboxylase beta Homo sapiens acetyl-Coenzyme A BG067718 Mm.88548 Energy/Metabolism 1898 (ACACB), carboxylase beta (ACACB), mRNA 1899 H3057E05 “Mus musculus protein tyrosine BG080698 Mm.4420 Signal Transduction 1900 phosphatase, non-receptor type 21 (Ptpn21), mRNA” 1901 H3057F01 “Mus musculus casein kinase 1, epsilon BG080793 Mm.30199 Signal Transduction 1902 (Csnkle), mRNA” 1903 H3057H04 “Mus musculus HSP40-like protein BG080820 Mm.46746 Heat Shock/Stress 1904 mRNA, partial sequence” 1905 H3057H06 solute carrier family 16 Mus musculus solute carrier family 16 C87415 Mm.5045 Energy/Metabolism 1906 (monocarboxylic acid transporters), (monocarboxylic acid transporters), member 2 (Slc16a2), member 2 (Slc16a2), mRNA 1907 H3058A10 Fas-interacting serine/threonine kinase 3 Mus musculus Fas-interacting BG080836 Mm.29026 Apoptosis 1908 (Fist3) serine/threonine kinase 3 (Fist3) mRNA, complete cds 1909 H3058C03 Bcl2-like 10 (Bcl2110), Mus musculus Bcl2-like 10 (Bcl2110), BG080862 Mm.25988 Apoptosis 1910 mRNA 1911 H3058C09 “Mus musculus Jun oncogene (Jun), BG080846 Mm.482 Signal Transduction 1912 mRNA” 1913 H3058D09 “Mus musculus guanine nucleotide BG080868 Mm.27307 Signal Transduction 1914 binding protein (G protein), gamma 3 subunit (Gng3), mRNA” 1915 H3058G06 transient receptor potential-related Mus musculus transient receptor BG080898 Mm.143646 Energy/Metabolism 1916 protein (ChaK), potential-related protein (ChaK), mRNA 1917 H3059A10 sodium bicarbonate cotransporter isom 3 Mus musculus sodium bicarbonate BG067865 Mm.34957 Energy/Metabolism 1918 (kNBC-3), cotransporter isoform 3 (kNBC-3), mRNA 1919 H3059B02 “Homo sapiens regulator of G-protein BG067869 Mm.31378 Signal Transduction 1920 signalling 12 (RGS12), mRNA” 1921 H3059B03 “Mus musculus protein kinase C delta BG080928 Mm.142839 Signal Transduction 1922 mRNA, complete cds” 1923 H3059B07 “Mus sp. JAK1 protein tyrosine kinase BG067874 Mm.28598 Signal Transduction 1924 mRNA, complete cds” 1925 H3059D07 alanyl-tRNA synthetase (AARS), Homo sapiens alanyl-tRNA synthetase BG080951 Mm.24174 Energy/Metabolism 1926 (AARS), mRNA 1927 H3059D11 KIAA1093 protein, partial cds Homo sapiens mRNA for KIAA1093 BG067897 Mm.22829 Apoptosis 1928 protein, partial cds 1929 H3059F12 “Mus musculus GTP binding protein BG067921 Mm.15793 Signal Transduction 1930 (GTP2) mRNA, complete cds” 1931 H3059G11 intronless glutamine synthetase gene Mouse intronless glutamine synthetase BG067932 Mm.41660 Energy/Metabolism 1932 gene, complete cds 1933 H3060A10 M. musculus arachidonate epidermis- M. musculus mRNA for arachidonate BG067951 Mm.1122 Energy/Metabolism 1934 type 12(S)-lipoxygenase epidermis-type 12(S)-lipoxygenase 1935 H3060B09 “Homo sapiens mitogen-activated BG081019 Mm.24022 Signal Transduction 1936 protein kinase kinase kinase kinase 5 (MAP4K5), mRNA” 1937 H3060D04 Mm.24594 Mm.24594 Energy/Metabolism 1938 1939 H3060H04 “Mus musculus JNK-binding protein 1 BG081077 Mm.25540 Signal Transduction 1940 (Jnkbp1-pending), mRNA” 1941 H3060H07 Mm.25580 Mm.25580 Energy/Metabolism 1942 1943 H3061B06 UDP-N-acetyl-alpha-D- Mus musculus UDP-N-acetyl-alpha-D- BG068045 Mm.38441 Energy/Metabolism 1944 galactosamine: polypeptide N- galactosamine: polypeptide N- acetylgalactosaminyltransferase 3 acetylgalactosaminyltransferase 3 (Galnt3), (Galnt3), mRNA 1945 H3061E04 cysteine dioxygenase, type I (CDO1), Homo sapiens cysteine dioxygenase, BG081135 Mm.29996 Energy/Metabolism 1946 type I (CDO1), mRNA 1947 H3061H08 guanine deaminase (Gda), Mus musculus guanine deaminase BG081171 Energy/Metabolism 1948 (Gda), mRNA 1949 H3062C04 spermine synthase (Sms), Mus musculus spermine synthase (Sms), BG081202 Energy/Metabolism 1950 mRNA 1951 H3062E02 isocitrate dehydrogenase Mus musculus isocitrate dehydrogenase BG081213 Mm.18213 Energy/Metabolism 1952 mRNA, complete cds 1953 H3062H07 “Mus musculus inositol 1,4,5- BG081243 Mm.2726 Signal Transduction 1954 triphosphate receptor 1 (Itpr1), mRNA” 1955 H3062H08 Mm.11827 Mm.11827 Energy/Metabolism 1956 1957 H3063A03 “Mus musculus calpain 7 (Capn7), BG081250 Mm.142370 Signal Transduction 1958 mRNA” 1959 H3063A08 Prsc1 Mus musculus protease, cysteine, 1 BG068219 Mm.17185 Energy/Metabolism 1960 (Prsc1), mRNA 1961 H3063A09 “Mus musculus novel ras effector 1 BG068220 Mm.10133 Signal Transduction 1962 (Norel-pending), mRNA” 1963 H3063C09 beta-1,4-galactosyltransferase VI Mus musculus beta-1,4- BG081279 Mm.26364 Energy/Metabolism 1964 galactosyltransferase VI mRNA, complete cds 1965 H3063H10 LAT2 (Slc7a8) Mus musculus mRNA for LAT2 protein BG068299 Mm.27830 Energy/Metabolism 1966 (Slc7a8 gene) 1967 H3064C02 “Mus musculus large tumor suppressor BG081357 Mm.35642 Signal Transduction 1968 1 (Lats1) mRNA, partial cds” 1969 H3064C04 kinesin-like 5 (mitotic kinesin-like Homo sapiens kinesin-like 5 (mitotic Mm.28386 Cell Cycle 1970 protein 1) (KNSL5), kinesin-like protein 1) (KNSL5), mRNA 1971 H3064E02 vacuolar adenosine triphosphatase Mus musculus vacuolar adenosine BG081377 Mm.29771 Energy/Metabolism 1972 subunit A gene triphosphatase subunit A gene, complete cds 1973 H3064H04 HMG box protein Mus musculus HMG box protein Mm.41766 Transcription/Chromatin 1974 mRNA, complete cds 1975 H3065C08 “Mus musculus calmodulin dependent BG081448 Mm.24381 Signal Transduction 1976 phosphatase catalytic subunit (Cam-Prp) mRNA, 3′ end” 1977 H3065C11 “Mus musculus Chetk-alpha gene for BG081451 Signal Transduction 1978 choline/ethanolamine kinase-alpha, exon 1 and 5′-flanking region” 1979 H3065D10 “Homo sapiens RAP1A, member of BG068432 Mm.144498 Signal Transduction 1980 RAS oncogene family (RAP1A), mRNA” 1981 H3065E07 UDP-glucose dehydrogenase (Ugdh), Mus musculus UDP-glucose BG068439 Mm.10709 Energy/Metabolism 1982 dehydrogenase (Ugdh), mRNA 1983 H3066H07 heme oxygenase-2 Mus musculus heme oxygenase-2 BG081591 Energy/Metabolism 1984 mRNA, complete cds 1985 H3067A07 potassium channel modulatory factor Mus musculus potassium channel BG081603 Mm.29194 Energy/Metabolism 1986 DEBT-91 (Debt91), modulatory factor DEBT-91 (Debt91), mRNA 1987 H3067B08 “Mus musculus phosphoinositide 3- BG081616 Mm.3058 Signal Transduction 1988 kinase regulatory subunit p85alpha mRNA, complete cds” 1989 H3067E02 “Mus musculus RAS-related C3 BG068616 Mm.29014 Signal Transduction 1990 botulinum substrate 1, guanine nucleotide exchange factor 1 (Racgefl- pending), mRNA” 1991 H3068A08 kinesin-like 5 (mitotic kinesin-like Homo sapiens kinesin-like 5 (mitotic Mm.28386 Cell Cycle 1992 protein 1) (KNSL5), kinesin-like protein 1) (KNSL5), mRNA 1993 H3068A11 ferritin light chain 1 (Ftl1), Mus musculus ferritin light chain 1 BG081695 Energy/Metabolism 1994 (Ftl1), mRNA 1995 H3068F03 ornithine decarboxylase antizyme Mus musculus ornithine decarboxylase BG081746 Mm.104010 Energy/Metabolism 1996 inhibitor (Oazi), antizyme inhibitor (Oazi), mRNA 1997 H3069C09 “Mus musculus Rho-associated coiled- BG081800 Mm.6710 Signal Transduction 1998 coil forming kinase 1 (Rock1), mRNA” 1999 H3069D09 cDNA FLJ12814 fis, clone Homo sapiens cDNA FLJ12814 fis, BG081823 Mm.27228 Energy/Metabolism 2000 NT2RP2002520, weakly similar to clone NT2RP2002520, weakly similar transcription factor RFX-B (RFXB) to Homo sapiens transcription factor RFX-B (RFXB) mRNA 2001 H3069G01 choline/ethanolaminephosphotransferase Homo sapiens BG081849 Mm.14816 Energy/Metabolism 2002 (CEPT1), choline/ethanolaminephosphotransferase (CEPT1), mRNA 2003 H3070A09 RHOA proto-oncogene multi-drug- Homo sapiens RHOA proto-oncogene BG081880 Mm.757 Energy/Metabolism 2004 resistance protein, 3 end multi-drug-resistance protein mRNA, 3 end 2005 H3070A12 quinoid dihydropteridine reductase Homo sapiens quinoid dihydropteridine BG081883 Mm.30204 Energy/Metabolism 2006 (QDPR), reductase (QDPR), mRNA 2007 H3070B09 partial Kcnq1 gene potassium channel Mus musculus partial Kcnq1 gene for BG081892 Energy/Metabolism 2008 protein, exons 10-14 potassium channel protein, exons 10-14 2009 H3070C08 hydroxysteroid dehydrogenase-1, Mus musculus hydroxysteroid BG081903 Mm.16941 Energy/Metabolism 2010 delta<5>-3-beta (Hsd3b1), dehydrogenase-1, delta<5>-3-beta (Hsd3b1), mRNA 2011 H3070E04 ATP-specific succinyl-CoA synthetase Mus musculus ATP-specific succinyl- BG068897 Mm.19154 Energy/Metabolism 2012 beta subunit (Scs), partial cds CoA synthetase beta subunit (Scs) mRNA, partial cds 2013 H3071A03 ATPase, class VI, type 11A (Atp11a), Mus musculus ATPase, class VI, type BG081967 Mm.148756 Energy/Metabolism 2014 11A (Atp11a), mRNA 2015 H3071G11 “Homo sapiens RAP2B, member of BG082041 Mm.26939 Signal Transduction 2016 RAS oncogene family (RAP2B), mRNA” 2017 H3071H04 glycerol-3-phosphate acyltransferase Mouse glycerol-3-phosphate Mm.87773 acyltransferase mRNA, complete cds 2018 H3072A08 glyceraldehyde-3-phosphate Mus musculus glyceraldehyde-3- BG082061 Energy/Metabolism 2019 dehydrogenase (Gapd) phosphate dehydrogenase (Gapd), mRNA 2020 H3072B11 “Mus musculus PLC-L2 mRNA for BG069051 Mm.28034 Signal Transduction 2021 phospholipase C-L2, complete cds” 2022 H3072F03 Mm.22651 Mm.22651 Energy/Metabolism 2023 2024 H3072G09 potassium voltage-gated channel, Mus musculus potassium voltage-gated BG069106 Mm.4489 Energy/Metabolism 2025 subfamily H (eag-related), member 1 channel, subfamily H (eag-related), (Kcnh1), member 1 (Kcnh1), mRNA 2026 H3073F09 Mm.27123 Mm.27123 Energy/Metabolism 2027 2028 H3073F10 “Mus musculus 80 kDa m-calpain BG082209 Mm.6958 Signal Transduction 2029 subunit (calp80) mRNA, complete cds” 2030 H3073G07 granzyme M Mus musculus mRNA for granzyme M, BG082217 Mm.22302 Energy/Metabolism 2031 complete cds 2032 H3074A02 inhibitor of apoptosis protein 1 Mus musculus inhibitor of apoptosis BG069214 Mm.2026 Apoptosis 2033 protein 1 mRNA, complete cds 2034 H3074A03 NIMA (never in mitosis gene a)-related Mus musculus NIMA (never in mitosis Mm.143817 Cell Cycle 2035 expressed kinase 7 (Nek7), gene a)-related expressed kinase 7 (Nek7), mRNA 2036 H3074C12 dUTPase Mus musculus dUTPase mRNA, BG082266 Energy/Metabolism 2037 complete cds 2038 H3074F08 “Mus musculus protein phosphatase BG082298 Mm.11711 Signal Transduction 2039 type 2A catalytic subunit alpha isoform mRNA, complete cds” 2040 H3074G02 H. sapiens 40 kDa protein kinase related H. sapiens 40 kDa protein kinase related Mm.1700 2041 to rat ERK2 to rat ERK2 2042 H3074H09 NAALADase II protein Homo sapiens mRNA for NAALADase BG082322 Mm.26132 Energy/Metabolism 2043 II protein 2044 H3075A04 Mm.26128 Mm.26128 Energy/Metabolism 2045 2046 H3075A09 esterase-22 = endoplasmic reticulum- esterase-22 = endoplasmic reticulum- BG069315 Mm.29110 Energy/Metabolism 2047 targeting protein of beta-glucuronidase targeting protein of beta-glucuronidase [mice,, 2022 nt] [mice, mRNA, 2022 nt] 2048 H3075F01 ATP-specific succinyl-CoA synthetase Mus musculus ATP-specific succinyl- BG069442 Mm.19154 Energy/Metabolism 2049 beta subunit (Scs), partial cds CoA synthetase beta subunit (Scs) mRNA, partial cds 2050 H3075F08 F1F0-ATP synthase, g subunit Mus musculus mRNA for F1F0-ATP BG082389 Mm.14663 Energy/Metabolism 2051 synthase, g subunit 2052 H3075F11 “Mus musculus heat shock protein 20- BG069463 Mm.21549 Heat Shock/Stress 2053 like protein mRNA, complete cds” 2054 H3075G06 molybdenum cofactor synthesis-step 1 Mus musculus molybdenum cofactor BG082399 Mm.36112 Energy/Metabolism 2055 proteins A and B splice type I (Mocs1) synthesis-step 1 proteins A and B splice s, partial cds, alternatively spliced type I (Mocs1) mRNAs, partial cds, alternatively spliced 2056 H3075H02 peptidyl arginine deiminase, type II Mus musculus peptidyl arginine BG082407 Mm.2296 Energy/Metabolism 2057 (Pdi2), deiminase, type II (Pdi2), mRNA 2058 H3076B05 “Mus musculus Rho interacting protein BG069493 Mm.4620 Signal Transduction 2059 2 (Rhoip2-pending), mRNA” 2060 H3076C12 fatty-acid-Coenzyme A ligase, long- Homo sapiens fatty-acid-Coenzyme A BG069344 Mm.12166 Energy/Metabolism 2061 chain 4 (FACL4), ligase, long-chain 4 (FACL4), mRNA 2062 H3076F04 “AC005290, complete sequence [Mus BG069372 Mm.1967 Signal Transduction 2063 musculus]” 2064 H3076F12 “Homo sapiens regulator of G protein BG082484 Mm.31378 Signal Transduction 2065 signaling RGS12 (RGS) mRNA, complete cds” 2066 H3076G06 “Mus musculus signal transducer and BG069385 Mm.21935 Signal Transduction 2067 activator of transcription 2 (Stat2), mRNA” 2068 H3076G11 similar to argininosuccinate lyase (H. sapiens) Homo sapiens similar to BG082495 Mm.23869 Energy/Metabolism 2069 (LOC63402), argininosuccinate lyase (H. sapiens) (LOC63402), mRNA 2070 H3076H06 “Mus musculus adenylate kinase 4 BG082501 Mm.142051 Signal Transduction 2071 (Ak4), mRNA” 2072 H3076H10 “Mus musculus casein kinase II, alpha BG069401 Mm.28881 Signal Transduction 2073 2, polypeptide (Csnk2a2), mRNA” 2074 H3077B02 solute carrier family 12, member 2 Mus musculus solute carrier family 12, BG069505 Mm.4168 Energy/Metabolism 2075 (Slc12a2), member 2 (Slc12a2), mRNA 2076 H3077C01 X28 region near ALD locus containing Homo sapiens X28 region near ALD BG069516 Mm.28056 Energy/Metabolism 2077 dual specificity phosphatase 9 (DUSP9), locus containing dual specificity ribosomal protein L18a (RPL18a), phosphatase 9 (DUSP9), ribosomal Ca2+/Calmodulin-dependent protein protein L18a (RPL18a), kinase I (CAMKI), creatine transporter ( Ca2+/Calmodulin-dependent protein kinase I (CAMKI), creatine transporter ( 2078 H3077F08 ATPase, H(+)-transporting, lysosomal, Homo sapiens ATPase, H(+)- BG082574 Mm.26909 Energy/Metabolism 2079 noncatalytic accessory protein 1B transporting, lysosomal, noncatalytic (ATP6N1B), accessory protein 1B (ATP6N1B), mRNA 2080 H3077H01 hypothetical protein FLJ10726 Homo sapiens hypothetical protein Mm.30718 2081 (FLJ10726), FLJ10726 (FLJ10726), mRNA 2082 H3078G02 NIMA (never in mitosis gene a)-related Mus musculus NIMA (never in mitosis Mm.143817 Cell Cycle 2083 expressed kinase 7 (Nek7), gene a)-related expressed kinase 7 (Nek7), mRNA 2084 H3078H09 Rat L-gulono-gamma-lactone oxidase Rat L-gulono-gamma-lactone oxidase BG082674 Mm.26207 Energy/Metabolism 2085 mRNA, complete cds 2086 H3078H11 TRPM-2, cytosolic epoxide hydrolase, Homo sapiens TRPM-2, cytosolic BG082676 Mm.26207 Energy/Metabolism 2087 nicotinic acetylcholine receptor alpha2 epoxide hydrolase, nicotinic subunit, and focal adhesion kinase acetylcholine receptor alpha2 subunit, genes, sequence and focal adhesion kinase genes, complete cds, complete sequence 2088 H3079D11 solute carrier family 12, member 2 Mus musculus solute carrier family 12, BG069726 Mm.4168 Energy/Metabolism 2089 (Slc12a2), member 2 (Slc12a2), mRNA 2090 H3079D12 “Mus musculus phospholipase D3 BG069727 Mm.6483 Signal Transduction 2091 (Pld3), mRNA” 2092 H3079E06 “Mus musculus interferon regulatory BG069733 Mm.4179 Heat Shock/Stress 2093 factor 6 (Irf6), mRNA” 2094 H3079F01 cDNA: FLJ22083 fis, clone HEP14459, Homo sapiens cDNA: FLJ22083 fis, BG069739 Mm.22675 Energy/Metabolism 2095 highly similar to HUM3H3M 3- clone HEP14459, highly similar to hydroxy-3-methylglutaryl coenzyme A HUM3H3M Homo sapiens 3-hydroxy- synthase 3-methylglutaryl coenzyme A synthase mRNA 2096 H3079F05 “Mus musculus calcyclin binding BG069742 Mm.10702 Signal Transduction 2097 protein (CACYBP) mRNA, partial cds” 2098 H3079G04 cystathionine beta-synthase (CBS) gene, Homo sapiens cystathionine beta- BG082744 Mm.24225 Energy/Metabolism 2099 major and minor alternative splice synthase (CBS) gene, major and minor products alternative splice products, complete cds 2100 H3079G06 “Mus musculus interferon regulatory BG069754 Mm.3960 Heat Shock/Stress 2101 factor 3 (Irf3), mRNA” 2102 H3079G12 cDNA DKFZp727E011 (from clone Homo sapiens mRNA; cDNA BG082752 Mm.24225 Energy/Metabolism 2103 DKFZp727E011); partial cds DKFZp727E011 (from clone DKFZp727E011); partial cds 2104 H3079H11 M. musculus RPS3a gene M. musculus RPS3a gene BG069771 Mm.6957 Apoptosis 2105 2106 H3080A09 “Homo sapiens similar to cullin 5 (H. BG069781 Mm.21710 Signal Transduction 2107 sapiens)(LOC63330), mRNA” 2108 H3080B11 TF-1 cell apoptosis related protein-15 Mus musculus TF-1 cell apoptosis BG069793 Mm.28441 Apoptosis 2109 (Tfar15), related protein-15 (Tfar15), mRNA 2110 H3080G08 Mus musculus ribonuclease P2 BG069849 Mm.12440 Energy/Metabolism 2111 (Rnasep2-pending), mRNA 2112 H3080G10 “Mus musculus adenomatosis polyposis BG069851 Mm.7883 Signal Transduction 2113 coli (Apc), mRNA” 2114 H3080H10 Mus musculus RNA guanylyltransferase BG069862 Mm.26153 Energy/Metabolism 2115 and 5-phosphatase (Rngtt), mRNA 2116 H3081A12 fatty acid-Coenzyme A ligase, long Mus musculus fatty acid-Coenzyme A BG069876 Mm.143689 Energy/Metabolism 2117 chain 4 (Facl4), ligase, long chain 4 (Facl4), mRNA 2118 H3081D02 Bcl-2-related ovarian killer protein-like- Mus musculus Bcl-2-related ovarian BG082842 Mm.3295 Apoptosis 2119 pending (Bokl-pending), killer protein-like-pending (Bokl- pending), mRNA 2120 H3081E08 TNF-alpha converting enzyme Mus musculus TNF-alpha converting BG082857 Mm.27681 Apoptosis 2121 precursor,, alternatively spliced enzyme precursor, mRNA, alternatively spliced, complete cds 2122 H3081H02 aldo-keto reductase AKR1C13 Mus musculus aldo-keto reductase BG082884 Mm.27447 Energy/Metabolism 2123 (Akr1c13), AKR1C13 (Akr1c13), mRNA 2124 H3082B04 Mus musculus inducible 6- BG070045 Mm.19669 Energy/Metabolism 2125 phosphofructo-2-kinase mRNA, complete cds 2126 H3082C01 Mus musculus serine protease inhibitor BG070053 Mm.89871 Energy/Metabolism 2127 1-5 (Spi1-5), mRNA 2128 H3082E03 Mus musculus programmed cell death 8 BG082930 Mm.30050 Apoptosis 2129 (apoptosis inducing factor) (Pdcd8), mRNA 2130 H3082E10 H. sapiens mitogen inducible gene mig- Mm.29842 Signal Transduction 2131 2, complete CDS 2132 H3082F03 M. musculus (balb-c) gene for BG082939 Mm.4628 Energy/Metabolism 2133 sphingomyelin phosphodiesterase 2134 H3083C01 Homo sapiens kinesin-like 5 (mitotic Mm.28386 Cell Cycle 2135 kinesin-like protein 1) (KNSL5), mRNA 2136 H3083D06 Mus musculus Bcl2-associated BG069990 Mm.688 Apoptosis 2137 athanogene 1 (Bag1), mRNA 2138 H3083D09 Homo sapiens cDNA FLJ14310 fis, BG069993 Mm.7156 Energy/Metabolism 2139 clone PLACE3000271 2140 H3083E02 “Mus musculus beta-site APP cleaving BG069998 Mm.24044 Signal Transduction enzyme (Bace), mRNA” 2141 H3083H02 “Mus musculus guanine nucleotide BG070116 Mm.5305 Signal Transduction 2142 binding protein, beta-2, related sequence 1 (Gnb2-rs1), mRNA” 2143 H3083H05 Mus musculus mRNA for tumor BG070119 Mm.27681 Energy/Metabolism 2144 necrosis factor alpha converting enzyme (TACE/ADAM17), complete cds 2145 H3084E05 glutathione S-transferase, mu 5 (Gstm5), Mus musculus glutathione S-transferase, BG070174 Mm.667 Energy/Metabolism 2146 mu 5 (Gstm5), mRNA 2147 H3084F02 Mm.24864 Mm.24864 Energy/Metabolism 2148 2149 H3084G03 Mouse c-fos gene; cellular homolog to BG070196 Mm.5043 Signal Transduction 2150 viral oncogene 2151 H3085B01 M. musculus mRNA for casein kinase I- BG083155 Mm.43737 Signal Transduction 2152 alpha 2153 H3085C02 Mus musculus Traf and Tnf receptor BG070243 Mm.155228 Apoptosis 2154 associated protein (Ttrap-pending), mRNA 2155 H3085C04 Mus musculus solute carrier family 12, BG070245 Mm.4168 Energy/Metabolism 2156 member 2 (Slc12a2), mRNA 2157 H3085D10 Mus musculus guanine deaminase BG083182 Mm.25912 Energy/Metabolism 2158 (Gda), mRNA 2159 H3085G03 Mouse cytochrome beta-558 mRNA, 3 BG083209 Mm.448 Energy/Metabolism 2160 end 2161 H3086E09 Homo sapiens BCL2-associated BG070363 Mm.44239 Apoptosis 2162 athanogene 5 (BAG5), mRNA 2163 H3086F10 B. taurus CI-SGDH mRNA for BG083295 Mm.28058 Energy/Metabolism 2164 ubiquinone oxidoreductase complex 2165 H3086H09 “Mus musculus mRNA for Rho guanine BG083317 Mm.22261 Signal Transduction 2166 nucleotide-exchange factor, splice variant NET1A” 2167 H3087A12 uterine lactotransferrin Mouse uterine lactotransferrin mRNA BG070413 Mm.7612 Energy/Metabolism 2168 2169 H3087C10 “Mus musculus rho GTPase activating BG083351 Signal Transduction 2170 protein 6 (Arhgap6), mRNA” 2171 H3087G09 “Mus musculus heat shock protein 030 BG070480 Mm.104491 Heat Shock/Stress 2172 (Hsp030), mRNA” 2173 H3087H05 acetoacetyl-coenzyme A thiolase (EC Human mRNA for acetoacetyl- BG083405 Mm.1776 Energy/Metabolism 2174 2.3.1.9) coenzyme A thiolase (EC 2.3.1.9) 2175 H3087H09 “Mus musculus calcium binding protein BG083409 Mm.1221 Signal Transduction 2176 A6 (calcyclin) (S100a6), mRNA” 2177 H3088A07 glutathione S-transferase, mu 2 (Gstm2), Mus musculus glutathione S-transferase, BG070501 Mm.7446 Energy/Metabolism 2178 mu 2 (Gstm2), mRNA 2179 H3088C12 CPP32 apoptotic protease, partial cds Mus musculus CPP32 apoptotic BG083524 Mm.153450 Apoptosis 2180 protease mRNA, partial cds 2181 H3088E07 “Mus musculus choline kinase (Chk), BG070547 Mm.5262 Signal Transduction 2182 mRNA” 2183 H3088F03 “Mus musculus protein tyrosine BG083549 Mm.4124 Signal Transduction 2184 phosphatase 4a3 (Ptp4a3), mRNA” 2185 H3089A06 Mus musculus ATPase, H+ BG083588 Mm.10727 Energy/Metabolism 2186 transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2 (Atp6b2), mRNA 2187 H3089A11 Mus musculus ATP-binding cassette BG083593 Mm.21629 Energy/Metabolism 2188 protein (Abcf2) mRNA, partial cds 2189 H3089F09 “Mus musculus protein kinase Chk2 BG083482 Mm.126031 Signal Transduction 2190 (Rad53-pending), mRNA” 2191 H3089G12 Mus musculus zinc transporter like 1 BG083497 Mm.28851 Energy/Metabolism 2192 (Zntl1) mRNA, complete cds 2193 H3089H11 Mouse normal c-myc gene and BG083596 Mm.2444 Signal Transduction 2194 translocated homologue from J558 plasmocytoma cells (cDNA sequence) 2195 H3090B01 “Mus musculus mothers-against-dpp- BG083610 Mm.15185 Signal Transduction 2196 related-1 mRNA, complete cds” 2197 H3090B05 uracil-DNA glycosylase gene, Mus musculus uracil-DNA glycosylase BG070697 Mm.112312 Energy/Metabolism 2198 alternatively spliced gene, complete cds, alternatively spliced 2199 H3090C08 ornithine decarboxylase antizyme Mus musculus ornithine decarboxylase BG070710 Mm.6775 Energy/Metabolism 2200 inhibitor (Oazi), antizyme inhibitor (Oazi), mRNA 2201 H3090C10 N-terminal asparagine amidohydrolase Mus musculus N-terminal asparagine BG083629 Mm.22635 Energy/Metabolism 2202 (Ntan1) gene amidohydrolase (Ntan1) gene, complete cds 2203 H3090D01 “Mus musculus mitogen activated BG083632 Mm.4358 Signal Transduction 2204 protein kinase kinase kinase 12 (Map3k12), mRNA” 2205 H3091B08 partial gene encoding Mus musculus partial gene encoding BG070787 Mm.42205 Energy/Metabolism 2206 deoxyribonuclease I and 5 UTR deoxyribonuclease I and 5 UTR 2207 H3091D08 “Mus musculus guanine nucleotide BG083726 Mm.133949 Signal Transduction 2208 binding protein, alpha 14 (Gna14), mRNA” 2209 H3091D11 tumor necrosis factor (ligand) Mus musculus tumor necrosis factor BG070891 Mm.22585 Apoptosis 2210 superfamily, member 19 (Tnfsf19- (ligand) superfamily, member 19 pending), (Tnfsf19-pending), mRNA 2211 H3091E02 5(3)-deoxyribonucleotidase (Dnt- Mus musculus 5(3)- BG070894 Mm.41722 Energy/Metabolism 2212 pending), deoxyribonucleotidase (Dnt-pending), mRNA 2213 H3091F08 N-terminal Asn amidase (Ntan1), Mus musculus N-terminal ASn amidase BG070912 Mm.22635 Energy/Metabolism 2214 (Ntan1), mRNA 2215 H3091G12 solute carrier family 1, member 7 Mus musculus solute carrier family 1, BG070928 Mm.1056 Energy/Metabolism 2216 (Slc1a7), member 7 (Slc1a7), mRNA 2217 H3091H05 “Mus musculus H-ras gene, partial cds” BG070933 Mm.6793 Signal Transduction 2218 2219 H3091H07 deiodinase, iodothyronine type III Rattus norvegicus deiodinase, BG070934 Mm.154427 Energy/Metabolism 2220 (Dio3), iodothyronine type III (Dio3), mRNA 2221 H3092E03 Balb/c cytochrome c oxidase subunit Mus musculus Balb/c cytochrome c BG083822 Mm.43415 Energy/Metabolism 2222 VIaL oxidase subunit VIaL mRNA, complete cds 2223 H3092E04 caspase 8 associated protein 2 Mus musculus caspase 8 associated BG070820 Mm.22279 Apoptosis 2224 (Casp8ap2), protein 2 (Casp8ap2), mRNA 2225 H3092G01 “Mus musculus p38delta MAP kinase BG083840 Mm.27970 Signal Transduction 2226 mRNA, complete cds” 2227 H3092H01 vacuolar adenosine triphosphatase Mus musculus vacuolar adenosine BG070846 Mm.29771 Energy/Metabolism 2228 subunit A gene triphosphatase subunit A gene, complete cds 2229 H3092H09 “Mus musculus mitogen-activated BG083857 Signal Transduction 2230 protein kinase 8 interacting protein 2 (Mapk8ip2), mRNA” 2231 H3092H10 glycogenin 1 (Gyg1), Mus musculus glycogenin 1 (Gyg1), BG070855 Mm.6375 Energy/Metabolism 2232 mRNA 2233 H3093B07 chloride channel 5 (Clcn5), Mus musculus chloride channel 5 BG083875 Mm.104172 Energy/Metabolism 2234 (Clcn5), mRNA 2235 H3093D09 Tom22 Homo sapiens mRNA for Tom22, BG083900 Mm.9326 Energy/Metabolism 2236 complete cds 2237 H3093F02 uridine monophosphate kinase (UMPK), Homo sapiens uridine monophosphate BG083915 Energy/Metabolism 2238 kinase (UMPK), mRNA 2239 H3093G07 “Homo sapiens Putative prostate cancer BG071015 Mm.24156 Signal Transduction 2240 tumor suppressor (N33), mRNA” 2241 H3093G08 GST-5 = glutathione S-transferase-sperm GST-5 = glutathione S-transferase-sperm BG071016 Mm.11346 Energy/Metabolism 2242 antigen MSAg-5 fusion protein {3 antigen MSAg-5 fusion protein {3 region} [mice, testis, Recombinant region} [mice, testis, mRNA Partial, 860 nt] Recombinant Partial, 860 nt] 2243 H3093H01 mannosyl (alpha-1,6-)-glycoprotein Homo sapiens mannosyl (alpha-1,6-)- BG084016 Mm.24293 Energy/Metabolism 2244 beta-1,2-N- glycoprotein beta-1,2-N- acetylglucosaminyltransferase acetylglucosaminyltransferase (MGAT2), (MGAT2), mRNA 2245 H3094C01 Mus musculus gene for prostacyclin BG084049 Energy/Metabolism 2246 synthase, 5-flanking region and partial cds 2247 H3094D01 Mus musculus cytochrome P450 side BG071067 Mm.108678 Energy/Metabolism 2248 chain cleavage enzyme 11a1 (Cyp11a1), mRNA 2249 H3094D02 “Mus musculus GNB1 gene for G BG071068 Mm.2344 Signal Transduction 2250 protein beta1 subunit, exon 12 and complete cds” 2251 H3094D04 Mus musculus GLUT4 vesicle protein BG071070 Mm.29010 Energy/Metabolism 2252 mRNA, partial cds 2253 H3094E12 Mm.26092 Energy/Metabolism 2254 2255 H3094G04 Homo sapiens cDNA FLJ12225 fis, BG083967 Mm.12983 Energy/Metabolism 2256 clone MAMMA1001139, weakly similar to SRE-2 PROTEIN 2257 H3094G10 Homo sapiens mitogen-activated protein Mm.29588 2258 kinase kinase kinase kinase 3 (MAP4K3), mRNA 2259 H3094H06 Mus musculus Bcl2-interacting killer- BG071119 Mm.17912 Apoptosis 2260 like (Biklk), mRNA 2261 H3095D11 Mus musculus mitogen activated protein 2262 kinase kinase kinase 12 (Map3k12), mRNA 2263 H3095E06 Mus musculus glutathione S-transferase BG084006 Mm.282 Energy/Metabolism like (Gsttl-pending), mRNA 2264 H3095F10 Homo sapiens calcineurin binding BG071186 Mm.154496 2265 protein 1 (KIAA0330), mRNA 2266 H3095G05 Rattus norvegicus Fucosidase, alpha-L- BG084074 Mm.21580 Energy/Metabolism 2267 1, tissue (Fuca), mRNA 2268 H3095H12 Mus musculus carbonic anhydrase 4 BG071207 Mm.1641 Energy/Metabolism (Car4), mRNA 2269 H3096A03 cytochrome c oxidase, subunit IV Mus musculus cytochrome c oxidase, BG084085 Mm.2136 Energy/Metabolism 2270 (Cox4), subunit IV (Cox4), mRNA 2271 H3096D01 “Mus musculus protein phosphatase 4, BG071232 Mm.28082 Signal Transduction 2272 catalytic subunit (Ppp4c), mRNA” 2273 H3096E12 clone TSIP1 p53-induced apoptosis Mus musculus clone TSIP1 p53- BG084126 Mm.142872 Apoptosis 2274 differentially expressed sequence induced apoptosis differentially expressed mRNA sequence 2275 H3096F11 HNK-1 sulfotransferase (HNK-1ST), Homo sapiens HNK-1 sulfotransferase BG084134 Mm.26817 Energy/Metabolism 2276 (HNK-1ST), mRNA 2277 H3097A02 Homo sapiens leucine aminopeptidase BG084150 Mm.34832 Energy/Metabolism 2278 (LOC51056), mRNA 2279 H3097A03 Mus musculus cytochrome c oxidase, BG084151 Mm.2136 Energy/Metabolism 2280 subunit IV (Cox4), mRNA 2281 H3097A05 Homo sapiens sulfite oxidase (SUOX), BG084153 Mm.23352 Energy/Metabolism 2282 mRNA 2283 H3097B01 Mus musculus branched chain BG084158 Mm.4606 Energy/Metabolism 2284 aminotransferase 1, cytosolic (Bcat1), mRNA 2285 H3097B03 Mus musculus solute carrier family 11 BG084160 Mm.36460 Energy/Metabolism 2286 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2), mRNA 2287 H3097C12 Mm.22409 Energy/Metabolism 2288 2289 H3097F02 Mus musculus sialyltransferase 8 BG084201 Mm.4954 Energy/Metabolism 2290 (alpha-2, 8-sialytransferase) B (Siat8b), mRNA 2291 H3097F06 Homo sapiens FACL5 for fatty acid BG084205 Mm.30263 Energy/Metabolism 2292 coenzyme A ligase 5 (LOC51703), mRNA 2293 H3097G07 “Mus musculus retinoblastoma-binding BG084218 Mm.24216 Signal Transduction 2294 protein 9 (Rbbp9), mRNA” 2295 H3097H08 “Mus musculus retinoblastoma binding BG084231 Mm.12145 Signal Transduction 2296 protein 4 (Rbbp4), mRNA” 2297 H3098A08 B. taurus PSST subunit of the NADH: B. taurus mRNA for PSST subunit of BG084240 Mm.28712 Energy/Metabolism 2298 ubiquinone oxidoreductase complex the NADH: ubiquinone oxidoreductase complex 2299 H3098D02 “Mus musculus protein tyrosine BG084265 Mm.2817 Signal Transduction 2300 phosphatase, receptor-type, F interacting protein, binding protein 2 (Ppfibp2), mRNA” 2301 H3098D12 “Mus musculus mitogen activated AU041108 Mm.1059 Signal Transduction 2302 protein kinase kinase 1 (Map2k1), mRNA” 2303 H3098E11 “Mus musculus chaperonin subunit 2 BG084277 Mm.40849 Heat Shock/Stress 2304 (beta) (Cct2), mRNA” 2305 H3098H02 carbonyl reductase (LOC51181), Homo sapiens carbonyl reductase BG084296 Energy/Metabolism 2306 (LOC51181), mRNA 2307 H3099A05 5-nucleotidase (purine), cytosolic type B Homo sapiens 5-nucleotidase (purine), BG084308 Mm.29601 Energy/Metabolism 2308 (NT5B), cytosolic type B (NT5B), mRNA 2309 H3099C01 solute carrier family 34 (sodium Mus musculus solute carrier family 34 BG084323 Energy/Metabolism 2310 phosphate), member 2 (Slc34a2), (sodium phosphate), member 2 (Slc34a2), mRNA 2311 H3099D04 cytochrome c oxidase Vb subunit gene Mouse cytochrome c oxidase Vb BG071472 Mm.16769 Energy/Metabolism 2312 subunit gene, complete cds 2313 H3099E08 cDNA FLJ13488 fis, clone Homo sapiens cDNA FLJ13488 fis, BG084341 Mm.22363 2314 PLACE1003915, weakly similar to clone PLACE1003915, weakly similar PROBABLE ARGINYL-TRNA to PROBABLE ARGINYL-TRNA SYNTHETASE, CYTOPLASMIC (EC SYNTHETASE, CYTOPLASMIC (EC 6.1.1.19) 6.1.1.19) 2315 H3100C01 rod cGMP phosphodiesterase delta Mus musculus rod cGMP BG084383 Mm.12925 Energy/Metabolism 2316 subunit (Pde6d) gene phosphodiesterase delta subunit (Pde6d) gene, complete cds 2317 H3100C10 potassium intermediate/small Homo sapiens potassium BG084391 Mm.17734 Energy/Metabolism 2318 conductance calcium-activated channel, intermediate/small conductance subfamily N, member 2 (KCNN2), calcium-activated channel, subfamily N, member 2 (KCNN2), mRNA 2319 H3100E04 inhibitor of apoptosis protein 1 Mus musculus inhibitor of apoptosis BG084405 Mm.2026 Apoptosis 2320 protein 1 mRNA, complete cds 2321 H3101A08 ribosomal protein L23 (Rpl23), Mus musculus ribosomal protein L23 BG084450 Mm.12144 Energy/Metabolism 2322 (Rpl23), mRNA 2323 H3101C10 glyceraldehyde-3-phosphate Mus musculus glyceraldehyde-3- BG071626 Mm.5289 Energy/Metabolism 2324 dehydrogenase (Gapd), phosphate dehydrogenase (Gapd), mRNA 2325 H3101D05 phosphatidylethanolamine N- Mus musculus BG071633 Mm.2731 Energy/Metabolism 2326 methyltransferase (Pemt), phosphatidylethanolamine N- methyltransferase (Pemt), mRNA 2327 H3101E05 solute carrier family 34 (sodium Mus musculus solute carrier family 34 BG071644 Mm.3786 Energy/Metabolism 2328 phosphate), member 2 (Slc34a2), (sodium phosphate), member 2 (Slc34a2), mRNA 2329 H3101G05 “Mus musculus DNA J protein (Dnaj3), AU044106 Mm.29186 Heat Shock/Stress mRNA” 2330 H3101H02 “Rattus norvegicus mytonic dystrophy BG071671 Mm.38330 Signal Transduction 2331 kinase-related Cdc42-binding kinase (MRCK) mRNA, complete cds” 2332 H3102A07 phosphatidylserine synthase 1 (Ptdss1), Mus musculus phosphatidylserine BG071685 Mm.9440 Energy/Metabolism 2333 synthase 1 (Ptdss1), mRNA 2334 H3102C06 choline transporter (CHOT1), Rattus norvegicus choline transporter BG071707 Mm.28056 Energy/Metabolism 2335 (CHOT1), mRNA 2336 H3102D02 apoptotic chromatin condensation Mus musculus apoptotic chromatin BG071714 Mm.30236 Apoptosis 2337 inducer in the nucleus (Acinus- condensation inducer in the nucleus pending), (Acinus-pending), mRNA 2338 H3102D09 “Mus musculus retinoblastoma binding BG084566 Mm.1603 Signal Transduction 2339 protein 7 (Rbbp7), mRNA” 2340 H3102E01 potassium channel modulatory factor Mus musculus potassium channel BG071725 Mm.29194 Energy/Metabolism 2341 DEBT-91 (Debt91), modulatory factor DEBT-91 (Debt91), mRNA 2342 H3102F08 N-acylsphingosine amidohydrolase 1 Mus musculus N-acylsphingosine BG071742 Mm.22547 Energy/Metabolism 2343 (Asah1), amidohydrolase 1 (Asah1), mRNA 2344 H3102G07 “Mus musculus protein tyrosine BG071749 Mm.147428 Signal Transduction 2345 phosphatase, non-receptor type 11 (Ptpn11), mRNA” 2346 H3102H03 isoleucine-tRNA synthetase (IARS), Homo sapiens isoleucine-tRNA BG084601 Mm.21118 Energy/Metabolism 2347 synthetase (IARS), mRNA 2348 H3102H07 2,3-bisphosphoglycerate mutase Mus musculus 2,3-bisphosphoglycerate BG084605 Mm.22706 Energy/Metabolism 2349 (Bpgm), mutase (Bpgm), mRNA 2350 H3102H09 ribonuclease H1 (Rnaseh1), Mus musculus ribonuclease H1 BG071762 Mm.10152 Energy/Metabolism 2351 (Rnaseh1), mRNA 2352 H3103A05 “Mus musculus phospholipase A2, BG084614 Mm.4186 Signal Transduction 2353 group 4 (Pla2g4), mRNA” 2354 H3103B07 Mus musculus BCL2/adenovirus E1B BG084628 Mm.142818 Apoptosis 2355 19 kDa-interacting protein 3-like (Bnip31), mRNA 2356 H3103D01 “Mus musculus protein phosphatase 1, BG071790 Mm.7793 Signal Transduction 2357 catalytic subunit, gamma isoform (Ppp1cc), mRNA” 2358 H3103D11 “Mus musculus regulator of G-protein BG071811 Mm.44606 Signal Transduction 2359 signaling 17 (Rgs17), mRNA” 2360 H3103E12 Mus musculus Bcl2-like 10 (Bcl2l10), BG071824 Mm.25988 Apoptosis 2361 mRNA 2362 H3103F06 “Mus musculus small GTPase (Rab11a) BG071829 Mm.1387 Signal Transduction 2363 gene, complete cds” 2364 H3104A11 Mus musculus thioredoxin-like (32 kD) BG071869 Mm.19169 Energy/Metabolism 2365 (Txnl), mRNA 2366 H3104D01 Mouse mRNA for beta-1,4- BG071892 Mm.15622 Energy/Metabolism 2367 galactosyltransferase 2368 H3104E06 Mus musculus ATP-binding cassette BG071908 Mm.41002 Energy/Metabolism 2369 protein (Abcc1b) mRNA, partial cds 2370 H3105A09 Pseudomonas aeruginosa PA01, section Pseudomonas aeruginosa PA01, section BG071952 Energy/Metabolism 2371 341 of 529 of the genome 341 of 529 of the complete genome 2372 H3105A10 cDNA FLJ12989 fis, clone Homo sapiens cDNA FLJ12989 fis, BG084872 Mm.154589 Energy/Metabolism 2373 NT2RP3000085, moderately similar to clone NT2RP3000085, moderately ACETYL-/PROPIONYL-COENZYME similar to ACETYL-/PROPIONYL- A CARBOXYLASE ALPHA CHAIN COENZYME A CARBOXYLASE [CONTAINS: BIOTIN ALPHA CHAIN [CONTAINS: CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYLASE (EC BIOTIN CARBOXYL CARRIER 6.3.4.14); BIOTIN CARBOXYL CARRIER 2374 H3105B07 “Mus musculus Cctz-2 gene for BG084881 Mm.29622 Heat Shock/Stress 2375 chaperonin containing TCP-1 zeta-2 subunit, exon 1, 2, 3” 2376 H3105C03 CGI-30 protein (LOC51611), Homo sapiens CGI-30 protein BG084888 Mm.5915 Energy/Metabolism 2377 (LOC51611), mRNA 2378 H3105C04 natural killer cell BY55 precursor Mus musculus natural killer cell BY55 BG084889 Mm.11526 Apoptosis 2379 (By55-pending), precursor (By55-pending), mRNA 2380 H3105C10 “Mus musculus mRNA for LIMK2b, BG071976 Mm.42927 Signal Transduction 2381 complete cds” 2382 H3105D09 masc apoptosis-associated speck-like Mus musculus masc mRNA for BG071986 Mm.24163 Apoptosis 2383 protein containing CARD apoptosis-associated speck-like protein containing CARD, complete cds 2384 H3105E08 tyrosine 3-monooxygenase/tryptophan Mus musculus tyrosine 3- BG084914 Mm.14722 Energy/Metabolism 2385 5-monooxygenase activation protein, monooxygenase/tryptophan 5- theta polypeptide (Ywhaq), monooxygenase activation protein, theta polypeptide (Ywhaq), mRNA 2386 H3105G04 “Mus musculus mitogen-activated BG084932 Mm.987 Signal Transduction 2387 protein kinase kinase kinase kinase 4 (Map4k4), mRNA” 2388 H3105G10 pyrroline 5-carboxylate reductase isom Homo sapiens pyrroline 5-carboxylate BG072021 Mm.29379 Energy/Metabolism 2389 (P5CR2), reductase isoform (P5CR2), mRNA 2390 H3107D11 H3107D11 Energy/Metabolism 2391 2392 H3107E03 H3107E03 Energy/Metabolism 2393 2394 H3107G10 alpha-N-acetylglucosaminidase Mus musculus alpha-N- BG072192 Mm.6142 Energy/Metabolism 2395 (Sanfilippo disease IIIB) (Naglu), acetylglucosaminidase (Sanfilippo disease IIIB) (Naglu), mRNA 2396 H3107G12 carnitine octanoyltransferase (COT), Homo sapiens carnitine BG085029 Mm.28197 Energy/Metabolism 2397 octanoyltransferase (COT), mRNA 2398 H3108C03 3-5 exonuclease TREX1 Mus musculus 3-5 exonuclease TREX1 BG072232 Mm.17632 Energy/Metabolism 2399 mRNA, complete cds 2400 H3108E02 “Homo sapiens mitogen-activated BG072253 Mm.18856 Signal Transduction 2401 protein kinase 6 (MAPK6), mRNA” 2402 H3108E05 “Mus musculus RAS, dexamethasone- BG072256 Mm.3903 Signal Transduction 2403 induced 1 (Rasd1), mRNA” 2404 H3108F08 TF-1 cell apoptosis related protein-15 Mus musculus TF-1 cell apoptosis BG085103 Mm.28441 Apoptosis 2405 (Tfar15), related protein-15 (Tfar15), mRNA 2406 H3108H04 “Mus musculus adenylyl cyclase type 9 BG072288 Mm.4294 Signal Transduction 2407 mRNA, complete cds” 2408 H3108H12 laminin B1 Mouse laminin B1 mRNA, complete BG085129 Mm.148395 Apoptosis 2409 cds 2410 H3109A04 “Mus musculus receptor (calcitonin) BG072299 Mm.1574 Signal Transduction 2411 activity modifying protein 2 (Ramp2), mRNA” 2412 H3109F07 ATPase, Ca++ transporting, cardiac Mus musculus ATPase, Ca++ BG085195 Mm.42255 Energy/Metabolism 2413 muscle, slow twitch 2 (Atp2a2), transporting, cardiac muscle, slow twitch 2 (Atp2a2), mRNA 2414 H3110B08 tyrosine 3-monooxygenase/tryptophan Mus musculus tyrosine 3- BG085234 Mm.14722 Energy/Metabolism 2415 5-monooxygenase activation protein, monooxygenase/tryptophan 5- theta polypeptide (Ywhaq), monooxygenase activation protein, theta polypeptide (Ywhaq), mRNA 2416 H3110B12 “Homo sapiens casein kinase I alpha BG072410 Mm.43737 Signal Transduction 2417 isoform (CSNK1A1) mRNA, complete cds” 2418 H3110F10 epoxide hydrolase 1, microsomal Mus musculus epoxide hydrolase 1, BG072453 Mm.9075 Energy/Metabolism 2419 (Ephx1), microsomal (Ephx1), mRNA 2420 H3110H11 “Mouse brain calmodulin-dependent BG072475 Mm.293 Signal Transduction 2421 phosphatase (calcineurin) catalytic subunit mRNA, 3′ end” 2422 H3111A02 brain cDNA, clone MNCb-1429, similar Mus musculus brain cDNA, clone BG085276 Mm.30215 Energy/Metabolism 2423 to peroxiredoxin V (PrxV) gene MNCb-1429, similar to Mus musculus peroxiredoxin V (PrxV) gene 2424 H3111A08 “Mus musculus signal transducer and BG085280 Signal Transduction 2425 transcription activator 5a (Stat5a) gene, partial cds” 2426 H3111F09 Rat Y-b3 glutathione-S-transferase Rat Y-b3 glutathione-S-transferase BG072517 Mm.29640 Energy/Metabolism 2427 mRNA, complete cds 2428 H3111G06 arginase type II (Arg2), Mus musculus arginase type II (Arg2), BG085317 Mm.3506 Energy/Metabolism 2429 mRNA 2430 H3111G12 zinc transporter like 2 (Zntl2) Mus musculus zinc transporter like 2 BG085322 Mm.28490 Energy/Metabolism 2431 (Zntl2) mRNA, complete cds 2432 H3112A04 Mus musculus carnitine BG085333 Mm.29499 Matrix/Structural 2433 palmitoyltransferase 2 (Cpt2), mRNA Proteins 2434 H3112B05 “Homo sapiens calcium-regulated heat- BG072550 Mm.33981 Heat Shock/Stress 2345 stable protein (24 kD) (CRHSP-24), mRNA” 2436 H3112B07 Rat mRNA for 3-oxoacyl-CoA thiolase BG085346 Mm.142498 Energy/Metabolism 2437 2438 H3112F06 “Mus musculus Cctb gene for BG085384 Mm.3670 Heat Shock/Stress 2439 chaperonin containing TCP-1 beta subunit, complete cds” 2440 H3112G09 Mus musculus ATPase, H+ BG085399 Mm.1081 Energy/Metabolism 2441 transporting, lysosomal (vacuolar proton pump), 42 kDa (Atp6d), mRNA 2442 H3113B07 13 kDa differentiation-associated protein Homo sapiens 13 kDa differentiation- BG085428 Mm.27886 Energy/Metabolism 2443 (LOC55967), associated protein (LOC55967), mRNA 2444 H3113B08 F1F0ATP synthase complex E subunit Mus musculus F1F0ATP synthase Mm.19370 Energy/Metabolism 2445 (Atp5k) gene complex E subunit (Atp5k) gene, complete cds 2446 H3113E03 “Mus musculus MAP kinase-interacting BG085457 Mm.6797 Signal Transduction 2447 serine/threonine kinase 2 (Mknk2), mRNA” 2448 H3113F04 “Mus musculus kappaB-Ras1 mRNA, BG072675 Mm.25648 Signal Transduction 2449 complete cds” 2450 H3113F06 ribonuclease/angiogenin inhibitor Homo sapiens ribonuclease/angiogenin BG085471 Mm.6586 Energy/Metabolism 2451 (RNH), inhibitor (RNH), mRNA 2452 H3113G07 “Homo sapiens phospholipase C, BG085484 Mm.22370 Signal Transduction 2453 gamma 2 (phosphatidylinositol- specific) (PLCG2), mRNA” 2454 H3113G08 ornithine decarboxylase antizyme 3 Mus musculus ornithine decarboxylase BG085485 Mm.154432 Energy/Metabolism 2455 (Oaz3), antizyme 3 (Oaz3), mRNA 2456 H3113H12 “Mus musculus manic fringe homolog BG072704 Mm.517 Signal Transduction 2457 (Drosophila)(Mfng), mRNA” 2458 H3114A05 glutathione peroxidase 4 (Gpx4), Mus musculus glutathione peroxidase 4 BG072706 Mm.2400 Energy/Metabolism 2459 (Gpx4), mRNA 2460 H3114A06 spermidine/spermine N1-acetyl Mus musculus spermidine/spermine BG085499 Mm.2734 Energy/Metabolism 2461 transferase (Sat), N1-acetyl transferase (Sat), mRNA 2462 H3114C12 cytosolic class 3 aldehyde Mus musculus cytosolic class 3 BG085522 Mm.14798 Energy/Metabolism 2463 dehydrogenase (Adh4) gene, 5 flanking aldehyde dehydrogenase (Adh4) gene, 5 region sequence flanking region sequence 2464 H3114D10 M. musculus RPS3a gene M. musculus RPS3a gene BG072742 Mm.6957 Apoptosis 2465 2466 H3114F11 Mus musculus interferon gamma BG085554 Mm.153463 Signal Transduction 2467 receptor 2 (Ifngr2), mRNA 2468 H3114G12 “Mus musculus copper chaperone for BG072776 Mm.21414 Heat Shock/Stress 2469 superoxide dismutase (Ccsd) mRNA, complete cds” 2470 H3114H06 PIG-M mannosyltransferase Rattus norvegicus PIG-M mRNA for BG085572 Mm.26612 Energy/Metabolism 2471 mannosyltransferase, complete cds 2472 H3115A05 “Mus musculus phospholipase C, delta BG085579 Mm.23963 Signal Transduction (Plcd), mRNA” 2473 H3115B07 Mus musculus S100A9 gene for BG072801 Mm.2128 Signal Transduction 2474 S100A9 protein exons 1-3 2475 H3115C02 clone UWGC: mbac82 from 14D1-D2 Mus musculus clone UWGC: mbac82 BG072808 Mm.353 Energy/Metabolism 2476 (T-Cell Receptor Alpha Locus), from 14D1-D2 (T-Cell Receptor Alpha sequence Locus), complete sequence 2477 H3115C11 “Mus musculus protein phosphatase 2A BG072817 Mm.3785 Signal Transduction 2478 B′alpha3 regulatory subunit mRNA, partial cds” 2479 H3115D08 F1F0-ATP synthase, g subunit Mus musculus mRNA for F1F0-ATP BG072826 Mm.14663 Energy/Metabolism 2480 synthase, g subunit 2481 H3115H06 ribosomal protein L29 Mm.2235 Energy/Metabolism 2482 2483 H3115H10 ATP synthase gamma-subunit precursor Mus musculus mRNA for ATP synthase BG072870 Mm.12677 Energy/Metabolism 2484 gamma-subunit precursor, complete cds 2485 H3116D11 cytochrome c oxidase, subunit VIIa 3 Mus musculus cytochrome c oxidase, BG072912 Mm.2151 Energy/Metabolism 2486 (Cox7a3), subunit VIIa 3 (Cox7a3), mRNA 2487 H3116E02 “Mus musculus adenylate cyclase BG085699 Mm.44245 Signal Transduction 2488 activating polypeptide 1 receptor 1 (Adcyap1r1), mRNA” 2489 H3116G12 H3116G12 Energy/Metabolism 2490 2491 H3117A12 kinesin-related mitotic motor protein Mus musculus mRNA for kinesin- Mm.42203 2492 related mitotic motor protein 2493 H3117C04 “Homo sapiens MEBP-1 mRNA for BG072981 Mm.6803 Heat Shock/Stress 2494 MAPK-ERK binding protein-1, complete cds” 2495 H3117G06 Rat glycogen phosphorylase brain Rat glycogen phosphorylase brain BG073025 Mm.30072 Energy/Metabolism 2496 isozyme, 5 end of cds isozyme mRNA, 5 end of cds 2497 H3118E12 apoptosis inhibitor bcl-x (bcl-x) gene, Mus musculus apoptosis inhibitor bcl-x AW548292 Mm.148197 Apoptosis exon 3 and cds (bcl-x) gene, exon 3 and complete cds 2498 H3118H09 mastocytoma N-deacetylase/N- Mus musculus mastocytoma N- BG085858 Mm.4084 Energy/Metabolism 2499 sulfotransferase (Mndns), deacetylase/N-sulfotransferase (Mndns), mRNA 2500 H3119A04 H+ ATP synthase subunit c Mus musculus H+ ATP synthase BG085863 Mm.258 Energy/Metabolism 2501 subunit c mRNA, complete cds 2502 H3119B04 Heat Shock/Stress 2503 2504 H3119B06 Na, K-ATPase beta-3 subunit (Atp1b3) Mus musculus Na, K-ATPase beta-3 BG073136 Mm.424 Energy/Metabolism 2505 gene, exon 7 and cds subunit (Atp1b3) gene, exon 7 and complete cds 2506 H3119B09 cytochrome b-561 (Cyb561), Mus musculus cytochrome b-561 BG085878 Mm.18942 Energy/Metabolism 2507 (Cyb561), mRNA 2508 H3119G03 “Mus musculus protein tyrosine BG073186 Mm.28909 Signal Transduction 2509 phosphatase 4a1 (Ptp4a1), mRNA” 2510 H3119G08 glutathione S-transferase, alpha 4 Mus musculus glutathione S-transferase, BG073190 Mm.2662 Energy/Metabolism 2511 (Gsta4), alpha 4 (Gsta4), mRNA 2512 H3119G12 cDNA DKFZp564A126 (from clone Homo sapiens mRNA; cDNA BG085933 Mm.22710 Energy/Metabolism 2513 DKFZp564A126); partial cds DKFZp564A126 (from clone DKFZp564A126); partial cds 2514 H3119H03 Mus musculus FVB/N collagen pro- BG073196 Mm.22621 Matrix/Structural 2515 alpha-1 type I chain mRNA, complete Proteins cds 2516 H3119H04 fatty-acid-Coenzyme A ligase, long- Homo sapiens fatty-acid-Coenzyme A BG073197 Mm.27944 Energy/Metabolism 2517 chain 3 (FACL3), ligase, long-chain 3 (FACL3), mRNA 2518 H3119H06 “Homo sapiens casein kinase 1, gamma BG085938 Mm.29873 Signal Transduction 2519 2 (CSNK1G2), mRNA” 2520 H3120A10 isocitrate dehydrogenase Mus musculus isocitrate dehydrogenase BG085953 Mm.2966 Energy/Metabolism 2521 mRNA, complete cds 2522 H3120D01 “Mus musculus MEK kinase 3, mRNA, BG085978 Mm.27041 Signal Transduction 2523 partial cds” 2524 H3120F08 geranylgeranyl diphosphate synthase 1 Mus musculus geranylgeranyl BG086008 Mm.4076 Energy/Metabolism 2525 (Ggps1), diphosphate synthase 1 (Ggps1), mRNA 2526 H3120H05 full length insert cDNA clone ZC24D06 Homo sapiens full length insert cDNA BG086026 Energy/Metabolism 2527 clone ZC24D06 2528 H3121A04 protein phosphatase type-1 catalytic Homo sapiens protein phosphatase BG086037 Mm.4572 Energy/Metabolism 2529 subunit delta isom (PPCS1D) type-1 catalytic subunit delta isoform (PPCS1D) mRNA, complete cds 2530 H3121C02 “Mus musculus follistatin-like (Fstl), BG086054 Mm.22763 Signal Transduction 2531 mRNA” 2532 H3121E04 retinal short-chain Mus musculus retinal short-chain BG086076 Mm.14063 Energy/Metabolism 2533 dehydrogenase/reductase 1 (Rsdr1- dehydrogenase/reductase 1 (Rsdr1- pending), pending), mRNA 2534 H3122B07 “Mus musculus heat-responsive protein BG073398 Mm.2607 Heat Shock/Stress 2535 12 (Hrsp12), mRNA” 2536 H3122D07 “Mus musculus heat shock protein, 74 kDa, BG073420 Mm.2849 Heat Shock/Stress 2537 A (Hspa9a), mRNA” 2538 H3122E12 ATP synthase beta subunit (ATPSB) Human ATP synthase beta subunit BG073436 Mm.17869 Energy/Metabolism 2539 gene (ATPSB) gene, complete cds 2540 H3122F01 ATP synthase beta subunit (ATPSB) Human ATP synthase beta subunit BG073437 Mm.17869 Energy/Metabolism 2541 gene (ATPSB) gene, complete cds 2542 H3122F04 ATP-binding cassette, sub-family D Mus musculus ATP-binding cassette, BG086172 Mm.87806 Energy/Metabolism 2543 (ALD), member 4 (Abcd4), sub-family D (ALD), member 4 (Abcd4), mRNA 2544 H3122F12 sterol-carrier protein X Mus musculus sterol-carrier protein X BG086180 Mm.1779 Matrix/Structural 2545 mRNA, complete cds Proteins 2546 H3122G01 sterol-carrier protein X Mus musculus sterol-carrier protein X BG086181 Mm.1779 Matrix/Structural 2547 mRNA, complete cds Proteins 2548 H3122H03 brain cDNA, clone MNCb-0663, similar Mus musculus brain cDNA, clone BG086194 Mm.28124 2549 to augmenter of liver regeneration (Alr) MNCb-0663, similar to Mus musculus augmenter of liver regeneration (Alr) mRNA 2550 H3123C04 “Mus musculus GNB3 gene for GTP- BG073494 Mm.35708 Signal Transduction 2551 binding protein beta3 subunit, complete cds” 2552 H3123D10 BCL2/adenovirus E1B 19 kD-interacting Homo sapiens BCL2/adenovirus E1B BG073508 Mm.21795 Apoptosis 2553 protein 1 (BNIP1), 19 kD-interacting protein 1 (BNIP1), mRNA 2554 H3123G10 mannoside Mus musculus mannoside BG073537 Mm.2672 Energy/Metabolism 2555 acetylglucosaminyltransferase 1 acetylglucosaminyltransferase 1 (Mgat1), (Mgat1), mRNA 2556 H3123H05 “Homo sapiens tumor protein p53- BG086271 Mm.23595 Signal Transduction 2557 binding protein, 2 (TP53BP2), mRNA” 2558 H3123H07 novel cell death-regulatory protein Mus musculus novel cell death- BG086273 Mm.21162 Apoptosis 2559 GRIM19 (Grim19) regulatory protein GRIM19 (Grim19) mRNA, complete cds 2560 H3124B02 “Mus musculus cold inducible RNA- BG086286 Mm.17898 Heat Shock/Stress 2561 binding protein (Cirbp), mRNA” 2562 H3124D02 ferrochelatase (Fech), Mus musculus ferrochelatase (Fech), BG086309 Mm.1070 Energy/Metabolism 2563 mRNA 2564 H3124D04 caspase 9 (Casp9), Mus musculus caspase 9 (Casp9), BG086310 Mm.102926 Apoptosis 2565 mRNA 2566 H3124D06 DNA fragmentation factor, 40 kD, beta Mus musculus DNA fragmentation BG086312 Mm.38853 Apoptosis 2567 subunit (Dffb), factor, 40 kD, beta subunit (Dffb), mRNA 2568 H3124D11 mitotic arrest deficient 1-like 1 Mus musculus mitotic arrest deficient Mm.27250 Cell Cycle 2569 (Mad111), 1-like 1 (Mad111), mRNA 2570 H3124E02 hepatocyte growth factor-like protein Mouse hepatocyte growth factor-like BG073592 Mm.21989 Energy/Metabolism 2571 gene protein gene, complete cds 2572 H3124F04 microsomal glutathione S-transferase Mus musculus microsomal glutathione BG086330 Mm.14796 Energy/Metabolism 2573 (Gst), S-transferase (Gst), mRNA 2574 H3124H01 NADH dehydrogenase (ubiquinone) 1 Homo sapiens NADH dehydrogenase BG086348 Mm.8688 Energy/Metabolism 2575 beta subcomplex, 10 (22 kD, PDSW) (ubiquinone) 1 beta subcomplex, 10 (NDUFB10), (22 kD, PDSW) (NDUFB10), mRNA 2576 H3125A06 “Mus musculus glycogen synthase BG086363 Signal Transduction 2577 kinase 3 beta (Gsk3b), mRNA” 2578 H3125A09 glutathione peroxidase 3 (Gpx3), Mus musculus glutathione peroxidase 3 BG073718 Mm.7156 Energy/Metabolism 2579 (Gpx3), mRNA 2580 H3125B05 “Homo sapiens heat shock transcription BG086370 Mm.75856 Heat Shock/Stress 2581 factor 2 binding protein (HSF2BP), mRNA” 2582 H3125C08 ribonuclease III (RN3) Homo sapiens ribonuclease III (RN3) BG086378 Energy/Metabolism 2583 mRNA, complete cds 2584 H3125C10 major histocompatibility locus class III Mus musculus major histocompatibility BG086380 Mm.1457 Energy/Metabolism 2585 regions Hsc70t gene, partial cds; locus class III regions Hsc70t gene, smRNP, G7A, NG23, MutS homolog, partial cds; smRNP, G7A, NG23, MutS CLCP, NG24, NG25, and NG26 genes; homolog, CLCP, NG24, NG25, and and unknown genes NG26 genes, complete cds; and unknown genes 2586 H3125D09 “Homo sapiens suppression of BG086389 Mm.4908 Heat Shock/Stress 2587 tumorigenicity 13 (colon carcinoma) (Hsp70-interacting protein) (ST13), mRNA” 2588 H3125E01 cytosolic acyl coenzyme A thioester Homo sapiens cytosolic acyl coenzyme BG086391 Mm.142740 Energy/Metabolism 2589 hydrolase (HBACH), A thioester hydrolase (HBACH), mRNA 2590 H3125F03 thioredoxin (Txn), Mus musculus thioredoxin (Txn), BG086400 Mm.1275 Energy/Metabolism 2591 mRNA 2592 H3125F07 protein translocase, JM26 protein, UDP- Homo sapiens protein translocase, Mm.27393 Matrix/Structural 2593 galactose translocator, pim-2 JM26 protein, UDP-galactose Proteins protooncogene homolog pim-2h, and translocator, pim-2 protooncogene shal-type potassium channel genes; homolog pim-2h, and shal-type JM12 protein and transcription potassium channel genes, complete cds; JM12 protein and transcription 2594 H3125H05 M. musculus RPS3a gene M. musculus RPS3a gene Mm.16228 Apoptosis 2595 2596 H3126B12 “Mus musculus protein kinase inhibitor, BG086437 Mm.10091 Signal Transduction 2597 gamma (Pkig), mRNA” 2598 H3126C12 protease (prosome, macropain) 28 Mus musculus protease (prosome, BG073636 Mm.830 Energy/Metabolism 2599 subunit, alpha (Psme1), macropain) 28 subunit, alpha (Psme1), mRNA 2600 H3126F10 spermine synthase (Sms), Mus musculus spermine synthase (Sms), BG086479 Mm.3553 Energy/Metabolism 2601 mRNA 2602 H3127G05 palmitoyl-protein thioesterase (Ppt), Mus musculus palmitoyl-protein BG086559 Mm.43660 Energy/Metabolism 2603 thioesterase (Ppt), mRNA 2604 H3127G08 cDNA FLJ13974 fis, clone Homo sapiens cDNA FLJ13974 fis, BG086562 Mm.41565 Energy/Metabolism 2605 Y79AA1001581, weakly similar to clone Y79AA1001581, weakly similar ACETYL-COENZYME A to ACETYL-COENZYME A SYNTHETASE (EC 6.2.1.1) SYNTHETASE (EC 6.2.1.1) 2606 H3128D01 s-adenosylmethionine synthetase Mouse s-adenosylmethionine BG086604 Mm.14064 Energy/Metabolism 2607 synthetase mRNA 2608 H3128D02 thioredoxin interacting factor (Vdup1) Mus musculus thioredoxin interacting BG086605 Mm.77432 Energy/Metabolism 2609 gene factor (Vdup1) gene, complete cds 2610 H3129C03 solute carrier family 4 (anion Mus musculus solute carrier family 4 BG086676 Mm.7248 Energy/Metabolism 2611 exchanger), member 1 (Slc4a1), (anion exchanger), member 1 (Slc4a1), mRNA 2612 H3129C06 protein-L-isoaspartate (D-aspartate) O- Mus musculus protein-L-isoaspartate BG086679 Mm.25169 Energy/Metabolism 2613 methyltransferase 1 (Pcmt1), (D-aspartate) O-methyltransferase 1 (Pcmt1), mRNA 2614 H3129D08 “Homo sapiens candidate tumor BG086692 Mm.43482 Signal Transduction 2615 suppressor p33 ING1 homolog (LOC51147), mRNA” 2616 H3129E06 OXA1L gene sequence Homo sapiens OXA1L gene complete BG086699 Mm.142455 Apoptosis 2617 sequence 2618 H3129E10 “Mus musculus Pro-rich, PH, SH2 BG086702 Mm.8538 Signal Transduction 2619 domain-containing signaling mediator (PSM) mRNA, complete cds” 2620 H3129E12 Mus musculus IFN alpha-treated BG086704 Mm.23836 Heat Shock/Stress 2621 embryonic fibroblast mRNA 2622 H3129F04 clone TA-9 ATP synthase b chain Mus musculus clone TA-9 ATP Mm.30112 Energy/Metabolism 2623 homolog, partial cds synthase b chain homolog mRNA, partial cds 2624 H3129G02 serine palmitoyltransferase, long chain Mus musculus serine BG074002 Mm.6505 Energy/Metabolism 2625 base subunit 1 (Sptlc1), palmitoyltransferase, long chain base subunit 1 (Sptlc1), mRNA 2626 H3129G06 peroxisomal assembly protein PEX3P Mus musculus peroxisomal assembly BG086720 Energy/Metabolism 2627 (Pex3) gene, promoter and exon 1 protein PEX3P (Pex3) gene, promoter and exon 1 2628 H3129H03 hydroxylacyl-Coenzyme A Mus musculus hydroxylacyl-Coenzyme BG086728 Mm.2491 Energy/Metabolism 2629 dehydrogenase (Hadh), A dehydrogenase (Hadh), mRNA 2630 H3129H05 K—Cl cotransporter KCC3 Homo sapiens K—Cl cotransporter BG086729 Mm.21915 Energy/Metabolism 2631 KCC3 mRNA, complete cds 2632 H3130B10 SERCA2 gene, alternative transcripts Mus musculus SERCA2 gene, BG074044 Mm.42255 Energy/Metabolism 2633 alternative transcripts 2634 H3130B11 “Mouse Cu—Zn superoxide dismutase BG074045 Mm.5274 Heat Shock/Stress 2635 mRNA, complete cds” 2636 H3130C02 “Mus musculus calcineurin inhibitor BG086761 Mm.56 Signal Transduction 2637 mRNA, complete cds, alternatively spliced” 2638 H3130D06 Na, K-ATPase beta subunit (ATP1B) Human Na, K-ATPase beta subunit BG086774 Energy/Metabolism 2639 gene, exons 1 and 2 (ATP1B) gene, exons 1 and 2 2640 H3130D08 NADH/NADPH mitogenic oxidase Rattus norvegicus NADH/NADPH Mm.2866 2641 subunit p65-mox mitogenic oxidase subunit p65-mox mRNA, complete cds 2642 H3130H07 3-hydroxy-3-methylglutaryl-Coenzyme Mm.10633 2643 A synthase 2 mHS 2644 H3131A03 “Mus musculus heat shock protein, 86 kDa BG074109 Mm.1843 Heat Shock/Stress 2645 1 (Hsp86-1), mRNA” 2646 H3131A05 ATP synthase gamma-subunit precursor Mus musculus mRNA for ATP synthase BG074111 Mm.12677 Energy/Metabolism 2647 gamma-subunit precursor complete cds 2648 H3131A07 enoyl coenzyme A hydratase 1, Mus musculus enoyl coenzyme A BG074113 Mm.2112 Energy/Metabolism 2649 peroxisomal (Ech1), hydratase 1, peroxisomal (Ech1), mRNA 2650 H3131A12 MA-3 (apoptosis-related gene) Mouse MA-3 (apoptosis-related gene) BG086831 Mm.26035 Apoptosis 2651 mRNA, complete cds 2652 H3131B04 sterol-carrier protein X Mus musculus sterol-carrier protein X BG086835 Mm.1779 Matrix/Structural 2653 mRNA, complete cds Proteins 2654 H3131C10 dolichyl-di-phosphooligosaccharide- Mus musculus dolichyl-di- BG074138 Mm.7236 Energy/Metabolism 2655 protein glycotransferase (Ddost), phosphooligosaccharide-protein glycotransferase (Ddost), mRNA 2656 H3131D05 solute carrier family 39 (iron-regulated Mus musculus solute carrier family 39 BG074144 Mm.28756 Energy/Metabolism 2657 transporter), member 1 (Slc39a1), (iron-regulated transporter), member 1 (Slc39a1), mRNA 2658 H3131G02 caspase 12 (Casp12), Mus musculus caspase 12 (Casp12), BG086881 Mm.42163 Apoptosis 2659 mRNA 2660 H3131H01 H. sapiens gene for rho GDP BG086892 Mm.30016 Signal Transduction 2661 dissociation inhibitor (GDI) 2662 H3132C10 “Mus musculus neuroblastoma ras BG086925 Mm.734 Signal Transduction 2663 oncogene (Nras), mRNA” 2664 H3132F06 “Homo sapiens pleiomorphic adenoma BG074245 Mm.23923 Signal Transduction 2665 gene-like 2 (PLAGL2), mRNA” 2666 H3132G04 “Homo sapiens ER-associated DNAJ; BG086956 Mm.37516 Heat Shock/Stress 2667 ER-associated Hsp40 co-chaperone; hDj9; ERj3 (LOC51726), mRNA” 2668 H3132G09 vacuolar ATPase subunit H Homo sapiens vacuolar ATPase subunit BG086960 Mm.27082 Energy/Metabolism 2669 H mRNA, complete cds 2670 H3132H07 “Mus musculus tumor susceptibility BG086965 Mm.22688 Signal Transduction 2671 protein 101 (tsg101) gene, complete cds” 2672 H3133A06 glutathione S-transferase, mu 1 (Gstm1), Mus musculus glutathione S-transferase, BG086970 Mm.2011 Energy/Metabolism 2673 mu 1 (Gstm1), mRNA 2674 H3133B05 cytochrome c oxidase subunit VIb Homo sapiens cytochrome c oxidase BG074277 Mm.400 Energy/Metabolism 2675 (COX6B), subunit VIb (COX6B), mRNA 2676 H3133C08 “Mus musculus RAB7, member RAS BG086994 Mm.4268 Signal Transduction 2677 oncogene family (Rab7), mRNA” 2678 H3133D04 NADH dehydrogenase (ubiquinone) Homo sapiens NADH dehydrogenase BG087002 Mm.2206 Energy/Metabolism 2679 flavoprotein 2 (24 kD) (NDUFV2), (ubiquinone) flavoprotein 2 (24 kD) (NDUFV2), mRNA 2680 H3133D06 Mm.21535 Heat Shock/Stress 2681 2682 H3133E07 glycine amidinotransferase (L- Homo sapiens glycine BG087011 Mm.29975 Energy/Metabolism 2683 arginine: glycine amidinotransferase) amidinotransferase (L-arginine: glycine (GATM), amidinotransferase) (GATM), mRNA 2684 H3133H01 “Mus musculus heat shock 70 protein BG087043 Mm.2144 Heat Shock/Stress 2685 (Hsc70) gene, complete cds” 2686 H3133H05 M. musculus arylsulfatase A M. musculus mRNA for arylsulfatase A BG087046 Mm.620 Energy/Metabolism 2687 2688 H3133H07 voltage-dependent anion channel 3 Mus musculus voltage-dependent anion BG087048 Mm.133962 Energy/Metabolism 2689 (Vdac3), channel 3 (Vdac3), mRNA 2690 H3134C07 DNA, DLEC1 to ORCTL4 gene region, Homo sapiens DNA, DLEC1 to BG087037 Mm.42275 Energy/Metabolism 2691 section 1/2 (DLEC1, ORCTL3, ORCTL4 gene region, section 1/2 ORCTL4 genes) (DLEC1, ORCTL3, ORCTL4 genes, complete cds) 2692 H3134D06 GrpE-like 2, mitochondrial mt- Mm.12959 Heat Shock/Stress 2693 GrpE#2 2694 H3135A03 NADH dehydrogenase (ubiquinone) 1 Homo sapiens NADH dehydrogenase BG087056 Mm.19834 Energy/Metabolism 2695 alpha subcomplex, 8 (19 kD, PGIV) (ubiquinone) 1 alpha subcomplex, 8 (NDUFA8), (19 kD, PGIV) (NDUFA8), mRNA 2696 H3135B06 cDNA DKFZp434D175 (from clone Homo sapiens mRNA; cDNA BG087066 Mm.30110 Energy/Metabolism 2697 DKFZp434D175); partial cds DKFZp434D175 (from clone DKFZp434D175); partial cds 2698 H3135B10 “Mus musculus PL-6 (P16), mRNA” BG087070 Mm.27312 Signal Transduction 2699 2700 H3135D06 galactose-1-phosphate uridyltransferase Mus musculus galactose-1-phosphate BG087088 Mm.2420 Energy/Metabolism 2701 (GALT) gene uridyltransferase (GALT) gene, complete cds 2702 H3135F04 Mm.87124 Mm.87124 Energy/Metabolism 2703 2704 H3135F06 Heat Shock/Stress 2705 H3135G03 serine protease inhibitor 3 (Spi3), Mus musculus serine protease inhibitor BG087117 Mm.2623 Energy/Metabolism 2706 3 (Spi3), mRNA 2707 H3135G07 protoporphyrinogen oxidase (Ppox), Mus musculus protoporphyrinogen BG087120 Mm.4730 Energy/Metabolism 2708 oxidase (Ppox), mRNA 2709 H3135H04 rhodanese (Tst) Mus musculus rhodanese (Tst) mRNA, Mm.15312 2710 complete cds 2711 H3135H10 D-dopachrome tautomerase gene Mus musculus D-dopachrome BG087134 Mm.5731 Energy/Metabolism 2712 tautomerase gene, complete cds 2713 H3136A06 calcium-sensitive chloride conductance Mus musculus calcium-sensitive BG087141 Mm.20897 Energy/Metabolism 2714 protein-1 (mCLCA1) chloride conductance protein-1 (mCLCA1) mRNA, complete cds 2715 H3136B09 branched chain ketoacid dehydrogenase Mus musculus branched chain ketoacid BG087153 Mm.25848 Energy/Metabolism 2716 E1, alpha polypeptide (Bckdha), dehydrogenase E1, alpha polypeptide (Bckdha), mRNA 2717 H3136C07 BCL2/adenovirus E1B 19 kDa- Mus musculus BCL2/adenovirus E1B BG087162 Mm.2159 Apoptosis 2718 interacting protein 1, NIP3 (Bnip3), 19 kDa-interacting protein 1, NIP3 (Bnip3), mRNA 2719 H3136D05 serine protease Mus musculus serine protease mRNA, BG087171 Mm.24276 Energy/Metabolism 2720 complete cds 2721 H3136E12 gene uncoupling protein-2 Mus musculus gene for uncoupling Mm.144413 2722 protein-2, complete cds 2723 H3136F07 guanine monphosphate synthetase Homo sapiens guanine monphosphate BG087194 Mm.28299 Energy/Metabolism 2724 (GMPS), synthetase (GMPS), mRNA 2725 H3136F10 serine protease inhibitor 3 (Spi3), Mus musculus serine protease inhibitor BG087196 Energy/Metabolism 2726 3 (Spi3), mRNA 2727 H3136G10 solute carrier family 12, member 2 Mus musculus solute carrier family 12, BG074576 Mm.4168 Energy/Metabolism 2728 (Slc12a2), member 2 (Slc12a2), mRNA 2729 H3136H12 “Mus musculus IkB kinase-beta (Ikkb) BG087220 Mm.28269 Signal Transduction 2730 mRNA, complete cds” 2731 H3137A09 pyruvate decarboxylase (Pcx), Mus musculus pyruvate decarboxylase BG087228 Mm.1845 Energy/Metabolism 2732 (Pcx), mRNA 2733 H3137B06 ornithine aminotransferase (Oat), Mus musculus ornithine BG087236 Mm.13694 Energy/Metabolism 2734 aminotransferase (Oat), mRNA 2735 H3137B09 “Homo sapiens Rho guanine nucleotide BG087239 Mm.41604 Signal Transduction 2736 exchange factor (GEF) 4 (ARHGEF4), mRNA” 2737 H3137C10 ATP-binding cassette, sub-family A Homo sapiens ATP-binding cassette, BG087249 Mm.38313 Energy/Metabolism 2738 (ABC1), member 3 (ABCA3), sub-family A (ABC1), member 3 (ABCA3), mRNA 2739 H3137D07 ATP-binding cassette, sub-family E Mus musculus ATP-binding cassette, BG087256 Mm.5831 Energy/Metabolism 2740 (OABP), member 1 (Abce1), sub-family E (OABP), member 1 (Abce1), mRNA 2741 H3137D08 VLCAD gene Mus musculus VLCAD gene BG074630 Mm.18630 Energy/Metabolism 2742 2743 H3137D09 solute carrier family 4 (anion Mus musculus solute carrier family 4 BG074631 Mm.4580 Energy/Metabolism 2744 exchanger), member 2 (Slc4a2), (anion exchanger), member 2 (Slc4a2), mRNA 2745 H3137E02 NADH dehydrogenase (ubiquinone) Fe—S Homo sapiens NADH dehydrogenase BG087262 Mm.21669 Energy/Metabolism 2746 protein 2 (49 kD) (NADH-coenzyme (ubiquinone) Fe—S protein 2 (49 kD) Q reductase) (NDUFS2), (NADH-coenzyme Q reductase) (NDUFS2), mRNA 2747 H3137E03 anion exchanger 3 brain and anion Mus musculus anion exchanger 3 brain BG074636 Mm.5053 Energy/Metabolism 2748 exchanger 3 cardiac isoms (Slc4a3) and anion exchanger 3 cardiac isoforms gene, alternatively spliced (Slc4a3) gene, complete cds, alternatively spliced 2749 H3137G05 ribosomal protein L17 isolog Homo sapiens ribosomal protein L17 BG087283 Mm.44225 Energy/Metabolism 2750 (LOC63875), isolog (LOC63875), mRNA 2751 H3137G09 Mouse mRNA for protein tyrosine BG087286 Mm.4220 Signal Transduction 2752 phosphatase PTPT9 2753 H3138B02 neuronal apoptosis inhibitory protein 6 Mus musculus neuronal apoptosis BG087312 Mm.13437 Apoptosis 2754 (Naip6) gene; and Naip3 gene, exons 2-9 inhibitory protein 6 (Naip6) gene, and 11-16 complete cds; and Naip3 gene, exons 2-9 and 11-16 2755 H3138C04 phosphoglucomutase 1 (PGM1), Homo sapiens phosphoglucomutase 1 BG087325 Mm.22403 Energy/Metabolism 2756 (PGM1), mRNA 2757 H3138D04 hypothetical protein FLJ10545 Homo sapiens hypothetical protein BG074710 Mm.9870 Energy/Metabolism 2758 (FLJ10545), FLJ10545 (FLJ10545), mRNA 2759 H3138D07 voltage-dependent anion channel 2 Mus musculus voltage-dependent anion BG087336 Mm.569 Energy/Metabolism 2760 (Vdac2), channel 2 (Vdac2), mRNA 2761 H3138E10 aldehyde dehydrogenase 5 (ALDH5), Homo sapiens aldehyde dehydrogenase BG087349 Mm.24457 Energy/Metabolism 2762 5 (ALDH5), mRNA 2763 H3138F05 ADP-ribosylation factor 4 (Arf4), Mus musculus ADP-ribosylation factor BG087356 Mm.1486 Energy/Metabolism 2764 4 (Arf4), mRNA 2765 H3138G02 solute carrier family 22 (organic cation Mus musculus solute carrier family 22 BG087364 Mm.42253 Energy/Metabolism 2766 transporter), member 5 (Slc22a5), (organic cation transporter), member 5 (Slc22a5), mRNA 2767 H3138G09 alpha glucosidase 2, alpha neutral Mus musculus alpha glucosidase 2, BG087370 Mm.3196 Energy/Metabolism 2768 subunit (G2an), alpha neutral subunit (G2an), mRNA 2769 H3138H04 long-chain acyl-CoA synthetase Homo sapiens mRNA for long-chain BG074754 Mm.28962 Energy/Metabolism 2770 acyl-CoA synthetase, complete cds 2771 H3138H07 78 kDa gastrin-binding protein Human 78 kDa gastrin-binding protein BG087380 Mm.16773 Energy/Metabolism 2772 mRNA, complete cds 2773 H3138H10 M. musculus mRNA for cathepsin D BG087383 Mm.2147 Signal Transduction 2774 2775 H3139B06 “Mus musculus protein tyrosine BG087401 Mm.5400 Signal Transduction 2776 phosphatase, non-receptor type 13 interacting protein (Ptpn13ip), mRNA” 2777 H3139C01 ubi-d4/requiem gene, exons 2 through Mus musculus ubi-d4/requiem gene, BG087408 Mm.2651 Apoptosis 2778 11 and partial cds exons 2 through 11 and partial cds 2779 H3139E01 “Mus musculus heat shock 70 protein BG087426 Heat Shock/Stress 2780 (Hsc70) gene, complete cds” 2781 H3139F01 sterol O-acyltransferase 1 (Soat1), Mus musculus sterol O-acyltransferase 1 BG087432 Mm.28099 Energy/Metabolism 2782 (Soat1), mRNA 2783 H3140A02 solute carrier family 9 Mus musculus solute carrier family 9 BG087460 Mm.4312 Energy/Metabolism 2784 (sodium/hydrogen exchanger), member (sodium/hydrogen exchanger), member 1 (Slc9a1), 1 (Slc9a1), mRNA 2785 H3140A08 “Mus musculus mitogen activated BG087465 Mm.4437 Signal Transduction 2786 protein kinase 14 (Mapk14), mRNA” 2787 H3140A09 CPT I = carnitine palmitoyltransferase I CPT I = carnitine palmitoyltransferase I Mm.18522 Energy/Metabolism 2788 {3 region} [mice, JVS, hearts, Partial, {3 region} [mice, JVS, hearts, mRNA 678 nt, segment 1 of 2] Partial, 678 nt, segment 1 of 2] 2789 H3140B07 major histocompatibility locus class III Mus musculus major histocompatibility Mm.1511 2790 region: butyrophilin-like protein gene, locus class III region: butyrophilin-like partial cds; Notch4, PBX2, RAGE, protein gene, partial cds; Notch4, lysophatidic acid acyl transferase-alpha, PBX2, RAGE, lysophatidic acid acyl palmitoyl-protein thioestera transferase-alpha, palmitoyl-protein thioestera 2791 H3140C11 clone RP11-486I22, sequence Homo sapiens clone RP11-486I22, BG074864 Mm.3479 Energy/Metabolism 2792 complete sequence 2793 H3140D05 ectonucleotide Homo sapiens ectonucleotide BG087491 Mm.30145 Energy/Metabolism 2794 pyrophosphatase/phosphodiesterase 5 pyrophosphatase/phosphodiesterase 5 (putative function) (ENPP5), (putative function) (ENPP5), mRNA 2795 H3140D07 peroxiredoxin 3 (Prdx3), Mus musculus peroxiredoxin 3 (Prdx3), BG087493 Mm.29821 Energy/Metabolism 2796 mRNA 2797 H3140D12 electron-transfer-flavoprotein, alpha Homo sapiens electron-transfer- BG087498 Mm.26949 Energy/Metabolism 2798 polypeptide (glutaric aciduria II) flavoprotein, alpha polypeptide (ETFA), (glutaric aciduria II) (ETFA), mRNA 2799 H3140E04 protein tyrosine phosphatase (70zshp) Mouse protein tyrosine phosphatase BG074880 Mm.1484 Energy/Metabolism 2800 (70zshp) mRNA, complete cds 2801 H3140E08 glutamate dehydrogenase (Glud), Mus musculus glutamate dehydrogenase BG087506 Mm.10600 Energy/Metabolism 2802 (Glud), mRNA 2803 H3141F03 solute carrier family 12, member 7 Mus musculus solute carrier family 12, BG087669 Mm.24510 Energy/Metabolism 2804 (Slc12a7), member 7 (Slc12a7), mRNA 2805 H3141G03 chs HMG CoA synthase, partial cds Mus musculus chs HMG CoA synthase BG087678 Mm.10633 Matrix/Structural 2806 mRNA, partial cds Proteins 2807 H3142A02 “Mus musculus protein phosphatase 2a, BG087694 Mm.7418 Signal Transduction 2808 catalytic subunit, beta isoform (Ppp2cb), mRNA” 2809 H3142A08 ubiquinol-cytochrome c reductase core Homo sapiens ubiquinol-cytochrome c BG075002 Mm.988 Energy/Metabolism 2810 protein II (UQCRC2), reductase core protein II (UQCRC2), mRNA 2811 H3142E09 “Mus musculus tumor-suppressing BG087715 Mm.139675 Signal Transduction 2812 subchromosomal transferable fragment 4 (Tssc4), mRNA” 2813 H3142G01 Mm.31203 Heat Shock/Stress 2814 H3142G02 methylenetetrahydrofolate Homo sapiens BG087719 Mm.29584 Energy/Metabolism 2815 dehydrogenase (NADP+ dependent), methylenetetrahydrofolate methenyltetrahydrofolate dehydrogenase (NADP+ dependent), cyclohydrolase, myltetrahydrofolate methenyltetrahydrofolate synthetase (MTHFD1), cyclohydrolase, formyltetrahydrofolate synthetase (MTHFD1), mRNA 2816 H3141D09 peroxisome membrane protein PEX2 Mus musculus peroxisome membrane BG075110 Mm.16453 Energy/Metabolism 2817 protein PEX2 mRNA, complete cds 2818 H3143D10 “Mouse cAMP-dependent protein kinase BG075111 Mm.19111 Signal Transduction 2819 alpha subunit gene, exon 10” 2820 H3143D12 presenilin-associated protein Homo sapiens presenilin-associated BG087589 Mm.29650 Energy/Metabolism 2821 protein mRNA, complete cds 2822 H3143H07 “Mus musculus osmotic stress protein BG075154 Mm.4150 Heat Shock/Stress 2823 94 (Osp94) mRNA, complete cds” 2824 H3144B03 NADH-ubiquinone dehydrogenase 1 Homo sapiens NADH-ubiquinone BG087636 Mm.4537 Energy/Metabolism 2825 beta subcomplex dehydrogenase 1 beta subcomplex mRNA, complete cds 2826 H3144C01 glyoxalase I (GLO1), Homo sapiens glyoxalase I (GLO1), BG087642 Mm.17362 Energy/Metabolism 2827 mRNA 2828 H3144C11 “Mus musculus heat shock 70 kD protein BG087650 Mm.24162 Heat Shock/Stress 2829 5 (glucose-regulated protein, 78 kD) (Hspa5), mRNA” 2830 H3144E06 neuronal cell death related gene in Rattus norvegicus neuronal cell death AW555571 Mm.19440 Apoptosis neuron-7 (DN-7) related gene in neuron-7 (DN-7) mRNA, complete cds 2831 H3144F09 “Homo sapiens RAB7, member RAS BG075214 Mm.34027 Signal Transduction 2832 oncogene family-like 1 (RAB7L1), mRNA” 2833 H3144G02 “Homo sapiens phosphodiesterase 5A, BG087768 Mm.103149 Signal Transduction 2834 cGMP-specific (PDE5A), mRNA” 2835 H3144H01 mitofilin, partial cds Homo sapiens mitofilin mRNA, partial Mm.10706 2836 cds 2837 H3145A03 “Mus musculus partial Prkar1a gene for BG075240 Mm.30039 Signal Transduction 2838 cAMP-dependent protein kinase regulatory subunit RIalpha, exons 8-10 and 3′UTR” 2839 H3145A06 zinc transporter ZnT-3 (ZnT-3) Mus musculus zinc transporter ZnT-3 BG075243 Mm.1396 Energy/Metabolism 2840 (ZnT-3) mRNA, complete cds 2841 H3145E01 H. sapiens gene phosphate carrier H. sapiens gene for phosphate carrier BG075286 Mm.5246 Energy/Metabolism 2842 2843 H3145E12 hyaluronidase 2 (Hyal2), Mus musculus hyaluronidase 2 (Hyal2), BG075294 Mm.4834 Energy/Metabolism 2844 mRNA 2845 H3145F11 Heat Shock/Stress 2846 2847 H3145H03 M. musculus mRNA for mitogen BG075319 Mm.8385 Signal Transduction 2848 activated protein kinase (erk-1) 2849 H3145H09 peroxiredoxin 4 (Prdx4), Mus musculus peroxiredoxin 4 (Prdx4), BG075324 Mm.19127 Energy/Metabolism 2850 mRNA 2851 H3145H10 peroxiredoxin 4 (Prdx4), Mus musculus peroxiredoxin 4 (Prdx4), BG087872 Mm.19127 Energy/Metabolism 2852 mRNA 2853 H3146A04 “Mus musculus myo-inositol 1- BG075331 Mm.29357 Signal Transduction 2854 phosphate synthase A1 (IsynA1) mRNA, complete cds” 2855 H3146B10 cDNA FLJ13847 fis, clone Homo sapiens cDNA FLJ13847 fis, BG087895 Mm.24210 Energy/Metabolism 2856 THYRO1000852, highly similar to clone THYRO1000852, highly similar branched-chain amino acid to Human branched-chain amino acid aminotransferase (ECA40) aminotransferase (ECA40) mRNA 2857 H3146F01 RHOA proto-oncogene multi-drug- Homo sapiens RHOA proto-oncogene BG087931 Mm.757 Energy/Metabolism 2858 resistance protein, 3 end multi-drug-resistance protein mRNA, 3 end 2859 H3146G06 cDNA: FLJ22871 fis, clone KAT02533 Homo sapiens cDNA: FLJ22871 fis, Mm.30065 Energy/Metabolism 2860 clone KAT02533 2861 H3146H06 CTL2 gene Homo sapiens CTL2 gene BG087957 Mm.28209 Energy/Metabolism 2862 2863 H3147B08 “Mus musculus RAB11B, member RAS BG087979 Mm.35727 Signal Transduction 2864 oncogene family (Rab11b), mRNA” 2865 H3147D12 apoptosis inhibitory protein 5 (Api5), Mus musculus apoptosis inhibitory BG088003 Mm.692 Apoptosis 2866 protein 5 (Api5), mRNA 2867 H3147E03 “Mus musculus signal transducer and BG088006 Mm.25298 Signal Transduction 2868 activator of transcription 3 interacting protein 1 (Stat3ip1-pending), mRNA” 2869 H3147E04 “Mus musculus heat shock protein, 84 kDa BG088007 Mm.2180 Heat Shock/Stress 2870 1 (Hsp84-1), mRNA” 2871 H3147E05 “Mus musculus heat shock protein, 84 kDa BG088008 Mm.2180 Heat Shock/Stress 2872 1 (Hsp84-1), mRNA” 2873 H3147E06 “Mus musculus heat shock protein, 84 kDa BG088009 Mm.2180 Heat Shock/Stress 2874 1 (Hsp84-1), mRNA” 2875 H3148B04 ferredoxin reductase (Fdxr), Mus musculus ferredoxin reductase BG088056 Mm.4719 Energy/Metabolism 2876 (Fdxr), mRNA 2877 H3148E08 ornithine decarboxylase antizyme gene Mus musculus ornithine decarboxylase BG088091 Mm.683 Energy/Metabolism 2878 antizyme gene, complete cds 2879 H3148F05 NADH dehydrogenase (ubiquinone) Fe—S Homo sapiens NADH dehydrogenase BG088100 Mm.2041 Energy/Metabolism 2880 protein 1 (75 kD) (NADH-coenzyme (ubiquinone) Fe—S protein 1 (75 kD) Q reductase) (NDUFS1), (NADH-coenzyme Q reductase) (NDUFS1), mRNA 2881 H3148G06 “Mus musculus MgcRacGAP mRNA BG088110 Mm.27141 Signal Transduction 2882 for GTPase activating protein, complete cds” 2883 H3149B10 “Mus musculus protein kinase C, zeta BG088144 Mm.28561 Signal Transduction 2884 (Pkcz), mRNA” 2885 H3149B11 membrane protein, palmitoylated (55 kDa) Mus musculus membrane protein, Mm.2814 Matrix/Structural 2886 (Mpp1), palmitoylated (55 kDa) (Mpp1), mRNA Proteins 2887 H3149C10 triosephosphate isomerase (Tpi), Mus musculus triosephosphate BG075608 Mm.4222 Energy/Metabolism 2888 isomerase (Tpi), mRNA 2889 H3149E11 sodium channel, voltage-gated, type II, Homo sapiens sodium channel, voltage- BG088175 Energy/Metabolism 2890 beta polypeptide (SCN2B), gated, type II, beta polypeptide (SCN2B), mRNA 2891 H3149H04 5-3 exoribonuclease 2 (Xrn2), Mus musculus 5-3 exoribonuclease 2 BG088199 Mm.3065 Energy/Metabolism 2892 (Xrn2), mRNA 2893 H3150C08 “Mus musculus Ste-20 related kinase BG088221 Mm.29404 Signal Transduction 2894 (Spak-pending), mRNA” 2895 H3150D02 “Mus musculus presenilin 1 (Psen1), BG088227 Mm.998 Signal Transduction 2896 mRNA” 2897 H3150F06 farnesyltransferase, CAAX box, alpha Mus musculus farnesyltransferase, BG075707 Mm.3496 Energy/Metabolism 2898 (Fnta), CAAX box, alpha (Fnta), mRNA 2899 H3150G03 cDNA: FLJ21905 fis, clone HEP03764 Homo sapiens cDNA: FLJ21905 fis, BG088257 Mm.4290 Energy/Metabolism 2900 clone HEP03764 2901 H3151C06 “Homo sapiens PTPL1-associated BG088297 Signal Transduction 2902 RhoGAP 1 (PARG1), mRNA” 2903 H3151D08 defender against cell death 1 (Dad1), Mus musculus defender against cell BG075765 Mm.2547 Apoptosis 2904 death 1 (Dad1), mRNA 2905 H3151D11 prosaposin (psap\SGP-1) gene Mus musculus prosaposin (psap\SGP-1) BG088310 Mm.3363 Energy/Metabolism 2906 gene, complete cds 2907 H3151E12 “Mus musculus downstream of tyrosine BG088318 Mm.156 Signal Transduction 2908 kinase 1 (Dok1), mRNA” 2909 H3151F06 M. musculus xanthine dehydrogenase M. musculus mRNA for xanthine BG075778 Mm.11223 Energy/Metabolism 2910 dehydrogenase 2911 H3152A02 Rat beta-galactoside-alpha 2,6- Rat beta-galactoside-alpha 2,6- BG075800 Mm.1944 Energy/Metabolism 2912 sialyltransferase sialyltransferase mRNA 2913 H3152D06 5-aminolevulinic acid synthase, 3 end Mouse 5-aminolevulinic acid synthase BG088378 Mm.1217 Energy/Metabolism 2914 mRNA, 3 end 2915 H3152G07 MAD2 (mitotic arrest deficient, yeast, Homo sapiens MAD2 (mitotic arrest Mm.9648 Cell Cycle 2916 homolog)-like 2 (MAD2L2), deficient, yeast, homolog)-like 2 (MAD2L2), mRNA 2917 H3152H05 ATPase, class II, type 9A (Atp9a), Mus musculus ATPase, class II, type 9A BG075876 Mm.10288 Energy/Metabolism 2918 (Atp9a), mRNA 2918 H3152H07 NADH dehydrogenase (ubiquinone) 1 Homo sapiens NADH dehydrogenase BG088418 Mm.28058 Energy/Metabolism 2919 beta subcomplex, 5 (16 kD, SGDH) (ubiquinone) 1 beta subcomplex, 5 (NDUFB5), (16 kD, SGDH) (NDUFB5), mRNA 2920 H3153A02 “Mus musculus calpain small subunit BG088424 Mm.6534 Signal Transduction 2921 gene, exons 3 through 9 and partial cds” 2922 H3153A07 “Homo sapiens zinedin (ZIN), mRNA” BG088429 Mm.21612 Signal Transduction 2923 2924 H3153B11 Mm.666 Mm.666 Energy/Metabolism 2925 2926 H3153C09 Mus musculus tissue inhibitor of BG088451 Mm.19191 Matrix/Structural 2927 metalloproteinase 2 (Timp2), mRNA Proteins 2928 H3153C10 “Homo sapiens protein phosphatase 2 BG088452 Mm.21428 Signal Transduction 2930 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B), mRNA” 2931 H3153D05 “Rattus norvegicus Diacylglycerol BG075920 Mm.102207 Signal Transduction 2932 kinase 90 kDa (Dagk), mRNA” 2933 H3153D07 p75NTR-associated cell death executor Mus musculus p75NTR-associated cell BG088461 Mm.90787 Apoptosis 2934 (Nade) death executor (Nade) mRNA, complete cds 2935 H3153E04 NADH dehydrogenase (ubiquinone) 1 Homo sapiens NADH dehydrogenase BG088469 Mm.29683 Energy/Metabolism 2936 beta subcomplex, 7 (18 kD, B18) (ubiquinone) 1 beta subcomplex, 7 (NDUFB7), (18 kD, B18) (NDUFB7), mRNA 2937 H3153E08 M. musculus mRNA for MAP kinase- BG088472 Mm.29725 Signal Transduction 2938 activated protein kinase 2 2939 H3153F08 apoptotic cell clearance receptor Mus Musculus apoptotic cell clearance BG088494 Mm.38825 Apoptosis 2940 PtdSerR receptor PtdSerR mRNA, complete cds 2941 H3153G02 endonuclease G-like 1 (ENDOGL1), Homo sapiens endonuclease G-like 1 BG088499 Mm.11669 Energy/Metabolism 2942 (ENDOGL1), mRNA 2943 H3153G08 “Mus musculus RAS-related C3 BG088482 Mm.1972 Signal Transduction 2944 botulinum substrate 2 (Rac2), mRNA” 2945 H3153H05 peroxisomal delta3, delta2-enoyl- Mus musculus peroxisomal delta3, BG075962 Mm.28883 Energy/Metabolism 2946 Coenzyme A isomerase (Peci-pending), delta2-enoyl-Coenzyme A isomerase (Peci-pending), mRNA 2947 H3154A03 “Mus musculus RAN, member RAS BG088511 Mm.7521 Signal Transduction 2948 oncogene family (Ran), mRNA” 2949 H3154C11 M. musculus glutamyl-tRNA synthetase M. musculus mRNA for glutamyl-tRNA BG088535 Mm.27190 Energy/Metabolism 2950 synthetase 2951 H3154E07 “Mus musculus growth arrest specific 6 BG088548 Mm.3982 Signal Transduction 2952 (Gas6), mRNA” 2953 H3154F02 asparagine synthetase Mus musculus asparagine synthetase BG088553 Mm.2942 Energy/Metabolism 2954 mRNA, complete cds 2955 H3155B01 beclin 1 (coiled-coil, myosin-like Mus musculus beclin 1 (coiled-coil, BG088587 Mm.30040 Apoptosis 2956 BCL2-interacting protein) (Becn1), myosin-like BCL2-interacting protein) (Becn1), mRNA 2957 H3155B07 NADH dehydrogenase (ubiquinone) Fe—S Homo sapiens NADH dehydrogenase BG076060 Mm.30113 Energy/Metabolism 2958 protein 3 (30 kD) (NADH-coenzyme ubiquinone) Fe—S protein 3 (30 kD) Q reductase) (NDUFS3), (NADH-coenzyme Q reductase) (NDUFS3), mRNA 2959 H3155C04 “Rattus norvegicus mRNA for inositol BG076067 Mm.22360 Signal Transduction 2960 hexakisphosphate kinase, complete cds” 2961 H3155C10 UDP glucuronosyltransferase (UGT1- Mus musculus UDP BG076072 Mm.42472 Energy/Metabolism 2962 06) glucuronosyltransferase (UGT1-06) mRNA, complete cds 2963 H3155E04 NDUFV1 gene, exons 6-10 Homo sapiens NDUFV1 gene, exons 6-10 BG076088 Mm.29842 Energy/Metabolism 2964 2965 H3155F02 Heat Shock/Stress 2966 2967 H3155G03 Rat endoplasmic reticulum alpha- Rat endoplasmic reticulum alpha- BG088635 Mm.33138 Energy/Metabolism 2968 mannosidase mannosidase mRNA, complete cds 2969 H3156A10 H3156A10 Apoptosis 2970 2971 H3156C03 “Mus musculus protein phosphatase 1D BG088678 Mm.61848 Signal Transduction 2972 magnesium-dependent, delta isoform (Ppm1d), mRNA” 2973 H3156C05 cDNA DKFZp586F2224 (from clone Homo sapiens mRNA; cDNA BG076153 Mm.28030 Energy/Metabolism 2974 DKFZp586F2224) DKFZp586F2224 (from clone DKFZp586F2224) 2975 H3156C08 “Mus musculus metaxin (Mtx), mRNA” BG076156 Mm.22508 Heat Shock/Stress 2976 2977 H3156H04 H3156H04 Energy/Metabolism 2978 2979 H3157B03 catalase 1 (Cas1), Mus musculus putative phosphatase BG076224 Mm.1458 Energy/Metabolism 2980 (Pps), mRNA 2981 H3157B10 “Mus musculus heat shock protein, BG088755 Mm.27897 Heat Shock/Stress 2982 DNAJ-like 2 (Hsj2), mRNA” 2983 H3157C04 caspase 6 (Casp6), Mus musculus catalase 1 (Cas1), mRNA BG076235 Mm.4215 Energy/Metabolism 2984 2985 H3157C09 M. musculus aspartate aminotransferase Mus musculus caspase 6 (Casp6), BG076240 Mm.28814 Apoptosis 2986 gene exon 10 and 3-flank mRNA 2987 H3157D01 M. musculus aspartate aminotransferase M. musculus aspartate aminotransferase BG076244 Mm.18916 Matrix/Structural 2988 gene exon 10 and 3-flank gene exon 10 and 3-flank Proteins 2989 H3157D12 microsomal glutathione S-transferase 3 Homo sapiens microsomal glutathione BG088778 Mm.29823 Energy/Metabolism 2990 (MGST3), S-transferase 3 (MGST3), mRNA 2991 H3157E04 “Mus musculus phosphatidylinositol 3- BG088781 Mm.41943 Signal Transduction 2992 kinase, catalytic, alpha polypeptide (Pik3ca), mRNA” 2993 H3157E05 solute carrier family 30 (zinc Mus musculus solute carrier family 30 BG076257 Mm.27801 Energy/Metabolism 2994 transporter), member 4 (Slc30a4), (zinc transporter), member 4 (Slc30a4), mRNA 2995 H3157H01 sterol O-acyltransferase 1 (Soat1), Mus musculus sterol O-acyltransferase 1 BG088808 Mm.28099 Matrix/Structural 2996 (Soat1), mRNA Proteins 2997 H3158B04 ornithine decarboxylase antizyme Mus musculus ornithine decarboxylase BG088828 Mm.6775 Energy/Metabolism 2998 inhibitor (Oazi), antizyme inhibitor (Oazi), mRNA 2999 H3158C04 Mus musculus maternal embryonic BG076315 Mm.1178 Matrix/Structural 3000 message 3 (Mem3), mRNA Proteins 3001 H3158C07 Heat Shock/Stress 3002 3003 H3158E03 methylenetetrahydrofolate Mus musculus BG076333 Mm.443 Energy/Metabolism 3004 dehydrogenase (NAD+ dependent), methylenetetrahydrofolate methenyltetrahydrofolate dehydrogenase (NAD+ dependent), cyclohydrolase (Mthfd2), methenyltetrahydrofolate cyclohydrolase (Mthfd2), mRNA 3005 H3158F09 cDNA: FLJ22903 fis, clone KAT05624 Homo sapiens cDNA: FLJ22903 fis, BG088873 Mm.20841 Energy/Metabolism 3006 clone KAT05624 3007 H3158F10 “Mus musculus Ccth gene for BG076350 Mm.28037 Heat Shock/Stress 3008 chaperonin containing TCP-1 eta subunit, complete cds” 3009 H3158G12 “Mus musculus metallothionein-like 5, BG076362 Mm.56287 Heat Shock/Stress 3010 testis-specific (tesmin) (Mtl5), mRNA” 3011 H3158H01 “Mus musculus protein phosphatase 5 BG076363 Mm.3294 Signal Transduction 3012 (PP5) mRNA, complete cds” 3013 H3159A03 Mm.10331 Mm.10331 Apoptosis 3014 3015 H3159C05 “Mus musculus Rab3D (rab3d) gene, BG076387 Mm.29968 Signal Transduction 3016 complete cds” 3017 H3159D05 “Homo sapiens phosphorylase kinase, BG088924 Mm.28827 Signal Transduction 3018 beta (PHKB), mRNA” 3019 H3159F12 “Mus musculus phosphofructokinase-1 BG088948 Mm.26550 Signal Transduction 3020 A isozyme (Pfka) mRNA, complete cds” 3021 H3159G05 glutathione S-transferase, mu 2 (Gstm2), Mus musculus glutathione S-transferase, BG088952 Mm.14601 Energy/Metabolism 3022 mu 2 (Gstm2), mRNA 3023 P1G4 Ant 1 3024 mFRDA Frataxin NM_008044 Energy/Metabolism 3025 mSOD2 Mn SOD (SOD2) NM_013671 Energy/Metabolism 3026 P1G9 mtDNA-12s rRNA 3027 P1G10 mtDNA-16s rRNA 3028 P1H10 mtDNA-ATPase 6 3029 P1H11 mtDNA-ATPase 8 3030 P1G11 mtDNA-COX 1 3031 P1G12 mtDNA-COX 2 3032 P1H1 mtDNA-COX 3 3033 P1H9 mtDNA-Cyt b 3034 P1H2 mtDNA-NADH 1 3035 P1H3 mtDNA-NADH 2 3036 P1H4 mtDNA-NADH 3 3037 P1H5 mtDNA-NADH 4 3038 P1H6 mtDNA-NADH 4L 3039 P1H7 mtDNA-NADH 5 3040 P1H8 mtDNA-NADH 6

TABLE 5 IMAGE Clone Res. Num Gene Genbank Acc. # ID Unigene Cluster Gen.Clone 1 mtDNA-12s rRNA V00711 In House-Clone 2 mtDNA-16s rRNA V00711 In House-Clone 3 mtDNA-ATPase 6 V00711 In House-Clone 4 mtDNA-ATPase 8 V00711 In House-Clone 5 mtDNA-COX 1 V00711 In House-Clone 6 mtDNA-COX 2 V00711 In House-Clone 7 mtDNA-COX 3 V00711 In House-Clone 8 mtDNA-Cyt b V00711 In House-Clone 9 mtDNA-NADH 1 V00711 In House-Clone 10 mtDNA-NADH 2 V00711 In House-Clone 11 mtDNA-NADH 3 V00711 In House-Clone 12 mtDNA-NADH 4 V00711 In House-Clone 13 mtDNA-NADH 4L V00711 In House-Clone 14 mtDNA-NADH 5 V00711 In House-Clone 15 mtDNA-NADH 6 V00711 In House-Clone 16 2′-5′)oligoadenylate synthetase 1 X04958, AI449562 Mm.14301 577664 M33863 17 14-3-3 protein beta AF058797.1 AA624796 Mm.34454 1039350 18 14-3-3 protein epsilon D87663.1 AA240827 Mm.678 670982 19 14-3-3 protein eta U57311 AI325059 Mm.3308 558536 20 14-3-3 protein gamma AF058799 Mm.10802 464892 21 14-3-3 protein theta (tau) U57312 AA422980 Mm.14722 803843 22 14-3-3 protein zeta U79231 AA671451 Mm.3360 1039129 23 25-hydroxyvitamin D3 24-hydroxylase D49438 AA240836 Mm.6575 657172 precursor 24 25-hydroxyvitamin D3 24-hydroxylase D49438 AI226268 Mm.6575 658678 precursor 25 2-amino-3ketobutyrate-coenzyme A ligase AF093403 AI037094 Mm.18618 315143 26 2-oxoglutarate dehydrogenase E1 U02971 W98443 424460 component 27 3,2-trans-enoyl-CoA isom, mito precursor Z14049 AI194961 1886651 28 38g cent. In House-Clone 29 3-beta hydroxy-5-ene steroid M27137 AA274685 766591 dehydrogenase type I 30 3-beta hydroxy-5-ene steroid M75886 AI266804 Mm.30433 1891212 dehydrogenase type II 31 3-beta hydroxy-5-ene steroid M77015 AA209060 Mm.335 676577 dehydrogenase type III 32 3-methyl-2-oxobutanoate dehydrogenase L16992 Mm.12819 422840 (lipoamide) 33 41.2a cent. In House-Clone 34 44b cent. In House-Clone 35 45.2b cent. In House-Clone 36 55e cent. In House-Clone 37 5-aminolevulinate synthase precursor M15268 AA189529 Mm.1217 635215 (EST) 38 65c cent. In House-Clone 39 66a cent. In House-Clone 40 67 cent. In House-Clone 41 a-amylase V00719 AI325237 Mm.7074 608852 42 acatyl-CoA acetyltransferase 1 L42293 Mm.28099 472233 43 acatyl-CoA acetyltransferase 2 AF078751 AA239043 694062 44 Aconitase (iron responsive element) X61147 AA212704 677092 45 Aconitase (iron responsive element) X61147 AA238899 697949 46 Acyl-CoA dehyd, med-chain specific U07159 AA104184 Mm.10530 568149 precursor (MCAD) 47 Acyl-CoA dehyd, short-chain specific L11163 AI050239 Mm.18759 1379035 precursor 48 Acyl-CoA dehyd, very-long-chain specific U41497 AA250410 Mm.18630 670916 precursor 49 Acyl-CoA dehydrog, long-chain spec. U21489 AA254905 Mm.2445 719580 precursor (LCAD) 50 adapt In House-Clone 51 Adenine nucleotide translocator 2, AA033138.1 465520 fibroblast (Ant2) 52 adenylate kinase isoenzyme 2 (EST) AI155541 AA061587 Mm.29460 483322 53 Adenylosuccinate synthase AA388461 749837 54 adenylyl cyclase type VII U12919 W65619 387280 55 ADP, ATP carrier protein, fibroblast U27316 Mm.658 585992 isoform 2 (ant2) 56 ADP, ATP carrier protein, heart isoform T1 U27315 AA717872 Mm.16228 1152250 57 adrenodoxin precursor L29123 AA461849 Mm.1061 851558 58 Alcohol dehydrogenase 5 AA183192 636207 59 Alcohol dehydrogenase I AA221141 695105 60 Aldehyde dehydrogenase U07235 AA122975 579570 61 aldehyde dehydrogenase (NAD+) 2 U07235 AI503977 Mm.2621 1001020 precursor 62 Alpha-1 protease inhibitor U38477 AA212578 Mm.16672 676745 63 Ant 1 In House-Clone 64 Antioxidant protein 1 M28723 W91307 423832 65 Antioxidant protein 1 M28723 Mm.29821 599017 66 Antioxidant protein-2 (AO2) AA243957 Mm6587 694088 67 Apoptosis inhibitor 2 AA144490 597715 68 Apoptosis inhibitor 3 AA097958 550702 69 apoptosis regulator BAX, membrane L22472 AI323521 Mm19904 557643 isoform alpha 70 Apoptosis-inducing factor AF100927 AA866777 1434491 71 ASC In House-Clone 72 ATP synth lipid-binding protein P1 L19737 AI481739 Mm.258 888863 precursor (subunit 9) 73 ATP synthase A Channel AA106406 AA106406 Mm.5293 519329 74 ATP synthase F0 component L19737 AA139793 580898 75 ATP synthase F0 component AA269701 735887 76 ATP/GTP binding protein AA184876 642977 77 ATPase, Ca++ transporting, cardiac W34420.1 318735 muscle, fast twitch 1 78 ATPase, Ca2+ transporting, heart W34420 318735 79 ATPase-like vacule proton channel AA276030 776055 80 ATP-binding cassette transporter 7 U43892 AU019072 Mm.4739 1920872 81 Bcl-2 protein U10102 AA051441 478723 82 Branched chain alpha ketoacid dehydrog. Mm.8903 578018 Kinase 83 branched chain alpha-ketoacid dehyd chain L47335 Mm.25848 314098 E1-alpha 84 Branched-chain a-ketoacid dehydrog. E1b AA050586 476163 85 Branched-chain amino transferase I AA003372 426976 86 BZP In House-Clone 87 C II 3 In House-Clone 88 C IV is In House-Clone 89 Calcium channel, voltage-dependent, L AA511037.1 890932 type, alpha 2 delta subunit 90 calm 1 In House-Clone 91 Calmodulin 3 AA109041.1 571789 92 carbonate dehydratase, hepatic X51971 AI256540 Mm.35538 1889415 93 Carbonic Anhydrase IV U37091 AA71129 Mm.1614 1167078 94 carbonyl reductase (NADPH) - mouse X07411, W11423 Mm.21454 317572 D26123 95 carnitine O-acetyltransferase (carnitine X85983 AI528757 Mm.20396 602213 acetylase) 96 carnitine O-palmitoyltransferase II U01163 Mm.29499 580316 precursor 97 Carnitine palmitoyltransferase 2 Mm.29499 580316 98 Caspase 2 AA200808 639403 99 Caspase I AA098139 550766 100 Catalase AA239490 Mm 4215 678773 101 CCAAT/enhancer binding protein AA271223.1 738252 C/EBP), alpha 102 CEBP In House-Clone 103 Cellular apoptosis succep. Protein AA471761 874148 104 chaperonin-10 U09659 Mm.12970 422572 105 CI 18K In House-Clone 106 CI B8 In House-Clone 107 col 1 In House-Clone 108 col 3 In House-Clone 109 coproporphyrinogen III oxidase precursor D16333 W71884 Mm.35820 390487 110 coproporphyrinogen oxidase D16333 AA108600 570602 111 coproporphyrinogen oxidase D16333 AA259342 734795 112 coproporphyrinogen oxidase D16333 W53951 367358 113 Core binding factor beta AA146442.1 596552 114 creatine kinase Z13968, AA690010 Mm.970 1167886 Z13969 115 Creatine Kinase, muscle X03233 AA166212 Mm.2375 608246 116 Creatine kinase-complete M74149 AA270310 Mm.16831 736251 117 Creatine kinase-mitochondrial Z13968 AI528837 Mm.970 607301 118 cyt C oxydase polypeptide VIIa- X58486 AA960158 Mm.2151 1248366 liver/heart precursor 119 cyto C oxydase polypeptide VIa-heart U08439 AA415934 Mm.21050 846138 precursor 120 cyto C oxydase polypeptide VIa-liver L06465 Mm.19094 533628 precursor 121 cytochrome c oxidase chain IV precursor X54691, AA260009 Mm.2136 746546 M37829 122 cytochrome c oxidase chain Va precursor X15963 AI131665 Mm.360 1884978 123 cytochrome c oxidase chain Vb precursor X53157 AI035302 Mm.16769 1432845 124 cytochrome c oxidase chain VIb NM_001863 AI503861 991287 (HUMAN) 125 cytochrome c oxidase chain VIc M20153 AA062417 516889 126 cytochrome c oxidase chain VIIc X52940 AA031250 Mm.14831 464966 127 cytochrome c oxidase chain VIII U37721 Mm.14022 481408 128 Cytochrome C oxidase sub VII AA050684 476180 129 cytochrome C oxydase polypeptide VIII-H U15541 AI323348 Mm.3841 463967 precursor 130 cytochrome C, somatic X01756 AA221965 Mm.35389 658678 131 cytochrome C-type heme lyase (CCHL) U36778 Mm.3988 400735 132 cytochrome-b5 reductase (HUMAN) NM_000398 AA816039 1120651 133 CYTOSOLIC BRANCH CHAIN AA286063 776036 AMINOTRANSFERASE 134 DD 43 In House-Clone 135 DD 47 In House-Clone 136 DD 48 In House-Clone 137 DD 53 In House-Clone 138 DD 64 In House-Clone 139 DD 68 In House-Clone 140 DD 69 In House-Clone 141 DD 73 In House-Clone 142 DD 83 In House-Clone 143 DD 84 In House-Clone 144 DD10a In House-Clone 145 DD11b In House-Clone 146 DD14 In House-Clone 147 DD15c In House-Clone 148 DD16c In House-Clone 149 DD17c In House-Clone 150 DD19a In House-Clone 151 DD23ba In House-Clone 152 DD24d In House-Clone 153 DD25c In House-Clone 154 DD26f In House-Clone 155 DD2a In House-Clone 156 DD33a/pgf In House-Clone 157 DD39 In House-Clone 158 DD4c In House-Clone 159 DD7a In House-Clone 160 defender against cell death 1 AA033006 464622 161 DiGeorge syndrome chromosome region 6 W54234.1 356181 162 dihydrolipoamide dehydrogenase (E3) J03490 AA548170 Hs.74635 994825 (HUMAN) 163 dihydrolipoamide transacylase precursor L42996 AA254971 Mm.3636 719973 164 Dimethyl glycine dehydrogenase AA288418 748958 165 DNA polymerase gamma U53584 Mm.3616 575332 166 Dynamin AA266438 317587 167 Dynamin 2 W13111 457445 168 E1B 19k/Bcls-binding prot. Homolog AA105295 571367 (NIP3) 169 ER V In House-Clone 170 ERV-1 U40494 AI413376 Mm.28124 367232 171 EST highly similar to S-100 prot a-chain AA466432 872869 172 ESTs AA253853.1 660997 173 ESTs AA268402.1 721970 174 ESTs W14142.1 329863 175 ESTs, Highly similar to CREATINE AA038095.1 472860 KINASE, SARCOMERIC MITO. PRECUR. 176 ESTs, Highly similar to CREATINE AI322288.1 336085 KINASE, SARCOMERIC MITO. PRECUR. 177 ESTs, Highly similar to W13931.1 330218 DERMATOPONTIN [Bos taurus] 178 ESTs, Highly similar to MATERNAL AA104976.1 533314 EFFECT PROTEIN STAUFEN 179 ESTs, Highly similar to NADH- AA288040.1 748891 UBIQUINONE OXIDOREDUCTASE 13 KD-B SUB 180 ESTs, Highly similar to NADH- AA222463.1 671212 UBIQUINONE OXIDOREDUCTASE SGDH SUB PREC. 181 ESTs, Highly similar to NUCLEAR AA060802.1 482952 FACTOR NF-KAPPA-B P100 SUBUNIT 182 ESTs, Highly similar to PINCH AA289280.1 790449 PROTEIN 183 ESTs, Highly similar to PTERIN-4- W14332.1 331681 ALPHA-CARBINOLAMINE DEHYDRATASE 184 ESTs, Highly similar to PUTATIVE W66757.1 387449 REGULATORY PROTEIN TSC-22 185 ESTs, Highly similar to SUCCINATE AA108475.1 572339 DEHYDROGENASE 186 ESTs, Highly similar to (define not AA190123.1 642467 available 4588044) 187 ESTs, Highly similar to putative AA184876.1 642977 ATP/GTP-binding protein 188 ESTs, Weakly similar to (define not AA467585.1 833160 available 3668141) [H. sapiens] 189 ESTs, Weakly similar to survival motor AA538419.1 932748 neuron [M. musculus] 190 ESTs, Weakly similar to vesicle membrane AA259674.1 735186 protein 191 Excitatory amino acid transporter 3 D43797 AA065502 Mm.24741 524046 192 ferredoxin--NADP+ reductase precursor D49920 AA879949 Mm.4719 1230740 193 ferrochelatase precursor M59288 Mm.1070 635652 194 Friedreich ataxia S75712 AA930748 1150363 195 Fructose 1-6 bis-phosphate D42083 AI385602 Mm.2974 336727 196 Fructose bis-phosphate aldolase W53351 AI553136 Mm.7729 902910 197 Fructose Bisphosphate aldolase A Y00516 AA518639 903419 198 Fuzzy onion homolog (mouse) AA674474 1093002 199 GAMMA-ADAPTIN AA238435.1 693837 200 GAPD In House-Clone 201 GILZ In House-Clone 202 Gluamate receptor, ionotropic, kainate 5 AA261334 Mm.2879 733368 (gamma 2) 203 Gluamate receptor, ionotropic, NMDA1 W44130 Mm.3292 354244 (Zeta 1) 204 Gluamate receptor, ionotropic, NMDA2C AI256808 Mm.39090 1852361 epsilon 3) 205 Glucose dependent insulinotropic U34295 AA871367 Mm.5115 1096156 polypeptide 206 Glucose Phospahate Isomerase I complex M14220 AA276216 776210 207 Glucose Phospahate Isomerase I complex M14220 W29397 337413 208 Glucose-6-phosphate isomerase L09104 AI327180 Mm.589 437357 209 glutamate dehydrogenase (NAD(P)+) X57024 AA543797 Mm.10600 949005 precursor 210 glutamate oxaloacetate transaminase-2 X06917, Mm.18916 617490 J02622 211 Glutaryl-CoA dehydrogenase precursor U18992 Mm.2475 573351 (GCD) 212 Glutathione peroxidase-3 (plasma Gpx) U13705 AA097557 Mm7156 552393 213 Glutathione peroxidase-4 (phospholipid AA034666 Mm2400 466963 Gpx) 214 Glutathione peroxidase-heart isoform AF045769.1 AI327053 Mm.2400 420345 (Gpx4) 215 Glutathione peroxidase-plasma isoform U13705.1 AI042912 Mm.7156 1432410 216 Glyceraldehyde 3-phosphate AA122891 579715 dehydrogenase 217 Glycerol 3-phosphate acyltransferase M77003 AA209041 676437 218 Glycerophosphate dehydrogenase M13366 AI414023 Mm.10669 303389 219 Glycogen Phosphorylase (RAT) J03080 AA240684 656882 220 GP4 In House-Clone 221 Gpx In House-Clone 222 GTP2 In House-Clone 223 GTP-binding protein AA509565 890444 224 H+-transporting ATP synthase chain alpha L01062 AI573940 Mm.4069 1920315 225 H+-transporting ATP synthase chain beta AF030559 AI452208 Mm.17869 576006 226 H+-transporting ATP synthase chain delta AA940343 AA896697 Mm.22514 1279053 (EST) 227 H+-transporting ATP synthase chain e U59283 AI115240 1885128 228 H+-transporting ATP synthase chain e U59283 M481625 876416 229 H+-transporting ATP synthase chain U43893 AA210528 640931 gamma 230 heat shock protein 60 precursor X55023, AA154729 Mm.1777 540881 X53584 231 heat shock protein 70 precursor D11089 AI132204 Mm.2849 1481709 232 heat shock protein, 70 K (hsp68) M12573 AA647374 Mm.6388 1108306 (fragment) 233 Heat shock protein, 84 kDa 1 M18186 Mm.2180 538585 234 Hexokinase W11571 318642 235 Hexokinase W74835 389177 236 hexokinase I (3′-seq) J05277 AI661880 Mm.5290 717383 237 hexokinase I (5′-seq) J05277 AA197916 Mm.5290 654873 238 high mobility group protein homolog AA048831.1 478865 HMG4 (Hmg4) mRNA, complete cds 239 HK-40s Ribosomal protein S15 AA033398 466295 240 HK-40s Ribosomal protein S4 AA000082 425352 241 HK-A111Acient ubiquinating protein W82989 405768 242 HK-A16060s Ribosomal protein L15 AA068842 532770 243 HK-A17360s Ribosomal protein L3 AA108363 570533 244 HK-A21060s Ribosomal protein L1A AA170607 619006 245 HK-A216RNA splicing protein AA183061 636766 246 HK-A262E2F transcription factor AA396123 751755 247 HK-A272Capping protein AA414612 779754 248 HK-A316Actin-gamma (smooth muscle) M26689 AA710883 Mm.16562 1166855 249 HK-A97Hypozanthine phosphoribosyl J00423 W48168 Mm.18675 355084 transferase 250 HK-Actin-alpha (skeletal muscle) M12347 AI035279 Mm.4581 1480709 251 HK-Actin-gamma M21495 AI314957 Mm.29913 192859 252 HK-Alkaline Phosphatase AA032457 465052 253 HK-b-actin X03672 AA079937 Mm.297 536615 254 HK-calcium binding protein Cab45 U45977 AI266799 Mm.30149 1891202 255 HK-DNA ligase I W66626 388245 256 HK-Glyceraldehyde 3-phosphate W14827 AA119563 Mm.5289 538210 dehydrogenase (G3PDH) 257 HK-Glyceraldehyde phosphate M32599 AA466618 Mm.5289 817984 dehydrogenase 258 HK-HPRT In House-Clone 259 HK-Hypozanthine phosphoribosyl J00423 AI256193 Mm.18675 1890233 transferase 260 HK-Murine ornithine decarboxylase M10624 AI325192 Mm.15259 608003 261 HK-Myosin 1 L00923 AI098184 Mm.3390 1481939 262 HK-Phospholipase A2 (14-3-3 zeta/delta) D78647 AA1714341 Mm.3360 617315 263 HK-Ribosomal Protein S29 L31609 AA032465 Mm.35816 465138 264 HK-Ubiquitin X51703 AI181949 Mm.235 1451597 265 House mouse; Musculus domesticus W82212.1 403728 mRNA for LN1, complete cds 266 Huntingtin AI876894 AI876894 — 1922060 267 hydroxymethylglutaryl-CoA lyase S65036 AA838929 1261134 268 hydroxymethylglutaryl-CoA synthase, U12790, Mm.10633 518481 mitochondrial U12791 269 IG ALPHA CHAIN C REGION AA098196.1 551003 270 IMAGE EST AA009059.1 441176 271 IMAGE EST AA028306 464099 272 IMAGE EST AA035899.1 468817 273 IMAGE EST AA051664.1 479709 274 IMAGE EST AA118290 574435 275 IMAGE EST AA200984.1 639212 276 IMAGE EST AA203878 640734 277 IMAGE EST AA215024 652207 278 IMAGE EST AA221250 670393 279 IMAGE EST AA245545 699280 280 IMAGE EST AA250652 697537 281 IMAGE EST AA266097.1 716941 282 IMAGE EST AA275684 775722 283 IMAGE EST AA388512 790857 284 IMAGE EST AA466026.1 809016 285 IMAGE EST AA519027.1 904900 286 IMAGE EST W08090.1 331768 287 IMAGE EST W09924 315773 288 IMAGE EST W09924.1 315773 289 IMAGE EST W15031 330502 290 IMAGE EST W41309.1 351420 291 IMAGE EST W89418.1 420553 292 IMAGE EST-CCAAT enhancer binding AA271223 738252 protein 293 IMAGE EST-Glucocorticoid-induced W66757 387449 leucine zipper GILZ protein 294 IMAGE EST-homolog of Unc33 W08090 331768 (C. Elegans)/Collaspin reponse mediated prot. 2 295 IMAGE EST-sarcoplasmic creatine kinase W18057 336085 296 IMAGE EST-Sim to gamma sarcoglycan W41309 351420 297 IMAGE EST-yeast bile transporter AA473289 803488 298 Interferon gamma receptor AA541842.1 920516 299 Interleukin 1 receptor-associated kinase AA276835.1 777580 300 isocitrate dehydrogenase (NADP) U51167 Mm.2966 571468 301 Kin 17 In House-Clone 302 Lactate Dehydrogenase- M27554 AA880398 1277670 303 Lactate Dehydrogenase-A4 M17516 AI506641 Mm.26504 1024774 304 Lactate Dehydrogenase-sperm specific M17587, AA110449 Mm.16563 516582 L10389 305 M. musculus mRNA for fibromodulin W63981.1 374228 306 M. musculus mRNA for GTP-binding AA020462.1 455401 protein 307 MAD homolog 4 (Drosophila) AA030901.1 466551 308 Malate dehydrogenase (cyto) W13686 318346 309 Malate dehydrogenase (mito) M16229 AA266087 717095 310 malate dehydrogenase precursor, X07295, Mm.21743 407143 mitochondrial M16229 311 MAP KINASE PHOSPHATASE-1 AA125367.1 575665 312 Maternal embryonic message 3 AA388122.1 775464 313 MCK In House-Clone 314 mDP 6 In House-Clone 315 metal response element DNA-binding AA545607.1 945218 protein M96 mRNA, complete cds 316 methylenetetrahydrofolate dehydrogenase J04627 Mm.443 440345 (NAD+) 317 methylmalonyl-CoA mutase alpha chain X51941 Mm.4299 571282 precursor 318 Microtubule-associated protein 4 AA003769.1 437523 319 Mito matrix prot P1 precursor (hsp60) AA184322 633625 320 Mitochondrial LON protease AA061310 AA061310 — 514859 321 mitochondrial transcription factor A - U57939 Mm.276 539693 mouse 322 mitochondrial uncoupling protein M21247 AI131780 Mm.4177 1498957 323 monoamine oxidase A - mouse S78615 AI643185 864614 324 Mouse breast heat shock 73 prot (hsc73) M19141 Mm.2944 538418 325 Mouse calcineurin catalytic subunit AA245461.1 699236 mRNA, complete cds 326 Mouse Circadian output locomotor cycles AF000998 AI156715 Mm.3552 1494023 kaput 327 Mouse heatshock protein 27 U03560.1 AA596241 Mm.13849 1052188 328 Mouse heatshock protein 86 J04633 AI649095 1970053 329 Mouse med. Chain acyl-CoA U07159 AA061679 483333 dehydrogenase 330 Mouse mHox protein L06502 W17990 Mm.3869 335936 331 Mouse Skd3 mRNA U09874 Mm.3990 602340 332 mRNA for sarco/endoplasmic reticulum AA222567.1 695695 Ca2+-ATPase (SERCA2) 333 mTF 1 In House-Clone 334 Mus musculus Balb/c zinc finger protein W11161.1 316427 PZF (Pzf) mRNA, complete cds 335 Mus musculus calcium-binding protein AA466432.1 872869 S100A1 mRNA, complete cds 336 Mus musculus cytoplasmic protein Ndr1 AA473269.1 803416 (Ndr1) mRNA, complete cds 337 Mus musculus FGF-binding protein (FGF- AA403432.1 717457 BP) mRNA, complete cds 338 Mus musculus GTP binding protein AA509565.1 890444 (GTP2) mRNA, complete cds 339 Mus musculus hemin-sensitive initiation AA036546.1 466971 factor 2 alpha kinase mRNA, complete cds 340 Mus musculus mRNA for glutamate AI043222 Mm.42021 1431493 receptor channel alpha 4 subunit 341 Mus musculus mRNA for GM3 synthase, AA274576.1 748275 complete cds 342 Mus musculus PAF acetylhydrolase AI324436.1 536464 mRNA, complete cds 343 Mus musculus pantophysin gene, complete AA271505.1 737944 cds 344 Mus musculus rab6/rab5-associated W77711.1 401958 protein (rab6) mRNA, partial cds 345 Mus musculus skeletal muscle LIM AA047966.1 477066 protein (FLH1) mRNA, complete cds 346 Mus musculus Stra13 mRNA, complete AA064241.1 480896 cds 347 mWS3 In House-Clone 348 Myeloid cell leukemia sequence 1 U35623, AA387843 Mm.1639 761106 AF063886 349 Myostatin AA052179.1 418993 350 NAD(P)+ transhydrogenase (B-specific) Z49204 AI323702 Mm.3842 580717 precursor 351 NADH dehydrogenase mwfe W83104 404499 352 NADH-ubiquinone oxidoreductase 13 kDa L38438 AA397301 599804 subunit 353 NADH-ubiquinone oxidoreductase 13 kDa U59509 AA035972 468848 subunit 354 NADP transhydrogenase Z49204 AI323702 Mm.3842 580717 355 Nitric Oxide Synthase-2 AA512708 Mm2893 922250 356 Nitric Oxide Synthase-3 AA177240 Mm12837 620940 357 Nuclear respiratory factor-1 AF098077 AI594316 1006311 358 Nuclear respiratory factor-2 U20532 Mm.1025 635541 359 ornithine carbamoyltransferase precursor X07092 AI266937 Mm.2611 1891345 360 ornithine-oxo-acid transaminase precursor X64837 AI196410 Mm.13694 1887672 361 p63a In House-Clone 362 PACD In House-Clone 363 PEBP2 In House-Clone 364 Peripheral myelin protein, 22 kDa AA416246.1 846064 365 peripheral-type benzodiazepine receptor 1 U12419 AA068577 524463 366 Perox. Proliferator receptor (PPAR) U01841 W34083 Mm.3020 317536 Gamma 367 Peroxisomal/Mitochondrial dienoyl-CoA W29607 338088 isomerase 368 Phosphofructokinase 1 J03928, AI480449 Mm.1166 862787 AF123533 369 phospholipase A2, platelet, synovial fluid X74266 AA871547 Mm.4675 1096251 370 phosphoprotein phosphatase M81475 AI449151 Mm.1567 619279 371 PMP 35 L27842 AI573377 Mm.16453 534171 372 probable aconitate hydratase, AI385870 AA275929 Mm.30065 775753 mitochondrial (EST) 373 Procollagen Type 1 AA073604 536306 374 Procollagen, type I, alpha 1 AA073604.1 536306 375 Procollagen, type III, alpha 1 W89883.1 420322 376 Procollagen, type VI, alpha 1 W33786.1 352450 377 Protein Phosphatase inhibitor 2 (IPP2) AA041826 AA041826 Mm.29617 475407 378 protoporphyrinogen oxidase U25114, Mm.4730 482868 D45185 379 pyruvate carboxylase L09192 AI303529 Mm.1845 1888741 380 Pyruvate decarboxylase AA308254 473778 381 Pyruvate dehydrogenase M76727 AA423301 820409 382 pyruvate dehydrogenase (lipoamide) M76728 AI323722 Mm.4223 513684 383 pyruvate dehydrogenase (lipoamide) M76727 AA466268 Mm.34775 888842 384 Pyruvate dehydrogenase E1 a subunit L13318 AA238899 888842 (human) 385 pyruvate kinase D38379 AI035313 Mm.2635 1432851 386 Pyruvate kinase D63764 AI195164 Mm.8359 1886895 387 Pyruvate kinase AA475121 873690 388 Pyruvate kinase-like protein W17814 334876 389 RAB1 In House-Clone 390 RAB1, member RAS oncogene family AA175510.1 619501 391 Rat NRBF1 AA259674 735186 392 Rnase P-complex (RS Williams work) U31228 AI614577 523232 393 S100 In House-Clone 394 sarc. In House-Clone 395 Sim to 6-Phosphofructo-2-kinase (human) M19938 AA397024 693346 396 Sim to acetyl CoA acetyl transferase (hum) D90228 AA272067 761668 397 Sim to acetyl Coenzyme A synthetase AA109675 570550 398 Sim to acetyl Coenzyme A synthetase AA537637 949423 399 Sim to a-ketoglutarate (hum) D10523 W13320 329728 400 Sim to Aldehyde dehydrogense (HUM) Mm.24457 423605 401 Sim to arginyl-tRNA synthetase (Sac Cer) Mm.22363 576572 402 Sim to ATP synthase epsilon (Bov) AA108733 571214 403 Sim to ATP synthase F chain PIR: A54211 W82194 403660 404 Sim to ATP synthase lipid binding (Hum) X69908 AA239148 698109 405 Sim to b-enolase (human) X56832 W11965 316967 406 Sim to branched-chain a-ketoacid TR: G924921 AA059497 480575 dehydrogenase kinase 407 Sim to carbon catabolite repressor prot. AA051133 438774 (Sac) 408 Sim to carbon catabolite repressor prot. AA404014 717197 (Sac) 409 Sim to carnitine/acylcarnitine carrier AA245413 699181 410 Sim to citrate synthase (Por) W14146 329884 411 Sim to cytochrome b5 (outer mito mem) AA203975 640762 412 Sim to cytochrome c oxidase VI B (Hum) X13923 AA139624 581175 413 Sim to cytochrome c oxidase VII X80899 AA050684 476180 414 Sim to electron trans flavoprotein a sub J04058 AA060723 481934 (Hum) 415 Sim to electron trans flavoprotein b sub X71129 W18161 333641 (Hum) 416 Sim to enolase a subunit (Hum) M14328 AA204262 643854 417 Sim to Fructose 1-6-bisphosphate (Hum) L10320 AA276043 776124 418 Sim to glucose dehydrogenase (Bac. Sub) AA241896 680935 419 Sim to Glutamate/Malate trans (BOV) Mm.28466 582075 420 Sim to Glutathione-S-transferase (RAT) Mm.27395 317849 421 Sim to glycerol 3-phosphate W41175 351221 dehydrogenase 1 (rat) 422 Sim to glycogen phosphorylase (Hum) J03544 W16286 334236 423 Sim to hepatocyte gluc transporter AA002666 426758 424 Sim to mito RNA pol (HUM) AI892781 Mm.34645 608625 425 Sim to Mito. 2-oxoglutarate/malate carrier X66114 W54000 367801 (Human) 426 Sim to mito. Elongation factor TS (Bov) AA245481 699237 427 Sim to NADH-ubiquin. oxidoreduct. 13 kd AA288040 748891 sub. 428 Sim to NADH-ubiquin. oxidoreduct. 49 kd AA109715 572585 sub. 429 Sim to NADH-ubiquin. oxidoreduct. 9 kd AA521758 903911 sub. 430 Sim to NADH-ubiquin. oxidoreduct. ashl. W83085 404593 431 Sim to NADH-ubiquin. oxidoreduct. b14 AA462323 871020 sub. 432 Sim to NADH-ubiquin. oxidoreduct. W54068 367925 B14.5 sub. 433 Sim to NADH-ubiquin. oxidoreduct. b15 AA434897 818906 sub.

idoreduct. b17 W54448 367651

idoreduct. b22 AA415725 846155

idoreduct. b9 W83574 406509

idoreduct. Kfy1 W97248 423071

idoreduct. mn11 AA267638 723360

idoreduct. sgdh AA222463 671212

idoreduct. 15 kd AA014507 439668

somal prot. S14 W89487 419614

ctase AA241313 653324

ctase AA259674 735186

hyltransferase, AA208877 676311

se Mm.26793 578465

enase M32246 AA108475 572339

W11644 318134

r mito. mem. Q01852 AA498767 888708

uctase AA087137 493604

uctase, core prot. AA108590 572127

drogenase AA067191 523796

hate uridyltrans TR: G881394 AA473123 805218

at synaptic AA220458 695279

In House-Clone

L1)/RPB- AA047966 477066

In House-Clone

In House-Clone

X15684 AA275871 776543

ein M88463 AA497767 917403

le selenoprotein S49657, AI482284 Mm.554 917537 M29603

tein precursor, L36062 AA389406 Mm.3436 569013

cursor M62361 Mm.1779 580813

Cyt B560 TR: G1019861 AA137762 580040

) precursor Z18857, AA415267 Mm.2597 791140 L35525

u/Zn Sod) AA039044 Mm5274 474545

xtracellular AI314465 Mm2407 1907770

evisiae) AI323032.1 477535

AA220458.1 695279 469 Surfeit locus protein 1 M14689 AA274488 Mm.6874 748268 470 tetrahydrofolylpolyglutamate synthase U32197 AA030778 Mm.3830 463571 precursor 471 Thioredoxin AA242573 681159 472 Thioredoxin Mm.3533 579774 473 Thioredoxin Reductase AI529082 Mm 25543 1887250 474 thiosulfate sulfurtransferase U35741 AI196763 Mm.15312 1887427 475 Thiosulfate sulfurtransferase (mito) Tst1 U35741 AI195057 Mm.15312 188763 476 TIMP2 In House-Clone 477 Tissue inhibitor of metalloproteinase 2 AA444490.1 831964 478 Tissue inhibitor of metalloproteinase 2 AA518165.1 902923 479 TOAD In House-Clone 480 transforming protein bcl-2-alpha L31532 AA867214 Mm.5155 1265430 481 transforming protein bcl-2-beta M16506 AA867214 1265430 482 transforming protein bcl-w (3′ seq) AF030769.1 AA563148 975210 483 transforming protein bcl-w (5′-seq) AF030769.1 AA667328 1139352 484 Transketolase (Tkt) U05809 AI132421 Mm.9307 1481358 485 Type II Peroxiredoxin 1 W83228 Mm42948 405943 486 Uncoupling Prot homology (UCPH) AA260521 748122 487 Uncoupling Protein 2 Mm.12556 423616 488 Uncoupling protein 3 AA062091 482847 489 Unknown EST 608265 490 uracil-DNA glycosylase U55040 W48179 355462 491 voltage-dependent anion channel 1 U230840 AA244874 680076 492 voltage-dependent anion channel 2 U30838 AI507203 Mm.569 931442 493 voltage-dependent anion channel 3 U30839 AA616007 Mm.38513 1066900

Example 3

Identification of Mutations Causing Disease

The mitochondrial respiratory complex I is assembled from seven mtDNA genes and thirty-six nDNA genes. Patients with complex I defects have phenotypes ranging from midlife-onset optic atrophy to lethal childhood Leigh's disease. Mitochondrial biology expression profiles were determined for patients with a variety of complex I defects. Samples are collected from a variety of patients with complex I defects. Each sample is reverse transcribed, labeled, and hybridized, together with standard target, to a human array comprising probes selected from Example 1. The hybridization measurements are analyzed, leading to the identification of several novel mtDNA mutations and dominant and recessive nDNA mutations.

Example 4

Profile for Complex IV Leigh's Syndrome

The mitochondrial biology expression profile was determined for a complex IV Leigh's syndrome (LS) patient. LS is a subacute neurodegenerative condition characterized by necrotic lesions in the brain stem, basal ganglia, thalamus and spinal cord. Death is usually within 2 years of onset of symptoms that may include motor and/or intellectual retardation, abnormal breathing rhythm, nystagmus, opthalmoparesis, optic atrophy, ataxia, and dystonia. The Leigh's syndrome patient had a typical complex IV cytochrome c oxidase deficiency associated with surfeit 1 (SURF-1) gene mutations. This patient was from a consanguineous marriage and was homozygous for a nonsense mutation in the SURF-I gene. Expression profiling of muscle and cultured cell samples from this patient using a human array of Example 1 was performed, in comparison to a control reference standard. NDUFS8 expression was not significantly altered. However, many nuclear and mitochondrially encoded complex I genes were down-regulated, including mtDNA transcripts ND4, NDLA, and ND6. Nuclear genes SURF-1, SOD2, 70 kD heat shock protein, voltage dependent anion channel (VDAC4), adenine nucleotide translocase 2 (ANT2), and glutathione peroxidase 3 were down-regulated.

Example 5

Profile for Complex I Leigh's Syndrome

Mitochondrial biology expression profiles were determined for twelve complex I Leigh's syndrome patients (Procaccio, VF (2001) EuroMit5 Abstract). Sequencing of all 43 genes known to be part of complex I, of each patient, identified one patient as a compound heterozygote for two missense mutations in the 23 kD NADH dehydrogenase (NDUFS8) gene of complex I. This patient had a respiratory complex I defect apparent in skeletal muscle and cultured lymphoblastoid cells. Samples were collected from cultured lymphoblastoid cells from this patient and control reference lymphoblastoid cells. Samples were reverse transcribed and differentially labeled and hybridized to a human array comprising probes selected from Example 1. The expression profile was determined using a hierarchical clustering method. Mitochondrial biology expression profiles from the other patients were similarly determined using appropriate samples and controls. Expression profiles of all patients were characteristic of complex I deficiencies, including down-regulation of all mtDNA and some nDNA complex I genes and up-regulation of the adenine nucleotide translocator genes (ANTI and ANT2).

Example 6

Diagiosis of Complex IV Leigh's Syndrome

The mitochondrial biology expression profile for Leigh's syndrome SURF-1 nonsense mutations, as determined in Example 4, is used to diagnose patients. Samples are collected from patients and mitochondrial biology expression microarray-tested using a human array containing probes for at least SURF-1, ND4, NDL4, ND6, SOD2, 70 kD heat shock protein, VDAC4, ANT2, and glutathione peroxidase 3.

Example 7

A Mouse MitoChip

A mouse Mitochip was printed with probes for 452 genes. Some of these genes were represented by two or more probes, providing internal controls for the reproducibility of gene expression quantitation. An additional 37 control spots were included on the array. Of these, 25 were probes for housekeeping genes to allow normalization between samples. The remaining 12 spots were various controls for hybridization and positioning. Table 2 lists the functional categories and number for all of the housekeeping genes on this array. The cDNA clones that represent each gene were either from the I.M.A.G.E. consortium or cloned by The Center for Molecular Medicine and published in (Murdock et al., 1999). A complete annotation of each gene was compiled and GenBank accession numbers and Unigene cluster numbers were determined. Table 5 provides a list of the probes on this array.

Example 8

Profile of Sod2 Heterozygote Mutant Mice at Various Ages

Oxidative stress has been implicated in aging and degenerative disease. Mitochondria are thought to be the main source of reactive oxygen species such as superoxide anion. Mitochondrial superoxide anion is normally detoxified by manganese superoxide dismustase (MnSOD, the Sod2 gene). However, when, free radical metabolism is perturbed, oxidative damage to protein, DNA, and lipids may occur. To demonstrate the effects of increased superoxide anion toxicity on mitochondrial physiology with age, the mitochondrial biology expression profiles of mice with a 50% reduction in MnSOD (Sod2 +/−) were determined at various ages. Samples were collected from young (5 months), middle-aged (10-14 months), and old (20-25 months) wild-type and Sod2 +/− mice. Samples were reverse transcribed and differentially labeled from the corresponding controls. The labeled mutant sample and the corresponding labeled control were hybridized with the mouse array of Example 2. Relative to the control mice, the old Sod2 +/− mice showed induction of antioxidant and apoptosis genes including glutathione peroxidase 3, apoptosis inhibitory factor 3, caspase 1, and the peripheral benzodiazepine receptor.

Example 9

Profile of Sod2 Homozygote Mutant Mice

Manganese superoxide dismutase (MnSOD, the Sod2 gene) is a gene expression product involved in mitochondrial biology. Sod2 −/− animals die soon after birth due to the superoxide inactivation of mitochondrial iron-sulfur center enzymes resulting in dilated cardiomyopathy. The mitochondrial biology expression profile of Sod2 −/− mice is determined using the mouse MitoChip of Example 2. RNA samples are collected from Sod2 −/− mice and Sod2 +/+ mice. The Sod2 −/− sample is reverse transcribed and labeled with Cy3 phosphoramidite. The Sod2 +/+ sample is reverse transcribed and labeled with Cy5 phosphoramidite. The labeled samples are incubated with a mouse array under conditions of high stringency hybridization. The hybridization of both samples is measured with a microarray reader. The hybridization measurements are recorded.

Example 10

Profile of GP×I Mutant Mice

Glutathione peroxidase 1 (GP×1) is an expressed sequence involved in mitochondrial biology. GP×1 −/− animals show mild growth inhibition and reduced OXPHOS efficiency. The mitochondrial biology expression profile of GP×1 −/− mice is determined using a mouse array of Example 2. RNA samples are collected from GP×1 −/− mice and GP×1 +/+ mice. The GP×1 −/− sample is reverse transcribed and labeled with Cy3 phosphoramidite. The GP×1 +/+ sample is reverse transcribed and labeled with Cy5 phosphoramidite. The labeled samples are incubated with a mouse array under conditions of high stringency hybridization. The hybridization of both samples is measured with a microarray reader. The hybridization measurements are recorded.

Example 11

Profile of Sod2 Heterozygote GP×1 Homozygote Doubly Mutant Mice

The mitochondrial biology expression profile of Sod2 −/+ plus GP×1 −/− mice is determined using a mouse array of Example 2. RNA samples are collected from Sod2 +plus GP×1 −/− mice and Sod2 +/+ plus GP×1 +/+ mice. The Sod2 −/+ plus GP×1 −/− sample is reverse transcribed and labeled with Cy3 phosphoramidite. The Sod2 +/+ plus GP×1 +/+ sample is reverse transcribed and labeled with CyS phosphoramidite. The labeled samples are incubated with a mouse array under conditions of high stringency hybridization. The hybridization of both samples is measured with a microarray reader. The hybridization measurements are recorded.

Example 12

Profile of Mutant Mice Overexpressing Sod2 and/or GP×1

The mitochondrial biology expression profiles are determined using a mouse array, for mice overexpressing MnSOD and for mice overexpressing MnSOD plus GP×1.

Example 13

Profile of ρ⁰ Mutant Cell Line

A mouse array of Example 2 was used to determine the mitochondrial biology expression profile of the mouse mutant cell line ρ⁰, the most extreme case of mitochondrial dysfunction. The LMEB4 (ρ⁰) cell line was profiled against its parental LM(TK)-cell line. The mouse mutant cell line ρ⁰ lacks mitochondrial DNA. To maintain the LMEB4 cell line in culture, it must be grown in media supplemented with glucose, pyruvate, and uridine (GUP media). A scatter plot of the gene expression ratios is shown in FIG. 3. Samples from the ρ⁰ cell line and from the LM(TK) cell line were reverse transcribed and differentially labeled using a standard two-color fluorescent system, and hybridized to a mouse array of Example 2. Mouse array analysis confirmed that all mtDNA-encoded transcripts were absent from the LMEB4 cells, and that there was a reduction in NDNA OXPHOS gene expression, aconitase, and nuclear receptor binding factor 1 (NRBF1). There was an increase in expression of key glycolytic genes, mitochondrial ribosomal proteins, the LON protease, heat shock protein 84 (HSP 84), Bcl-X binding protein, and antioxidant protein 1. Invariably, the nuclear-encoded OXPHOS complex subunits were also down-regulated between 3 and 38-fold with a mean of 4.5 (the mean was calculated excluding the single outlying complex I subunit NADH-dehydrogenase mwfe which was down-regulated 38-fold). Mitochondrial transport proteins such as the Glutamate-malate transporter were down-regulated as was the mitochondrial protein import subunit gene Tim17 and several amino acid metabolism genes. By contrast, glycolytic genes such as pyruvate kinase, glucose phosphate isomerase and glucose-6-phosphate dehydrogenase were up-regulated 2 to 3-fold. Phosphofructokinase was up 1.6-fold. Anti-apoptotic genes such as apoptosis inhibitor 2 and 3 were up-regulated as was the pro-apoptotic Bcl-Xs binding protein BNIP3 and Caspase 2. The other Bcl protein family members that are on the array were not changed significantly. The multi-function mitochondrial LON protease was up-regulated 2. 1-fold.

Example 14

Profile of CAP^(R) Mutant Cell Line

A mouse array of Example 2 was used to determine the mitochondrial biology expression profile of the mouse mutant cell line harboring a mutation for chloramphenicol resistance (CAP^(R)), and the CAP^(R) 501-1 cell line having a mtDNA mutation in the 16S rRNA gene. The CAP^(R) mutation in chimeric mice causes cataracts, reduced photoreceptor response, vacuolization of the retinal pigment epithelium, and hamartomatous outgrowths of the optic nerve head. Mice inheriting the CAP^(R) mutation showed a marked increase in embryonic lethality, and those that were born died within two weeks with growth retardation, dilated cardiomyopathy, and mitochondrial abnormalities. CAP^(R) 501-1 was compared to the CAPS LM(TK)-cell line. These two cell lines are both derived from mouse L929 cells. Samples from the CAP^(R) cell line and from wild-type cells were reverse transcribed and differentially labeled with a standard two-color fluorescent system, and hybridized to a mouse array of Example 2. The CAP^(R) cell line had up-regulation of all thirteen mtDNA transcripts, but down-regulation of multiple nDNA OXPHOS genes. The CAP^(R) 501-1 cell line versus the LM(TK)-gene expression scatter plot showed that all mtDNA transcripts were up-regulated 3.1 to 3.5-fold while the nuclear encoded OXPHOS subunits were down-regulated 2.1 to 5.3-fold. Procollagen type III and VI were also up-regulated 3.5 to 4-fold.

Example 15

Profile of Treatment to Cell Line

Mouse arrays of this invention were used to demonstrate how treatment changes, such as changing cell culture conditions, affect gene expression. The control cell line LM(TK)-grown in standard medium was profiled against a culture of LM(TK)-cells grown in media supplemented with glucose, pyruvate, and uridine (LM(TK)-(GUP)). Samples from the treated fibroblast cell line and from untreated fibroblast cells were reverse transcribed and differentially labeled with a standard two-color fluorescent system, and hybridized to a mouse array of Example 2. Treatment resulted in a down-regulation of the LON protease and HSP 84. The scatter plot of this experiment showed that other than the same core group of genes that were up-regulated in the NZB cell line mentioned in Example 17, few genes were significantly different in their expression. The hybridization spots of three genes that showed the highest differences were HSP70, the LON protease, and E.T.F. The 70 kDa heat shock protein (HSP70) was down-regulated 3.4-fold. HSP70 has been shown to be a chaperone protein involved in mitochondrial protein import that forms an ATP-dependent motor with the inner mitochondrial membrane translocase and the polypeptide in transit (Voos, W. et al., “Mechanisms of protein translocation into mitochondria,” [ 1999] Biochimica et Biophysica Acta 1422:235-54). The entire HSP70 control spot was of medium intensity, while the experimental spot was only medium intensity in the center. The LON protease was down-regulated 9.7 fold in LM(TK)-cells grown in GUP. The control LON protease spot was of medium high intensity over the entire spot and of low intensity in the experimental spot. The electron transfer flavoprotein (ETF), which shuttles electrons gathered during fatty acid metabolism to the electron transport chain, was down-regulated 3.8 fold. The E.T.F control spot was high intensity and the experimental spot very low intensity. Some of the nuclear encoded OXPHOS subunits as well as several proteins involved in amino acid metabolism were down-regulated 1.5 to 2-fold with mean ratio of 1.65. Since most of these genes fell below the +/−1.7 ratio cutoff, further analysis was needed to determine if the expression pattern was significant. There were no differences in mtDNA transcript levels and no consistent pattern of up-regulation of glycolytic genes.

Example 16

Profile of Sod2 Mutant Mice After Treatment and Before Symptoms

Treatment of Sod2 mutant mice with MnTBAP prevents cardiac and liver pathology, however after 12 days the MnTBAP-treated mutant animals develop a prominent movement disorder which leads to debilitation by three weeks, in association with spongiform changes and gliosis in the cortex and specific brain stem nuclei associated with motor function. It is thought that the severe neuropathology results from poor exchange of MnTBAP across the blood brain barrier. The mitochondrial biology expression profile of MnTBAP-untreated, Sod2 mutant mice and MnTBAP-treated, Sod2 mutant mice was determined using the mouse array of Example 2. Samples were collected from 8 day old Sod2 mice without MnTBAP treatment, 8 day old Sod2 mice with MnTBAP treatment, and 12 day old Sod2 mice with MnTBAP treatment. Samples were also collected from age-matched controls. About 20 genes were found to be differentially expressed in all three groups of Sod2 knockout mice compared to the corresponding age-matched controls. The about 20 genes included bioenergetic genes such as the mitochondrial creating phosphokinase, antioxidant enzymes like the glutathione peroxidase 3, and apoptotic factors including caspase I and apoptosis inhibitor factor 3. The excitatory amino acid transporter 3, fiataxin, and one EST of unknown function were also induced. Mitochondrial biology expression profiling demonstrated changes in expression before neuropathic changes were manifested.

Example 17

Organ-Specific Profiles of Mutant Mice

The NZB mouse line mtDNA and the “common haplotype” mtDNAs (129/Sv, C57B1/6J, C3H, BALB/c, and others which are thought to have arisen as the progeny of a single female (Ferris et al.,1982) differ by 108 nucleotides, and these polymorphic differences have been used to monitor the segregation of heteroplasmic populations of mtDNAs in mice created by embryo fusion techniques (Jenuth, J. P. et al., “Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA,” [1996] Nat Genet 14:146-51; Jenuth, J. P. et al., “Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice,” (1997) Nat Genet 16:93-5; Meirelles, F. V., and Smith, L. C., “Mitochondrial genotype segregation in a mouse heteroplasmic lineage produced by embryonic karyoplast transplantation,” (1997) Genetics 145:445-51; Meirelles, F. V. and Smith, L. C., “Mitochondrial genotype segregation during preimplantation development in mouse heteroplasmic embryos,” [1998] Genetics 148:877-83). Tissues from the NZB and CAP^(R) mice were profiled on a mouse array. Messenger RNA was isolated from the brain, liver, spleen, kidney, heart, and skeletal muscle of a male mouse heteroplasmic for the NZB mtDNA and a male mouse that was 80% chimeric for ES cell-derived CAP^(R) cells as defined by coat color. Due to the severity of the CAP^(R) mutation it was not possible to analyze the mitochondrial gene expression changes in mice that were homoplasmic for the CAP^(R) mtDNA. Control mRNA for each of the tissue samples was isolated from sex, age, and nuclear background-matched control mice. All of the tissue samples were genotyped to determine the levels of heteroplasmy for the NZB and CAP^(R) mtDNA in each of the tissues. Equal levels of the NZB and “common” mtDNA were found in the six tissues analyzed from the NZB mtDNA-positive mice. The six tissues from the CAP^(R) chimera had varying levels of CAP^(R) mtDNA with the kidney and spleen having the highest amounts, 65% and 50% CAP^(R) mtDNA, respectively. The heart contained approximately 20% CAP^(R) mtDNA, while brain, liver, and muscle all contained between 5% and 10% CAP^(R) mtDNA. Analysis of the NZB-mtDNA tissue samples did not reveal any differentially expressed genes in the heart, liver, brain, and kidney. A scatter plot from the NZB heart is shown in FIG. 4. The scatter plots from the liver, brain, and kidney are virtually identical in that nearly every gene has an expression ratio of 1. Analysis of the NZB-mtDNA spleen and muscle showed several genes that were differentially expressed in the two tissues. The NZB-mtDNA muscle showed a 1.5 to 2.1-fold reduction in all mtDNA transcripts, pyruvate dehydrogenase was down 2.2-fold, and there was a general trend for nuclear-encoded OXPHOS subunits to be down-regulated 1.4 to 1.8-fold. The vesicular transport protein, pantophysin, was down-regulated 4-fold and the glycogenolysis rate-limiting enzyme, glycogen phosphorylase, was down 3-fold. There were not any genes that were significantly up-regulated in the muscle. A similar pattern of mtDNA-encoded gene expression was observed in the NZB-mtDNA spleen with all transcripts down 1.8 to 2-fold. However, there were no differences in nuclear OXPHOS subunit expression levels like that observed in the NZB-mtDNA skeletal muscle. In contrast to the NZB-mtDNA muscle, several genes were up-regulated in the spleen. In direct opposition to the results in the NZB cell line, both probes of the heme biosynthesis gene coproporphyrinogen oxidase III derected up-regulation 3-fold in the spleen. The integral membrane protein SURF 4 was up 2-fold and the amino acid metabolism gene 2-amino-3-ketobutyrate CoA ligase was up 4.8-fold. Glycogen phosphorylase, down 3-fold in the muscle, was up 4.8 fold in the spleen. The muscle and spleen results suggest that the polymorphisms between the NZB and “common” mtDNA may have a functional consequence in some tissues but not others. Analysis of the CAP^(R) tissue samples did not show any genes to be differentially expressed in the kidney, heart, muscle, liver, or spleen. The kidney, having the highest percentage of mutant mtDNAs, had expression ratios around 1 for nearly every gene. The two outliers on the kidney scatter plot that appear to be down-regulated can be explained by hybridization artifacts causing a high background in the control sample. The CAP^(R) brain sample was the only tissue that had any differentially expressed genes. Skd 3 was up-regulated 2.2-fold, glutathione peroxidase was up 2.4-fold and apoptosis-inhibitor 3 was up 2.4-fold. Although no genes were down-regulated in the brain more than 1.8-fold, closer analysis of the brain samples did reveal a trend that was not observed in any of the other tissues. Several nuclear-encoded OXPHOS subunits were down-regulated between 1.3 and 1.6-fold. These included five Complex I subunits, three Complex IV subunits and five Complex V subunits as well as VDAC 1 and 3. None of the Complex II and III subunits or mtDNA transcripts followed this trend. Principal component analysis of NZB and CAP^(R) mouse tissues, separately and together with the cell lines, was performed.

Example 18

Identification of Genes for Mitochondrial Arrays

Mice mutant in mitochondrial biology were used to identify genes involved in mitochondrial biology. Mice deficient in the heart/muscle isoform of the adenine nucleotide translocator (ANTI) exhibit many hallmarks of human oxidative phosphorylation (OXPHOS) disease, including dramatic proliferation of skeletal mitochondria. Samples were collected from the gastrocnemius muscle of ANTI and wild-type mice, reverse transcribed and differentially labeled, and hybridized with a mouse microarray chip (Mouse Unigene 1, Incyte Genomics Inc., Palo Alto, California) containing over 8000 sequence-verified cDNAs. Analysis of the hybridization results identified more than 150 differentially expressed genes. Gene sequences that were not previously recognized as being involved in mitochondrial biology were used to generate probes that were placed on the mouse array of Example 2. Homologous human gene sequences were used to generate probes that were placed on the human array of Example 1.

Example 19

Profile of Age-Related Changes in Chimpanzee Using Human Mitochondrial Array

Age-related changes in the mitochondrial biology expression profile in chimpanzees are determined using a human array of Example 1. Samples from young adult chimpanzee muscle and samples from most-mortem tissues of older chimps are reverse-transcribed, differentially labeled, and hybridized with a human array of Example 1.

Example 20

Profile of Putative Neutral Variant Mutant Mouse

The NZB cell line was profiled to examine the changes in mitochondrial gene expression resulting from a more neutral set of mtDNA polymorphisms. As mentioned previously, the NZB mtDNA contains 108 sequence differences compared to the “common” mouse mtDNA genotype found in LM(TK). While these differences were reported to be neutrally polymorphic (Jenuth et al., [1996] Nature Genetics 14:146-151; Meirelles and Smith [1997] Genetics 145:445451), the only evidence to support that hypothesis is that transgenic mice containing a high percentage of NZB mitochondria have no overt phenotypes (Levy, S. E., “Genetic Alteration of the Mouse Mitochondrial Genome and Effects on Gene Expression,” (2000) Ph.D. Thesis, Emory University; Jenuth et al. [1997] Nature Genetics 16:93-95; Meirelles and Smith [1998] Genetics 148:877-883). An NZB cybrid cell line was profiled on a mouse mitochondrial array. The scatter plot of gene expression ratios between the NZB cell line and the parental LM(TK)-(without GUP supplementation) shows that both probes of the fatty acid metabolism gene Acyl-CoA dehydrogenase (medium-chain) detected up-regulation 3.6-fold. Procollagen III and VI were up-regulated 6.2 and 6.8-fold, respectively. Two independent probes of the coproporphyrinogen oxidase III gene that is involved in heme biosynthesis detected down regulation 2.6 and 2.3-fold. Also down-regulated was the peripheral-type benzodiazepine receptor. This receptor has been implicated in a variety of mitochondrial functions including the regulation of mitochondrial protein import under conditions of oxidative stress, calcium homeostasis, and steroidogenesis (Culty, M. et al., “In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis,” [1999] J. Steroid Biochemistry & Molecular Biology 69:123-30; Wright, G., and Reichenbecher, V. “The effects of superoxide and the peripheral benzodiazepine receptor ligands on the mitochondrial processing of manganese-dependent superoxide dismutase,” [1999] Experimental Cell Research 246:443-50). The glycolytic genes glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate isomerase were up-regulated 1.7 and 2.1-fold, respectively. Glycolytic genes were also up-regulated in the NZB cell line. This indicates that the sequence polymorphisms between the NZB and “common” mtDNAs are not entirely neutral and cause changes in mitochondrial function when combined with the LM(TK)-nucleus. Thus, the NZB mtDNA does not appear to be completely interchangeable with the “common” mtDNA genome. An interesting group of genes that were up-regulated in the NZB cell line were the pro-inflammatory genes Caspase 1 and platelet activating factor (PAF) acetylhydrolase, the mitochondrial RNA polymerase, and glutathione peroxidase 3.

Example 21

Hierarchical Clustering of Cell Lines

Principal component analysis (PCA) and hierarchical clustering were performed on the cell line data (Examples 13-15 and 20) to group genes based on similarities in their expression patterns over all the samples. PCA analysis was used to reduce the dimensionality of the data by calculating three principal axes that encompass as much of the variability in all of the samples as possible. Each of the samples was then plotted on those axes in three-dimensional space. The PCA results revealed that the NZB cell line clustered away from the other cell lines, consistent with it having fewer differentially expressed genes in common with the other samples. The LMEB4 ρ0, 501-1 and LM(TK)-(GUP) cell lines all arrayed along one common principle axis, probably due to the commonality of a down-regulation of nuclear OXPHOS genes. However, they were divergent in the other two axes. The LM(TK)-(GUP) and NZB did share one axis, possibly due to a partial reduction in OXPHOS genes and a concomitant induction of glycolytic gene expression. However, both showed few differences when compared to the CAP R 501-1 and LMEB4 ρ0 samples. A hierarchical clustering algorithm was used to group genes with similar expression profiles across all of the samples. Both genes as well as samples were clustered together using a Euclidean distance measurement and average linkage. The clustering results revealed seven groups of genes with similar expression patterns in the cell line samples. Certain classes of genes were found to change together. Similar to the PCA analysis, the expression changes seen in the LM(TK)-(GUP) and NZB samples clustered closest together with the CAP R 501-1 and LMEB4 ρ0 samples branching successively further away. The Group 1 genes are involved in fatty acid metabolism. Group 2 genes, mainly down-regulated in the LM(TK)-(GUP) sample, include malate dehydrogenase, lactate dehydrogenase, glucose phosphate isomerase, and several amino acid metabolism genes. Group 3 genes are diverse clusters of genes that change in expression coordinately across the 5 samples. It includes some nuclear-encoded OXPHOS subunits, a few antioxidant and transport proteins as well as pyruvate kinase and a GTP-binding protein. Group 4 is a small, diverse cluster of genes mainly up-regulated in the CAP R 501-1 cell line. This group includes several of the same genes found to be up-regulated in the Ant1(−/−) mouse by differential display analysis (Murdock et al., 1999). Also in this group are two NADP-transhydrogenases, carbonate dehydratase and cytochrome b5 reductase. Group 5 is almost exclusively nuclear-encoded OXPHOS subunits. The voltage-dependent anion channel (VDAC) genes and several antioxidant proteins also cluster in this group. Group 6 is composed almost entirely of mtDNA-encoded transcripts. Group 7 is the heterogeneous group of genes that were up-regulated in each of the samples analyzed and included Caspase 1, PAF acetylhydrolase, the mitochondrial RNA polymerase, and glutathione peroxidase 3. Hierarchical clustering packages are available in the art, i.e. Expression Profiler (http://ep.ebi.ac.uk/EP/ from the European Bioinformatics Institute, Cambridge, UK). PCA is described in Bioinformatics 2001, volume 17, number 9, pages 763-774.

The following examples describe the preparation of a mitochondrial biology expression array, sample preparation, hybridization, scanning, and data normalization.

Example 22

PCR Amplification

PCR amplifications were performed with standard PCR techniques. Probes were made my amplifying clones using a universal primer set (Forward primer 5′-CTGCAAGGCG ATTAAGTTGGGTAAC-3′ Reverse primer 5′-GTGAGCGGATAACAATAATCAC ACAGGAAACAGC-3′) in a 100 μl PCR reaction containing PCR buffer (10 mM Tris, 1.5 mM MgC12, 50 mM KCl, pH8.3), 0.2 mM dNTPs, 0.2 mM each primer, 1.25 U Taq (Sigma, St Louis, Mo.). 0.5-1 μl of bacterial culture was added to each PCR reaction and thermal cycling was done as follows: 4 minutes at 94 C followed by 35 cycles of 15 seconds at 94 C, 30 seconds at 66 C and 1 minute 30 seconds at 72 C. Following cycling, reactions were held at 72 C for 4 minutes to complete all extension reactions. All PCR products were confirmed by agarose gel electrophoresis through a 1.5% gel. After satisfactory amplification, products were quantitated by UV 260/280 ratio and desiccated in a Savant Speed-Vac (Holbrook, N.Y.). Dried products were then resuspended in 3×SSC (450 mM NaCl, 40 mM sodium citrate) at a concentration of 400-600 ng/μl for arraying.

Example 23

Slide Preparation

Before arraying probes, the glass microscope slides for the arrays were coated with poly-Lysine to provide a substrate for DNA binding. Standard glass microscope slides (Gold Seal, Beckton-Dickson, Franklin Lakes, N.J.) were cleaned in a solution of 2.5 M NaOH, 60% ethanol for two hours. After cleaning, slides were rinsed five times in fresh water. The slides were then soaked in a solution of 0.01 % poly-L-lysine, .01× PBS for 1 hour followed by rinsing in fresh water. After rinsing, the slides were dried in a vacuum oven at 45° C. for 15 minutes.

Example 24

Printing

Arrays were printed onto poly-L-lysine coated glass slides using the GMS 417 Arrayer (Affymetrix/Genetic Microsystems, Woburn, Mass.). The arrays were printed using a 4-pin print head with a spot size of 150 μm (approximately 33 μpL of volume per spot) and a center-to-center spot spacing of 375 μm. A humidity level of 65-70% was maintained during the printing of the arrays by a custom humidifier system. After printing, the arrays were allowed to dry for 1 hour at room temperature. The arrays were then processed by rehydrating over a warm solution of 1×SSC for 5 minutes followed by rapid drying on a 95° C. heat block. Following drying, the DNA was crosslinked to the slide by exposing the arrays to 65 mJ of ultraviolet energy (Stratalinker, Stratagene, La Jolla, Calif.). To block non-specific interactions on the arrays during hybridization, the slides were then treated with a solution of 60 mM succinic anhydride and 40 mM sodium borate in 1-methyl-2-pyrrolidinone for 15 minutes at room temperature. The arrays were then denatured in 95° C. water for 2 minutes and dehydrated by rapid immersion in 95% ethanol. The arrays were then dried by centrifugation at 20 ×g for 5 minutes.

Example 25

Sample Preparation

Total RNA preparations were performed using the TRizol reagent (Life Technologies, Gaithersburg, Md.) as per the manufacture's directions. For cell culture samples, a 90% confluent 225ml flask was lysed directly in the flask with 18 ml of TRIzol. At least three flasks were pooled for each cell line to reduce any variability caused by culture conditions. For each mouse tissue, RNA was isolated from approximately 500 mg of tissue that was mechanically homogenized. in 6ml of TRizol. Following the isolation of total RNA, poly-A+ MRNA was isolated using Qiagen Oligotex (Valencia, Calif.) as per the manufacture's directions.

Example 26

Reverse Translation Labeling, and Hybridization

To produce targets for hybridization to the MitoChip arrays, 2 μg of poly-A+ RNA was labeled with fluorescent nucleotides by reverse transcription. The poly-A+ RNA was mixed with 3 mg of anchored oligo-dT and incubated at 70° C. for 10 minutes followed by 10 minutes on ice. The denatured and annealed RNA was then reverse transcribed in a 30 μl reaction mix containing reaction buffer (50 mM Tris-HCl, 75 mM KCl, 3 mM MgC12 pH 8.3), 10 mM dithio-threatol, 500 μM dATP,dGTP,dTTP, 300 μM dCTP, 20 U SuperScript reverse transcriptase (Life Technologies, Gaithersburg, Md.) and 100 μM of either Cy5-dCTP (control samples) or Cy3-dCTP (experimental samples). The reactions were incubated at 42° C. for 2 hours. Following incubation, 15 μl of 0.1 M NaOH was added to degrade the remaining template RNA and the sample incubated at 70° C. for 10 minutes. The reaction was neutralized by the addition of 15 μl of 0.1 M HCl followed by 440 μl of TE buffer (10 mM Tris, 1 mM EDTA, pH 7.4). The synthesized cDNA was purified by size-exclusion filtration using Microcon YM-3 centrifugal filter devices (Millipore, Bedford, Mass.). After purification, 10 μg of poly-A RNA (Sigma, St Louis, Mo.) and 10 μg of yeast transfer RNA (tRNA) (Life Technologies, Gaithersburg, Md.) was added. The final sample volume was adjusted to 12 μl and 525 mM NaCl, 52.5 mM sodium citrate, 0.25% SDS. The sample was denatured at 100° C. for 2 minutes and added to the array. The sample and the array were hybridized under high stringency hybridization conditions. The sample and array were covered by a 22 mm×22 mm coverslip and placed in a humidified hybridization chamber (Corning, Acton, Mass.) and incubated at 65° C. for 12-16 hours. Following hybridization, the arrays were washed with successive 5-minute washes in 2×SSC, 0.1%SDS; 1×SSC; and 0.1×SSC. After the final wash, the arrays were dried by centrifugation at 20×g and scanned using the GMS 418 Array Scanner (Affymetrix/Genetic Microsystems, Woburn, Mass.).

Example 27

Array Scanning and Data Analyses

Scanned arrays were saved as 16-bit TIFF files and analyzed using Biodiscovery's Imagene software (Los Angeles, Calif.). Data mining and clustering analysis was performed using Biodiscovery's GeneSight software. Prior to data analysis, all cell culture samples were normalized using all spots on the array. All mouse tissue samples were normalized to the housekeeping genes on the mouse array. Local background was calculated for each individual spot and any spot with a signal intensity less than 3 times over background or that had poor morphology was excluded from the data analyses. Only differential expression values of greater than 1.7 were considered significant. All data mining and clustering analysis performed using GeneSight was on expression ratio data that was transformed by taking the natural log (ln) of all values and normalized by Z-score. The data is transformed because of the non-Gaussian distribution of the expression ratio values. Because the ratios are bounded on the lower limit by zero, a non-Gaussian distribution is normally observed. To allow for additional statistical manipulations, the data was transformed for a more uniform distribution. The Z-score normalization method involved subtracting the mean from every observation and dividing by its standard deviation, effectively normalizing each spot to all other spots on the array.

Example 28

Sample Hybridization to Mitochondrial Array

Control cDNA samples were prepared from mRNA isolated from the LM(TK)-cell line and labeled with the CyS dye. Each experimental MRNA sample was labeled with the Cy3 dye, combined with the Cy5 control sample and the mixture used to hybridize the array. A representative image of a hybridized array is shown in FIG. 2. Any spot on an array that appeared red was due to hybridization of a large proportion of the CyS-labeled control LM(TK)-sample and any sample that was green was due to the hybridization of a large proportion of the Cy3-labeled experimental sample. Any spot that is yellow is an about equal co-hybridization of the two targets. The fluorescence ratio was quantitated for each spot, permitting calculation of the relative abundance of each gene's MRNA in the two samples.

Example 29

Normalization

The two fluorescent dyes that were used to label the cDNA produced during the reverse transcription of the MRNA have different structures and different emission maxima. Therefore, the two images that represent the hybridization of each of the fluorescently labeled samples were normalized to each other to account for the differences in dye behavior prior to calculating the expression ratios between the two images. One image was normalized to the other by averaging all of the spots in each image to derive a constant that was then applied to each spot. Alternatively, a predetermined set of genes that were expressed equally in the two samples under all conditions could have been used. The expression ratios of these genes were used to calculate a constant that was then applied to all spots on the array. A set of 25 housekeeping genes in Table 2 was included on a mouse array for normalization and both of these methods were used in the analysis of the mouse cell line and tissue samples. Housekeeping gene expression in the cultured cells was much more variable than in the tissue samples. Because of the variability in the housekeeping gene expression patterns in the cell line samples, normalization was done using all of the spots on the array. The expression of the housekeeping genes was much more consistent in the tissue samples and normalization using either the housekeeping genes or the average of all of the genes gave similar results.

Example 30

Clones useful for making control probes for the arrays of this invention are listed in

Table 6. Sequences of the genes useful for making the control probes are provided in the sequence listings hereof. TABLE 6 SEQ GenBank ID NO. Gene Name Complete Gene Name Accession No. 3041 Beta Actin Human beta actin X63432 3042 Plant control CAB Arabidopsis photosystem X56062 I chlorophyll a/b binding protein 3043 Plant control rbcL Arabidopsis ribulose-1,5- U91966 bisphosphate carboxylase/oxygenase large subunit 3044 Plant control Arabidopsis RUBISCO X14212 RUBISCO activase

It will be appreciated by those of ordinary skill in the art that samples, sample collection techniques, sample preparation techniques, probes, probe generation techniques, genes involved in mitochondrial biology, hybridization techniques, array printing techniques, physiological conditions, cell lines, mutant strains, organisms, tissues, solid substrates, and methods of data analyses other than those specifically disclosed herein are available in the art and can be employed in the practice of this invention. All art-known functional equivalents are intended to be encompassed within the scope of this invention.

REFERENCE TO SEQUENCE LISTINGS

Tables 3-5 list sequence information on the clones that are useful for making probes for practicing the methods of this invention. Clone identification numbers are usually from NIA (National Institutes of Aging, National Institutes of Health, Bethesda, Md., USA), ResGen Invitrogen (Carlsband, Calif., USA) or IMAGE Consortium, LLNL (Livermore, Calif., USA). Gene names and descriptions are provided for the gene interrogated by a probe made from the corresponding clone. GenBank Accession Number and Unigene Cluster ID are provided where available. The functions of certain genes are included in Table 4. Sequences of the 5′ and 3′ ends of the clones listed in Tables 34 are provided when available. If no 5′ or 3′ sequence was available, gene sequence from the GenBank Accession No. provided for that clone is listed in some cases. The GenBank sequence may be larger than the sequence of the clone. The instant invention may be practiced without the sequence information provided herein using the clones or GenBank listings. Other sequences derived from the genes interrogated by probes generated from clones listed in Tables 3-5 are useful for making equivalent probes using information known in the art, i.e., unique segments of such genes may be used.

The sequence listings that correspond to the clones listed in Table 3, covering human probes SEQ ID NOS: 1-994, contain information including: the sequence identification number; a GenBank Accession No. corresponding to the listed sequence or the gene interrogated by the probe containing the listed sequence; another GenBank Accession No. in parentheses which is associated with the listed sequence in Table 3; a Research Genetics (ResGen Invitrogen, Carlsbad, Calif., USA) Clone ID No. identifying the clone from which the sequence was derived; the name of the gene from which the clone was derived; a description of the gene; the Unigene Cluster ID No. of the gene; the IMAGE Clone ID No., which is often the same as the ResGen Clone ID No., and information in parentheses identifying the sequence as 5′ or 3′ of the clone; the length of the insert of the clone; the source of the clone; the type of clone, such as cDNA; and the nucleic acid sequence.

Sequence listings for control probes are provided as SEQ ID NOS:3041-3044.

The sequence listings that correspond to the clones listed in Table 4, covering mouse probes SEQ ID NOS:995-3040, contain information including: the sequence identification number; a GenBank Accession No. corresponding to the listed sequence; the 5′ and/or 3′ sequence of the corresponding clone, or the gene from which the corresponding clone was derived; the name and description of the gene from which the corresponding clone was derived; the Unigene Cluster ID No. of the gene from which the corresponding clone was derived; the name of the clone from which the instant sequence was derived; additional description of the gene; a set of titles usually including Clone Name, Rearray Sequence, Parent Sequence, Other EST, and Blast Link; a list of names including, in order of the above-mentioned titles, the name of the clone from which the sequence was derived, the name of the sequence with a suffix identifying it as the 5′ (−5) or 3′ (−3) sequence of the clone, the name of the parent sequence, and the name of another EST (expressed sequence tag), if it exists, which would be the other of the 3′ or 5′ sequence; the length of the sequence provided; and the nucleic acid sequence. 

1. An array comprising at least two isolated nucleotide molecules, each molecule having a sequence capable of uniquely hybridizing to a nucleic acid molecule which is an expression product of a gene involved in mitochondrial biology.
 2. An array comprising two or more isolated nucleic acid molecules or spots, each spot comprising a plurality of isolated nucleic acid molecules, each molecule having a sequence consisting essentially of a sequence selected from the group consisting of the sequences of human probe set #1, SEQ ID NOS: 1 to 994, or mouse probe set #2, SEQ ID NOS: 995 to 3040, and sequences having at least 70% homology to the foregoing sequences.
 3. The array of claim 2 printed on a glass slide.
 4. The array of claim 2 comprising more than about ten spots.
 5. The array of claim 2 comprising more than about twenty-five spots.
 6. The array of claim 2 comprising all of the isolated nucleic acid molecules having the sequences of human probe set #1, SEQ ID NOS: 1 to
 994. 7. The array of claim 2 comprising all of the isolated nucleic acid molecules having the sequences of mouse probe set #2, SEQ ID NOS: 995 to
 3040. 8. The array of claim 2 also comprising one or more spots comprising control nucleic acid molecules, SEQ ID NOS:3041-3044.
 9. A method for determining an expression profile of a sample containing nucleic acid comprising: a) providing the sample; b) providing an array of claim 2; c) contacting said array with said sample under conditions allowing selective hybridization; and d) measuring hybridization of nucleic acid in said sample to said array to produce an expression profile.
 10. The method of claim 9 wherein said sample is from a mouse or a human.
 11. A method for determining an expression profile of a first labeled sample containing nucleic acid relative to a second, differently labled sample containing nucleic acid comprising: a) providing the first labeled sample; b) providing the second, differently labeled sample; c) providing an array of claim 2; d) contacting the array with the first sample and the second sample under conditions allowing selective hybridization; e) measuring hybridization of said first and said second samples to said array; and f) comparing the hybridization of said first sample to the hybridization of said second sample to produce an expression profile.
 12. The method of claim 11 wherein said second sample is a reference or a standard.
 13. A method for determining an expression profile diagnostic of an energy-metabolism-related physiological condition comprising: a) providing a labeled first sample from a first group of one or more individuals with said physiological condition; b) providing a differently labeled second sample from a second group of one or more individuals without said physiological condition; c) providing an array of claim 2; d) contacting the array with the first sample and the said second sample under conditions allowing selective hybridization; e) measuring hybridization of said first and said second samples to said array; and f) comparing the hybridization of said first sample to the hybridization of said second sample to produce an expression profile diagnostic of said physiological condition.
 14. A method of making an array comprising: a) providing a prepared substrate; and b) printing two or more spots in known positions on said substrate, each spot comprising a plurality of isolated nucleic acid molecules, each molecule having a sequence consisting essentially of a sequence selected from the group consisting of human probe set #1, SEQ ID NOS: 1 to 994, mouse probe set #2, SEQ ID NOS: 995 to 3040, and sequences having at least 70% homology to the foregoing sequences.
 15. The method of claim 14 wherein said array comprises all of said isolated nucleic acid molecules in human probe set #1, SEQ ID NOS: 1 to
 994. 16. The method of claim 14 wherein said array comprises all of said isolated nucleic acid molecules in mouse probe set #2, SEQ ID NOS: 995 to
 3040. 17. A method of diagnosing a first individual with Complex IV Leigh's Syndrome comprising detecting in a first sample from said first individual at least about a 1.7-fold decrease in the amount of expression of genes comprising ND4, NDL4, ND6, SURF-1, SOD2, 70 kD heat shock protein, VDAC4, ANT2, and glutathione peroxidase 3 compared to the amount of expression of said genes in a second sample from a second individual without Complex IV Leigh's Syndrome.
 18. A library of at least two isolated nucleic acid molecules, each molecule having a sequence consisting essentially of a sequence selected from the group consisting of human probe set #1, SEQ ID NOS: 1 to 994, mouse probe set #2, SEQ ID NOS: 995 to 3040, and sequences having at least 70% homology to the foregoing sequences.
 19. An array comprising at least two spots, each spot comprising a plurality of isolated nucleic acid molecules, each molecule comprising a sequence with at least 70% homology to a sequence selected from the group consisting of human probe set #1, SEQ ID NOS: 1 to
 994. 20. An array comprising at least two spots, each spot comprising a plurality of isolated nucleic acid molecules, each molecule comprising a sequence with at least 70% homology to a sequence selected from the group consisting of mouse probe set #2, SEQ ID NOS: 995 to
 3040. 